HRP20221324T1 - Farmaceutski pripravci koji sadrže inzulin - Google Patents
Farmaceutski pripravci koji sadrže inzulin Download PDFInfo
- Publication number
- HRP20221324T1 HRP20221324T1 HRP20221324TT HRP20221324T HRP20221324T1 HR P20221324 T1 HRP20221324 T1 HR P20221324T1 HR P20221324T T HRP20221324T T HR P20221324TT HR P20221324 T HRP20221324 T HR P20221324T HR P20221324 T1 HRP20221324 T1 HR P20221324T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- moles
- ethoxy
- pharmaceutical preparation
- preparation according
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 21
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 16
- 229940125904 compound 1 Drugs 0.000 claims 15
- 239000000825 pharmaceutical preparation Substances 0.000 claims 13
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 12
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 10
- 239000011780 sodium chloride Substances 0.000 claims 8
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims 7
- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical compound CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 claims 5
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 5
- 229950011186 semaglutide Drugs 0.000 claims 5
- 108010060325 semaglutide Proteins 0.000 claims 5
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 4
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 3
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000002705 Glucose Intolerance Diseases 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000011661 metabolic syndrome X Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Manipulator (AREA)
Claims (14)
1. Farmaceutski pripravak, naznačen time što sadrži A14E, B16H, B25H, B29K((Nε-ikozandioil-γGlu-[2-(2-{2-[2-(2-aminoetoksi)etoksi]acetilamino}etoksi)etoksi]-acetil)), dezB30 ljudski inzulin (Spoj 1); i semaglutid;
i što dodatno sadrži
od 1 do 2% (tež./tež.) glicerola; od 45 do 75 mM fenola; od 0 do 19 mM m-krezola; od 1,5 do 2,5 molova cinkovih iona na šest molova Spoja 1;
od 5 do 50 mM natrijevog klorida; i ima vrijednost pH u rasponu od 7,2 do 8,0.
2. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što je količina Spoja 1 u rasponu od 3,5 do 5,0 mM.
3. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1-2, naznačen time što je količina semaglutida u rasponu od 0,30 do 0,70 mM.
4. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time što sadrži od 45 do 75 mM fenola, primjerice od 55 mM do 65 mM fenola; ili što sadrži 50 mM, 51 mM, 52 mM, 53 mM, 54 mM, 55 mM, 56 mM, 57 mM, 58 mM, 59 mM, 60 mM, 61 mM, 62 mM, 63 mM, 64 mM, 65 mM, 66 mM, 67 mM, 68 mM, 69 mM ili 70 mM fenola.
5. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time što sadrži od 0 do 19 mM m-krezola, primjerice od 0 mM do 15 mM m-krezola; ili što sadrži 0 mM, 1 mM, 2 mM, 3 mM, 4 mM, 5 mM, 6 mM, 7 mM, 8 mM, 9 mM, 10 mM, 11 mM, 12 mM, 13 mM, 14 mM ili 15 mM m-krezola.
6. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1-5, naznačen time što sadrži manje od 25 mM natrijevog klorida.
7. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži
od 4,0 do 4,5 mM Spoja 1;
od 1 do 2% (tež./tež.) glicerola;
od 50 do 70 mM fenola;
od 0 do 15 mM m-krezola; od 2,0 do 2,5 molova cinkovih iona na šest molova Spoja 1;
najviše 25 mM natrijevog klorida; i
ima vrijednost pH u rasponu od 7,2 do 7.6.
8. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži
4,2 mM Spoja 1;
1,5% (tež./tež.) glicerola;
60 mM fenola;
0 mM m-krezola;
2,2 mola cinkovih iona na šest molova Spoja 1;
20 mM natrijevog klorida; i
ima vrijednost pH od 7,4.
9. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži
4,2 mM Spoja 1;
1,5% (tež./tež.) glicerola;
60 mM fenola;
10 mM m-krezola;
2,2 mola cinkovih iona na šest molova Spoja 1;
20 mM natrijevog klorida; i
ima vrijednost pH od 7,4.
10. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži A14E, B16H, B25H, B29K((Nε-ikozandioil-γGlu-[2-(2-{2-[2-(2-aminoetoksi)etoksi]acetilamino}etoksi)etoksi]acetil)), dezB30 ljudski inzulin (Spoj 1); i semaglutid; i što dodatno sadrži 1,5% (tež./tež.) glicerola; 60 mM fenola; 10 mM m-krezola; 2,2 mola cinkovih iona na šest molova Spoja 1; 20 mM natrijevog klorida; i ima vrijednost pH od 7,4.
11. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži
4,2 mM A14E, B16H, B25H, B29K((Nε-ikozandioil-γGlu-[2-(2-{2-[2-(2-aminoetoksi)etoksi]acetilamino}etoksi)etoksi]acetil)), dezB30 ljudskog inzulina (Spoj 1);
0,49 mM semaglutida;
1,5% (tež./tež.) glicerola;
60 mM fenola;
10 mM m-krezola;
2,2 mola cinkovih iona na šest molova Spoja 1;
20 mM natrijevog klorida; i
ima vrijednost pH od 7,4.
12. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što sadrži
4,2 mM A14E, B16H, B25H, B29K((Nε-ikozandioil-γGlu-[2-(2-{2-[2-(2-aminoetoksi)etoksi]acetilamino}etoksi)etoksi]acetil)), dezB30 ljudskog inzulina (Spoj 1);
0,3 mM semaglutida;
1,5% (tež./tež.) glicerola;
60 mM fenola;
10 mM m-krezola;
2,2 mola cinkovih iona na šest molova Spoja 1;
20 mM natrijevog klorida; i
ima vrijednost pH od 7,4.
13. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1-12, naznačen time što je namijenjen upotrebi kao medikament za liječenje metaboličkog poremećaja.
14. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 12, naznačen time što je namijenjen upotrebi kao medikament za liječenje ili ublažavanje bolesti, poremećaja ili stanje koje se odnosi na dijabetes, dijabetes tipa 1, dijabetes tipa 2, intoleranciju glukoze, hiperglikemiju, dislipidemiju, pretilost, ili metabolički sindrom (metabolički sindrom X, sindrom otpornosti na inzulin).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16204688 | 2016-12-16 | ||
EP20208962.9A EP3821905B1 (en) | 2016-12-16 | 2017-12-15 | Insulin containing pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20221324T1 true HRP20221324T1 (hr) | 2022-12-23 |
Family
ID=57570394
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20221324TT HRP20221324T1 (hr) | 2016-12-16 | 2017-12-15 | Farmaceutski pripravci koji sadrže inzulin |
HRP20211281TT HRP20211281T1 (hr) | 2016-12-16 | 2021-08-10 | Pripravci koji sadrže inzulin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20211281TT HRP20211281T1 (hr) | 2016-12-16 | 2021-08-10 | Pripravci koji sadrže inzulin |
Country Status (28)
Country | Link |
---|---|
US (5) | US20180169190A1 (hr) |
EP (2) | EP3554534B1 (hr) |
JP (2) | JP6690062B2 (hr) |
KR (2) | KR102580007B1 (hr) |
CN (2) | CN110087674B (hr) |
AU (2) | AU2017378102B2 (hr) |
BR (1) | BR112019011761A2 (hr) |
CA (1) | CA3046583A1 (hr) |
CL (1) | CL2019001586A1 (hr) |
CO (1) | CO2019006017A2 (hr) |
DK (2) | DK3821905T3 (hr) |
ES (2) | ES2886837T3 (hr) |
HR (2) | HRP20221324T1 (hr) |
HU (2) | HUE055231T2 (hr) |
IL (2) | IL267224B2 (hr) |
MA (1) | MA49116A (hr) |
MX (2) | MX2019006463A (hr) |
MY (1) | MY194504A (hr) |
PE (2) | PE20210857A1 (hr) |
PH (1) | PH12019501363A1 (hr) |
PL (2) | PL3554534T3 (hr) |
PT (1) | PT3554534T (hr) |
RS (2) | RS62295B1 (hr) |
RU (1) | RU2758367C2 (hr) |
SA (1) | SA520420276B1 (hr) |
SI (1) | SI3554534T1 (hr) |
TW (2) | TWI700091B (hr) |
WO (1) | WO2018109162A1 (hr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
MA49116A (fr) | 2016-12-16 | 2020-03-25 | Novo Nordisk As | Compositions pharmaceutiques contenant de l'insuline |
CN113423691A (zh) | 2018-12-11 | 2021-09-21 | 赛诺菲 | 肽结合剂 |
AU2020399194A1 (en) | 2019-12-10 | 2022-07-28 | Sanofi | A method of forming a conjugate of a sulfonamide and a polypeptide |
MX2022008130A (es) * | 2019-12-30 | 2022-10-03 | Gan & Lee Pharmaceuticals Co Ltd | Derivado de insulina. |
EP4361174A1 (en) * | 2021-06-25 | 2024-05-01 | Gan & Lee Pharmaceuticals Co., Ltd. | Acylated insulin-containing pharmaceutical composition |
JP7437833B1 (ja) | 2023-09-21 | 2024-02-26 | 俊二 二宮 | 検体検査用のカラー濾紙及びその製造方法 |
Family Cites Families (224)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2832685A (en) | 1952-05-24 | 1958-04-29 | Crest Foods Co Inc | Solubilization of milk proteins |
GB894095A (en) | 1960-02-08 | 1962-04-18 | Tanaka Shoichi | A therapeutic device for personal wear |
US3528960A (en) | 1968-10-07 | 1970-09-15 | Lilly Co Eli | N-carboxyaroyl insulins |
US3719655A (en) | 1969-12-05 | 1973-03-06 | Lilly Co Eli | Process for the crystallization of the ammonium and alkali metal salts in insulin |
US3869437A (en) | 1970-05-08 | 1975-03-04 | Nat Res Dev | Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin |
US3950517A (en) | 1970-05-08 | 1976-04-13 | National Research Development Corporation | Insulin derivatives |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4033941A (en) | 1975-12-17 | 1977-07-05 | Eli Lilly And Company | Process for purifying glucagon |
GB1492997A (en) | 1976-07-21 | 1977-11-23 | Nat Res Dev | Insulin derivatives |
JPS6030650B2 (ja) | 1979-10-26 | 1985-07-17 | 日本油脂株式会社 | 座薬基剤組成物 |
JPS5767548A (en) | 1980-10-14 | 1982-04-24 | Shionogi & Co Ltd | Insulin analog and its preparation |
NL193099C (nl) | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
US4849227A (en) | 1986-03-21 | 1989-07-18 | Eurasiam Laboratories, Inc. | Pharmaceutical compositions |
PH23446A (en) | 1986-10-20 | 1989-08-07 | Novo Industri As | Peptide preparations |
US5266310A (en) | 1987-09-17 | 1993-11-30 | Boehringer Ingelheim International Gmbh | Stabilization of therapeutically active proteins in pharmaceutical preparations |
JPH01254699A (ja) | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
EP0425482B1 (en) | 1988-07-20 | 1993-08-18 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
US5225323A (en) | 1988-11-21 | 1993-07-06 | Baylor College Of Medicine | Human high-affinity neurotransmitter uptake system |
US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
JPH04502465A (ja) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
DE3844211A1 (de) | 1988-12-29 | 1990-07-05 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5514646A (en) | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
WO1990012814A1 (en) | 1989-04-20 | 1990-11-01 | Mount Sinai School Of Medicine Of The City University Of New York | Hepatospecific insulin analogues |
CA1340994C (en) | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
AU6417790A (en) | 1989-09-22 | 1991-04-18 | Tsi-Madison Research Institute | Method and compositions for one-step cryopreservation of embryos |
KR930001305B1 (ko) | 1989-10-19 | 1993-02-25 | 니뽕 유우시 가부시끼가이샤 | 당 응답형 고분자 복합체(Polymer Complexes of Sugar Response Type) |
US5179189A (en) | 1990-01-19 | 1993-01-12 | Nova Pharmaceutical Corporation | Fatty acid terminated polyanhydrides |
DK45590D0 (hr) | 1990-02-21 | 1990-02-21 | Novo Nordisk As | |
DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
DK158390D0 (da) | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
AU8091091A (en) | 1990-07-26 | 1992-02-18 | University Of Iowa Research Foundation, The | Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule |
EP0548238A1 (en) | 1990-09-13 | 1993-06-30 | Smithkline Beecham Corporation | Non-aqueous liquid oral suspensions |
DK10191D0 (da) | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
US5336782A (en) | 1991-04-24 | 1994-08-09 | Kuraray Co., Ltd. | Long chain carboxylic acid imide ester |
EP0952855B1 (en) | 1991-07-03 | 2005-07-27 | Meditech Research Limited | Use of hyaluronan in gene therapy |
ATE144137T1 (de) | 1991-07-26 | 1996-11-15 | Smithkline Beecham Corp | W/o mikroemulsionen |
US5268453A (en) | 1991-08-08 | 1993-12-07 | Scios Inc. | Tissue-selective insulin analogs |
US5206219A (en) | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
ZA928916B (en) | 1991-11-26 | 1994-05-18 | Lilly Co Eli | Tri-arginine insulins |
SG44748A1 (en) | 1991-12-18 | 1997-12-19 | Hoechst Ag | Process for obtaining insulin-containing solutions |
WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
EP0671929A4 (en) | 1992-10-16 | 1996-09-25 | Smithkline Beecham Corp | COMPOSITIONS. |
EP0666752A4 (en) | 1992-10-16 | 1996-09-11 | Smithkline Beecham Corp | THERAPEUTIC MICROEMULSIONS. |
WO1994019001A1 (en) | 1993-02-17 | 1994-09-01 | Smithkline Beecham Corporation | Microemulsions comprising therapeutic peptides |
JPH08507078A (ja) | 1993-02-17 | 1996-07-30 | スミスクライン・ビーチャム・コーポレイション | 治療用ペプチド含有のミクロエマルジョン |
DK0686045T3 (da) | 1993-02-23 | 2001-03-05 | Genentech Inc | Stabilisering af med organisk opløsningsmiddel behandlede polypeptider med et hjælpestof |
US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
BR9407508A (pt) | 1993-09-17 | 1997-01-07 | Novo Nordisk As | Derivado de insulina composição farmaceutica e processo para o tratamento de diabete em um paciente com necessidade deste tratamento |
US6869930B1 (en) | 1993-09-17 | 2005-03-22 | Novo Nordisk A/S | Acylated insulin |
GB9323588D0 (en) | 1993-11-16 | 1994-01-05 | Cortecs Ltd | Hydrophobic preparation |
ATE264096T1 (de) | 1994-03-07 | 2004-04-15 | Nektar Therapeutics | Verfahren und mittel zur verabreichung von insulin über die lunge |
US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US5646242A (en) | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
GB2296712B (en) | 1995-01-05 | 1999-02-24 | British Gas Plc | Absorbents for separating nitrogen from a feed gas |
AU720966B2 (en) | 1995-03-17 | 2000-06-22 | Novo Nordisk A/S | Insulin derivatives |
US6251856B1 (en) | 1995-03-17 | 2001-06-26 | Novo Nordisk A/S | Insulin derivatives |
US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
US20010041786A1 (en) | 1995-06-07 | 2001-11-15 | Mark L. Brader | Stabilized acylated insulin formulations |
JPH11509195A (ja) | 1995-06-30 | 1999-08-17 | ノボ ノルディスク アクティーゼルスカブ | 糖尿病の特徴を有する疾患の予防 |
US20030104981A1 (en) | 1995-11-03 | 2003-06-05 | Jelena Mandic | Human insulin analogues |
US6451970B1 (en) | 1996-02-21 | 2002-09-17 | Novo Nordisk A/S | Peptide derivatives |
AU3255397A (en) | 1996-07-05 | 1998-02-02 | Novo Nordisk A/S | Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides |
AU3255297A (en) | 1996-07-11 | 1998-02-09 | Novo Nordisk A/S | Selective acylation method |
US5981489A (en) | 1996-07-18 | 1999-11-09 | Alza Corporation | Non-aqueous protic peptide formulations |
ES2218622T3 (es) | 1996-07-26 | 2004-11-16 | Aventis Pharma Deutschland Gmbh | Derivados de insulina con actividad de union al zinc incrementada. |
IL119029A0 (en) | 1996-08-07 | 1996-11-14 | Yeda Res & Dev | Long-acting drugs and pharamaceutical compositions comprising them |
US6160541A (en) | 1997-01-21 | 2000-12-12 | Lear Automotive Dearborn Inc. | Power consumption control for a visual screen display by utilizing a total number of pixels to be energized in the image to determine an order of pixel energization in a manner that conserves power |
CZ295207B6 (cs) | 1997-01-30 | 2005-06-15 | Novartis Ag | Tvrdá želatinová tobolka obsahující cyklosporin A |
US5898067A (en) | 1997-02-07 | 1999-04-27 | Novo Nordisk A/S | Crystallization of proteins |
US6310038B1 (en) | 1997-03-20 | 2001-10-30 | Novo Nordisk A/S | Pulmonary insulin crystals |
PE79099A1 (es) | 1997-06-13 | 1999-08-24 | Lilly Co Eli | Formulaciones de insulina estables |
US20020155994A1 (en) * | 1997-10-24 | 2002-10-24 | Svend Havelund | Aggregates of human insulin derivatives |
CN1276731A (zh) | 1997-10-24 | 2000-12-13 | 伊莱利利公司 | 不溶性胰岛素组合物 |
ATE243711T1 (de) | 1997-10-24 | 2003-07-15 | Novo Nordisk As | Aggregate von menschlichen insulinderivaten |
ZA989744B (en) | 1997-10-31 | 2000-04-26 | Lilly Co Eli | Method for administering acylated insulin. |
EP1030688B1 (en) | 1997-11-12 | 2004-09-29 | Alza Corporation | Method for dermally administering polypeptides |
CO4970787A1 (es) | 1997-12-23 | 2000-11-07 | Lilly Co Eli | Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea |
WO1999065941A1 (en) | 1998-06-12 | 1999-12-23 | Kings College London | Insulin analogue |
GB9814172D0 (en) | 1998-06-30 | 1998-08-26 | Andaris Ltd | Formulation for inhalation |
AU758351B2 (en) | 1998-08-25 | 2003-03-20 | Alkermes, Inc. | Stable spray-dried protein formulations |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
US7030083B2 (en) | 1998-09-09 | 2006-04-18 | University Of Washington | Treatment of eclampsia and preeclampsia |
CN1210058C (zh) | 1998-10-16 | 2005-07-13 | 诺沃挪第克公司 | 用于肺送递的稳定的浓缩胰岛素制剂 |
US6660715B2 (en) | 1998-11-19 | 2003-12-09 | Massachusetts Institute Of Technology | Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery |
US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
DK1146896T3 (da) | 1999-01-26 | 2002-09-02 | Lilly Co Eli | Formuleringer, som indeholder monodisperse hexamere acylerede insulin-analoger |
WO2000047203A1 (en) | 1999-02-12 | 2000-08-17 | Mqs, Inc. | Formulation and system for intra-oral delivery of pharmaceutical agents |
US6267985B1 (en) | 1999-06-30 | 2001-07-31 | Lipocine Inc. | Clear oil-containing pharmaceutical compositions |
WO2000061178A1 (en) | 1999-04-13 | 2000-10-19 | Inhale Therapeutics Systems, Inc. | Pulmonary administration of dry powder formulations for treating infertility |
JP2002543092A (ja) | 1999-04-27 | 2002-12-17 | イーライ・リリー・アンド・カンパニー | 肺投与用インスリン結晶 |
US6746853B1 (en) | 1999-05-19 | 2004-06-08 | Xencor, Inc. | Proteins with insulin-like activity useful in the treatment of diabetes |
AU5144400A (en) | 1999-05-19 | 2000-12-05 | Xencor, Inc. | Novel proteins with insulin-like activity useful in the treatment of diabetes |
US6309633B1 (en) | 1999-06-19 | 2001-10-30 | Nobex Corporation | Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same |
WO2001000674A1 (en) | 1999-06-29 | 2001-01-04 | Eli Lilly And Company | Insulin crystals for pulmonary administration |
CN1409640A (zh) | 1999-12-16 | 2003-04-09 | 伊莱利利公司 | 稳定性改善的多肽组合物 |
AU2001220765A1 (en) | 2000-01-24 | 2001-07-31 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
ES2266187T3 (es) | 2000-03-24 | 2007-03-01 | Genentech, Inc. | Uso de la insulina para el tratamiento de trastornos del cartilago. |
AU2001263775A1 (en) | 2000-06-02 | 2001-12-11 | Novo-Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
CN1141974C (zh) | 2000-06-07 | 2004-03-17 | 张昊 | 结肠定位释放的口服生物制剂 |
KR100508695B1 (ko) | 2001-02-13 | 2005-08-17 | 한국과학기술연구원 | 인슐린의 경구투여용 제형과 그의 제조방법 |
US7060675B2 (en) | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
AU2002248464A1 (en) | 2001-02-21 | 2002-09-12 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
CN1160122C (zh) | 2001-04-20 | 2004-08-04 | 清华大学 | 一种制备口服胰岛素油相制剂的方法 |
OA13136A (en) | 2001-05-21 | 2006-12-13 | Nektar Therapeutics | Pulmonary administration of chemically modified insulin. |
US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US7186797B2 (en) | 2001-08-10 | 2007-03-06 | Epix Pharmaceuticals, Inc. | Polypeptide conjugates with extended circulating half-lives |
PE20030536A1 (es) | 2001-09-07 | 2003-07-03 | Biocon Ltd | Metodos para sintetizar conjugados polipeptido de insulina-oligomero, y conjugados polipeptido de proinsulina-oligomero y metodos de sintetizar dichos conjugados |
US7030082B2 (en) | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US6770625B2 (en) | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7312192B2 (en) | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
JP2005526009A (ja) | 2001-12-02 | 2005-09-02 | ノボ ノルディスク アクティーゼルスカブ | 新規グルコース依存性インスリン |
US7317000B2 (en) | 2001-12-02 | 2008-01-08 | Novo Nordisk A/S | Glucose-dependent insulins |
EP1460992B1 (en) | 2001-12-03 | 2009-03-11 | Dor Biopharma, Inc. | Stabilized reverse micelle compositions and uses thereof |
WO2003050276A1 (en) | 2001-12-05 | 2003-06-19 | Dow Global Technologies Inc. | Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications |
WO2003053460A1 (en) | 2001-12-19 | 2003-07-03 | Eli Lilly And Company | Crystalline compositions for controlling blood glucose |
KR20040070237A (ko) | 2001-12-20 | 2004-08-06 | 일라이 릴리 앤드 캄파니 | 연장된 작용 시간을 갖는 인슐린 분자 |
UA46669C2 (uk) | 2001-12-29 | 2005-12-15 | Товариство З Обмеженою Відповідальністю "Мако" | Спосіб приготування готової лікарської форми інсуліну пролонгованої дії |
WO2003075950A1 (en) | 2002-03-13 | 2003-09-18 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
ATE496064T1 (de) | 2002-05-07 | 2011-02-15 | Novo Nordisk As | Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten |
JP2005526126A (ja) | 2002-05-07 | 2005-09-02 | ノボ ノルディスク アクティーゼルスカブ | インスリンアスパルト及びインスリンデテミアを含む可溶性製剤 |
AU2003236521A1 (en) | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
CN1165549C (zh) | 2002-06-15 | 2004-09-08 | 江苏万邦生化医药股份有限公司 | 胰岛素的纯化方法 |
EP1545526A4 (en) | 2002-09-17 | 2009-09-23 | Merck & Co Inc | ELIMINATION OF AN ALDEHYDE IMPURITY IN A REACTIVE POLYSTYRENE RESIN |
US20050065066A1 (en) * | 2002-12-20 | 2005-03-24 | Kaarsholm Niels Christian | Stabilised insulin compositions |
US20060258561A1 (en) * | 2003-03-13 | 2006-11-16 | Novo Nordisk A/S | Novel NPH insulin preparations |
US20040185068A1 (en) | 2003-03-18 | 2004-09-23 | Zhi-Jian Yu | Self-emulsifying compositions, methods of use and preparation |
JP2007524592A (ja) | 2003-06-03 | 2007-08-30 | ノボ・ノルデイスク・エー/エス | 安定化された薬学的ペプチド組成物 |
CN1812808B (zh) | 2003-06-03 | 2012-07-04 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
EA014887B1 (ru) | 2003-06-17 | 2011-02-28 | Сембайосиз Джинетикс Инк. | Способ экспрессии инсулина в семенах растения, способ получения семян растений, содержащих инсулин, и растения, способные производить семена, содержащие инсулин |
US20050054818A1 (en) | 2003-07-02 | 2005-03-10 | Brader Mark Laurence | Crystalline compositions for controlling blood glucose |
WO2005005477A2 (en) | 2003-07-11 | 2005-01-20 | Novo Nordisk A/S | Stabilised insulin compositions |
EP2085406A1 (en) | 2003-07-25 | 2009-08-05 | ConjuChem Biotechnologies Inc. | Long lasting insulin derivatives and methods thereof |
BRPI0413276B8 (pt) | 2003-08-05 | 2021-05-25 | Novo Nordisk As | derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica |
US20060198819A1 (en) | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
WO2005016312A1 (en) | 2003-08-13 | 2005-02-24 | Nobex Corporation | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents |
TW200526254A (en) | 2003-09-19 | 2005-08-16 | Novo Nordisk As | Novel GLP-1 derivatives |
US20050118206A1 (en) | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
EP1687428A1 (en) | 2003-11-14 | 2006-08-09 | Novo Nordisk A/S | Processes for making acylated insulin |
KR101243648B1 (ko) | 2003-11-20 | 2013-03-14 | 노보 노르디스크 에이/에스 | 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제 |
US7371381B2 (en) | 2003-12-12 | 2008-05-13 | Amgen Inc. | Anti-galanin antibodies and uses thereof |
DE10358387A1 (de) | 2003-12-13 | 2005-07-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung |
EP1734938B1 (en) | 2004-03-26 | 2012-06-20 | Universita' Degli Studi Di Parma | Insulin highly respirable microparticles |
AU2005329255B2 (en) | 2004-04-15 | 2010-09-30 | Chiasma, Inc. | Compositions capable of facilitating penetration across a biological barrier |
RU2006143544A (ru) | 2004-05-10 | 2008-06-20 | Нэстек Фармасьютикал Кампани Инк. (Us) | Композиции и способ для облегченной чресслизистой доставки паратиреоидного гормона |
EP1768694A1 (en) | 2004-07-09 | 2007-04-04 | Novo Nordisk A/S | Phamaceutical preparations comprising insulin |
EP2626368B1 (en) | 2004-07-19 | 2016-12-21 | Biocon Limited | Insulin-oligomer conjugates, formulations and uses thereof |
JP2008513356A (ja) | 2004-08-09 | 2008-05-01 | アリオス バイオファーマ インク. | 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法 |
CA2578175C (en) | 2004-08-23 | 2014-10-14 | Mannkind Corporation | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
EP2444071A1 (en) | 2004-09-27 | 2012-04-25 | Sigmoid Pharma Limited | Minicapsule formulations |
CN101060856B (zh) * | 2004-11-22 | 2011-01-19 | 诺和诺德公司 | 可溶、稳定的含胰岛素制剂 |
CN101102789B (zh) | 2004-12-03 | 2012-05-30 | 罗得岛医院 | 阿尔茨海默病的诊断和治疗 |
EP1843790A2 (en) | 2005-01-27 | 2007-10-17 | Novo Nordisk A/S | Insulin derivatives conjugated with structurally well defined branched polymers |
ES2428510T3 (es) | 2005-02-02 | 2013-11-08 | Novo Nordisk A/S | Derivados de insulina |
WO2006082205A1 (en) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Insulin derivatives |
US20090123563A1 (en) | 2005-02-07 | 2009-05-14 | Novo Nordisk A/S | Pharmaceutical Preparations Comprising Insulin, Zinc Ions and Zinc-Binding Ligand |
WO2006086856A1 (en) | 2005-02-15 | 2006-08-24 | Messadek, Jallal | Combination therapeutic compositions and method of use |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
WO2006097521A1 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Pegylated single-chain insulin |
WO2006103657A2 (en) | 2005-03-31 | 2006-10-05 | Dexcel Pharma Technologies Ltd. | A solid composition for intra-oral delivery of insulin |
EP1909824B1 (en) | 2005-04-08 | 2011-05-18 | Amylin Pharmaceuticals, Inc. | Pharmaceutical formulations comprising incretin peptide and aprotic polar solvent |
EP1888118B1 (en) | 2005-05-25 | 2016-08-17 | Novo Nordisk A/S | Polypeptide formulations stabilized with ethylenediamine |
WO2007006320A1 (en) | 2005-07-12 | 2007-01-18 | Sherine Hassan Abbas Helmy | Drinkable oral insulin liquid and capsules |
WO2007041481A1 (en) | 2005-09-29 | 2007-04-12 | Biodel, Inc. | Rapid acting and prolonged acting insulin preparations |
JP4710533B2 (ja) | 2005-10-07 | 2011-06-29 | 株式会社豊田自動織機 | 牽引車両のドローバー装置 |
CA2626357A1 (en) | 2005-10-20 | 2007-04-26 | Nastech Pharmaceutical Company Inc. | Intranasal administration of rapid acting insulin |
ES2371361T3 (es) | 2005-12-28 | 2011-12-30 | Novo Nordisk A/S | Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones. |
WO2007081824A2 (en) | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
JP2009527526A (ja) | 2006-02-21 | 2009-07-30 | ノボ・ノルデイスク・エー/エス | 単鎖インスリンのアナログとその製薬的製剤 |
ATE482977T1 (de) | 2006-02-27 | 2010-10-15 | Novo Nordisk As | Insulinderivate |
WO2007104738A2 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
WO2007104737A1 (en) | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Acylated single chain insulin |
KR101441444B1 (ko) | 2006-05-09 | 2014-09-18 | 노보 노르디스크 에이/에스 | 인슐린 유도체 |
US8796205B2 (en) | 2006-05-09 | 2014-08-05 | Novo Nordisk A/S | Insulin derivative |
EP2049149B1 (en) | 2006-07-31 | 2015-04-15 | Novo Nordisk A/S | Pegylated extended insulins |
CN101541830A (zh) | 2006-09-22 | 2009-09-23 | 诺沃-诺迪斯克有限公司 | 蛋白酶抗性的胰岛素类似物 |
WO2008043033A2 (en) | 2006-10-04 | 2008-04-10 | Case Western Reserve University | Fibrillation-resistant insulin and insulin analogues |
WO2008132224A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
WO2008132229A2 (en) | 2007-04-30 | 2008-11-06 | Novo Nordisk A/S | Highly concentrated insulin solutions and compositions |
CN101677944A (zh) | 2007-06-01 | 2010-03-24 | 诺沃-诺迪斯克有限公司 | 稳定的非含水药物组合物 |
JP2011504871A (ja) | 2007-06-01 | 2011-02-17 | ノボ・ノルデイスク・エー/エス | 固体又は半固体担体中にペプチド薬剤を含む自然に分散可能なプレコンセントレイト |
EP2167032B1 (en) | 2007-06-13 | 2019-08-07 | Novo Nordisk A/S | Pharmaceutical formulation comprising an insulin derivative |
WO2009010428A1 (en) | 2007-07-16 | 2009-01-22 | Novo Nordisk A/S | Protease stabilized, pegylated insulin analogues |
ES2558930T3 (es) | 2007-08-13 | 2016-02-09 | Novo Nordisk A/S | Análogos de la insulina de acción rápida |
WO2009022013A1 (en) | 2007-08-15 | 2009-02-19 | Novo Nordisk A/S | Insulin analogues with an acyl and aklylene glycol moiety |
JP5721432B2 (ja) | 2007-08-15 | 2015-05-20 | ノボ・ノルデイスク・エー/エス | アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン |
US20090087484A1 (en) | 2007-09-28 | 2009-04-02 | Alza Corporation | Formulation and dosage form for increasing oral bioavailability of hydrophilic macromolecules |
PT2597103T (pt) * | 2007-11-16 | 2017-02-08 | Novo Nordisk As | Composições farmacêuticas contendo insulina e um péptido insulinotrófico |
WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
EP2910571B1 (en) | 2008-03-18 | 2016-10-05 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
US8993516B2 (en) | 2008-04-14 | 2015-03-31 | Case Western Reserve University | Meal-time insulin analogues of enhanced stability |
TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
BRPI0919946A2 (pt) | 2008-10-30 | 2016-02-16 | Novo Nordisk As | tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente |
CN102227213A (zh) | 2008-11-28 | 2011-10-26 | 诺沃—诺迪斯克有限公司 | 适合于衍生化的胰岛素肽的口服施用的药物组合物 |
CN102245633A (zh) | 2008-12-09 | 2011-11-16 | 诺沃—诺迪斯克有限公司 | 新的胰岛素类似物 |
NZ594044A (en) * | 2009-02-13 | 2014-08-29 | Boehringer Ingelheim Int | Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics |
CN102481343A (zh) | 2009-09-16 | 2012-05-30 | 诺沃—诺迪斯克有限公司 | 稳定的含胰岛素的非水液体药物组合物 |
CN102665676B (zh) * | 2009-11-02 | 2015-04-01 | 诺沃-诺迪斯克有限公司 | 非共价结合的白蛋白和酰化胰岛素的药物溶液 |
RU2012133075A (ru) | 2010-01-12 | 2014-02-20 | Ново Нордиск А/С | Фармацевтическая композиция для перорального введения инсулиновых пептидов |
RU2598273C2 (ru) * | 2010-06-23 | 2016-09-20 | Ново Нордиск А/С | Производные инсулина, содержащие дополнительные дисульфидные связи |
US8815798B2 (en) | 2010-06-23 | 2014-08-26 | Novo Nordisk A/S | Insulin analogues containing additional disulfide bonds |
JP2013540771A (ja) | 2010-10-15 | 2013-11-07 | ノヴォ ノルディスク アー/エス | 新規n末端修飾インスリン誘導体 |
JP2013545782A (ja) * | 2010-12-14 | 2013-12-26 | ノヴォ ノルディスク アー/エス | 長時間作用型インスリンと組み合わせた速効型インスリン |
WO2012171994A1 (en) | 2011-06-15 | 2012-12-20 | Novo Nordisk A/S | Multi substituted insulins |
CN104364260B (zh) * | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
WO2014009316A1 (en) | 2012-07-09 | 2014-01-16 | Novo Nordisk A/S | Novel use of insulin derivatives |
US10137172B2 (en) | 2013-04-30 | 2018-11-27 | Novo Nordisk A/S | Administration regime |
WO2014202780A1 (en) | 2013-06-21 | 2014-12-24 | Novo Nordisk A/S | Novel uses of glp-1 receptor agonists in patients treated with insulin and/or suffering from type 1 diabetes |
ES2676065T3 (es) * | 2013-10-07 | 2018-07-16 | Novo Nordisk A/S | Nuevo derivado de un análogo de la insulina |
CN104587455A (zh) * | 2013-10-31 | 2015-05-06 | 江苏万邦生化医药股份有限公司 | 一种胰岛素制剂 |
FR3013049B1 (fr) | 2013-11-14 | 2015-11-13 | You-Ping Chan | Analogue de l'insuline glargine |
MX2016008978A (es) * | 2014-01-09 | 2016-10-04 | Sanofi Sa | Formulaciones farmaceuticas de analogos de insulina y/o derivados de insulina estabilizadas y que estan libres de glicerol. |
US20170028031A1 (en) | 2014-03-07 | 2017-02-02 | Klavs Holger Jørgensen | Novel fast acting insulin preparations |
TWI685348B (zh) | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
AR102869A1 (es) | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
MA49116A (fr) | 2016-12-16 | 2020-03-25 | Novo Nordisk As | Compositions pharmaceutiques contenant de l'insuline |
-
2017
- 2017-12-15 MA MA049116A patent/MA49116A/fr unknown
- 2017-12-15 RU RU2019118696A patent/RU2758367C2/ru active
- 2017-12-15 RS RS20211060A patent/RS62295B1/sr unknown
- 2017-12-15 TW TW106144072A patent/TWI700091B/zh active
- 2017-12-15 CN CN201780077665.4A patent/CN110087674B/zh active Active
- 2017-12-15 BR BR112019011761-0A patent/BR112019011761A2/pt unknown
- 2017-12-15 ES ES17832941T patent/ES2886837T3/es active Active
- 2017-12-15 HU HUE17832941A patent/HUE055231T2/hu unknown
- 2017-12-15 HR HRP20221324TT patent/HRP20221324T1/hr unknown
- 2017-12-15 AU AU2017378102A patent/AU2017378102B2/en active Active
- 2017-12-15 DK DK20208962.9T patent/DK3821905T3/da active
- 2017-12-15 TW TW108137665A patent/TWI700092B/zh active
- 2017-12-15 MY MYPI2019003286A patent/MY194504A/en unknown
- 2017-12-15 CA CA3046583A patent/CA3046583A1/en active Pending
- 2017-12-15 PL PL17832941T patent/PL3554534T3/pl unknown
- 2017-12-15 PE PE2020002022A patent/PE20210857A1/es unknown
- 2017-12-15 MX MX2019006463A patent/MX2019006463A/es unknown
- 2017-12-15 EP EP17832941.3A patent/EP3554534B1/en active Active
- 2017-12-15 PT PT178329413T patent/PT3554534T/pt unknown
- 2017-12-15 EP EP20208962.9A patent/EP3821905B1/en active Active
- 2017-12-15 JP JP2019531948A patent/JP6690062B2/ja active Active
- 2017-12-15 CN CN202210905188.9A patent/CN115154591B/zh active Active
- 2017-12-15 HU HUE20208962A patent/HUE060149T2/hu unknown
- 2017-12-15 KR KR1020217021581A patent/KR102580007B1/ko active IP Right Grant
- 2017-12-15 IL IL267224A patent/IL267224B2/en unknown
- 2017-12-15 ES ES20208962T patent/ES2930149T3/es active Active
- 2017-12-15 RS RS20221009A patent/RS63773B1/sr unknown
- 2017-12-15 SI SI201730873T patent/SI3554534T1/sl unknown
- 2017-12-15 PE PE2019001239A patent/PE20191205A1/es unknown
- 2017-12-15 IL IL300839A patent/IL300839B2/en unknown
- 2017-12-15 DK DK17832941.3T patent/DK3554534T3/da active
- 2017-12-15 US US15/843,016 patent/US20180169190A1/en not_active Abandoned
- 2017-12-15 WO PCT/EP2017/083013 patent/WO2018109162A1/en active Application Filing
- 2017-12-15 KR KR1020197016684A patent/KR102374354B1/ko active IP Right Grant
- 2017-12-15 PL PL20208962.9T patent/PL3821905T3/pl unknown
-
2018
- 2018-06-29 US US16/023,328 patent/US10265385B2/en active Active
-
2019
- 2019-02-20 US US16/280,603 patent/US10596231B2/en active Active
- 2019-06-03 MX MX2021002083A patent/MX2021002083A/es unknown
- 2019-06-05 SA SA520420276A patent/SA520420276B1/ar unknown
- 2019-06-10 CO CO2019006017A patent/CO2019006017A2/es unknown
- 2019-06-10 CL CL2019001586A patent/CL2019001586A1/es unknown
- 2019-06-14 PH PH12019501363A patent/PH12019501363A1/en unknown
-
2020
- 2020-04-07 JP JP2020068954A patent/JP6788139B2/ja active Active
- 2020-08-04 US US16/984,990 patent/US20200384088A1/en not_active Abandoned
-
2021
- 2021-08-10 HR HRP20211281TT patent/HRP20211281T1/hr unknown
-
2022
- 2022-03-11 US US17/692,238 patent/US20220202909A1/en active Pending
- 2022-08-19 AU AU2022218612A patent/AU2022218612B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20221324T1 (hr) | Farmaceutski pripravci koji sadrže inzulin | |
HRP20192299T1 (hr) | Liječenje nafld i nash | |
HRP20180468T1 (hr) | Novi derivat analoga inzulina | |
HRP20191477T1 (hr) | Farmaceutski sastav s-ketamin hidroklorida | |
JP2015514120A5 (hr) | ||
MX2020012041A (es) | Formulacion farmaceutica. | |
BR112015022197A8 (pt) | uso de um composto para fabricação de um medicamento ou composição farmacêutica para o tratamento de cataplexia | |
MX338338B (es) | Composiciones y metodos utiles para el tratamiento de enfermedades respiratorias. | |
NO20082538L (no) | Stabiliserte lantankarbonatsammensetninger | |
MX2017004614A (es) | Preparacion compuesta, que contiene derivado novedoso de acido 3-(4-(benciloxi)fenil)hex-4-inoico y otro ingrediente activo, para prevenir o tratar enfermedades metabolicas. | |
EA200701519A1 (ru) | Живая аттенуированная ротавирусная вакцина для перорального введения | |
AR105712A1 (es) | Composiciones de insulina de rápida acción | |
BRPI0705488A (pt) | composição nanoparticulada estável, métodos de preparar a mesma e de prevenir e/ou tratar uma infecção bacteriana, composição farmacêutica, e, forma de dosagem | |
BRPI0806392A8 (pt) | uso de aclidínio, aclidínio, método de tratamento ou prevenção e composição farmacêutica | |
JP2017502074A5 (hr) | ||
RS52821B (en) | LONG-TERM TREATMENT OF HIV INFECTION WITH TCM278 | |
MX2020010300A (es) | Sales monoacidas de 6-aminoisoquinolinas y usos de las mismas. | |
EA201291410A1 (ru) | Фармацевтические композиции, содержащие 4-амино-5-фтор-3-[6-(4-метилпиперазин-1-ил)-1h-бензимидазол-2-ил]-1h-хинолин-2-она лактат моногидрат | |
ATE550023T1 (de) | Stabile feste zubereitung mit 4,5- epoxymorphinanderivat | |
AR092993A1 (es) | Laquinimod para reducir el daño talamico en la esclerosis multiple | |
BR112012030641A2 (pt) | métodos e composições para terapia farmacêutica oral | |
WO2018005801A3 (en) | Novel non-systemic tgr5 agonists | |
Iqbal et al. | Uses and effects of mercury in medicine and dentistry | |
WO2018160178A8 (en) | Pharmaceutically acceptable salts of b-guanidinopropionic acid with improved properties and uses thereof | |
EA201391063A1 (ru) | Аполипопротеин a-iv в качестве антидиабетического пептида |