HRP990116B1 - NOVEL 8a AND 9a- 15-MEMBERED LACTAMES - Google Patents

NOVEL 8a AND 9a- 15-MEMBERED LACTAMES

Info

Publication number: HRP990116B1
Authority: HR; Croatia
Prior art keywords: meaning; alkyl; group; hydrogen; ketone
Prior art date: 1999-04-20

Application number

HR990116A

Other languages

English (en)

Croatian (hr)

Inventor

Lazarevski Gorjana

Alihod�i� Sulejman

Kobrehel Gabrijela

Mutak Stjepan

Original Assignee

GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-20

Filing date

1999-04-20

Publication date

2007-10-31

1999-04-20 Application filed by GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. filed Critical GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.

1999-04-20 Priority to HR990116A priority Critical patent/HRP990116B1/xx

2000-04-19 Priority to TR2001/03019T priority patent/TR200103019T2/xx

2000-04-19 Priority to NZ515279A priority patent/NZ515279A/xx

2000-04-19 Priority to KR1020017013433A priority patent/KR20020007379A/ko

2000-04-19 Priority to AT00920937T priority patent/ATE333461T1/de

2000-04-19 Priority to EP00920937A priority patent/EP1181298B1/en

2000-04-19 Priority to CNB008078238A priority patent/CN1246327C/zh

2000-04-19 Priority to BR0009943-0A priority patent/BR0009943A/pt

2000-04-19 Priority to EA200101103A priority patent/EA003928B1/ru

2000-04-19 Priority to UA2001117855A priority patent/UA72246C2/uk

2000-04-19 Priority to PCT/HR2000/000009 priority patent/WO2000063223A1/en

2000-04-19 Priority to AU41347/00A priority patent/AU772272B2/en

2000-04-19 Priority to DK00920937T priority patent/DK1181298T3/da

2000-04-19 Priority to CZ20013730A priority patent/CZ20013730A3/cs

2000-04-19 Priority to PL00351523A priority patent/PL351523A1/xx

2000-04-19 Priority to PT00920937T priority patent/PT1181298E/pt

2000-04-19 Priority to HU0200868A priority patent/HUP0200868A3/hu

2000-04-19 Priority to DE60029439T priority patent/DE60029439T2/de

2000-04-19 Priority to CA002370273A priority patent/CA2370273A1/en

2000-04-19 Priority to MXPA01010627A priority patent/MXPA01010627A/es

2000-04-19 Priority to SK1494-2001A priority patent/SK14942001A3/sk

2000-04-19 Priority to EEP200100544A priority patent/EE04553B1/xx

2000-04-19 Priority to ES00920937T priority patent/ES2267519T3/es

2000-04-19 Priority to SI200030881T priority patent/SI1181298T1/sl

2000-04-19 Priority to US09/959,204 priority patent/US6593360B1/en

2000-04-19 Priority to IL14599000A priority patent/IL145990A0/xx

2000-04-19 Priority to JP2000612313A priority patent/JP2002542254A/ja

2000-04-19 Priority to GEAP20006202A priority patent/GEP20032929B/en

2000-04-24 Priority to ARP000101906A priority patent/AR028823A1/es

2001-10-16 Priority to IS6110A priority patent/IS6110A/is

2001-10-16 Priority to ZA200108481A priority patent/ZA200108481B/xx

2001-10-18 Priority to NO20015068A priority patent/NO320704B1/no

2001-10-31 Publication of HRP990116A2 publication Critical patent/HRP990116A2/hr

2001-11-20 Priority to BG106117A priority patent/BG65281B1/bg

2003-01-23 Priority to HK03100592.9A priority patent/HK1049842B/zh

2007-10-31 Publication of HRP990116B1 publication Critical patent/HRP990116B1/xx

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
150000002576 ketones Chemical class 0.000 abstract 5
229910052757 nitrogen Inorganic materials 0.000 abstract 4
229910052760 oxygen Inorganic materials 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000004429 atom Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052717 sulfur Inorganic materials 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
229960002626 clarithromycin Drugs 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000004677 hydrates Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000565 sulfonamide group Chemical group 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Hydrogenated Pyridines (AREA)
Steroid Compounds (AREA)

HR990116A 1999-04-20 1999-04-20 NOVEL 8a AND 9a- 15-MEMBERED LACTAMES HRP990116B1 (en)

Priority Applications (34)

Application Number	Priority Date	Filing Date	Title
HR990116A HRP990116B1 (en)	1999-04-20	1999-04-20	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
DE60029439T DE60029439T2 (de)	1999-04-20	2000-04-19	Neue 8a- und 9a-lactame mit 15 ringatomen
CA002370273A CA2370273A1 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
KR1020017013433A KR20020007379A (ko)	1999-04-20	2000-04-19	신규 ８ａ 및 ９ａ-15-원 락탐
NZ515279A NZ515279A (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
EP00920937A EP1181298B1 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
MXPA01010627A MXPA01010627A (es)	1999-04-20	2000-04-19	Nuevas 8a y 9a lactamas de 15 miembros.
BR0009943-0A BR0009943A (pt)	1999-04-20	2000-04-19	8a- e 9a lactamas de 15 elementos
EA200101103A EA003928B1 (ru)	1999-04-20	2000-04-19	НОВЫЕ 15-ЧЛЕННЫЕ 8а- И 9а- ЛАКТАМЫ
UA2001117855A UA72246C2 (uk)	1999-04-20	2000-04-19	15-ЧЛЕННІ 8а- ТА 9а-ЛАКТАМИ З КЛАСУ 6-О-МЕТИЛЕРИТРОМІЦИНУ А, СПОСІБ ЇХ ОДЕРЖАННЯ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ТА СПОСІБ ЛІКУВАННЯ БАКТЕРІАЛЬНИХ ІНФЕКЦІЙ
PCT/HR2000/000009 WO2000063223A1 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
AU41347/00A AU772272B2 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
DK00920937T DK1181298T3 (da)	1999-04-20	2000-04-19	Hidtil ukendte 15-leddede 8a- og 9a-lactamer
CZ20013730A CZ20013730A3 (cs)	1999-04-20	2000-04-19	Nové 15tičlenné 8a-A 9a-laktamy
PL00351523A PL351523A1 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams
PT00920937T PT1181298E (pt)	1999-04-20	2000-04-19	Novas 8a-e 9a-lactamas de 15 membros.
HU0200868A HUP0200868A3 (en)	1999-04-20	2000-04-19	Novel 8a- and 9a-15-membered lactams, process for their preparation, pharmaceutical compositions containing them and their use
TR2001/03019T TR200103019T2 (tr)	1999-04-20	2000-04-19	Yeni 8A-ve 9A-15-elemanlı laktamlar
AT00920937T ATE333461T1 (de)	1999-04-20	2000-04-19	Neue 8a- und 9a-lactame mit 15 ringatomen
CNB008078238A CN1246327C (zh)	1999-04-20	2000-04-19	新型8a－和9a－15－元内酰胺
SK1494-2001A SK14942001A3 (sk)	1999-04-20	2000-04-19	15-Členné 8a- a 9a-laktámy
EEP200100544A EE04553B1 (et)	1999-04-20	2000-04-19	15-llilised 8a- ja 9a-laktaamid ning nende valmistamismeetod
ES00920937T ES2267519T3 (es)	1999-04-20	2000-04-19	Nuevas 8a- y9a-lactamas de 15 miembros en su anillo.
SI200030881T SI1181298T1 (sl)	1999-04-20	2000-04-19	Novi 8a- in 9a-15-clenski laktami
US09/959,204 US6593360B1 (en)	1999-04-20	2000-04-19	8a- and 9a-15-membered lactams
IL14599000A IL145990A0 (en)	1999-04-20	2000-04-19	Novel 8a-and 9a-15-membered lactams
JP2000612313A JP2002542254A (ja)	1999-04-20	2000-04-19	新規な８ａ−及び９ａ−１５員ラクタム類
GEAP20006202A GEP20032929B (en)	1999-04-20	2000-04-19	6-O-Methyl-Erythromycin A Class, Novel 8a-and 9a-15-Membered Lactams, Method for Their Production and Pharmaceutical Composition for Treatment of Bacterial Infections
ARP000101906A AR028823A1 (es)	1999-04-20	2000-04-24	8a y 9a lactamas de 15 miembros de la clase 6-o-metil-eritromicina a, un procedimiento para su preparacion y una composicion farmaceutica util para el tratamiento de infecciones bacterianas en seres humanos y animales
IS6110A IS6110A (is)	1999-04-20	2001-10-16	Ný 8a- og 9a-15-atóma laktöm
ZA200108481A ZA200108481B (en)	1999-04-20	2001-10-16	8A- and 9A-15-membered lactams.
NO20015068A NO320704B1 (no)	1999-04-20	2001-10-18	Nye 8A- og 9A-15-ringlaktamer, anvendelse og fremgangsmate for fremstilling derav, samt farmasoytisk preparat.
BG106117A BG65281B1 (bg)	1999-04-20	2001-11-20	8а- и 9а-15-членни лактами
HK03100592.9A HK1049842B (zh)	1999-04-20	2003-01-23	新型8a-和9a-15-元內酰胺

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR990116A HRP990116B1 (en)	1999-04-20	1999-04-20	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES

Publications (2)

Publication Number	Publication Date
HRP990116A2 HRP990116A2 (en)	2001-10-31
HRP990116B1 true HRP990116B1 (en)	2007-10-31

Family

ID=10946907

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR990116A HRP990116B1 (en)	1999-04-20	1999-04-20	NOVEL 8a AND 9a- 15-MEMBERED LACTAMES

Country Status (33)

Country	Link
US (1)	US6593360B1 (no)
EP (1)	EP1181298B1 (no)
JP (1)	JP2002542254A (no)
KR (1)	KR20020007379A (no)
CN (1)	CN1246327C (no)
AR (1)	AR028823A1 (no)
AT (1)	ATE333461T1 (no)
AU (1)	AU772272B2 (no)
BG (1)	BG65281B1 (no)
BR (1)	BR0009943A (no)
CA (1)	CA2370273A1 (no)
CZ (1)	CZ20013730A3 (no)
DE (1)	DE60029439T2 (no)
DK (1)	DK1181298T3 (no)
EA (1)	EA003928B1 (no)
EE (1)	EE04553B1 (no)
ES (1)	ES2267519T3 (no)
GE (1)	GEP20032929B (no)
HK (1)	HK1049842B (no)
HR (1)	HRP990116B1 (no)
HU (1)	HUP0200868A3 (no)
IL (1)	IL145990A0 (no)
IS (1)	IS6110A (no)
MX (1)	MXPA01010627A (no)
NO (1)	NO320704B1 (no)
NZ (1)	NZ515279A (no)
PL (1)	PL351523A1 (no)
PT (1)	PT1181298E (no)
SK (1)	SK14942001A3 (no)
TR (1)	TR200103019T2 (no)
UA (1)	UA72246C2 (no)
WO (1)	WO2000063223A1 (no)
ZA (1)	ZA200108481B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0025688D0 (en)	2000-10-19	2000-12-06	Glaxo Group Ltd	Macrolides
HRP20020779A2 (en)	2002-09-27	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) *	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
EP1879903A1 (en)	2005-05-10	2008-01-23	GlaxoSmithKline istrazivacki centar Zagreb d.o.o.	Ether linked macrolides useful for the treatment of microbial infections
EP2988597B1 (en)	2013-04-04	2022-06-08	President and Fellows of Harvard College	Macrolides and methods of their preparation and use
JP2017531663A (ja)	2014-10-08	2017-10-26	プレジデントアンドフェローズオブハーバードカレッジ	１４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en)	2015-03-25	2016-09-29	President And Fellows Of Harvard College	Macrolides with modified desosamine sugars and uses thereof
GB201608236D0 (en)	2016-05-11	2016-06-22	Fidelta D O O	Seco macrolide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI7910768A8 (en) *	1979-04-02	1996-06-30	Pliva Pharm & Chem Works	Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI9011409A (en) *	1990-07-18	1995-10-31	Pliva Pharm & Chem Works	O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
WO1997042204A1 (en) *	1996-05-07	1997-11-13	Abbott Laboratories	6-o-substituted erythromycins and method for making them
AU1082599A (en) *	1997-10-16	1999-05-03	Merck & Co., Inc.	8a-azalides, compositions containing such compounds and methods of treatment
HRP980189B1 (en) *	1998-04-06	2004-04-30	Pliva Pharm & Chem Works	Novel 15-membered lactams ketolides

1999
- 1999-04-20 HR HR990116A patent/HRP990116B1/xx not_active IP Right Cessation
2000
- 2000-04-19 UA UA2001117855A patent/UA72246C2/uk unknown
- 2000-04-19 TR TR2001/03019T patent/TR200103019T2/xx unknown
- 2000-04-19 BR BR0009943-0A patent/BR0009943A/pt not_active IP Right Cessation
- 2000-04-19 DK DK00920937T patent/DK1181298T3/da active
- 2000-04-19 CZ CZ20013730A patent/CZ20013730A3/cs unknown
- 2000-04-19 HU HU0200868A patent/HUP0200868A3/hu unknown
- 2000-04-19 EP EP00920937A patent/EP1181298B1/en not_active Expired - Lifetime
- 2000-04-19 PL PL00351523A patent/PL351523A1/xx unknown
- 2000-04-19 CN CNB008078238A patent/CN1246327C/zh not_active Expired - Fee Related
- 2000-04-19 AT AT00920937T patent/ATE333461T1/de not_active IP Right Cessation
- 2000-04-19 NZ NZ515279A patent/NZ515279A/xx unknown
- 2000-04-19 CA CA002370273A patent/CA2370273A1/en not_active Abandoned
- 2000-04-19 WO PCT/HR2000/000009 patent/WO2000063223A1/en active IP Right Grant
- 2000-04-19 GE GEAP20006202A patent/GEP20032929B/en unknown
- 2000-04-19 JP JP2000612313A patent/JP2002542254A/ja active Pending
- 2000-04-19 ES ES00920937T patent/ES2267519T3/es not_active Expired - Lifetime
- 2000-04-19 AU AU41347/00A patent/AU772272B2/en not_active Ceased
- 2000-04-19 SK SK1494-2001A patent/SK14942001A3/sk unknown
- 2000-04-19 DE DE60029439T patent/DE60029439T2/de not_active Expired - Fee Related
- 2000-04-19 PT PT00920937T patent/PT1181298E/pt unknown
- 2000-04-19 IL IL14599000A patent/IL145990A0/xx unknown
- 2000-04-19 EE EEP200100544A patent/EE04553B1/xx not_active IP Right Cessation
- 2000-04-19 MX MXPA01010627A patent/MXPA01010627A/es active IP Right Grant
- 2000-04-19 US US09/959,204 patent/US6593360B1/en not_active Expired - Fee Related
- 2000-04-19 KR KR1020017013433A patent/KR20020007379A/ko not_active Application Discontinuation
- 2000-04-19 EA EA200101103A patent/EA003928B1/ru not_active IP Right Cessation
- 2000-04-24 AR ARP000101906A patent/AR028823A1/es unknown
2001
- 2001-10-16 ZA ZA200108481A patent/ZA200108481B/xx unknown
- 2001-10-16 IS IS6110A patent/IS6110A/is unknown
- 2001-10-18 NO NO20015068A patent/NO320704B1/no unknown
- 2001-11-20 BG BG106117A patent/BG65281B1/bg unknown
2003
- 2003-01-23 HK HK03100592.9A patent/HK1049842B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ20013730A3 (cs)	2002-04-17
HUP0200868A2 (hu)	2002-07-29
CA2370273A1 (en)	2000-10-26
CN1362964A (zh)	2002-08-07
HK1049842A1 (en)	2003-05-30
CN1246327C (zh)	2006-03-22
WO2000063223A1 (en)	2000-10-26
AU772272B2 (en)	2004-04-22
HK1049842B (zh)	2006-09-22
TR200103019T2 (tr)	2002-01-21
NO20015068L (no)	2001-12-13
DK1181298T3 (da)	2006-11-13
IS6110A (is)	2001-10-16
ATE333461T1 (de)	2006-08-15
BR0009943A (pt)	2002-01-08
AR028823A1 (es)	2003-05-28
ZA200108481B (en)	2003-03-26
DE60029439T2 (de)	2007-02-01
HRP990116A2 (en)	2001-10-31
ES2267519T3 (es)	2007-03-16
EE200100544A (et)	2003-02-17
MXPA01010627A (es)	2002-06-04
US6593360B1 (en)	2003-07-15
NZ515279A (en)	2003-04-29
NO320704B1 (no)	2006-01-16
EP1181298B1 (en)	2006-07-19
EA003928B1 (ru)	2003-10-30
NO20015068D0 (no)	2001-10-18
BG65281B1 (bg)	2007-11-30
EP1181298A1 (en)	2002-02-27
DE60029439D1 (de)	2006-08-31
UA72246C2 (uk)	2005-02-15
JP2002542254A (ja)	2002-12-10
PT1181298E (pt)	2006-11-30
GEP20032929B (en)	2003-03-25
HUP0200868A3 (en)	2003-03-28
EA200101103A1 (ru)	2002-04-25
AU4134700A (en)	2000-11-02
SK14942001A3 (sk)	2002-08-06
KR20020007379A (ko)	2002-01-26
BG106117A (en)	2002-07-31
PL351523A1 (en)	2003-05-05
IL145990A0 (en)	2002-07-25
EE04553B1 (et)	2005-10-17

Legal Events

Date	Code	Title	Description
2001-10-31	A1OB	Publication of a patent application
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2007-01-15	PPPP	Transfer of rights	Owner name: PLIVA-ISTRAZIVACKI INSTITUT D.O.O., HR
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