HRP20191444T1 - Alosterni modulatori proteina jezgre hepatitisa b - Google Patents
Alosterni modulatori proteina jezgre hepatitisa b Download PDFInfo
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- HRP20191444T1 HRP20191444T1 HRP20191444T HRP20191444T1 HR P20191444 T1 HRP20191444 T1 HR P20191444T1 HR P20191444 T HRP20191444 T HR P20191444T HR P20191444 T1 HRP20191444 T1 HR P20191444T1
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- 6alkyl
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- hydroxyl
- halogen
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- 101710132601 Capsid protein Proteins 0.000 title claims 2
- 230000003281 allosteric effect Effects 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 12
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- -1 cyano, carboxy Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 208000002672 hepatitis B Diseases 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000000234 capsid Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108091036055 CccDNA Proteins 0.000 claims 1
- 101150082208 DIABLO gene Proteins 0.000 claims 1
- 102100033189 Diablo IAP-binding mitochondrial protein Human genes 0.000 claims 1
- 241000700721 Hepatitis B virus Species 0.000 claims 1
- 108091030071 RNAI Proteins 0.000 claims 1
- 229940044665 STING agonist Drugs 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000000134 cyclophilin inhibitor Substances 0.000 claims 1
- 230000001973 epigenetic effect Effects 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229960001438 immunostimulant agent Drugs 0.000 claims 1
- 239000003022 immunostimulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000002777 nucleoside Substances 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/14—[b, e]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (9)
1. Spoj predstavljen sa:
naznačen time što
Y je S(O)y, gdje y je 2;
RY je izabran iz grupe koja se sastoji od H, metila, etila, propila, fenila i benzila;
Rm’ i Rm su svaki nezavisno izabrani iz grupe koja se sastoji od H, halogena, C1-6alkila (izborno supstituiran sa jednim, dva ili tri supstituenta svaki nezavisno izabran od halogena i hidroksila), C2-6alkenila (izborno supstituiran sa jednim, dva ili tri supstituenta svaki nezavisno izabran od halogena i hidroksila), NR’R" i hidroksila;
Rc je H;
R78 je izabran iz grupe koja se sastoji od H, halogena, hidroksila, nitro, cijano, karboksi, C1-6alkila, C2-6alkenila, C2-6alkinila, C1-6alkoksi, NR’R", -C(O)-C1-6alkila, -C(O)-C1-6alkoksi, fenila, heteroarila, C3-6cikloalkila, -S(O)w-C1-6alkila (gdje je w 1, 2 ili 3), -S(O)w-NR’R" (gdje je w 1, 2 ili 3), i -NR’-S(O)w, (gdje je w 1, 2 ili 3));
R79 je izabran iz grupe koja se sastoji od H, halogena, hidroksila, nitro, cijano, karboksi, C1-6alkila, C2-6alkenila, C2-6alkinila, C1-6alkoksi, NR’R", -C(O)-C1-6alkila, -C(O)-C1-6alkoksi, fenila, heteroarila, C3-6cikloalkila, -S(O)w-C1-6alkila (gdje je w 1, 2 ili 3), -S(O)w-NR’R" (gdje je w 1, 2 ili 3), i -NR’-S(O)w, (gdje je w 1, 2 ili 3));
R’ je izabran, nezavisno za svaki slučaj, od H, metila, etila i propila;
R" je izabran, nezavisno za svaki slučaj, od H, metila, etila, propila, butila, -C(O)-metila i -C(O)-etila, ili R’ i R" uzeti zajedno sa azotom za koji su vezani mogu formirati 4-6 –člani heterociklus;
svaka od grupa R4, R5, R6, R7, R8, R9 i R10 je nezavisno izabrana u svakom slučaju iz grupe koja se sastoji od vodika, C1-6alkila, C2-6alkinila, C2-6alkenila, halogena, hidroksila, nitro, cijano i NR’R";
pri čemu u svakom slučaju, C1-6alkil može biti izborno supstituiran sa jednim, dva, tri ili više supstituenata izabranih iz grupe koja se sastoji od halogena, hidroksila, nitro, cijano, karboksi, C2-6alkenila, C2-6alkinila, C1-6alkoksi, NR’R", -NR’-S(O)w i S(O)w-NR’R"; C1-6alkoksi može biti izborno supstituiran sa jednim, dva, tri ili više supstituenata izabranih iz grupe koja se sastoji od halogena, hidroksila, nitro, cijano, karboksi, C1-6alkila, NR’R", -NR’-S(O)w i S(O)w-NR’R"; C3-6cikloalkil može biti izborno supstituiran sa jednim, dva, tri ili više supstituenata izabranih iz grupe koja se sastoji od halogena, hidroksila, nitro, cijano, karboksi, C1-6alkila, C1-6alkoksi, -C(O)-C1-6alkila, -C(O)-C1-6alkoksi i NR’R"; fenil može biti izborno supstituiran sa jednim, dva ili tri supstituenta od kojih je svaki nezavisno izabran iz grupe koja se sastoji od halogena, hidroksila, C1-6alkila, C2-6alkenila, C2-6alkinila, C1-6alkoksi, NR’R", C(O)- NR’R", -C(O)-C1-6alkila, -C(O)-C1-6alkoksi, -S(O)w-C1-6alkila (gdje je w 1, 2 ili 3), NR’-S(O)w i -S(O)w-NR’R" (gdje je w 1, 2 ili 3) i heteroaril može biti izborno supstituiran sa jednim, dva ili tri supstituenta od kojih je svaki nezavisno izabran iz grupe koja se sastoji od halogena, hidroksila, C1-6alkila, C2-6alkenila, C2-6alkinila, C3-6cikloalkila, C1-6alkoksi, NR’R", C(O)- NR’R", -C(O)-C1-6alkila, -C(O)-C1-6alkoksi, -S(O)w-C1-6alkila (gdje je w 1, 2 ili 3), NR’-S(O)w i -S(O)w-NR’R" (gdje je w 1, 2 ili 3), i njegove farmaceutski prihvatljive soli.
2. Spoj prema patentnom zahtjevu 1, naznačen time što R5, R6 i R7 su izabrani od H i F.
3. Spoj prema bilo kojem od patentnih zahtjeva 1-2, naznačen time što R10 je izabran iz grupe koja se sastoji od H, metila i F.
4. Spoj prema bilo kojem od patentnih zahtjeva 1-3, naznačen time što svaki od R4, R5, R6, R7, R8, R9, R10 i R11 su H.
5. Farmaceutski prihvatljiva kompozicija koja sadrži spoj prema bilo kojem od patentnih zahtjeva 1-4, i farmaceutski prihvatljiv ekscipijens.
6. Spoj prema bilo kojem od patentnih zahtjeva 1-4 za uporabu u liječenju infekcije hepatitisa B.
7. Prvi spoj izabran od spojeva prema patentnim zahtjevima 1-4, i izborno jedan ili više dodatnih spojeva od kojih je svaki izabran od spojeva prema patentnim zahtjevima 1-4 za uporabu u liječenju infekcije hepatitisa B.
8. Spoj prema bilo kojem od patentnih zahtjeva 1-4, i drugi promotor sklapanja HBV kapsida za uporabu u liječenju infekcije hepatitisa B.
9. Prvi spoj izabran iz bilo kojeg od patentnih zahtjeva 1-4, i jedan ili više drugih HBV sredstava od kojih je svaki izabran iz grupe koja se sastoji od promotora sklapanja HBV kapsida, nukleozida koji interferiraju sa polimerazom HBF virusa, inhibitora ulaska virusa, inhibitora izlučivanja HBsAg, sredstava koja prekidaju formiranje nukleokapsida, inhibitora formiranja cccDNK, antivirusnog mutanta proteina jezgre, trans-tijela usmjerenih ka HBc, RNKi koje ciljno djeluju na RNK HBV, imunostimulanata, agonista TLR-7/9, inhibitora ciklofilina, HBV cjepiva, mimetika SMAC, epigenetičkih modulatora, inhibitora kinaze i agonista STING za uporabu u liječenju infekcije hepatitisa B.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461952467P | 2014-03-13 | 2014-03-13 | |
US201462010025P | 2014-06-10 | 2014-06-10 | |
EP15761201.1A EP3116316B1 (en) | 2014-03-13 | 2015-03-13 | Hepatitis b core protein allosteric modulators |
PCT/US2015/020444 WO2015138895A1 (en) | 2014-03-13 | 2015-03-13 | Hepatitis b core protein allosteric modulators |
Publications (1)
Publication Number | Publication Date |
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HRP20191444T1 true HRP20191444T1 (hr) | 2019-11-29 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20191444 HRP20191444T1 (hr) | 2014-03-13 | 2019-08-09 | Alosterni modulatori proteina jezgre hepatitisa b |
Country Status (23)
Country | Link |
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US (3) | US10183936B2 (hr) |
EP (3) | EP3116316B1 (hr) |
JP (2) | JP6602311B2 (hr) |
KR (1) | KR102363174B1 (hr) |
CN (2) | CN110437153A (hr) |
AP (1) | AP2016009477A0 (hr) |
AU (2) | AU2015229174B2 (hr) |
CA (1) | CA2942533C (hr) |
CL (1) | CL2016002269A1 (hr) |
DK (1) | DK3116316T3 (hr) |
DO (1) | DOP2016000233A (hr) |
ES (1) | ES2748029T3 (hr) |
HR (1) | HRP20191444T1 (hr) |
HU (1) | HUE046567T2 (hr) |
IL (3) | IL247575B (hr) |
MX (2) | MX363600B (hr) |
PH (1) | PH12016501762A1 (hr) |
PL (1) | PL3116316T3 (hr) |
PT (1) | PT3116316T (hr) |
RS (1) | RS59430B1 (hr) |
SG (2) | SG10202001506UA (hr) |
WO (1) | WO2015138895A1 (hr) |
ZA (1) | ZA201606209B (hr) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2649410T3 (es) | 2011-12-21 | 2018-01-11 | Novira Therapeutics Inc. | Agentes antivirales para la hepatitis B |
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