ATE496064T1 - Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten - Google Patents
Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthaltenInfo
- Publication number
- ATE496064T1 ATE496064T1 AT03722301T AT03722301T ATE496064T1 AT E496064 T1 ATE496064 T1 AT E496064T1 AT 03722301 T AT03722301 T AT 03722301T AT 03722301 T AT03722301 T AT 03722301T AT E496064 T1 ATE496064 T1 AT E496064T1
- Authority
- AT
- Austria
- Prior art keywords
- insulin
- formulations containing
- containing monomeric
- acylated
- soluble formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200200683 | 2002-05-07 | ||
PCT/DK2003/000288 WO2003094956A1 (en) | 2002-05-07 | 2003-05-02 | Soluble formulations comprising monomeric insulin and acylated insulin |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE496064T1 true ATE496064T1 (de) | 2011-02-15 |
Family
ID=29414624
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03722301T ATE496064T1 (de) | 2002-05-07 | 2003-05-02 | Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten |
Country Status (8)
Country | Link |
---|---|
US (2) | US20040006000A1 (de) |
EP (1) | EP1506230B1 (de) |
JP (2) | JP5599543B2 (de) |
AT (1) | ATE496064T1 (de) |
AU (1) | AU2003236201A1 (de) |
DE (1) | DE60335797D1 (de) |
ES (1) | ES2360182T3 (de) |
WO (1) | WO2003094956A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2360182T3 (es) * | 2002-05-07 | 2011-06-01 | Novo Nordisk A/S | Formulaciones solubles que comprenden insulina monomérica e insulina acilada. |
JP4463814B2 (ja) * | 2003-08-05 | 2010-05-19 | ノボ ノルディスク アクティーゼルスカブ | 新規のインスリン誘導体 |
JP5248113B2 (ja) * | 2004-11-12 | 2013-07-31 | ノヴォ ノルディスク アー/エス | ペプチドの安定な処方 |
ATE519780T1 (de) | 2005-12-28 | 2011-08-15 | Novo Nordisk As | Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen |
FR2896247B1 (fr) | 2006-01-13 | 2008-02-29 | Sanofi Aventis Sa | Composes dimeres agonistes des recepteurs des fgfs (fgfrs), leur procede de preparation et leur application en therapeutique |
BRPI0717098B8 (pt) | 2006-09-22 | 2021-05-25 | Novo Nordisk As | análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação |
US9387176B2 (en) | 2007-04-30 | 2016-07-12 | Novo Nordisk A/S | Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein |
ES2744384T3 (es) | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
JP5241849B2 (ja) | 2007-11-16 | 2013-07-17 | ノボ・ノルデイスク・エー/エス | インスリン及びインスリン分泌性ペプチドを含む薬学的組成物 |
WO2009112583A2 (en) | 2008-03-14 | 2009-09-17 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
MX2010009850A (es) | 2008-03-18 | 2010-09-30 | Novo Nordisk As | Analogos de insulina acilados y etabilizados contra proteasas. |
RU2458989C1 (ru) * | 2008-08-07 | 2012-08-20 | Байокон Лимитид | Способ получения аналогов инсулина из их соответствующих предшественников (варианты) |
PT3228320T (pt) | 2008-10-17 | 2020-03-26 | Sanofi Aventis Deutschland | Combinação de uma insulina e de um agonista do glp-1 |
JP4959005B2 (ja) | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー/エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
KR101635689B1 (ko) | 2009-01-28 | 2016-07-01 | 스마트쎌스, 인크. | 제어 약물 전달을 위한 접합체 기재 시스템 |
US8940690B2 (en) | 2009-01-28 | 2015-01-27 | National Institutes Of Health (Nih) | Synthetic conjugates and uses thereof |
HUE026102T2 (en) * | 2009-02-04 | 2016-05-30 | Sanofi Aventis Deutschland | Medical device and procedure for glycemic control |
JP2012520879A (ja) | 2009-03-20 | 2012-09-10 | スマートセルズ・インコーポレイテツド | 末端官能基化コンジュゲートおよびその用途 |
MY180661A (en) | 2009-11-13 | 2020-12-04 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine |
AU2010317994B2 (en) | 2009-11-13 | 2014-03-06 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
CN101912600B (zh) * | 2010-01-11 | 2014-01-29 | 杨国汉 | 改善胰岛素在溶液中稳定性的方法 |
US9180261B2 (en) * | 2010-01-12 | 2015-11-10 | Dance Biopharm Inc. | Preservative free insulin formulations and systems and methods for aerosolizing |
US10842951B2 (en) | 2010-01-12 | 2020-11-24 | Aerami Therapeutics, Inc. | Liquid insulin formulations and methods relating thereto |
US20140148384A1 (en) | 2010-08-30 | 2014-05-29 | Sanofi-Aventis Deutschland Gmbh | Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2 |
BR112013010345A2 (pt) | 2010-10-27 | 2017-07-25 | Novo Nordisk As | tratamento de diabetes melitus usando as injeções de insulina administradas com intervalos de variação da injeção |
WO2012055840A1 (en) * | 2010-10-28 | 2012-05-03 | Bayer Pharma Aktiengesellschaft | Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders |
RU2013130374A (ru) * | 2010-12-14 | 2015-01-20 | Ново Нордиск А/С | Препарат, содержащий инсулин, никотинамид и аминокислоту |
EP2651432A1 (de) | 2010-12-14 | 2013-10-23 | Novo Nordisk A/S | Schnellwirkendes insulin in verbindung mit langwirkendem insulin |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
BR112014004726A2 (pt) | 2011-08-29 | 2017-04-04 | Sanofi Aventis Deutschland | combinação farmacêutica para uso no controle glicêmico em pacientes de diabetes tipo 2 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
CN104364260B (zh) | 2012-04-11 | 2017-02-22 | 诺和诺德股份有限公司 | 胰岛素制剂 |
KR102205512B1 (ko) | 2012-11-13 | 2021-01-20 | 아도시아 | 치환된 음이온성 화합물을 포함하는 속효성 인슐린 제형 |
CA2890048C (en) | 2012-12-03 | 2022-05-03 | Merck Sharp & Dohme Corp. | O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues |
TWI641381B (zh) * | 2013-02-04 | 2018-11-21 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
EP2991672A1 (de) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Neuartiges verabreichungsschema |
US9896496B2 (en) | 2013-10-07 | 2018-02-20 | Novo Nordisk A/S | Derivative of an insulin analogue |
SG11201604706TA (en) | 2014-01-09 | 2016-07-28 | Sanofi Sa | Stabilized pharmaceutical formulations of insulin aspart |
JP7173953B2 (ja) * | 2014-01-09 | 2022-11-16 | サノフイ | インスリンアナログおよび/またはインスリン誘導体の安定化された医薬製剤 |
AU2015205621A1 (en) | 2014-01-09 | 2016-07-14 | Sanofi | Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives |
JP6641280B2 (ja) | 2014-01-09 | 2020-02-05 | サノフイSanofi | インスリンアナログおよび/またはインスリン誘導体の安定化された医薬製剤 |
JO3624B1 (ar) * | 2014-05-08 | 2020-08-27 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
EP3229828B1 (de) | 2014-12-12 | 2023-04-05 | Sanofi-Aventis Deutschland GmbH | Insulin-glargin/lixisenatid-fixierte verhältnisformulierung |
WO2016137569A1 (en) | 2015-02-25 | 2016-09-01 | Dance Biopharm, Inc. | Liquid insulin formulations and methods relating thereto |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
WO2018109162A1 (en) | 2016-12-16 | 2018-06-21 | Novo Nordisk A/S | Insulin containing pharmaceutical compositions |
GB201707187D0 (en) * | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
EP3727424A4 (de) | 2017-12-18 | 2021-10-27 | Merck Sharp & Dohme Corp. | Konjugatbasierte systeme für kontrollierte insulinfreisetzung |
US11413352B2 (en) | 2017-12-18 | 2022-08-16 | Merck, Sharp & Dohme LLC | Conjugate based systems for controlled insulin delivery |
US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
CR20220555A (es) | 2020-03-31 | 2023-01-23 | Protomer Tech Inc | Conjugados para reactividad selectiva a dioles vecinales |
EP4247429A1 (de) | 2020-11-19 | 2023-09-27 | Protomer Technologies Inc. | Aromatische borhaltige verbindungen und insulinanaloga |
TW202409070A (zh) | 2022-05-18 | 2024-03-01 | 美商普羅托莫科技公司 | 芳族含硼化合物及相關胰島素類似物 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU550068B2 (en) | 1981-03-10 | 1986-02-27 | Novo Nordisk A/S | Zinc insulin stabilized with calcium or magnesium salts |
NL193099C (nl) | 1981-10-30 | 1998-11-03 | Novo Industri As | Gestabiliseerde insuline-oplossing. |
FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
US4839341A (en) * | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
SI0792290T1 (en) * | 1993-09-17 | 2001-12-31 | Novo Nordisk As | Acylated insulin |
US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
DE69629210T2 (de) | 1995-03-17 | 2004-04-22 | Novo Nordisk A/S | Insulinabkömmlinge |
US20010041786A1 (en) | 1995-06-07 | 2001-11-15 | Mark L. Brader | Stabilized acylated insulin formulations |
US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
ZA984697B (en) * | 1997-06-13 | 1999-12-01 | Lilly Co Eli | Stable insulin formulations. |
DE19726167B4 (de) * | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
US6531448B1 (en) | 1997-12-23 | 2003-03-11 | Eli Lilly And Company | Insoluble compositions for controlling blood glucose |
HUP0104111A3 (en) * | 1998-10-16 | 2002-05-28 | Novo Nordisk As | Stable concentrated insulin preparations for pulmonary delivery |
ATE220917T1 (de) * | 1999-01-26 | 2002-08-15 | Lilly Co Eli | Monodisperse formulierungen, die hexamere acylierte insulinanaloge enthalten |
US6589229B1 (en) * | 2000-07-31 | 2003-07-08 | Becton, Dickinson And Company | Wearable, self-contained drug infusion device |
AU2003208316A1 (en) * | 2002-03-13 | 2003-09-22 | Novo Nordisk A/S | Minimising body weight gain in insulin treatment |
ES2360182T3 (es) * | 2002-05-07 | 2011-06-01 | Novo Nordisk A/S | Formulaciones solubles que comprenden insulina monomérica e insulina acilada. |
-
2003
- 2003-05-02 ES ES03722301T patent/ES2360182T3/es not_active Expired - Lifetime
- 2003-05-02 EP EP03722301A patent/EP1506230B1/de not_active Expired - Lifetime
- 2003-05-02 DE DE60335797T patent/DE60335797D1/de not_active Expired - Lifetime
- 2003-05-02 WO PCT/DK2003/000288 patent/WO2003094956A1/en active Application Filing
- 2003-05-02 AU AU2003236201A patent/AU2003236201A1/en not_active Abandoned
- 2003-05-02 JP JP2004503039A patent/JP5599543B2/ja not_active Expired - Fee Related
- 2003-05-02 AT AT03722301T patent/ATE496064T1/de not_active IP Right Cessation
- 2003-05-05 US US10/429,508 patent/US20040006000A1/en not_active Abandoned
-
2005
- 2005-07-29 US US11/193,200 patent/US7387996B2/en not_active Expired - Fee Related
-
2012
- 2012-08-03 JP JP2012173117A patent/JP2012233003A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2006511441A (ja) | 2006-04-06 |
JP2012233003A (ja) | 2012-11-29 |
US20050261168A1 (en) | 2005-11-24 |
AU2003236201A1 (en) | 2003-11-11 |
US20040006000A1 (en) | 2004-01-08 |
ES2360182T3 (es) | 2011-06-01 |
EP1506230A1 (de) | 2005-02-16 |
JP5599543B2 (ja) | 2014-10-01 |
EP1506230B1 (de) | 2011-01-19 |
US7387996B2 (en) | 2008-06-17 |
WO2003094956A1 (en) | 2003-11-20 |
DE60335797D1 (de) | 2011-03-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |