RS51126B - Postupak za pripremanje mezilata piperazin derivata - Google Patents

Postupak za pripremanje mezilata piperazin derivata

Info

Publication number
RS51126B
RS51126B YUP-644/03A YUP64403A RS51126B RS 51126 B RS51126 B RS 51126B YU P64403 A YUP64403 A YU P64403A RS 51126 B RS51126 B RS 51126B
Authority
RS
Serbia
Prior art keywords
formula
group
hydrogen
alkoxy
alkyl
Prior art date
Application number
YUP-644/03A
Other languages
English (en)
Inventor
P.M. van AAR Marcel
Stefanus J. Schouten
Jan Zorgdrager
Michiel C. Heslinga
Original Assignee
Solvay Pharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals B.V. filed Critical Solvay Pharmaceuticals B.V.
Publication of YU64403A publication Critical patent/YU64403A/sh
Publication of RS51126B publication Critical patent/RS51126B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

Postupak za pripremanje piperazin derivata, naznačen time, što mezilat jedinjenja koja imaju formulu (1)reagovanjem amina formule (2)sa jedinjenjem formule (3)i anhidridom metan sulfokiseline, u kojem formula X predstavlja grupu sa formulom (4)gde jeR1 vodonik ili fluoroR2 vodonik, alkil (1-4C), alkoksi (1-4C) ili okso grupa,A predstavlja heterocikličnu grupu od 5-7 atoma u prstenu pričemu je prisutno 1-3 heteroatoma iz grupe O, N i S.Y je metil, etil, etil supstituisan sa jednim ili više atoma fluora, cikloalkil (3-7C) metil opciono supstituisan sa jednim ili više atoma fluora, ili grupa formule (5)Gde je Z vodonik, fenil, fenil supstituisan sa 1-3 supstituenata iz grupe hidroksi, halogen, alkil (1-4C), alkoksi (1-4C) ili cijano, a R3 je vodonik ili 1-3 supstituenata iz grupe halogen, hidroksi, alkil (1-4C) ili alkoksi (1-4C).Prijava sadrži još 11 patentnih zahteva.
YUP-644/03A 2001-02-16 2002-02-14 Postupak za pripremanje mezilata piperazin derivata RS51126B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01200534 2001-02-16

Publications (2)

Publication Number Publication Date
YU64403A YU64403A (sh) 2006-05-25
RS51126B true RS51126B (sr) 2010-10-31

Family

ID=8179894

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-644/03A RS51126B (sr) 2001-02-16 2002-02-14 Postupak za pripremanje mezilata piperazin derivata

Country Status (35)

Country Link
US (1) US7030241B2 (sr)
EP (1) EP1362040B1 (sr)
JP (1) JP4328528B2 (sr)
KR (2) KR100859106B1 (sr)
CN (1) CN1176079C (sr)
AR (1) AR034206A1 (sr)
AT (1) ATE284875T1 (sr)
AU (1) AU2002250962B2 (sr)
BG (1) BG66101B1 (sr)
BR (1) BR0205683A (sr)
CA (1) CA2422703C (sr)
CZ (1) CZ301780B6 (sr)
DE (1) DE60202261T2 (sr)
DK (1) DK1362040T3 (sr)
DZ (1) DZ3489A1 (sr)
ES (1) ES2230481T3 (sr)
HK (1) HK1059934A1 (sr)
HR (1) HRP20030610B1 (sr)
HU (1) HUP0400772A3 (sr)
IL (1) IL153509A (sr)
IS (1) IS2417B (sr)
ME (1) MEP37508A (sr)
MX (1) MXPA03002359A (sr)
MY (1) MY130687A (sr)
NO (1) NO324460B1 (sr)
NZ (1) NZ524632A (sr)
PL (1) PL208363B1 (sr)
PT (1) PT1362040E (sr)
RS (1) RS51126B (sr)
RU (1) RU2272036C2 (sr)
SI (1) SI1362040T1 (sr)
SK (1) SK286143B6 (sr)
UA (1) UA75390C2 (sr)
WO (1) WO2002066449A2 (sr)
ZA (1) ZA200301590B (sr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
AR045362A1 (es) * 2003-08-18 2005-10-26 Solvay Pharm Bv Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona
US7405216B2 (en) * 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7423040B2 (en) * 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US7964604B2 (en) * 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
US7786126B2 (en) * 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en) * 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
BRPI0715445A2 (pt) 2006-08-31 2014-05-13 Solvay Pharm Bv Uso de um composto de bifeprunox, e, kit de titulação
US20090068290A1 (en) * 2006-08-31 2009-03-12 Michel Bourin Bifeprunox doses for treating schizophrenia
US20080132520A1 (en) * 2006-08-31 2008-06-05 Winsemius Antje A Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds
WO2009100258A1 (en) 2008-02-05 2009-08-13 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical solid state forms
WO2011023796A1 (en) 2009-08-31 2011-03-03 Abbott Healthcare Products B.V. Bifeprunox for treating addiction
UY32935A (es) 2009-10-12 2011-05-31 Abbott Healthcare Products Bv Polimorfos de pardoprunox

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE81975T1 (de) 1984-12-21 1992-11-15 Duphar Int Res Arzneimittel mit psychotroper wirkung.
EP0185429A1 (en) 1984-12-21 1986-06-25 Duphar International Research B.V New bicyclic heteroaryl piperazines
JPH0344383A (ja) * 1989-07-12 1991-02-26 Ihara Chem Ind Co Ltd ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法
JP3044383B2 (ja) * 1990-05-22 2000-05-22 コニカ株式会社 含窒素６員環化合物の製造方法
PT889889E (pt) * 1996-03-29 2007-01-31 Duphar Int Res Composto de piperazina e piperidina
SE9702799D0 (sv) * 1997-07-25 1997-07-25 Astra Ab New compounds
UA71590C2 (en) * 1998-11-13 2004-12-15 Duphar Int Res Piperazine and piperidine derivatives
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)

Also Published As

Publication number Publication date
WO2002066449A3 (en) 2002-10-24
NO324460B1 (no) 2007-10-22
DZ3489A1 (fr) 2002-08-29
IS6876A (is) 2003-07-17
HK1059934A1 (en) 2004-07-23
PL208363B1 (pl) 2011-04-29
MEP37508A (en) 2011-02-10
JP2004518741A (ja) 2004-06-24
HUP0400772A2 (hu) 2004-08-30
DE60202261D1 (de) 2005-01-20
PT1362040E (pt) 2005-05-31
CN1176079C (zh) 2004-11-17
JP4328528B2 (ja) 2009-09-09
EP1362040B1 (en) 2004-12-15
CA2422703A1 (en) 2002-08-29
BR0205683A (pt) 2004-07-06
HRP20030610B1 (en) 2006-02-28
DK1362040T3 (da) 2005-01-24
ES2230481T3 (es) 2005-05-01
CA2422703C (en) 2010-04-13
CZ301780B6 (cs) 2010-06-23
ATE284875T1 (de) 2005-01-15
MY130687A (en) 2007-07-31
AR034206A1 (es) 2004-02-04
NO20031754D0 (no) 2003-04-15
AU2002250962B2 (en) 2006-08-24
HUP0400772A3 (en) 2008-02-28
DE60202261T2 (de) 2005-05-19
NO20031754L (no) 2003-04-15
BG66101B1 (bg) 2011-04-29
SK3092003A3 (en) 2003-09-11
CN1463268A (zh) 2003-12-24
IL153509A0 (en) 2003-07-06
KR20030077523A (ko) 2003-10-01
ZA200301590B (en) 2004-02-05
SK286143B6 (sk) 2008-04-07
HRP20030610A2 (en) 2005-06-30
IL153509A (en) 2007-12-03
US20040077631A1 (en) 2004-04-22
KR101000733B1 (ko) 2010-12-14
IS2417B (is) 2008-10-15
UA75390C2 (en) 2006-04-17
YU64403A (sh) 2006-05-25
SI1362040T1 (en) 2005-06-30
BG108090A (bg) 2004-12-30
EP1362040A2 (en) 2003-11-19
US7030241B2 (en) 2006-04-18
MXPA03002359A (es) 2003-06-30
KR20080064206A (ko) 2008-07-08
KR100859106B1 (ko) 2008-09-18
RU2272036C2 (ru) 2006-03-20
WO2002066449A2 (en) 2002-08-29
CZ2003697A3 (cs) 2003-06-18
NZ524632A (en) 2004-03-26
PL369330A1 (en) 2005-04-18

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