HRP20110530T1 - Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 - Google Patents
Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 Download PDFInfo
- Publication number
- HRP20110530T1 HRP20110530T1 HR20110530T HRP20110530T HRP20110530T1 HR P20110530 T1 HRP20110530 T1 HR P20110530T1 HR 20110530 T HR20110530 T HR 20110530T HR P20110530 T HRP20110530 T HR P20110530T HR P20110530 T1 HRP20110530 T1 HR P20110530T1
- Authority
- HR
- Croatia
- Prior art keywords
- benzenesulfonyl
- indole
- dimethylamine
- propoxy
- ethoxy
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 4
- 208000035475 disorder Diseases 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- 108091005435 5-HT6 receptors Proteins 0.000 claims abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract 2
- 208000002193 Pain Diseases 0.000 claims abstract 2
- 201000011529 cardiovascular cancer Diseases 0.000 claims abstract 2
- 208000014951 hematologic disease Diseases 0.000 claims abstract 2
- 208000023504 respiratory system disease Diseases 0.000 claims abstract 2
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims 45
- ROSDSFDQCJNGOL-UHFFFAOYSA-N protonated dimethyl amine Natural products CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 42
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 13
- 125000001475 halogen functional group Chemical group 0.000 claims 10
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000012442 inert solvent Substances 0.000 claims 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical group [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
- DBTNKTDUMBHCDF-UHFFFAOYSA-N 1-(5-indol-1-ylsulfonyl-2-propan-2-ylphenoxy)-n,n-dimethylpropan-2-amine Chemical compound C1=C(OCC(C)N(C)C)C(C(C)C)=CC=C1S(=O)(=O)N1C2=CC=CC=C2C=C1 DBTNKTDUMBHCDF-UHFFFAOYSA-N 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 208000030212 nutrition disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229910000027 potassium carbonate Inorganic materials 0.000 claims 1
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 1
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 1
- 239000012312 sodium hydride Substances 0.000 claims 1
- 229910000104 sodium hydride Inorganic materials 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract 2
- 208000030814 Eating disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 235000014632 disordered eating Nutrition 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN940CH2007 | 2007-05-03 | ||
| PCT/IN2008/000247 WO2008136017A1 (fr) | 2007-05-03 | 2008-04-15 | Composés aminoalcoxy aryl sulfonamides et leur utilisation en tant que ligands 5-ht6 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110530T1 true HRP20110530T1 (hr) | 2011-09-30 |
Family
ID=39743760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110530T HRP20110530T1 (hr) | 2007-05-03 | 2011-07-14 | Spojevi aminoalkoksi aril sulfonamida i njihova upotreba kao ligandi 5-ht6 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8003670B2 (fr) |
| EP (1) | EP2155674B1 (fr) |
| JP (1) | JP5139512B2 (fr) |
| KR (1) | KR101162482B1 (fr) |
| CN (1) | CN101675032B (fr) |
| AT (1) | ATE513810T1 (fr) |
| AU (1) | AU2008246947B2 (fr) |
| BR (1) | BRPI0809873A2 (fr) |
| CA (1) | CA2683124C (fr) |
| CY (1) | CY1111836T1 (fr) |
| DK (1) | DK2155674T3 (fr) |
| EA (1) | EA016594B1 (fr) |
| ES (1) | ES2366496T3 (fr) |
| HK (1) | HK1138264A1 (fr) |
| HR (1) | HRP20110530T1 (fr) |
| IL (1) | IL201491A (fr) |
| MX (1) | MX2009011461A (fr) |
| NZ (1) | NZ581580A (fr) |
| SI (1) | SI2155674T1 (fr) |
| WO (1) | WO2008136017A1 (fr) |
| ZA (1) | ZA200907015B (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101337003B1 (ko) | 2012-02-13 | 2013-12-04 | 주식회사 평산 | 링 압연 공법을 이용한 풍력 타워용 플랜지 제조방법 |
| KR101338954B1 (ko) | 2012-02-13 | 2013-12-09 | 주식회사 평산 | 링 압연 공정을 이용한 비대칭 단면을 가지는 제품의 성형 장치 및 성형 방법 |
| RU2688161C2 (ru) | 2013-07-25 | 2019-05-20 | Университет Ягеллоньски | Пирролохинолиновые производные в качестве 5-нт6 антагонистов, способ их получения и применение |
| JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族複素環式化合物及び医薬におけるその応用 |
| US9974785B2 (en) | 2014-07-08 | 2018-05-22 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| WO2019180176A1 (fr) | 2018-03-21 | 2019-09-26 | Spherium Biomed, S.L. | Composition pour le traitement de la schizophrénie et/ou de la psychose |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
| EP0994862B1 (fr) | 1997-07-11 | 2005-06-01 | SmithKline Beecham plc | Derives sulphonamide comme antagonistes du recepteur 5-ht6 et procede pour leur preparation |
| GB9801392D0 (en) | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
| GB9803411D0 (en) | 1998-02-18 | 1998-04-15 | Smithkline Beecham Plc | Novel compounds |
| ATE375990T1 (de) | 1999-04-21 | 2007-11-15 | Nps Allelix Corp | Piperidin-indol derivate mit 5-ht6 affinität |
| GB9926302D0 (en) | 1999-11-05 | 2000-01-12 | Smithkline Beecham Plc | Novel compounds |
| CA2426031C (fr) | 2000-11-02 | 2011-10-04 | Wyeth | 1-aryl- ou 1-alkylsulfonyl-heterocyclylbenzazoles en tant que ligands de 5-hydroxytryptamine-6 |
| WO2002060871A2 (fr) | 2001-01-30 | 2002-08-08 | Eli Lilly And Company | Indol-5-ylesters d'acide benzenesulfonique utilises comme antagonistes du recepteur 5-ht¿6? |
| US7342021B2 (en) | 2001-02-08 | 2008-03-11 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| KR100600240B1 (ko) | 2001-06-07 | 2006-07-13 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 수용체 친화도를 갖는 신규한 인돌 유도체 |
| WO2003013510A1 (fr) | 2001-08-07 | 2003-02-20 | Smithkline Beecham P.L.C. | 3-arylsulfonyl-7-piperazinyl- indols, -benzofurans et benzothiophenes a affinite avec les recepteurs 5-ht6 pour le traitement de troubles du snc |
| JP2005528587A (ja) | 2002-02-01 | 2005-09-22 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 新規ヒト５−ｈｔ６受容体に関連する疾患のための診断用および治療用物質 |
| EP1471912A1 (fr) | 2002-02-05 | 2004-11-03 | Glaxo Group Limited | Technique de stimulation de la croissance neuronale |
| US7452888B2 (en) | 2002-03-27 | 2008-11-18 | Glaxo Group Limited | Quinoline derivatives and their use as 5-ht6 ligands |
| CN101544592B (zh) | 2002-11-28 | 2013-08-21 | 苏文生命科学有限公司 | N-芳基磺酰-3-取代吲哚制备的替代方法 |
| PT1567492E (pt) * | 2002-11-28 | 2013-07-22 | Suven Life Sciences Ltd | N-arilsulfonil-3-aminoalcoxi-indóis |
| AU2003292508A1 (en) | 2002-11-28 | 2004-06-18 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
| US7781476B2 (en) | 2002-12-18 | 2010-08-24 | Suven Life Sciences Limited | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| AU2002353193B2 (en) * | 2002-12-20 | 2010-03-25 | Cancer Research Technology Limited | 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents |
| ES2222828B1 (es) | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| WO2006038594A1 (fr) * | 2004-10-04 | 2006-04-13 | Ono Pharmaceutical Co., Ltd. | Inhibiteur de canal de calcium de type n |
| CN101258144B (zh) * | 2005-08-12 | 2012-05-30 | 苏文生命科学有限公司 | 作为功能性5-ht6配体的氨基芳基磺酰胺衍生物 |
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2008
- 2008-04-15 WO PCT/IN2008/000247 patent/WO2008136017A1/fr active Application Filing
- 2008-04-15 EP EP08763731A patent/EP2155674B1/fr active Active
- 2008-04-15 US US12/598,616 patent/US8003670B2/en not_active Expired - Fee Related
- 2008-04-15 AT AT08763731T patent/ATE513810T1/de active
- 2008-04-15 CA CA2683124A patent/CA2683124C/fr not_active Expired - Fee Related
- 2008-04-15 ES ES08763731T patent/ES2366496T3/es active Active
- 2008-04-15 BR BRPI0809873A patent/BRPI0809873A2/pt not_active IP Right Cessation
- 2008-04-15 DK DK08763731.0T patent/DK2155674T3/da active
- 2008-04-15 MX MX2009011461A patent/MX2009011461A/es active IP Right Grant
- 2008-04-15 EA EA200971017A patent/EA016594B1/ru not_active IP Right Cessation
- 2008-04-15 JP JP2010505014A patent/JP5139512B2/ja not_active Expired - Fee Related
- 2008-04-15 AU AU2008246947A patent/AU2008246947B2/en not_active Ceased
- 2008-04-15 KR KR1020097025160A patent/KR101162482B1/ko active IP Right Grant
- 2008-04-15 NZ NZ581580A patent/NZ581580A/en not_active IP Right Cessation
- 2008-04-15 SI SI200830379T patent/SI2155674T1/sl unknown
- 2008-04-15 CN CN2008800144405A patent/CN101675032B/zh not_active Expired - Fee Related
-
2009
- 2009-10-08 ZA ZA200907015A patent/ZA200907015B/xx unknown
- 2009-10-13 IL IL201491A patent/IL201491A/en active IP Right Grant
-
2010
- 2010-04-07 HK HK10103434.6A patent/HK1138264A1/xx not_active IP Right Cessation
-
2011
- 2011-07-14 HR HR20110530T patent/HRP20110530T1/hr unknown
- 2011-09-14 CY CY20111100881T patent/CY1111836T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101675032B (zh) | 2012-10-31 |
| SI2155674T1 (sl) | 2011-10-28 |
| KR101162482B1 (ko) | 2012-07-03 |
| EA200971017A1 (ru) | 2010-04-30 |
| KR20100007954A (ko) | 2010-01-22 |
| CA2683124C (fr) | 2012-09-25 |
| ATE513810T1 (de) | 2011-07-15 |
| EP2155674A1 (fr) | 2010-02-24 |
| AU2008246947B2 (en) | 2011-03-31 |
| ES2366496T3 (es) | 2011-10-20 |
| CN101675032A (zh) | 2010-03-17 |
| US8003670B2 (en) | 2011-08-23 |
| MX2009011461A (es) | 2009-11-10 |
| DK2155674T3 (da) | 2011-09-26 |
| CY1111836T1 (el) | 2015-10-07 |
| EP2155674B1 (fr) | 2011-06-22 |
| ZA200907015B (en) | 2010-07-28 |
| IL201491A0 (en) | 2010-05-31 |
| NZ581580A (en) | 2011-03-31 |
| JP5139512B2 (ja) | 2013-02-06 |
| US20100087484A1 (en) | 2010-04-08 |
| CA2683124A1 (fr) | 2008-11-13 |
| EA016594B1 (ru) | 2012-06-29 |
| JP2010526057A (ja) | 2010-07-29 |
| AU2008246947A1 (en) | 2008-11-13 |
| IL201491A (en) | 2015-04-30 |
| BRPI0809873A2 (pt) | 2018-11-13 |
| HK1138264A1 (en) | 2010-08-20 |
| WO2008136017A1 (fr) | 2008-11-13 |
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