HRP20040429B1 - Sulphonamide derivatives, the preparation thereof and the application of same as medicaments - Google Patents

Sulphonamide derivatives, the preparation thereof and the application of same as medicaments

Info

Publication number: HRP20040429B1
Authority: HR; Croatia
Prior art keywords: nitrogen; oxygen; sulfur; alkyl; atoms
Prior art date: 2001-11-14

Application number

HR20040429A

Other languages

English (en)

Croatian (hr)

Inventor

Merc�-Vidal Ram�n

Andaluz-Matar� Blas

Frigola-Constansa Jordi

Original Assignee

Laboratorios Del Dr. Esteve S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-11-14

Filing date

2004-05-14

Publication date

2007-10-31

2004-05-14 Application filed by Laboratorios Del Dr. Esteve S.A. filed Critical Laboratorios Del Dr. Esteve S.A.

2005-06-30 Publication of HRP20040429A2 publication Critical patent/HRP20040429A2/hr

2007-10-31 Publication of HRP20040429B1 publication Critical patent/HRP20040429B1/xx

Links

239000003814 drug Substances 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 6
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
239000001301 oxygen Substances 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052717 sulfur Chemical group 0.000 abstract 2
239000011593 sulfur Chemical group 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
HFFXLYHRNRKAPM-UHFFFAOYSA-N 2,4,5-trichloro-n-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C(=CC(Cl)=C(Cl)C=2)Cl)=N1 HFFXLYHRNRKAPM-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
-1 atoms halogen Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

HR20040429A 2001-11-14 2004-05-14 Sulphonamide derivatives, the preparation thereof and the application of same as medicaments HRP20040429B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES200102517A ES2187300B1 (es)	2001-11-14	2001-11-14	Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
PCT/ES2002/000518 WO2003042175A1 (es)	2001-11-14	2002-11-08	Derivados de sulfonamidas, su preparación y su aplicación como medicamentos

Publications (2)

Publication Number	Publication Date
HRP20040429A2 HRP20040429A2 (en)	2005-06-30
HRP20040429B1 true HRP20040429B1 (en)	2007-10-31

Family

ID=8499446

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040429A HRP20040429B1 (en)	2001-11-14	2004-05-14	Sulphonamide derivatives, the preparation thereof and the application of same as medicaments

Country Status (34)

Country	Link
US (4)	US7105515B2 (xx)
EP (2)	EP1445252B1 (xx)
JP (2)	JP4416505B2 (xx)
KR (1)	KR20040071685A (xx)
CN (1)	CN1271052C (xx)
AR (1)	AR037288A1 (xx)
AT (2)	ATE428694T1 (xx)
BR (1)	BR0214243A (xx)
CA (1)	CA2466965C (xx)
CO (1)	CO5590895A2 (xx)
CY (1)	CY1105362T1 (xx)
DE (2)	DE60232029D1 (xx)
DK (1)	DK1445252T3 (xx)
EC (1)	ECSP045105A (xx)
ES (4)	ES2187300B1 (xx)
HK (1)	HK1070053A1 (xx)
HR (1)	HRP20040429B1 (xx)
HU (1)	HUP0402317A2 (xx)
IL (2)	IL161885A0 (xx)
IS (2)	IS7263A (xx)
MA (1)	MA27093A1 (xx)
MX (1)	MXPA04004601A (xx)
NO (1)	NO20042478L (xx)
NZ (2)	NZ543393A (xx)
PL (1)	PL373894A1 (xx)
PT (2)	PT1445252E (xx)
RS (1)	RS41104A (xx)
RU (2)	RU2293082C2 (xx)
SG (1)	SG146442A1 (xx)
SI (1)	SI1445252T1 (xx)
TW (1)	TWI275585B (xx)
UA (1)	UA78252C2 (xx)
WO (1)	WO2003042175A1 (xx)
ZA (1)	ZA200404073B (xx)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2187300B1 (es) *	2001-11-14	2004-06-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
US20050065202A1 (en) *	2003-05-09	2005-03-24	Vidal Ramon Merce	Use of sulphonamide derivatives for the manufacture of a medicament for the prophylaxis and/or treatment of disorders of food ingestion
ES2222827B1 (es) *	2003-07-30	2006-03-01	Laboratorios Del Dr. Esteve, S.A.	Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2222829B1 (es) *	2003-07-30	2006-03-01	Laboratorios Del Dr. Esteve, S.A.	Derivados de 4-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2228268B1 (es) *	2003-07-30	2006-07-01	Laboratorios Del Dr. Esteve, S.A.	Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
ES2228267B1 (es) *	2003-07-30	2006-07-01	Laboratorios Del Dr. Esteve, S.A.	Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6.
ES2222832B1 (es) *	2003-07-30	2006-02-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de 6-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
ES2222830B1 (es) *	2003-07-30	2006-02-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de 7-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
SE0303480D0 (sv) *	2003-12-19	2003-12-19	Biovitrum Ab	Benzofuranes
BRPI0417895B8 (pt) *	2004-01-02	2021-05-25	Suven Life Sciences Ltd	composto, processo para a preparação de um composto e uso do composto
ES2246721B1 (es) *	2004-08-10	2007-03-16	Laboratorios Del Dr. Esteve, S.A.	Compuestos indolicos sustituidos, su preparacion y su uso como medicamentos.
EP1632491A1 (en) *	2004-08-30	2006-03-08	Laboratorios Del Dr. Esteve, S.A.	Substituted indole compounds and their use as 5-HT6 receptor modulators
CN101247853B (zh)	2005-04-13	2014-11-12	轴突公司	具有nos抑制活性的取代的吲哚化合物
JP5026690B2 (ja) *	2005-11-21	2012-09-12	株式会社ジャパンディスプレイイースト	表示装置
AU2007208109B2 (en) *	2006-01-24	2012-08-23	Eli Lilly And Company	Indole sulfonamide modulators of progesterone receptors
EP1837332A1 (en) *	2006-03-23	2007-09-26	Laboratorios Del Dr. Esteve, S.A.	Substituted tetrahydroisoquinoline compounds, their preparation and use in medicaments
AR060451A1 (es) *	2006-04-13	2008-06-18	Neuraxon Inc	Compuestos de indol 1,5 y 3,6-sustituidos con actividad inhibitoria de nos
EP1902733A1 (en) *	2006-09-19	2008-03-26	Laboratorios Del Dr. Esteve, S.A.	Combination of a NMDA-receptor ligand and a compound with 5-HT6 receptor affinity
EP1953141A1 (en) *	2007-01-31	2008-08-06	Laboratorios del Dr. Esteve S.A.	Aryl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
EP1953153A1 (en) *	2007-01-31	2008-08-06	Laboratorios del Dr. Esteve S.A.	Heterocyclyl-substituted sulfonamides for the treatment of cognitive or food ingestion related disorders
EP2018861A1 (en) *	2007-07-26	2009-01-28	Laboratorios del Dr. Esteve S.A.	5HT6-Ligands such as sulfonamide derivatives in drug-induced weight-gain
ES2358288T3 (es) *	2007-08-01	2011-05-09	Laboratorios Del Dr. Esteve S.A.	Combinación de al menos dos ligandos de 5ht6.
EP2036888A1 (en) *	2007-09-17	2009-03-18	Laboratorios del Dr. Esteve S.A.	Naphthyl-substituted sulfonamides
CA2705833A1 (en) *	2007-11-16	2009-05-22	Subhash C. Annedi	3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
AU2008321353A1 (en) *	2007-11-16	2009-05-22	The Arizona Board Of Regents On Behalf Of The University Of Arizona	Methods for treating visceral pain
NZ586082A (en) *	2007-11-16	2013-03-28	Neuraxon Inc	Indole compounds and methods for treating visceral pain
EP2116547A1 (en)	2008-05-09	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	Substituted N-imidazo(2, 1-b) thiazole-5-sulfonamide derivatives as 5-TH6 ligands
EP2116546A1 (en) *	2008-05-09	2009-11-11	Laboratorios Del. Dr. Esteve, S.A.	Substituted N-phenyl-2,3-dihydroimidazo[2,1-b]thiazole-5-sulfonamide derivatives as 5-HT6 ligands
HUE039972T2 (hu) *	2013-08-02	2019-02-28	Pfizer	Heterobicikloaril-RORC2-inhibitorok és eljárás alkalmazásukra
MA40759A (fr)	2014-09-26	2017-08-01	Pfizer	Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3472870A (en) *	1966-08-29	1969-10-14	Mead Johnson & Co	Sulfonamidotryptamines
US5578612A (en) *	1990-10-15	1996-11-26	Pfizer Inc.	Indole derivatives
CN1184425A (zh) *	1995-03-20	1998-06-10	伊莱利利公司	5－取代－3－(1,2,3,6－四氢吡啶－4－基)－和3－(哌啶－4－基)－1h－吲哚:新型5－ht1f激动剂
US5962473A (en) *	1996-08-16	1999-10-05	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
EP0875513A1 (en) *	1997-04-14	1998-11-04	Eli Lilly And Company	Substituted heteroaromatic 5-HT 1F agonists
US6380201B1 (en) *	1997-08-05	2002-04-30	Eli Lilly And Company	Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
ES2187300B1 (es) *	2001-11-14	2004-06-16	Laboratorios Del Dr. Esteve, S.A.	Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.

2001
- 2001-11-14 ES ES200102517A patent/ES2187300B1/es not_active Expired - Fee Related
2002
- 2002-08-11 UA UA20040604587A patent/UA78252C2/uk unknown
- 2002-11-08 NZ NZ543393A patent/NZ543393A/en unknown
- 2002-11-08 AT AT05021228T patent/ATE428694T1/de active
- 2002-11-08 SG SG200602676-9A patent/SG146442A1/en unknown
- 2002-11-08 RU RU2004117850/04A patent/RU2293082C2/ru not_active IP Right Cessation
- 2002-11-08 PL PL02373894A patent/PL373894A1/xx not_active Application Discontinuation
- 2002-11-08 KR KR10-2004-7007155A patent/KR20040071685A/ko not_active Application Discontinuation
- 2002-11-08 CN CNB028240804A patent/CN1271052C/zh not_active Expired - Fee Related
- 2002-11-08 HU HU0402317A patent/HUP0402317A2/hu unknown
- 2002-11-08 ES ES02785439T patent/ES2259387T3/es not_active Expired - Lifetime
- 2002-11-08 PT PT02785439T patent/PT1445252E/pt unknown
- 2002-11-08 PT PT05021228T patent/PT1666462E/pt unknown
- 2002-11-08 ES ES05021228T patent/ES2322068T3/es not_active Expired - Lifetime
- 2002-11-08 DE DE60232029T patent/DE60232029D1/de not_active Expired - Lifetime
- 2002-11-08 AR ARP020104303A patent/AR037288A1/es not_active Application Discontinuation
- 2002-11-08 CA CA2466965A patent/CA2466965C/en not_active Expired - Fee Related
- 2002-11-08 BR BR0214243-0A patent/BR0214243A/pt not_active IP Right Cessation
- 2002-11-08 AT AT02785439T patent/ATE319684T1/de active
- 2002-11-08 WO PCT/ES2002/000518 patent/WO2003042175A1/es active Application Filing
- 2002-11-08 MX MXPA04004601A patent/MXPA04004601A/es active IP Right Grant
- 2002-11-08 EP EP02785439A patent/EP1445252B1/en not_active Expired - Lifetime
- 2002-11-08 DK DK02785439T patent/DK1445252T3/da active
- 2002-11-08 NZ NZ533136A patent/NZ533136A/en unknown
- 2002-11-08 EP EP05021228A patent/EP1666462B1/en not_active Expired - Lifetime
- 2002-11-08 SI SI200230302T patent/SI1445252T1/sl unknown
- 2002-11-08 IL IL16188502A patent/IL161885A0/xx unknown
- 2002-11-08 JP JP2003544012A patent/JP4416505B2/ja not_active Expired - Fee Related
- 2002-11-08 RS YU41104A patent/RS41104A/sr unknown
- 2002-11-08 DE DE60209779T patent/DE60209779T2/de not_active Expired - Lifetime
- 2002-11-11 TW TW091132989A patent/TWI275585B/zh not_active IP Right Cessation
- 2002-11-13 US US10/293,206 patent/US7105515B2/en not_active Expired - Fee Related
2004
- 2004-05-06 ES ES200401084A patent/ES2249129B2/es not_active Expired - Fee Related
- 2004-05-13 IS IS7263A patent/IS7263A/is unknown
- 2004-05-13 EC EC2004005105A patent/ECSP045105A/es unknown
- 2004-05-14 HR HR20040429A patent/HRP20040429B1/xx not_active IP Right Cessation
- 2004-05-25 ZA ZA200404073A patent/ZA200404073B/en unknown
- 2004-05-26 CO CO04048713A patent/CO5590895A2/es not_active Application Discontinuation
- 2004-06-07 MA MA27723A patent/MA27093A1/fr unknown
- 2004-06-14 NO NO20042478A patent/NO20042478L/no not_active Application Discontinuation
- 2004-09-03 US US10/933,951 patent/US7176200B2/en not_active Expired - Fee Related
2005
- 2005-02-05 HK HK05101004A patent/HK1070053A1/xx not_active IP Right Cessation
- 2005-11-22 RU RU2005136355/04A patent/RU2005136355A/ru not_active Application Discontinuation
2006
- 2006-06-02 CY CY20061100709T patent/CY1105362T1/el unknown
- 2006-07-17 US US11/487,745 patent/US7498328B2/en not_active Expired - Fee Related
2007
- 2007-02-16 US US11/707,571 patent/US7452881B2/en not_active Expired - Fee Related
- 2007-12-05 IS IS8698A patent/IS8698A/is unknown
2008
- 2008-08-04 IL IL193234A patent/IL193234A0/en unknown
2009
- 2009-09-29 JP JP2009223711A patent/JP5132649B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2003042175A1 (es)	2003-05-22
US20030191124A1 (en)	2003-10-09
SG146442A1 (en)	2008-10-30
CO5590895A2 (es)	2005-12-30
MA27093A1 (fr)	2004-12-20
ES2322068T3 (es)	2009-06-16
PT1666462E (pt)	2009-05-07
HK1070053A1 (en)	2005-06-10
EP1445252B1 (en)	2006-03-08
US7176200B2 (en)	2007-02-13
US20050032791A1 (en)	2005-02-10
EP1666462A1 (en)	2006-06-07
DE60232029D1 (de)	2009-05-28
US7498328B2 (en)	2009-03-03
HUP0402317A2 (hu)	2005-02-28
EP1445252A1 (en)	2004-08-11
CN1271052C (zh)	2006-08-23
TWI275585B (en)	2007-03-11
JP2005513016A (ja)	2005-05-12
PL373894A1 (en)	2005-09-19
RS41104A (xx)	2006-10-27
EP1666462B1 (en)	2009-04-15
TW200407306A (en)	2004-05-16
US20060258653A1 (en)	2006-11-16
ES2187300A1 (es)	2003-05-16
BR0214243A (pt)	2004-12-21
IL161885A0 (en)	2005-11-20
RU2293082C2 (ru)	2007-02-10
CN1599718A (zh)	2005-03-23
IL193234A0 (en)	2009-02-11
RU2005136355A (ru)	2007-05-27
DE60209779T2 (de)	2006-11-16
CY1105362T1 (el)	2010-03-03
NO20042478L (no)	2004-08-12
NZ533136A (en)	2006-01-27
ES2187300B1 (es)	2004-06-16
AR037288A1 (es)	2004-11-03
KR20040071685A (ko)	2004-08-12
RU2004117850A (ru)	2005-11-20
SI1445252T1 (sl)	2006-06-30
CA2466965C (en)	2011-09-06
DK1445252T3 (da)	2006-06-19
UA78252C2 (en)	2007-03-15
US7105515B2 (en)	2006-09-12
JP2009298819A (ja)	2009-12-24
ATE319684T1 (de)	2006-03-15
IS8698A (is)	2007-12-05
US7452881B2 (en)	2008-11-18
ATE428694T1 (de)	2009-05-15
CA2466965A1 (en)	2003-05-22
HRP20040429A2 (en)	2005-06-30
MXPA04004601A (es)	2004-08-13
DE60209779D1 (de)	2006-05-04
JP4416505B2 (ja)	2010-02-17
ES2249129B2 (es)	2007-08-16
US20070167448A1 (en)	2007-07-19
ECSP045105A (es)	2004-07-23
JP5132649B2 (ja)	2013-01-30
NZ543393A (en)	2007-04-27
ZA200404073B (en)	2006-05-31
ES2259387T3 (es)	2006-10-01
ES2249129A1 (es)	2006-03-16
IS7263A (is)	2004-05-13
PT1445252E (pt)	2006-07-31

Legal Events

Date	Code	Title	Description
2005-06-30	A1OB	Publication of a patent application
2005-08-29	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2007-10-09	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20071009 Year of fee payment: 6
2007-10-31	B1PR	Patent granted
2009-05-09	PBON	Lapse due to non-payment of renewal fee	Effective date: 20081109

Publication	Publication Date	Title
HRP20040429B1 (en)	2007-10-31	Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
CY1111075T1 (el)	2015-06-11	Φαρμακευτικες συνθεσεις που περιεχουν τα παραγωγα της 3-αμινο-αζετιδινης, τα νεα παραγωγα τους και η προετοιμασια τους
HRP20080022T3 (en)	2008-02-29	Pyrrolopyridine derivatives and their use as crth2 antagonists
HRP20070529T3 (en)	2008-05-31	Imidazole derivatives as glutmate receptor antagonists
DK1261602T3 (da)	2004-08-30	Imidazol-2-carboxamidderivater som Raf-kinaseinhibitorer
BRPI0506817A (pt)	2007-05-29	inibidores seletivos de quinase
HRP20090162T1 (en)	2009-05-31	Quinolinone-carboxamide compounds as 5-ht4 receptor agonists
YU48390B (sh)	1998-07-10	Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate
HRP20080113T3 (en)	2008-04-30	Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
RS50519B (sr)	2010-05-07	Supstituisani derivati 8'-piri(mi)dinil-dihidrospiro- /cikloalkilamin/-pirimido/1,2-a/pirimidin-6-ona
HRP20070286T3 (en)	2007-08-31	Substituted diketopiperazines and their use as oxytocyn antagonists
HRP20000896B1 (en)	2006-03-31	Adenosine derivatives
HUP0400326A2 (hu)	2004-09-28	Orexin receptor antagonistákként alkalmazható ciklikus N-(aril-karbonil)-amin-származékok és ezeket tartalmazó gyógyszerkészítmények
NO20101069L (no)	2001-09-06	Anvendelse av visse NMDA-affinitetsantagonister som antidepressiva
HUP0002353A2 (hu)	2001-05-28	IV típusú foszfodiészteráz inhibitor hatású 1-cikloalkil-1,8-naftiridin-4-on-származékok és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
DE60103136D1 (de)	2004-06-09	Imidazol derivate als raf kinase inhibitoren
SE0201937D0 (sv)	2002-06-20	Therapeutic agents
NO20071008L (no)	2007-02-21	Fremgangsmate for fremstilling av N-piperidino-1,5-difenylpyrazol-3-karboksamidderivater
NO20050871L (no)	2005-02-18	6-amino-1H-indazol- og 4-aminobenzofuranforbindelser som fosfodiesterase 4-inhibitorer
HUP0303813A2 (hu)	2004-03-29	Antivirális szerként alkalmazható arilszulfonamid-származékok, eljárás a vegyületek előállítására és ezeket tartalmazó gyógyszerkészítmények
FI964463A (fi)	1996-11-06	Bisykliset amidiinijohdannaiset typpioksidinsyntetaasin inhibiittoreina
RS51126B (sr)	2010-10-31	Postupak za pripremanje mezilata piperazin derivata
WO2006053784A3 (en)	2006-07-06	1,7-naphthyridines as pde4 inhibitors
NZ221699A (en)	1990-03-27	Pyridazinone derivatives; pharmaceutical compositions and intermediates
DE60201089D1 (de)	2004-09-30	6-(2-chlor-6-fluor-phenyl)-triazolpyrimidine