AR099312A1 - Derivados de nucleósidos sustituidos con 4-difluorometil como inhibidores de la replicación del arn de influenza - Google Patents
Derivados de nucleósidos sustituidos con 4-difluorometil como inhibidores de la replicación del arn de influenzaInfo
- Publication number
- AR099312A1 AR099312A1 ARP150100356A ARP150100356A AR099312A1 AR 099312 A1 AR099312 A1 AR 099312A1 AR P150100356 A ARP150100356 A AR P150100356A AR P150100356 A ARP150100356 A AR P150100356A AR 099312 A1 AR099312 A1 AR 099312A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- independently
- phenyl
- together form
- aryl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La solicitud divulga derivados de nucleósidos como inhibidores de la replicación del ARN de influenza. En particular, la solicitud divulga el uso de derivados de nucleósidos purínicos y pirimidínicos como inhibidores de replicación del ARN de influenza y composiciones farmacéuticas que contienen tales compuestos. Reivindicación 1: Un compuesto inhibidor de la replicación del ARN de influenza de fórmula (1) caracterizado porque: Y es H o P(=X)(R)(R); R es O-R¹ o NHR¹; R¹ es -C(R²ᵃ)(R²ᵇ)C(=O)OR³; R es N(R⁴)C(R²ᵃ)(R²ᵇ)C(=O)OR³, -OP(=O)(OH)OP(=O)(OH)OH, o -OR³; R¹ es H, haloalquilo inferior, o arilo, en donde el arilo es fenilo o naftilenilo, opcionalmente sustituido con uno o más de alquilo inferior, alquenilo inferior, alquinilo inferior, alcoxi inferior, halo, haloalquilo inferior, -N(R¹ᵃ)₂, acilamino, -SO₂N(R¹ᵃ)₂, -C(=O)R¹ᵇ, -SO₂(R¹ᶜ), -NHSO₂(R¹ᶜ), nitro, ciano, o R¹; cada R¹ᵃ es independientemente H o alquilo inferior; cada R¹ᵇ es independientemente -OR¹ᵃ o -N(R¹ᵃ)₂; cada R¹ᶜ es alquilo inferior; cada R²ᵃ y R²ᵇ es independientemente H, alquilo inferior, (CH₂)ʳN(R¹ᵃ)₂, hidroxialquilo inferior, -CH₂SH, -(CH₂)S(O)ₚMe, -(CH₂)ₙNHC(=NH)NH₂, (1H-indol-3-il)metilo, (1H-indol-4-il)metilo, -(CH₂)ₘC(=O)R¹ᵇ, arilo y arilalquilo inferior, en donde el arilo está opcionalmente sustituido con uno o más de hidroxi, alquilo inferior, alcoxi inferior, halo, nitro o ciano; m es 0, 1, ó 2; n es 1, 2, ó 3; p es 1 ó 2; r es 1 ó 2; o R²ᵃ es H y R²ᵇ y R⁴ juntos forman (CH₂)ₙ; cada R³ es independientemente H, alquilo inferior, haloalquilo inferior, fenilo o fenil-alquilo inferior, en donde el fenilo y el fenil-alquilo inferior están opcionalmente sustituidos con alcoxi inferior; o R³ y R¹ juntos forman CH₂; cada R⁴ es independientemente H, alquilo inferior; o R²ᵇ y R⁴ juntos forman (CH₂)₃; Rʷ, Rʸ, y Rᶻ son cada uno independientemente H, OH o F; Rˣ es H, OH, o F; o R³ y Rˣ juntos forman una unión; o R¹ y Rˣ juntos forman una unión; X es O ó S; la Base es uracilo, citosina, guanina, adenina, timina, o heterocicloalquilo, cada uno de los cuales puede estar opcionalmente sustituido con uno o más de hidroxi, alquilo inferior, alcoxi inferior, halo, nitro o ciano; con la condición de que si Rʷ es H, Rʸ es H, y Rᶻ es H, entonces Rˣ no es H; y con la condición de que la fórmula (1) no es ((2R,3R,4R,5R)-5-(4-amino-2-oxopirimidin-1(2H)-il)-2-(difluorometil)-4-fluoro-3-hidroxitetrahidrofuran-2-il)metil tetrahidrógeno trifosfato; o una sal farmacológicamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461936569P | 2014-02-06 | 2014-02-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099312A1 true AR099312A1 (es) | 2016-07-13 |
Family
ID=53774368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100356A AR099312A1 (es) | 2014-02-06 | 2015-02-06 | Derivados de nucleósidos sustituidos con 4-difluorometil como inhibidores de la replicación del arn de influenza |
Country Status (20)
Country | Link |
---|---|
US (2) | US9370569B2 (es) |
EP (1) | EP3102215B1 (es) |
JP (1) | JP6581100B2 (es) |
KR (1) | KR102327464B1 (es) |
CN (1) | CN105979951B (es) |
AR (1) | AR099312A1 (es) |
AU (1) | AU2015213791B2 (es) |
CA (1) | CA2945693C (es) |
CL (1) | CL2016001973A1 (es) |
CR (1) | CR20160400A (es) |
EA (1) | EA033866B1 (es) |
HK (1) | HK1225617A1 (es) |
IL (1) | IL246929B (es) |
MA (1) | MA39317A1 (es) |
MX (1) | MX2016010105A (es) |
PE (1) | PE20170203A1 (es) |
PH (1) | PH12016501567A1 (es) |
SG (1) | SG11201606368WA (es) |
TW (1) | TWI620755B (es) |
WO (1) | WO2015120237A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA122121C2 (uk) | 2014-02-06 | 2020-09-25 | Хептерс Терап'Ютікс Лімітед | Біциклічні азотовмісні сполуки як агоністи мускаринового м1 рецептора i/або м4 рецептора |
EA033866B1 (ru) * | 2014-02-06 | 2019-12-03 | Рибосайенс Ллк | 4'-дифторметилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гриппа |
MA41213A (fr) | 2014-12-19 | 2017-10-24 | Alios Biopharma Inc | Nucléosides substitués, nucléotides et analogues de ceux-ci |
CN112156102B (zh) * | 2015-09-16 | 2023-10-03 | 济南高合医疗科技有限公司 | 一种nuc-1031单一异构体的晶型及其制备方法 |
CN106543220A (zh) | 2015-09-16 | 2017-03-29 | 博瑞生物医药(苏州)股份有限公司 | 氨基磷酸酯化合物及其制备方法和晶体 |
WO2019027905A1 (en) * | 2017-07-31 | 2019-02-07 | January Therapeutics, Inc. | ORGANOPHOSPHATE DERIVATIVES |
CN111434671B (zh) * | 2019-01-11 | 2023-07-11 | 凯思凯迪(上海)医药科技有限公司 | 肝脏特异性ampk激动剂及其制法和应用 |
US11198699B2 (en) * | 2019-04-02 | 2021-12-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
WO2020223530A1 (en) * | 2019-04-30 | 2020-11-05 | Cure Biopharma Inc. | Gemcitabine prodrugs |
JP2022532520A (ja) * | 2019-05-03 | 2022-07-15 | ターンズ・ファーマシューティカルズ・インコーポレイテッド | 癌を処置するための化合物 |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
WO2022221514A1 (en) | 2021-04-16 | 2022-10-20 | Gilead Sciences, Inc. | Methods of preparing carbanucleosides using amides |
WO2022266384A1 (en) * | 2021-06-17 | 2022-12-22 | Terns Pharmaceuticals, Inc. | Methods for treating cancer |
WO2023178133A1 (en) * | 2022-03-15 | 2023-09-21 | Rome Therapeutics, Inc. | Compounds and methods for treating disease |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
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US5192749A (en) * | 1990-05-21 | 1993-03-09 | Syntex (U.S.A.) Inc. | 4'-substituted nucleosides |
BR0114837A (pt) * | 2000-10-18 | 2006-05-09 | Pharmasset Ltd | nucleosìdeos modificados para tratamento de infecções viróticas e proliferação celular anormal |
US7105499B2 (en) | 2001-01-22 | 2006-09-12 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
GB0114286D0 (en) * | 2001-06-12 | 2001-08-01 | Hoffmann La Roche | Nucleoside Derivatives |
US20040229840A1 (en) | 2002-10-29 | 2004-11-18 | Balkrishen Bhat | Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase |
TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之2’-氟取代之碳-核苷類似物 |
CA2812962C (en) | 2010-09-22 | 2020-03-31 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
SG10201610936RA (en) | 2011-12-22 | 2017-02-27 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
EP3351552B1 (en) * | 2012-03-13 | 2021-05-19 | Gilead Sciences, Inc. | 2'-substituted carba-nucleoside analogs for antiviral treatment |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
CN104203253A (zh) * | 2012-03-21 | 2014-12-10 | 艾丽奥斯生物制药有限公司 | 取代的核苷、核苷酸及其类似物 |
AU2013266393B2 (en) | 2012-05-22 | 2017-09-28 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
EP2935304A1 (en) | 2012-12-19 | 2015-10-28 | IDENIX Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
EP3421482A1 (en) | 2012-12-21 | 2019-01-02 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
TW201542578A (zh) | 2013-06-26 | 2015-11-16 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
TW201524990A (zh) | 2013-10-11 | 2015-07-01 | Alios Biopharma Inc | 經取代之核苷、核苷酸及其類似物 |
EA033866B1 (ru) * | 2014-02-06 | 2019-12-03 | Рибосайенс Ллк | 4'-дифторметилзамещенные производные нуклеозидов в качестве ингибиторов репликации рнк вируса гриппа |
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2015
- 2015-02-06 EA EA201691554A patent/EA033866B1/ru not_active IP Right Cessation
- 2015-02-06 EP EP15746437.1A patent/EP3102215B1/en active Active
- 2015-02-06 PE PE2016001288A patent/PE20170203A1/es unknown
- 2015-02-06 WO PCT/US2015/014762 patent/WO2015120237A2/en active Application Filing
- 2015-02-06 SG SG11201606368WA patent/SG11201606368WA/en unknown
- 2015-02-06 MX MX2016010105A patent/MX2016010105A/es active IP Right Grant
- 2015-02-06 JP JP2016550192A patent/JP6581100B2/ja active Active
- 2015-02-06 CA CA2945693A patent/CA2945693C/en active Active
- 2015-02-06 MA MA39317A patent/MA39317A1/fr unknown
- 2015-02-06 CR CR20160400A patent/CR20160400A/es unknown
- 2015-02-06 AU AU2015213791A patent/AU2015213791B2/en active Active
- 2015-02-06 CN CN201580007707.8A patent/CN105979951B/zh active Active
- 2015-02-06 TW TW104104136A patent/TWI620755B/zh active
- 2015-02-06 US US14/615,928 patent/US9370569B2/en active Active
- 2015-02-06 KR KR1020167024454A patent/KR102327464B1/ko active IP Right Grant
- 2015-02-06 AR ARP150100356A patent/AR099312A1/es unknown
-
2016
- 2016-06-20 US US15/187,014 patent/US10092649B2/en active Active
- 2016-07-25 IL IL246929A patent/IL246929B/en active IP Right Grant
- 2016-08-05 CL CL2016001973A patent/CL2016001973A1/es unknown
- 2016-08-05 PH PH12016501567A patent/PH12016501567A1/en unknown
- 2016-12-06 HK HK16113894A patent/HK1225617A1/zh unknown
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