HRP20201463T1 - Postupak liječenja raka dojke selektivnim modulatorom androgenskog receptora (sarm) - Google Patents
Postupak liječenja raka dojke selektivnim modulatorom androgenskog receptora (sarm) Download PDFInfo
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- HRP20201463T1 HRP20201463T1 HRP20201463TT HRP20201463T HRP20201463T1 HR P20201463 T1 HRP20201463 T1 HR P20201463T1 HR P20201463T T HRP20201463T T HR P20201463TT HR P20201463 T HRP20201463 T HR P20201463T HR P20201463 T1 HRP20201463 T1 HR P20201463T1
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- Prior art keywords
- breast cancer
- positive
- negative
- use according
- sarm compound
- Prior art date
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- 206010006187 Breast cancer Diseases 0.000 title claims 25
- 208000026310 Breast neoplasm Diseases 0.000 title claims 23
- 229940083324 Selective androgen receptor modulator Drugs 0.000 title claims 20
- 239000000849 selective androgen receptor modulator Substances 0.000 title claims 20
- 101100420683 Drosophila melanogaster Sarm gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 17
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 9
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052794 bromium Inorganic materials 0.000 claims 7
- 229910052740 iodine Inorganic materials 0.000 claims 7
- 206010055113 Breast cancer metastatic Diseases 0.000 claims 6
- 229910052731 fluorine Inorganic materials 0.000 claims 6
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 4
- -1 bevacizumab Chemical compound 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 2
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical group F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 claims 2
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 claims 2
- 108010081348 HRT1 protein Hairy Chemical group 0.000 claims 2
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 claims 2
- 239000002136 L01XE07 - Lapatinib Substances 0.000 claims 2
- 102000007399 Nuclear hormone receptor Human genes 0.000 claims 2
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims 2
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 2
- 229960002932 anastrozole Drugs 0.000 claims 2
- YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 claims 2
- 239000003886 aromatase inhibitor Substances 0.000 claims 2
- 229940046844 aromatase inhibitors Drugs 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 229960000397 bevacizumab Drugs 0.000 claims 2
- 229960000255 exemestane Drugs 0.000 claims 2
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical group F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 claims 2
- 229960002258 fulvestrant Drugs 0.000 claims 2
- 229960004891 lapatinib Drugs 0.000 claims 2
- BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 claims 2
- 229960003881 letrozole Drugs 0.000 claims 2
- HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 claims 2
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 claims 2
- 229960002087 pertuzumab Drugs 0.000 claims 2
- 229940095743 selective estrogen receptor modulator Drugs 0.000 claims 2
- 239000000333 selective estrogen receptor modulator Substances 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 229960001603 tamoxifen Drugs 0.000 claims 2
- 229910052718 tin Inorganic materials 0.000 claims 2
- 229960005026 toremifene Drugs 0.000 claims 2
- XFCLJVABOIYOMF-QPLCGJKRSA-N toremifene Chemical compound C1=CC(OCCN(C)C)=CC=C1C(\C=1C=CC=CC=1)=C(\CCCl)C1=CC=CC=C1 XFCLJVABOIYOMF-QPLCGJKRSA-N 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- 229960001612 trastuzumab emtansine Drugs 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/02—Carbamic acids; Salts of carbamic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Electrotherapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (14)
1. Spoj selektivnog modulatora androgenskog receptora (SARM) predstavljen strukturom formule I:
[image]
naznačen time što
X je O;
G je O;
T je OH;
R je alkil, CH2F, CHF2, CF3, CF2CF3, aril, alkenil ili OH;
R1 je CH3;
R2 je H, F, CI, Br, I, CH3, CF3, OH, CN, NO2, NHCOCH3, NHCOCF3, NHCOR, alkil, arilalkil, OR, NH2, NHR, N(R)2 ili SR;
R3 je H, F, CI, Br, I, CN, N02, COR, COOH, CONHR, CF3 ili Sn(R)3;
Z je NO2, CN, COR, COOH ili CONHR;
Y je CF3, F, Br, Cl, I, CN ili Sn (R) 3;
Q je CN, alkil, halogen, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R ili SR;
n je cijeli broj 1-4; i
m je cijeli broj 1-3;
za uporabu u liječenju subjekta koji pati od AR-pozitivnog raka dojke, ER-pozitivnog raka dojke, trostrukog negativnog raka dojke, uznapredovalog raka dojke, vatrostalnog raka dojke, metastatskog raka dojke, ili raka dojke koji nije uspio u selektivnom modulatoru estrogenskog receptora (tamoksifen, toremifen), inhibitora aromataze (eksemestan, anastrozol, letrozol), trastuzumaba, ado-trastuzumab emtansina, pertuzumaba, lapatiniba, bevacizumaba, i / ili fulvestrant tretmana.
2. Spoj selektivnog modulatora androgenskog receptora (SARM) predstavljen strukturom formule I:
[image]
pri čemu
X je O;
G je O;
T je OH;
R je alkil, CH2F, CHF2, CF3, CF2CF3, aril, alkenil ili OH;
R1 je CH3;
R2 je H, F, CI, Br, I, CH3, CF3, OH, CN, NO2, NHCOCH3, NHCOCF3, NHCOR, alkil, arilalkil, OR, NH2, NHR, N(R)2 ili SR;
R3 je H, F, CI, Br, I, CN, N02, COR, COOH, CONHR, CF3, Sn(R)3;
Z je NO2, CN, COR, COOH ili CONHR;
Y je CF3, F, Br, CI, I, CN, ili Sn(R)3;
Q je CN, alkil, halogen, N(R)2, NHCOCH3, NHCOCF3, NHCOR, NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3, NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R ili SR;
n je cijeli broj 1-4; i
m je cijeli broj 1-3;
za uporabu u liječenju, suzbijanju ili inhibiranju metastaza u subjektu koji pati od raka dojke.
3. Spoj SARM za uporabu u skladu s bilo kojim od patentnih zahtjeva 1-2, naznačen time što je navedeni spoj SARM predstavljen strukturom formule II:
[image]
pri čemu
X je O;
G je O;
T je OH;
Z je CN;
Y je I, CF3, Br, CI ili Sn(R)3;
Q je CN, alkil, halogen, N(R)2, NHCOCH3, NHCOCF3, NHCOR,
NHCONHR, NHCOOR, OCONHR, CONHR, NHCSCH3, NHCSCF3,
NHCSR, NHSO2CH3, NHSO2R, OR, COR, OCOR, OSO2R, SO2R ili SR;
R je C1-C4 alkil, aril, fenil, alkenil ili hidroksil; i
R1 je CH3.
4. Spoj SARM za uporabu u skladu s bilo kojim od patentnih zahtjeva 1-2, naznačen time što je navedeni spoj SARM predstavljen strukturom formule VIII, IX, X, XI, XII, XIII ili XIV:
[image]
[image]
[image]
[image]
[image]
[image]
[image]
5. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni metastatski rak dojke AR-pozitivan metastatski rak dojke.
6. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni vatrostalni rak dojke AR-pozitivan vatrostalni rak dojke.
7. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni AR-pozitivan rak dojke AR-pozitivan vatrostalni rak dojke ili AR-pozitivan metastatski rak dojke.
8. Spoj SARM za uporabu u skladu s patentnim zahtjevom 2, naznačen time što je navedeni rak dojke metastatski rak dojke; vatrostalni rak dojke; AR-pozitivan rak dojke; AR-pozitivan vatrostalni rak dojke; AR-pozitivan metastatski rak dojke; trostruko negativni rak dojke; uznapredovali rak dojke; i / ili rak dojke koji nije uspio u selektivnom modulatoru estrogenskog receptora (tamoksifen, toremifen), inhibitora aromataze (eksemestan, anastrozol, letrozol), trastuzumaba, ado-trastuzumab emtansina, pertuzumaba, lapatiniba, bevacizumaba, i / ili fulvestrant tretmana.
9. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni ER-pozitivan rak dojke AR-pozitivan i ER-pozitivan rak dojke; ili AR-negativan i ER-pozitivan rak dojke.
10. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni AR-pozitivan rak dojke ER-negativan; ER-negativan, PR-negativan i HER2 negativan; ER-negativan, PR-negativan i HER2 pozitivan; ER-negativan, PR- pozitivan i HER2 negativan; ER-pozitivan, PR-negativan i HER2 negativan; ER-pozitivan, PR-pozitivan i HER2 negativan; ER-pozitivan, PR-negativan i HER2 pozitivan ili ER-negativan, PR-pozitivan i HER2 pozitivan.
11. Spoj SARM za uporabu u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time što je navedeni spoj njegova farmaceutski prihvatljiva sol, farmaceutski proizvod, hidrat, N-oksid, ili kristal navedenog selektivnog modulatora androgenskog receptora, ili bilo koja njihova kombinacija.
12. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što navedeni lijek nadalje produžuje preživljavanje subjekta koji pati od raka dojke i produžuje preživljavanje bez progresije pacijenta koji pati od raka dojke.
13. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni AR- pozitivan rak dojke ER, PR i HER2 negativan.
14. Spoj SARM za uporabu u skladu s patentnim zahtjevom 1, naznačen time što je navedeni AR- pozitivan rak dojke ER, PR i HER2 pozitivan.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261671366P | 2012-07-13 | 2012-07-13 | |
US201261726274P | 2012-11-14 | 2012-11-14 | |
PCT/US2013/029667 WO2014011220A2 (en) | 2012-07-13 | 2013-03-07 | A method of treating androgen receptor (ar)-positive breast cancers with selective androgen receptor modulator (sarms) |
EP13817231.7A EP2872482B1 (en) | 2012-07-13 | 2013-03-07 | A method of treating breast cancers with selective androgen receptor modulator (sarm) |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201463T1 true HRP20201463T1 (hr) | 2021-04-02 |
Family
ID=49914508
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20201463TT HRP20201463T1 (hr) | 2012-07-13 | 2020-09-14 | Postupak liječenja raka dojke selektivnim modulatorom androgenskog receptora (sarm) |
Country Status (20)
Country | Link |
---|---|
US (1) | US9604916B2 (hr) |
EP (2) | EP3733170A1 (hr) |
JP (3) | JP6226978B2 (hr) |
KR (2) | KR102122941B1 (hr) |
CN (3) | CN108143728A (hr) |
AU (3) | AU2013203600C1 (hr) |
CA (1) | CA2879049C (hr) |
CY (1) | CY1123542T1 (hr) |
DK (1) | DK2872482T3 (hr) |
ES (1) | ES2818915T3 (hr) |
HR (1) | HRP20201463T1 (hr) |
HU (1) | HUE052574T2 (hr) |
IL (1) | IL236681B (hr) |
IN (1) | IN2015DN01046A (hr) |
LT (1) | LT2872482T (hr) |
MX (2) | MX2015000572A (hr) |
PL (1) | PL2872482T3 (hr) |
PT (1) | PT2872482T (hr) |
RU (2) | RU2717835C2 (hr) |
WO (1) | WO2014011220A2 (hr) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
CA2626337C (en) | 2005-10-19 | 2015-12-29 | Chavah Pty Ltd | Reduction of side effects from aromatase inhibitors used for treating breast cancer |
US10010521B2 (en) | 2006-08-24 | 2018-07-03 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9844528B2 (en) | 2006-08-24 | 2017-12-19 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US9730908B2 (en) | 2006-08-24 | 2017-08-15 | University Of Tennessee Research Foundation | SARMs and method of use thereof |
US7968603B2 (en) | 2007-09-11 | 2011-06-28 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
KR102122941B1 (ko) | 2012-07-13 | 2020-06-15 | 지티엑스, 인코포레이티드 | 선택적 안드로겐 수용체 조절자(sarms)를 이용한 안드로겐 수용체(ar) 양성 유방암의 치료 방법 |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
JP5958483B2 (ja) * | 2013-07-31 | 2016-08-02 | 株式会社村田製作所 | 電力増幅モジュール |
EP3206675A4 (en) * | 2014-10-16 | 2018-07-11 | GTx, Inc. | METHODS OF TREATING UROLOGICAL DISORDERS USING SARMs |
SG11201703279XA (en) | 2014-10-22 | 2017-05-30 | Havah Therapeutics Pty Ltd | Methods of reducing mammographic breast density and/or breast cancer risk |
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