CO4340625A1 - Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos - Google Patents

Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos

Info

Publication number
CO4340625A1
CO4340625A1 CO94057765A CO94057765A CO4340625A1 CO 4340625 A1 CO4340625 A1 CO 4340625A1 CO 94057765 A CO94057765 A CO 94057765A CO 94057765 A CO94057765 A CO 94057765A CO 4340625 A1 CO4340625 A1 CO 4340625A1
Authority
CO
Colombia
Prior art keywords
pharmaceutical preparations
dihydropyridines
condensed
production
benzyl
Prior art date
Application number
CO94057765A
Other languages
English (en)
Inventor
Walter Losel
Otto Roos
Dietrich Arndts
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934343684 external-priority patent/DE4343684A1/de
Priority claimed from DE19934343641 external-priority patent/DE4343641A1/de
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of CO4340625A1 publication Critical patent/CO4340625A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

1. UN COMPUESTO DE LA FORMULA GENERAL I EN LA QUE A SIGNIFICA UN RADICAL BENZO, INDOLO O TIENO; EN QUE CUANDO A ES UN BENZO, m ES 2 O 3 (PREFERIBLE- MENTE 2, ESTANDO AMBOS R2 EN LAS POSICIONES 6 Y 7) Y LOS SUBSTITUYENTES R2, INDEPENDIENTEMENTE UNO DE OTRO, PUEDEN SER HIDROXI, ALCOXI (C1-C4), BENCILO- XI, HALOGENO (F, Cl, Br, I), ALQUIL (C1-C4), META- NOSULFONILOXI O METANOSULFONAMIDO, O DOS SUSTITU- YENTES R2 CONTIGUOS PUEDE SER UN COMUN -O-CH2-O- o -O-CH2-CH2-O-; Y CUANDO A ES INDOLO O TIENO, m ES CERO; R1 SIGNIFICA TIENILO O EL GRUPO FIGURA 1 EN LA QUE R7, R8 Y R9, INDEPENDIENTEMENTE UNOS DE OTROS, PUEDEN SER METILO, ETILO, PROPILO, FENILO O BENCILO, NO PUDIENDO SER MAS DE 2 DE LOS SUSTITU- YENTES, AL MISMO TIEMPO, FENILO O BENCILO; R3 Y R4, INDEPENDIENTEMENTE UNO DE OTRO, TIENEN UNO DE LOS SIGUIENTES SIGNIFICADOS (a) HIDROGENO, (b) ALQUELINO RAMIFICADO O SIN RAMIFICAR CON 3 A 6 ATOMOS DE CARBONO, (c) ALQUINILO RAMIFICADO O SIN RAMIFICAR CON 3 A 6 ATOMOS DE CARBONO, O (d) ALQUILO RAMIFICADO O SIN RAMIFICAR CON 1 A 12 ATOMOS DE CARBONO, PUDIENDO AL ALQUILO ESTAR SUS- TITUIDO CON HIDROXI, ALCOXI (C1-C4), DI-ALQUIL (C1-C4)-AMINO, FURILO, PIRIDILO, PIRROLIDINILO, N-METIL-PIRROLIDINILO, MORFOLINO, INDOLILO, NITRI- LO, TIENILO, ADAMANTILO, CICLOHEXILO, FENOXI, NAFTILOXI O FENILO, [PUDIENDO ESTE FENILO O EL FENILO CONTENIDO EN EL GRUPO FENOXI ESTAR SUSTI- TUIDO UNA, DOS O TRES VECES CON HIDROXI, ALCOXI (C1-C4), BENCILOXI, HALOGENO (F, Cl, Br, I) CF3, N3, CN, ALQUILO (C1-C4), ADAMANTILO, -SO2NH2, NHCOCH3, NHSO2CH3 o CH3SO20-, O CON EL PUENTE -O-CH2-0-] O CON DOS GRUPOS FENILO SIN SUSTITUIR; O R3 SIGNIFICA HIDROGENO Y R4 SIGNIFICA CICLOHEXI- LO, FENILO [PUDIENDO ESTE FENILO ESTAR SUSTITUIDO UNA, DOS O TRES VECES CON HIDROXI, ALCOXI (C1-C4), BENCILOXI, HALOGENO (F, Cl, Br, I), CF3, N3, AL- QUILO (C1-C4), ADAMANTILO, -SO2NH2, -NHCOCH3, NHSO2CH3, o CH3SO2O-, O CON EL PUENTE -O-CH2-O-], PIRIDILO O N-BENCIL-PIPERIDILO; o R3 Y R4, EN COMUN CON EL ATOMO DE NITROGENO, AL QUE ESTAN UNIDOS, SIGNIFICAN PIRROLIDINILO, PIPE- RIDINILO, MORFOLINILO, TIOMORFOLINILO O PIPERAZI- NILO, PUDIENDO EN ANILLO DE PIPERAZINILO ESTAR EVENTUALMENTE SUSTITUIDO EN N CON METILO, FENILO SIN SUSTITUIR, MONO- o DI-ALCOXI (C1-C4) FENILO, FENILO SUSTITUIDO CON CIANO, PIRIMIDINILO, FENIL- ALQUILO (C1-C4), ALQUIL (C1-C4) - FENILO, O SUS SALES CON ACIDOS O COMPUESTOS FORMADORES DE COMPLEJOS, FISIOLOGICAMENTE COMPATIBLES.
CO94057765A 1993-12-21 1994-12-21 Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos CO4340625A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19934343684 DE4343684A1 (de) 1993-12-21 1993-12-21 Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
DE19934343641 DE4343641A1 (de) 1993-12-21 1993-12-21 Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen

Publications (1)

Publication Number Publication Date
CO4340625A1 true CO4340625A1 (es) 1996-07-30

Family

ID=25932286

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94057765A CO4340625A1 (es) 1993-12-21 1994-12-21 Dihidropiridinas condensadas y su utilizacion para la produccion de preparados farmaceuticos

Country Status (19)

Country Link
US (5) US5607943A (es)
EP (1) EP0736012B1 (es)
JP (1) JPH09506880A (es)
CN (1) CN1138324A (es)
AT (1) ATE197706T1 (es)
AU (1) AU688833B2 (es)
CA (1) CA2178088A1 (es)
CO (1) CO4340625A1 (es)
DE (1) DE59409595D1 (es)
DK (1) DK0736012T3 (es)
ES (1) ES2152379T3 (es)
GR (1) GR3035108T3 (es)
IL (1) IL112102A0 (es)
PL (1) PL315052A1 (es)
PT (1) PT736012E (es)
SI (1) SI0736012T1 (es)
TW (1) TW334425B (es)
WO (1) WO1995017388A1 (es)
YU (1) YU75394A (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1138324A (zh) 1993-12-21 1996-12-18 贝林格尔·英格海姆公司 增环的二氢吡啶及其在制备药物制剂中的应用
DE19623142A1 (de) * 1996-06-10 1997-12-11 Huels Chemische Werke Ag Enantiomerenangereicherte, durch einen tertiären Kohlenwasserstoffrest substituierte Malonsäuremonoester sowie deren Herstellung
AU2002224835A1 (en) * 2000-11-14 2002-05-27 Byk Gulden Lomberg Chemische Fabrik G.M.B.H. Dihydroisoquinolines as novel phosphodiesterase inhibitors
US7384957B2 (en) * 2001-12-19 2008-06-10 H. Lundbeck A/S 3,4-dihydro-1H-isoquinolin-2-yl-derivatives
FR2853649B1 (fr) * 2003-04-09 2006-07-14 Servier Lab Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2332367T5 (es) 2003-04-09 2013-12-17 Dr. Reddy's Laboratories Ltd. Forma cristalina III de clorhidrato de moxifloxacina anhidro y su procedimiento de preparación
MX2007005980A (es) * 2004-12-10 2007-07-10 Alcon Inc Composiciones para el tratamiento de infecciones oticas.
MX2008014450A (es) 2006-05-18 2009-03-09 Mannkind Corp Inhibidores de cinasa intracelular.
US8962779B2 (en) 2013-07-16 2015-02-24 Dow Global Technologies Llc Method of forming polyaryl polymers
US9410016B2 (en) 2013-07-16 2016-08-09 Dow Global Technologies Llc Aromatic polyacetals and articles comprising them
US8933239B1 (en) 2013-07-16 2015-01-13 Dow Global Technologies Llc Bis(aryl)acetal compounds
US9063420B2 (en) 2013-07-16 2015-06-23 Rohm And Haas Electronic Materials Llc Photoresist composition, coated substrate, and method of forming electronic device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3013906A1 (de) * 1980-04-11 1981-10-15 C.H. Boehringer Sohn, 6507 Ingelheim Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) * 1988-08-16 1990-02-22 Boehringer Ingelheim Kg Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion
DE9017900U1 (es) * 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 6507 Ingelheim, De
CA2138788A1 (en) * 1992-06-22 1994-01-06 Dietrich Arndts Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions
CN1138324A (zh) 1993-12-21 1996-12-18 贝林格尔·英格海姆公司 增环的二氢吡啶及其在制备药物制剂中的应用

Also Published As

Publication number Publication date
GR3035108T3 (en) 2001-03-30
EP0736012B1 (de) 2000-11-22
TW334425B (en) 1998-06-21
PL315052A1 (en) 1996-09-30
WO1995017388A1 (de) 1995-06-29
IL112102A0 (en) 1995-03-15
US5837712A (en) 1998-11-17
YU75394A (sh) 1997-09-30
ES2152379T3 (es) 2001-02-01
US6180645B1 (en) 2001-01-30
ATE197706T1 (de) 2000-12-15
JPH09506880A (ja) 1997-07-08
PT736012E (pt) 2001-03-30
US5607943A (en) 1997-03-04
EP0736012A1 (de) 1996-10-09
US5925650A (en) 1999-07-20
US6465483B1 (en) 2002-10-15
SI0736012T1 (en) 2001-02-28
AU1314295A (en) 1995-07-10
CN1138324A (zh) 1996-12-18
CA2178088A1 (en) 1995-06-29
DK0736012T3 (da) 2001-01-29
DE59409595D1 (de) 2000-12-28
AU688833B2 (en) 1998-03-19

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