DE60029439D1 - Neue 8a- und 9a-lactame mit 15 ringatomen - Google Patents

Neue 8a- und 9a-lactame mit 15 ringatomen

Info

Publication number
DE60029439D1
DE60029439D1 DE60029439T DE60029439T DE60029439D1 DE 60029439 D1 DE60029439 D1 DE 60029439D1 DE 60029439 T DE60029439 T DE 60029439T DE 60029439 T DE60029439 T DE 60029439T DE 60029439 D1 DE60029439 D1 DE 60029439D1
Authority
DE
Germany
Prior art keywords
ringatomes
lactame
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60029439T
Other languages
English (en)
Other versions
DE60029439T2 (de
Inventor
Gorjana Lazarevski
Sulejman Alihodzic
Gabrijela Kobrehel
Stjepan Mutak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidelta doo
Original Assignee
Pliva Istrazivacki Institut doo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivacki Institut doo filed Critical Pliva Istrazivacki Institut doo
Application granted granted Critical
Publication of DE60029439D1 publication Critical patent/DE60029439D1/de
Publication of DE60029439T2 publication Critical patent/DE60029439T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
DE60029439T 1999-04-20 2000-04-19 Neue 8a- und 9a-lactame mit 15 ringatomen Expired - Fee Related DE60029439T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR990116A HRP990116B1 (en) 1999-04-20 1999-04-20 NOVEL 8a AND 9a- 15-MEMBERED LACTAMES
HR990116 1999-04-20
PCT/HR2000/000009 WO2000063223A1 (en) 1999-04-20 2000-04-19 Novel 8a- and 9a-15-membered lactams

Publications (2)

Publication Number Publication Date
DE60029439D1 true DE60029439D1 (de) 2006-08-31
DE60029439T2 DE60029439T2 (de) 2007-02-01

Family

ID=10946907

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029439T Expired - Fee Related DE60029439T2 (de) 1999-04-20 2000-04-19 Neue 8a- und 9a-lactame mit 15 ringatomen

Country Status (33)

Country Link
US (1) US6593360B1 (de)
EP (1) EP1181298B1 (de)
JP (1) JP2002542254A (de)
KR (1) KR20020007379A (de)
CN (1) CN1246327C (de)
AR (1) AR028823A1 (de)
AT (1) ATE333461T1 (de)
AU (1) AU772272B2 (de)
BG (1) BG65281B1 (de)
BR (1) BR0009943A (de)
CA (1) CA2370273A1 (de)
CZ (1) CZ20013730A3 (de)
DE (1) DE60029439T2 (de)
DK (1) DK1181298T3 (de)
EA (1) EA003928B1 (de)
EE (1) EE04553B1 (de)
ES (1) ES2267519T3 (de)
GE (1) GEP20032929B (de)
HK (1) HK1049842B (de)
HR (1) HRP990116B1 (de)
HU (1) HUP0200868A3 (de)
IL (1) IL145990A0 (de)
IS (1) IS6110A (de)
MX (1) MXPA01010627A (de)
NO (1) NO320704B1 (de)
NZ (1) NZ515279A (de)
PL (1) PL351523A1 (de)
PT (1) PT1181298E (de)
SK (1) SK14942001A3 (de)
TR (1) TR200103019T2 (de)
UA (1) UA72246C2 (de)
WO (1) WO2000063223A1 (de)
ZA (1) ZA200108481B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0025688D0 (en) 2000-10-19 2000-12-06 Glaxo Group Ltd Macrolides
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
US7435805B2 (en) * 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
EP1879903A1 (de) 2005-05-10 2008-01-23 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Etherverbrückte makrolide, die sich zur behandlung mikrobieller infektionen eignen
EP2988597B1 (de) 2013-04-04 2022-06-08 President and Fellows of Harvard College Makrolide sowie verfahren zu deren herstellung und verwendung
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
GB201608236D0 (en) 2016-05-11 2016-06-22 Fidelta D O O Seco macrolide compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI7910768A8 (en) * 1979-04-02 1996-06-30 Pliva Pharm & Chem Works Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
IL99995A (en) * 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
WO1997042204A1 (en) * 1996-05-07 1997-11-13 Abbott Laboratories 6-o-substituted erythromycins and method for making them
AU1082599A (en) * 1997-10-16 1999-05-03 Merck & Co., Inc. 8a-azalides, compositions containing such compounds and methods of treatment
HRP980189B1 (en) * 1998-04-06 2004-04-30 Pliva Pharm & Chem Works Novel 15-membered lactams ketolides

Also Published As

Publication number Publication date
CZ20013730A3 (cs) 2002-04-17
HUP0200868A2 (hu) 2002-07-29
CA2370273A1 (en) 2000-10-26
CN1362964A (zh) 2002-08-07
HK1049842A1 (en) 2003-05-30
CN1246327C (zh) 2006-03-22
WO2000063223A1 (en) 2000-10-26
AU772272B2 (en) 2004-04-22
HK1049842B (zh) 2006-09-22
TR200103019T2 (tr) 2002-01-21
NO20015068L (no) 2001-12-13
DK1181298T3 (da) 2006-11-13
IS6110A (is) 2001-10-16
ATE333461T1 (de) 2006-08-15
BR0009943A (pt) 2002-01-08
AR028823A1 (es) 2003-05-28
ZA200108481B (en) 2003-03-26
DE60029439T2 (de) 2007-02-01
HRP990116A2 (en) 2001-10-31
ES2267519T3 (es) 2007-03-16
EE200100544A (et) 2003-02-17
MXPA01010627A (es) 2002-06-04
US6593360B1 (en) 2003-07-15
NZ515279A (en) 2003-04-29
NO320704B1 (no) 2006-01-16
EP1181298B1 (de) 2006-07-19
EA003928B1 (ru) 2003-10-30
NO20015068D0 (no) 2001-10-18
BG65281B1 (bg) 2007-11-30
EP1181298A1 (de) 2002-02-27
UA72246C2 (uk) 2005-02-15
JP2002542254A (ja) 2002-12-10
PT1181298E (pt) 2006-11-30
GEP20032929B (en) 2003-03-25
HUP0200868A3 (en) 2003-03-28
EA200101103A1 (ru) 2002-04-25
AU4134700A (en) 2000-11-02
SK14942001A3 (sk) 2002-08-06
KR20020007379A (ko) 2002-01-26
HRP990116B1 (en) 2007-10-31
BG106117A (en) 2002-07-31
PL351523A1 (en) 2003-05-05
IL145990A0 (en) 2002-07-25
EE04553B1 (et) 2005-10-17

Similar Documents

Publication Publication Date Title
DE59813518D1 (de) Faktor x-analoge mit modifizierter proteasespaltstelle
DE19781981T1 (de) Neue Pestizidkombination
EE200200286A (et) Uued aminopropüülfosfiinhapped ning nende kasutamine
NL300295I1 (nl) 3,3-Diarylpropylaminen, de toepassing en bereiding hiervan
ID20910A (id) Celana latihan sekali pakai
ATE278686T1 (de) Phthalazines mit angiogenesis-hemmender wirkung
DE69627716D1 (de) Perfluorelastomer-zusammensetzung mit erhöhter vulkanisationseigenschaften
ID25977A (id) Popok sekali pakai
ID24555A (id) Popok sekali pakai
ID23076A (id) Popok sekali pakai
ID21406A (id) Celana latihan sekali pakai
ATE355264T1 (de) Neue aryloxy-alkyl-dialkylamine
DE69737411D1 (de) Induktor mit verbesserten Q-Wert
DE69701723D1 (de) Willkürlich gemustertes kochgeschirr
ID23083A (id) Popok sekali pakai
DE69824201D1 (de) Neue 9a-azalide
ID19801A (id) Turunan-turunan 5'-deoksi-sitidina
DE60029439D1 (de) Neue 8a- und 9a-lactame mit 15 ringatomen
DE59706428D1 (de) Schaltungsanordnung
ATE210661T1 (de) Neue tetrahydroiosoquinolin thiophenecarboximidamiden
DE69828937D1 (de) Piece d' interposition
NO20005551D0 (no) 2"-deoksyhygromycinderivater
FI972010A0 (fi) Arrangemang i en borrningsanordning
NO996127D0 (no) 13-dihydro-3'-aziridino-antracykliner
ID16612A (id) Jalur penuangan

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O.,

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee