HRP20170205T1 - Mutant gdf-5 za indukciju formiranja hrskavice - Google Patents
Mutant gdf-5 za indukciju formiranja hrskavice Download PDFInfo
- Publication number
- HRP20170205T1 HRP20170205T1 HRP20170205TT HRP20170205T HRP20170205T1 HR P20170205 T1 HRP20170205 T1 HR P20170205T1 HR P20170205T T HRP20170205T T HR P20170205TT HR P20170205 T HRP20170205 T HR P20170205T HR P20170205 T1 HRP20170205 T1 HR P20170205T1
- Authority
- HR
- Croatia
- Prior art keywords
- nucleic acid
- cartilage
- protein
- treatment
- variant
- Prior art date
Links
- 230000022159 cartilage development Effects 0.000 title claims 2
- 101100175316 Mus musculus Gdf5 gene Proteins 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 210000000845 cartilage Anatomy 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000007547 defect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 206010008723 Chondrodystrophy Diseases 0.000 claims 2
- 230000011164 ossification Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000005262 Chondroma Diseases 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 206010011219 Costochondritis Diseases 0.000 claims 1
- 101001023988 Homo sapiens Growth/differentiation factor 5 Proteins 0.000 claims 1
- 208000003618 Intervertebral Disc Displacement Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000026317 Tietze syndrome Diseases 0.000 claims 1
- 208000008919 achondroplasia Diseases 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000037824 growth disorder Diseases 0.000 claims 1
- 102000046039 human GDF5 Human genes 0.000 claims 1
- 230000003211 malignant effect Effects 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (5)
1. Varijanta zrelog humanog proteina GDF-5 kao što je predstavljena aminokiselinama 382 - 501 iz SEQ ID NO: 2 i koja sadrži aminokiselinsku supstituciju, izabranu iz grupe koja se sastoji od R399E, W417F i W417R.
2. Nukleinska kiselina koja kodira varijantu proteina prema patentnom zahtjevu 1.
3. Varijanta proteina prema patentnom zahtjevu 1 ili nukleinska kiselina prema patentnom zahtjevu 2, za uporabu u liječenju bolesti, gdje je formiranje hrskavice poželjno, ali je formiranje kosti nepoželjno.
4. Varijanta proteina ili nukleinska kiselina za uprabu prema patentnom zahtjevu 3 za uporabu u liječenju defekata hrskavice ili za liječenje traumatske rupture ili odvajanja hrskavice, posebno defekata hrskavice povezanih sa starenjem na primjer kao posljedica habanja, osteoartritisa, reumatoidnog artritisa, povreda povezanih sa sportom, bolesti koje mogu da utječu na hrskavicu kao što su hondrodistrofije, bolesti naznačene poremećajem rasta i kasnijom osifikacijom hrskavice, ahondroplazijom, kostohondritisom, hernijom spinalnog diska i ispravkom spinalnog diska, relapsom polihodritisa, ispravkom defekata hrskavice povezanih sa tumorima, bilo benignim ili malignim, kao što je hondrom ili hondrosarkom.
5. Farmaceutski pripravak koji sadrži varijantu proteina prema patentnom zahtjevu 1, nukleinska kiselina prema patentnom zahtjevu 2, vektor koji sadrži nukleinsku kiselinu prema patentnom zahtjevu 2 ili stanica domaćin koja sadrži nukleinsku kiselinu prema patentnom zahtjevu 2 kao aktivno sredstvo, izborno u kombinaciji sa farmaceutski prihvatljivim aditivima ili nosačima.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11191973.4A EP2602264A1 (en) | 2011-12-05 | 2011-12-05 | GDF-5 mutant for inducing cartilage formation |
| EP12795011.1A EP2788374B1 (en) | 2011-12-05 | 2012-12-05 | Gdf-5 mutant for inducing cartilage formation |
| PCT/EP2012/074549 WO2013083649A1 (en) | 2011-12-05 | 2012-12-05 | Gdf-5 mutant for inducing cartilage formation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170205T1 true HRP20170205T1 (hr) | 2017-06-16 |
Family
ID=47278877
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170205TT HRP20170205T1 (hr) | 2011-12-05 | 2017-02-08 | Mutant gdf-5 za indukciju formiranja hrskavice |
| HRP20190160TT HRP20190160T8 (hr) | 2011-12-05 | 2019-01-23 | Mutant gdf-5 za indukciju formiranja hrskavice |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20190160TT HRP20190160T8 (hr) | 2011-12-05 | 2019-01-23 | Mutant gdf-5 za indukciju formiranja hrskavice |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9718867B2 (hr) |
| EP (3) | EP2602264A1 (hr) |
| JP (1) | JP6185926B2 (hr) |
| KR (1) | KR102067724B1 (hr) |
| CN (1) | CN104039820B (hr) |
| AU (1) | AU2012347305B2 (hr) |
| BR (1) | BR112014013122A2 (hr) |
| CA (1) | CA2856458C (hr) |
| DK (2) | DK3168230T3 (hr) |
| EA (1) | EA028554B1 (hr) |
| ES (2) | ES2630853T3 (hr) |
| HK (1) | HK1198768A1 (hr) |
| HR (2) | HRP20170205T1 (hr) |
| HU (2) | HUE042191T2 (hr) |
| IN (1) | IN2014KN01026A (hr) |
| LT (2) | LT2788374T (hr) |
| MX (1) | MX351809B (hr) |
| PL (2) | PL3168230T3 (hr) |
| PT (2) | PT3168230T (hr) |
| RS (2) | RS55686B1 (hr) |
| SI (2) | SI2788374T1 (hr) |
| TR (1) | TR201901263T4 (hr) |
| WO (1) | WO2013083649A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101639269B1 (ko) | 2015-12-02 | 2016-07-13 | 주식회사 셀루메드 | 알칼라인 포스파타아제 어세이를 개선하기 위한 방법 |
| CN114786707A (zh) * | 2019-12-18 | 2022-07-22 | 默克专利股份公司 | Gdf-5突变体用于治疗疼痛和软骨破坏的用途 |
| CN111701075A (zh) * | 2020-06-24 | 2020-09-25 | 亘元(天津)生物医药科技有限公司 | 一种软骨修复材料、软骨重建生物支架及制备方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2153654A1 (en) | 1993-01-12 | 1994-07-21 | Se-Jin Lee | Growth differentiation factor-5 |
| IL110589A0 (en) | 1993-08-10 | 1994-11-11 | Bioph Biotech Entw Pharm Gmbh | Growth/differentiation factor of the TGF- beta family |
| WO1995016035A2 (en) | 1993-12-07 | 1995-06-15 | Genetics Institute, Inc. | Bmp-12, bmp-13 and tendon-inducing compositions thereof |
| WO1996014335A1 (en) | 1994-11-07 | 1996-05-17 | The Government Of The United States Of America, Asrepresented By The Secretary, Department Of Health And Human Services | Cartilage-derived morphogenetic proteins |
| DE69636728D1 (de) | 1995-04-19 | 2007-01-04 | Bioph Biotech Entw Pharm Gmbh | Neues protein und verfahren zu dessen herstellung |
| JPH0931098A (ja) | 1995-07-24 | 1997-02-04 | Hoechst Japan Ltd | 新規なタンパク質ｈｍｗヒトｍｐ５２ |
| ZA966489B (en) | 1995-08-03 | 1997-02-26 | Bioph Biotech Entw Pharm Gmbh | New protein human MP52 Arg. |
| DE19647853A1 (de) | 1996-11-19 | 1998-05-20 | Bioph Biotech Entw Pharm Gmbh | Verbindungen mit verbesserter knorpel- und/oder knocheninduzierender Aktivität |
| JPH11335398A (ja) | 1998-05-22 | 1999-12-07 | Hoechst Marion Roussel Kk | 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる軟骨・骨疾患の予防および治療薬 |
| EP1074620A1 (en) | 1999-08-06 | 2001-02-07 | HyGene AG | Monomeric protein of the TGF-beta family |
| JP2000119192A (ja) | 1998-10-09 | 2000-04-25 | Aventis Pharma Ltd | 骨誘導因子アンタゴニスト活性を有する成熟型蛋白質 |
| DE10026713A1 (de) | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| KR100530299B1 (ko) | 2003-08-11 | 2005-11-22 | 산도즈 게엠베하 | 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법 |
| EP1571159A1 (en) | 2004-03-04 | 2005-09-07 | Bayerische Julius-Maximilians-Universität Würzburg | Mutein of a bone morphogenetic protein and use thereof |
| EP1698691A1 (en) | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Growth factor mutants with improved biological activity |
| EP1721909A1 (en) | 2005-05-10 | 2006-11-15 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Growth factor mutants with altered biological attributes |
| JP2007054013A (ja) | 2005-08-26 | 2007-03-08 | Research Institute Of Innovative Technology For The Earth | 耐熱性ｌ−スレオニンアルドラ−ゼおよびそれをコードする遺伝子 |
| PL1948689T3 (pl) * | 2005-11-18 | 2012-09-28 | Biopharm Ges Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Mutanty czynników wzrostu o wysokiej aktywności |
| CN101443360B (zh) | 2006-03-27 | 2013-11-27 | 医学免疫有限公司 | Gm-csf受体结合元件 |
| EP1915986A1 (en) | 2006-10-23 | 2008-04-30 | BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH | Lipid growth factor formulations |
| KR101800596B1 (ko) | 2010-08-20 | 2017-11-22 | 와이어쓰 엘엘씨 | 디자이너 골형성 단백질 |
-
2011
- 2011-12-05 EP EP11191973.4A patent/EP2602264A1/en not_active Ceased
-
2012
- 2012-12-05 US US14/362,691 patent/US9718867B2/en active Active
- 2012-12-05 SI SI201230892A patent/SI2788374T1/sl unknown
- 2012-12-05 RS RS20170146A patent/RS55686B1/sr unknown
- 2012-12-05 RS RS20190038A patent/RS58253B1/sr unknown
- 2012-12-05 HU HUE16203435A patent/HUE042191T2/hu unknown
- 2012-12-05 EP EP12795011.1A patent/EP2788374B1/en active Active
- 2012-12-05 WO PCT/EP2012/074549 patent/WO2013083649A1/en active Application Filing
- 2012-12-05 PL PL16203435T patent/PL3168230T3/pl unknown
- 2012-12-05 IN IN1026KON2014 patent/IN2014KN01026A/en unknown
- 2012-12-05 DK DK16203435.9T patent/DK3168230T3/en active
- 2012-12-05 PT PT16203435T patent/PT3168230T/pt unknown
- 2012-12-05 ES ES12795011.1T patent/ES2630853T3/es active Active
- 2012-12-05 LT LTEP12795011.1T patent/LT2788374T/lt unknown
- 2012-12-05 SI SI201231517T patent/SI3168230T1/sl unknown
- 2012-12-05 KR KR1020147017053A patent/KR102067724B1/ko active IP Right Grant
- 2012-12-05 CN CN201280058254.8A patent/CN104039820B/zh active Active
- 2012-12-05 EA EA201491119A patent/EA028554B1/ru not_active IP Right Cessation
- 2012-12-05 EP EP16203435.9A patent/EP3168230B1/en active Active
- 2012-12-05 DK DK12795011.1T patent/DK2788374T3/en active
- 2012-12-05 MX MX2014006465A patent/MX351809B/es active IP Right Grant
- 2012-12-05 JP JP2014543942A patent/JP6185926B2/ja active Active
- 2012-12-05 PL PL12795011T patent/PL2788374T3/pl unknown
- 2012-12-05 AU AU2012347305A patent/AU2012347305B2/en not_active Ceased
- 2012-12-05 TR TR2019/01263T patent/TR201901263T4/tr unknown
- 2012-12-05 CA CA2856458A patent/CA2856458C/en active Active
- 2012-12-05 LT LTEP16203435.9T patent/LT3168230T/lt unknown
- 2012-12-05 PT PT127950111T patent/PT2788374T/pt unknown
- 2012-12-05 BR BR112014013122-8A patent/BR112014013122A2/pt not_active Application Discontinuation
- 2012-12-05 HU HUE12795011A patent/HUE033025T2/en unknown
- 2012-12-05 ES ES16203435T patent/ES2708675T3/es active Active
-
2014
- 2014-12-04 HK HK14112248.9A patent/HK1198768A1/xx not_active IP Right Cessation
-
2017
- 2017-02-08 HR HRP20170205TT patent/HRP20170205T1/hr unknown
-
2019
- 2019-01-23 HR HRP20190160TT patent/HRP20190160T8/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Li et al. | Regenerative approaches for cartilage repair in the treatment of osteoarthritis | |
| HRP20191852T1 (hr) | Polipeptidi | |
| HRP20170205T1 (hr) | Mutant gdf-5 za indukciju formiranja hrskavice | |
| TN2014000109A1 (en) | Fusion proteins for treating metabolic disorders | |
| EP3067364A3 (en) | Methods of treating fgf21-associated disorders | |
| EA201492053A1 (ru) | Белки фактора роста фибробластов 21 | |
| PH12014501849A1 (en) | Factor viii compositions and methods of making and using same | |
| MY162564A (en) | Modified binding proteins inhibiting the vegf-a receptor interaction | |
| EA201490521A1 (ru) | Варианты фактора роста фибробластов 21 | |
| WO2011123830A3 (en) | Alpha 1-antitrypsin compositions and methods of making and using same | |
| EP2470670A4 (en) | COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF PREPARATION AND USE THEREOF | |
| EA201492064A1 (ru) | Варианты фактора роста фибробластов 21 | |
| CL2011000013A1 (es) | Polipeptido factor estimulante de colonias de granulocitos bovino (bg-csf) que comprende uno o mas aminoacidos no codificados de manera natural; metodo de preparacion; composicion farmaceutica que lo comprende; y su uso para tratar un trastorno modulado por bg-csf. | |
| BR112012013868A8 (pt) | composição, proteína de fusão, polinucleotídeo, vetor ou constructo de gene, célula hospedeira , composição farmacêutica, método in vitro e uso de uma composição. | |
| IN2012DN02981A (hr) | ||
| JP2012502655A5 (hr) | ||
| RU2018108421A (ru) | Рекомбинантные белки и их применения в терапевтических целях | |
| HK1106161A1 (en) | Amide derivatives of hyaluronic acid in osteoarthrosis | |
| EA033004B1 (ru) | ХЕЛПЕРЗАВИСИМЫЙ АДЕНОВИРУСНЫЙ ВЕКТОР ДЛЯ ДОСТАВКИ И ДОЛГОВРЕМЕННОЙ ЭКСПРЕССИИ АНТАГОНИСТА РЕЦЕПТОРА ИНТЕРЛЕЙКИНА-1 (Il-1Ra) И ЕГО ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ ОСТЕОАРТРИТА | |
| MY170630A (en) | Freeze-dried formulations of fgf-18 | |
| MY157947A (en) | Novel peptides for treating and preventing immune-related disorders, including treating and preventing infection by modulating innate immunity | |
| SI2744831T1 (en) | TRANSFERIN-TUMSTATIN FUSION PROTEIN AND METHODS FOR THE MANUFACTURE AND USE OF LE-TEGA | |
| EP1885751A4 (en) | BONE-MORPHOGENETIC PROTEINS CONTAINING HEPARIN BINDING AND OSTEOUS DEVICES AND PHARMACEUTICAL PRODUCTS CONTAINING THEM | |
| BR112012000410B8 (pt) | uso de benzidamina ou dos sais de adição de ácido, e, composição farmacêutica | |
| CN102861320A (zh) | 治疗皮肤和粘膜创伤的喷雾剂 |