ATE482977T1 - Insulinderivate - Google Patents

Insulinderivate

Info

Publication number
ATE482977T1
ATE482977T1 AT07712327T AT07712327T ATE482977T1 AT E482977 T1 ATE482977 T1 AT E482977T1 AT 07712327 T AT07712327 T AT 07712327T AT 07712327 T AT07712327 T AT 07712327T AT E482977 T1 ATE482977 T1 AT E482977T1
Authority
AT
Austria
Prior art keywords
insulin derivatives
chain
amino group
present
lys residue
Prior art date
Application number
AT07712327T
Other languages
English (en)
Inventor
Charlotte Fynbo
Ib Jonassen
Thomas Kjeldsen
Peter Madsen
Patrick Garibay
Janos Kodra
Thomas Hoeg-Jensen
Tina Tagmose
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE482977T1 publication Critical patent/ATE482977T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT07712327T 2006-02-27 2007-02-27 Insulinderivate ATE482977T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06110441 2006-02-27
EP06118253 2006-08-01
PCT/EP2007/051835 WO2007096431A1 (en) 2006-02-27 2007-02-27 Insulin derivatives

Publications (1)

Publication Number Publication Date
ATE482977T1 true ATE482977T1 (de) 2010-10-15

Family

ID=38001155

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07712327T ATE482977T1 (de) 2006-02-27 2007-02-27 Insulinderivate
AT10168840T ATE557037T1 (de) 2006-02-27 2007-02-27 Insulin derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT10168840T ATE557037T1 (de) 2006-02-27 2007-02-27 Insulin derivate

Country Status (7)

Country Link
US (1) US8722620B2 (de)
EP (2) EP2256129B1 (de)
JP (2) JP5202338B2 (de)
AT (2) ATE482977T1 (de)
DE (1) DE602007009496D1 (de)
ES (1) ES2387955T3 (de)
WO (1) WO2007096431A1 (de)

Families Citing this family (43)

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BRPI0413276B8 (pt) * 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
WO2006082205A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
ES2428510T3 (es) 2005-02-02 2013-11-08 Novo Nordisk A/S Derivados de insulina
ES2371361T3 (es) * 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
KR101441444B1 (ko) * 2006-05-09 2014-09-18 노보 노르디스크 에이/에스 인슐린 유도체
US8796205B2 (en) 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
CN101541830A (zh) 2006-09-22 2009-09-23 诺沃-诺迪斯克有限公司 蛋白酶抗性的胰岛素类似物
WO2008132224A2 (en) 2007-04-30 2008-11-06 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
EP2167032B1 (de) 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmazeutische formulierung enthaltend ein insulinderivat
WO2009022013A1 (en) 2007-08-15 2009-02-19 Novo Nordisk A/S Insulin analogues with an acyl and aklylene glycol moiety
JP5721432B2 (ja) 2007-08-15 2015-05-20 ノボ・ノルデイスク・エー／エス アミノ酸含有アルキレングリコール反復単位を含むアシル部を有するインスリン
US8710000B2 (en) * 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
WO2009112583A2 (en) * 2008-03-14 2009-09-17 Novo Nordisk A/S Protease-stabilized insulin analogues
EP2910571B1 (de) * 2008-03-18 2016-10-05 Novo Nordisk A/S Proteasestabilisierte, acylierte insulinanaloga
ES2563553T3 (es) 2008-04-01 2016-03-15 Novo Nordisk A/S Conjugados de insulina-albúmina
BRPI0919946A2 (pt) * 2008-10-30 2016-02-16 Novo Nordisk As tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente
US8906850B2 (en) 2009-01-28 2014-12-09 Smartcells, Inc. Crystalline insulin-conjugates
EP2391217A4 (de) 2009-01-28 2015-05-20 Smartcells Inc Synthetische konjugate und ihre verwendung
ES2791683T3 (es) 2009-01-28 2020-11-05 Smartcells Inc Sistemas a base de conjugados para la administración controlada de fármacos
US8846103B2 (en) 2009-01-28 2014-09-30 Smartcells, Inc. Exogenously triggered controlled release materials and uses thereof
US8569231B2 (en) 2009-03-20 2013-10-29 Smartcells, Inc. Soluble non-depot insulin conjugates and uses thereof
WO2010107519A1 (en) 2009-03-20 2010-09-23 Smartcells, Inc. Terminally-functionalized conjugates and uses thereof
CN102665676B (zh) 2009-11-02 2015-04-01 诺沃-诺迪斯克有限公司 非共价结合的白蛋白和酰化胰岛素的药物溶液
CA2805902A1 (en) 2010-07-28 2012-02-02 Smartcells, Inc. Recombinant lectins, binding-site modified lectins and uses thereof
AU2011282977A1 (en) 2010-07-28 2013-02-21 Smartcells, Inc. Drug-ligand conjugates, synthesis thereof, and intermediates thereto
EP2598527A4 (de) 2010-07-28 2014-01-08 Smartcells Inc Rekombinant exprimierte insulinpolypeptide und anwendungen davon
RU2013123515A (ru) 2010-10-27 2014-12-10 Ново Нордиск А/С Лечение сахарного диабета с помощью инъекций инсулина, вводимых с различными интервалами
WO2012171994A1 (en) * 2011-06-15 2012-12-20 Novo Nordisk A/S Multi substituted insulins
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
US10137172B2 (en) 2013-04-30 2018-11-27 Novo Nordisk A/S Administration regime
AU2014329567B2 (en) 2013-10-04 2019-07-25 Merck Sharp & Dohme Corp. Glucose-responsive insulin conjugates
ES2676065T3 (es) 2013-10-07 2018-07-16 Novo Nordisk A/S Nuevo derivado de un análogo de la insulina
AR099569A1 (es) 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
EP3280450A4 (de) * 2015-04-08 2018-12-12 Merck Sharp & Dohme Corp. Auf glucose reagierende insulinkonjugate
TW201717998A (zh) 2015-08-25 2017-06-01 諾佛 儂迪克股份有限公司 新穎胰島素衍生物及其醫學用途
MA49116A (fr) 2016-12-16 2020-03-25 Novo Nordisk As Compositions pharmaceutiques contenant de l'insuline
CN107602437A (zh) * 2017-08-09 2018-01-19 上海昂德生物科技有限公司 活化酯的制备方法
MX2020001434A (es) 2017-08-17 2020-03-20 Novo Nordisk As Analogos de insulina acilados novedosos y usos de estos.
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
CN113423691A (zh) 2018-12-11 2021-09-21 赛诺菲 肽结合剂
BR112022009510A2 (pt) 2019-12-11 2022-08-16 Novo Nordisk As Análogo de insulina, composição farmacêutica, e, método de tratamento, prevenção ou alívio de uma doença ou distúrbio ou condição
CN113075342B (zh) * 2020-01-04 2024-02-27 东莞市东阳光仿制药研发有限公司 一种分离检测德谷胰岛素侧链有关物质的方法

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DE69924232D1 (de) * 1998-01-09 2005-04-21 Novo Nordisk As Stabilisierte insulin-zubereitungen
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US20040138099A1 (en) * 2002-11-29 2004-07-15 Draeger Eberhard Kurt Insulin administration regimens for the treatment of subjects with diabetes
EP1620465A2 (de) * 2003-04-29 2006-02-01 Eli Lilly And Company Insulin-analoge mit zeitverzögerter wirkung
US20060183667A1 (en) * 2003-07-11 2006-08-17 Novo Nordisk A/S Stabilised insulin compositions
WO2005005477A2 (en) 2003-07-11 2005-01-20 Novo Nordisk A/S Stabilised insulin compositions
BRPI0413276B8 (pt) * 2003-08-05 2021-05-25 Novo Nordisk As derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
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ES2428510T3 (es) * 2005-02-02 2013-11-08 Novo Nordisk A/S Derivados de insulina
ES2371361T3 (es) * 2005-12-28 2011-12-30 Novo Nordisk A/S Composiciones que comprenden una insulina acilada y zinc y método de producción de dichas composiciones.
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
KR101441444B1 (ko) * 2006-05-09 2014-09-18 노보 노르디스크 에이/에스 인슐린 유도체
US8796205B2 (en) * 2006-05-09 2014-08-05 Novo Nordisk A/S Insulin derivative
EP2167032B1 (de) 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmazeutische formulierung enthaltend ein insulinderivat
US8710000B2 (en) * 2007-11-08 2014-04-29 Novo Nordisk A/S Insulin derivative
PT2597103T (pt) 2007-11-16 2017-02-08 Novo Nordisk As Composições farmacêuticas contendo insulina e um péptido insulinotrófico
BRPI0919946A2 (pt) 2008-10-30 2016-02-16 Novo Nordisk As tratamento de diabetes melito usando injeções de insulina com frequência de injeção menor que diariamente
CA2795091A1 (en) 2010-05-10 2011-11-17 Novo Nordisk A/S Process for the preparation of insulin-zinc complexes

Also Published As

Publication number Publication date
JP2012214486A (ja) 2012-11-08
EP2256129A1 (de) 2010-12-01
ATE557037T1 (de) 2012-05-15
EP2256129B1 (de) 2012-05-09
JP5475836B2 (ja) 2014-04-16
WO2007096431A1 (en) 2007-08-30
EP1991576B1 (de) 2010-09-29
EP1991576A1 (de) 2008-11-19
DE602007009496D1 (de) 2010-11-11
JP5202338B2 (ja) 2013-06-05
JP2009528325A (ja) 2009-08-06
US20090137454A1 (en) 2009-05-28
US8722620B2 (en) 2014-05-13
ES2387955T3 (es) 2012-10-04

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties