HU186304B - Process for producing pename-sulfoxide-derivatives - Google Patents
Process for producing pename-sulfoxide-derivatives Download PDFInfo
- Publication number
- HU186304B HU186304B HU80479A HU47980A HU186304B HU 186304 B HU186304 B HU 186304B HU 80479 A HU80479 A HU 80479A HU 47980 A HU47980 A HU 47980A HU 186304 B HU186304 B HU 186304B
- Authority
- HU
- Hungary
- Prior art keywords
- dioxide
- penicillanate
- acid
- solution
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Die Erfindung betrifft ein Verfahren zur Herstellung von Penicillansaeure-1,1-dioxid und dessen Estern fuer die Anwendung als Arzneimittel. Ziel der Erfindung ist ein verbessertes Verfahren, mit dem die Produktausbeute erhoeht wird. Erfindungsgemaesz werden Verbindungen der Formel I, oder deren pharmazeutisch annehmbaren Basensalze, worin R&exp1! Wasserstoff oder ein esterbildender, in vivo leicht hydrolysierbarer Rest ist, in der Weise hergestellt, dasz eine Verbindung der Formel II oder deren Basensalze, worin R Wasserstoff, ein esterbildender, in vivo leicht hydrolysierbarer Rest oder eine herkoemmliche Penicillincarboxy-Schutzgruppe ist und X u. Y jeweils Wasserstoff, Chlor, Brom oder Jod sind, mit der Maszgabe, dasz, wenn X und Y beide die gleiche Bedeutung haben, sie beide Brom sein muessen, dehalogeniert wird und, wenn noetig, die herkoemmliche Penicillincarboxy-Schutzgruppe abgespalten wird.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1780879A | 1979-03-05 | 1979-03-05 | |
US1781079A | 1979-03-05 | 1979-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
HU186304B true HU186304B (en) | 1985-07-29 |
Family
ID=26690337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU80479A HU186304B (en) | 1979-03-05 | 1980-02-29 | Process for producing pename-sulfoxide-derivatives |
Country Status (36)
Country | Link |
---|---|
KR (1) | KR850001339B1 (de) |
AR (1) | AR225031A1 (de) |
AT (1) | AT366693B (de) |
AU (1) | AU522572B2 (de) |
BG (1) | BG33292A3 (de) |
CH (1) | CH644608A5 (de) |
CS (1) | CS215130B2 (de) |
DD (1) | DD149367A5 (de) |
DE (1) | DE3008257C2 (de) |
DK (2) | DK159852C (de) |
EG (1) | EG14437A (de) |
ES (1) | ES489185A0 (de) |
FI (1) | FI70024C (de) |
FR (1) | FR2450836B1 (de) |
GB (1) | GB2045755B (de) |
GR (1) | GR67234B (de) |
HK (1) | HK66587A (de) |
HU (1) | HU186304B (de) |
IE (1) | IE49535B1 (de) |
IL (1) | IL59515A (de) |
IN (1) | IN153685B (de) |
IT (1) | IT1130300B (de) |
KE (1) | KE3464A (de) |
LU (1) | LU82215A1 (de) |
MX (1) | MX6032E (de) |
MY (1) | MY8500319A (de) |
NL (1) | NL180317C (de) |
NO (2) | NO800618L (de) |
PL (1) | PL125197B1 (de) |
PT (1) | PT70897A (de) |
RO (1) | RO80112A (de) |
SE (2) | SE449103B (de) |
SG (1) | SG55884G (de) |
SU (1) | SU1192626A3 (de) |
UA (1) | UA6342A1 (de) |
YU (1) | YU42328B (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN159362B (de) * | 1981-03-23 | 1987-05-09 | Pfizer | |
US4419284A (en) * | 1981-03-23 | 1983-12-06 | Pfizer Inc. | Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide |
PT76527B (en) * | 1982-04-19 | 1985-12-09 | Gist Brocades Nv | A process for the preparation of penicillanic acid 1,1-dioxide and derivatives thereof |
IT1190897B (it) * | 1982-06-29 | 1988-02-24 | Opos Biochimica Srl | Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico |
US4606865A (en) * | 1982-09-20 | 1986-08-19 | Astra Lakemedel Aktiebolag | Methods for the preparation of α-bromodiethylcarbonate |
EP0139047A1 (de) * | 1983-10-18 | 1985-05-02 | Gist-Brocades N.V. | Verfahren zur Herstellung von 6,6-Dibromopenicillansäure-1,1-Dioxyd |
EP0139048A1 (de) * | 1983-10-18 | 1985-05-02 | Gist-Brocades N.V. | Verfahren zur Dehalogenierung von 6,6-Dibromopenicillansäure-1,1-Dioxyd |
US4596677A (en) * | 1984-04-06 | 1986-06-24 | Bristol-Myers Company | Anhydropenicillin intermediates |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN149747B (de) * | 1977-06-07 | 1982-04-03 | Pfizer | |
CA1158639A (en) * | 1978-12-11 | 1983-12-13 | Eric M. Gordon | 6-bromopenicillanic acid sulfone |
DE3068390D1 (en) * | 1979-01-10 | 1984-08-09 | Beecham Group Plc | Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds |
IE49880B1 (en) * | 1979-02-13 | 1986-01-08 | Leo Pharm Prod Ltd | Penicillin derivatives |
-
1980
- 1980-01-22 SE SE8000512A patent/SE449103B/sv not_active IP Right Cessation
- 1980-02-11 IN IN98/DEL/80A patent/IN153685B/en unknown
- 1980-02-27 SU SU802889601A patent/SU1192626A3/ru active
- 1980-02-27 UA UA2889601A patent/UA6342A1/uk unknown
- 1980-02-29 HU HU80479A patent/HU186304B/hu unknown
- 1980-03-03 YU YU585/80A patent/YU42328B/xx unknown
- 1980-03-03 GB GB8007122A patent/GB2045755B/en not_active Expired
- 1980-03-03 AR AR280148A patent/AR225031A1/es active
- 1980-03-03 IL IL59515A patent/IL59515A/xx unknown
- 1980-03-03 LU LU82215A patent/LU82215A1/fr unknown
- 1980-03-04 NL NLAANVRAGE8001285,A patent/NL180317C/xx not_active IP Right Cessation
- 1980-03-04 NO NO800618A patent/NO800618L/no unknown
- 1980-03-04 DD DD80219432A patent/DD149367A5/de unknown
- 1980-03-04 AU AU56104/80A patent/AU522572B2/en not_active Expired
- 1980-03-04 EG EG123/80A patent/EG14437A/xx active
- 1980-03-04 PL PL1980222448A patent/PL125197B1/pl unknown
- 1980-03-04 CS CS801496A patent/CS215130B2/cs unknown
- 1980-03-04 ES ES489185A patent/ES489185A0/es active Granted
- 1980-03-04 AT AT0119080A patent/AT366693B/de not_active IP Right Cessation
- 1980-03-04 RO RO80100366A patent/RO80112A/ro unknown
- 1980-03-04 IE IE429/80A patent/IE49535B1/en not_active IP Right Cessation
- 1980-03-04 PT PT70897A patent/PT70897A/pt unknown
- 1980-03-04 KR KR1019800000885A patent/KR850001339B1/ko active
- 1980-03-04 DE DE3008257A patent/DE3008257C2/de not_active Expired
- 1980-03-04 GR GR61347A patent/GR67234B/el unknown
- 1980-03-04 CH CH171080A patent/CH644608A5/de not_active IP Right Cessation
- 1980-03-04 DK DK092680A patent/DK159852C/da not_active IP Right Cessation
- 1980-03-04 FR FR8004764A patent/FR2450836B1/fr not_active Expired
- 1980-03-04 FI FI800661A patent/FI70024C/fi not_active IP Right Cessation
- 1980-03-05 BG BG8046874A patent/BG33292A3/xx unknown
- 1980-03-05 MX MX808687U patent/MX6032E/es unknown
- 1980-03-05 IT IT20367/80A patent/IT1130300B/it active
-
1982
- 1982-09-15 NO NO823127A patent/NO823127L/no unknown
-
1984
- 1984-08-13 SG SG558/84A patent/SG55884G/en unknown
- 1984-09-24 KE KE3464A patent/KE3464A/xx unknown
-
1985
- 1985-12-30 MY MY319/85A patent/MY8500319A/xx unknown
-
1986
- 1986-08-04 SE SE8603309A patent/SE8603309D0/xx not_active Application Discontinuation
-
1987
- 1987-09-17 HK HK665/87A patent/HK66587A/xx not_active IP Right Cessation
-
1990
- 1990-06-14 DK DK145690A patent/DK166353C/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HU90 | Patent valid on 900628 |