HN2000000051A - Derivados heterociclicos utiles como agentes anticancerosos - Google Patents
Derivados heterociclicos utiles como agentes anticancerososInfo
- Publication number
- HN2000000051A HN2000000051A HN2000000051A HN2000000051A HN2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A HN 2000000051 A HN2000000051 A HN 2000000051A
- Authority
- HN
- Honduras
- Prior art keywords
- useful
- target agents
- derivatives
- heterociclic
- heterociclic derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
- C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/44—Oxygen and nitrogen or sulfur and nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
LA PRESENTE INVENCION SE REFIERE A DERIVADOS NOVEDOSOS DE ISOTIAZOL QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPOLIFERATIVAS, TALES COMO CANCERES EN MAMIFEROS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13493399P | 1999-05-19 | 1999-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
HN2000000051A true HN2000000051A (es) | 2001-02-02 |
Family
ID=22465672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HN2000000051A HN2000000051A (es) | 1999-05-19 | 2000-04-12 | Derivados heterociclicos utiles como agentes anticancerosos |
Country Status (21)
Country | Link |
---|---|
US (1) | US6380214B1 (es) |
EP (1) | EP1187826B1 (es) |
JP (2) | JP3692041B2 (es) |
AR (1) | AR029634A1 (es) |
AT (1) | ATE349440T1 (es) |
AU (1) | AU4137400A (es) |
BR (1) | BR0010746A (es) |
CA (1) | CA2374247C (es) |
CO (1) | CO5170417A1 (es) |
DE (1) | DE60032601T2 (es) |
DZ (1) | DZ3042A1 (es) |
ES (1) | ES2276681T3 (es) |
GT (1) | GT200000069A (es) |
HN (1) | HN2000000051A (es) |
MA (1) | MA26733A1 (es) |
MX (1) | MXPA01011920A (es) |
PA (1) | PA8494101A1 (es) |
PE (1) | PE20010152A1 (es) |
TN (1) | TNSN00104A1 (es) |
UY (1) | UY26143A1 (es) |
WO (1) | WO2000071532A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
DK1268472T3 (da) | 2000-02-07 | 2004-12-06 | Bristol Myers Squibb Co | 3-aminopyrazolinhibitorer af cyclinafhængige kinaser |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US8329924B2 (en) * | 2001-06-11 | 2012-12-11 | Vertex Pharmaceuticals (Canada) Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
DK1401825T3 (da) * | 2001-06-11 | 2009-11-09 | Virochem Pharma Inc | Thiophenderivater som antivirale midler mod flavivirus-infektion |
SE0102617D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US6924276B2 (en) | 2001-09-10 | 2005-08-02 | Warner-Lambert Company | Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors |
MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
US6989451B2 (en) * | 2002-06-04 | 2006-01-24 | Valeant Research & Development | Heterocyclic compounds and uses thereof |
WO2003105843A1 (en) * | 2002-06-13 | 2003-12-24 | Kinetek Pharmaceuticals, Inc. | Methods of using isothiazole derivatives to treat cancer or inflammation |
KR20050047519A (ko) * | 2002-07-09 | 2005-05-20 | 파스젠, 엘엘씨. | 사람 및 동물에서의 미생물 감염의 치료방법 |
CN101602756B (zh) * | 2002-07-09 | 2014-11-12 | 法斯根公司 | 化合物、含该化合物的药物组合物以及该化合物的应用方法 |
WO2004011461A1 (en) | 2002-07-25 | 2004-02-05 | Pfizer Products Inc. | Isothiazole derivatives useful as anticancer agents |
CA2506546A1 (en) * | 2002-11-15 | 2004-06-17 | Exelixis, Inc. | Kinase modulators |
ES2345438T3 (es) | 2002-12-10 | 2010-09-23 | Virochem Pharma Inc. | Compuestos y metodos para el tratamiento o prevencion de infecciones por flavivirus. |
SE0300092D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
SE0300091D0 (sv) * | 2003-01-15 | 2003-01-15 | Astrazeneca Ab | Novel compounds |
TWI369353B (en) * | 2003-03-07 | 2012-08-01 | Santen Pharmaceutical Co Ltd | Novel compound having 4-pyridylalkylthio group as substituent |
DE602004007382T2 (de) | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
CL2004001834A1 (es) | 2003-07-23 | 2005-06-03 | Bayer Pharmaceuticals Corp | Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol |
CN1918127B (zh) * | 2004-02-17 | 2012-02-15 | 参天制药株式会社 | 具有引入了取代或无取代氨基的4-吡啶基烷硫基的环状化合物 |
CA2555712C (en) * | 2004-02-17 | 2013-04-23 | Santen Pharmaceutical Co., Ltd. | Novel cyclic compound having 4-pyridylalkylthio group having substituted or unsubstituted amino group introduced therein |
JP4626353B2 (ja) * | 2004-02-17 | 2011-02-09 | 参天製薬株式会社 | 置換又は無置換アミノ基を導入した4−ピリジルアルキルチオ基を有する新規環式化合物 |
US7687533B2 (en) | 2004-03-18 | 2010-03-30 | Pfizer Inc. | N-(1-arylpyrazol-4l) sulfonamides and their use as parasiticides |
MXPA06012394A (es) | 2004-04-30 | 2007-01-31 | Bayer Pharmaceuticals Corp | Derivados de pirazolilurea sustituidos utiles en el tratamiento de cancer. |
PT1784183E (pt) * | 2004-08-26 | 2012-03-09 | Pfizer | Processos para a preparação de derivados de isotiazole |
JP4585978B2 (ja) * | 2005-03-03 | 2010-11-24 | 参天製薬株式会社 | キノリルアルキルチオ基を有する新規環式化合物 |
KR20080016597A (ko) * | 2005-05-13 | 2008-02-21 | 바이로켐 파마 인코포레이티드 | 플라비바이러스 감염의 예방 또는 치료용 화합물 및 그의예방 또는 치료 방법 |
US7932390B2 (en) | 2006-06-29 | 2011-04-26 | Hoffman-La Roche Inc. | Substituted thieno[3,2-C]pyridine carboxylic acid derivatives |
AP2579A (en) | 2006-11-15 | 2013-01-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
EP2116530B1 (en) * | 2007-02-26 | 2012-11-14 | Santen Pharmaceutical Co., Ltd | Novel pyrrole derivative having ureide group and aminocarbonyl group as substituents |
WO2008153042A1 (ja) * | 2007-06-11 | 2008-12-18 | Kyowa Hakko Kirin Co., Ltd. | 抗腫瘍剤 |
MX2010001636A (es) | 2007-08-14 | 2010-03-15 | Hoffmann La Roche | Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos. |
US8748453B2 (en) * | 2009-06-25 | 2014-06-10 | Medolution Limited | Substituted heterocyclic compounds as kinases inhibitors and methods of use thereof |
SG11201405761WA (en) | 2012-03-16 | 2014-10-30 | Axikin Pharmaceuticals Inc | 3,5-diaminopyrazole kinase inhibitors |
NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
MX2017008526A (es) | 2014-12-23 | 2017-10-25 | Axikin Pharmaceuticals Inc | Inhibidores de 3,5-diaminopirazol quinasa. |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1950990A1 (de) * | 1968-10-17 | 1970-05-14 | Ciba Geigy | Verfahren zur Herstellung von neuen triazacyclischen Verbindungen |
GB1355513A (en) * | 1971-04-07 | 1974-06-05 | May & Baker Ltd | Isothiazole derivatives |
DE2408234A1 (de) * | 1974-02-21 | 1975-09-04 | Celamerck Gmbh & Co Kg | Isothiazolylharnstoffe |
US4059433A (en) * | 1976-06-18 | 1977-11-22 | Fmc Corporation | 3-Alkoxyisothiazole derivatives as herbicides |
US4057416A (en) * | 1976-06-18 | 1977-11-08 | Fmc Corporation | 3-Alkylthio-, 3-alkylsulfinyl-, and 3-alkylsulfonylisothiazole derivatives as herbicides |
US4075001A (en) * | 1976-06-18 | 1978-02-21 | Fmc Corporation | 3-Aminoisothiazole derivatives as herbicides |
DE3529247A1 (de) * | 1985-05-17 | 1986-11-20 | Bayer Ag, 5090 Leverkusen | Verwendung von thienylharnstoffen und -isoharnstoffen als leistungsfoerdernde mittel bei tieren, neue thienylharnstoffe und -isoharnstoffe und ihre herstellung |
DE3540377A1 (de) * | 1985-11-14 | 1987-05-21 | Bayer Ag | Thienooxazinone, verfahren zu ihrer herstellung und ihre verwendung als leistungsfoerderer |
DE3541631A1 (de) * | 1985-11-26 | 1987-05-27 | Bayer Ag | Selektiv-fungizide verwendung von thienylharnstoff-derivaten |
US4859699A (en) * | 1987-07-20 | 1989-08-22 | Sandoz Ltd. | Substituted N-benzoyl-N'-thienylureas |
US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
DE4328425A1 (de) * | 1993-08-24 | 1995-03-02 | Basf Ag | Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung |
TW276256B (es) * | 1993-08-26 | 1996-05-21 | Takeda Pharm Industry Co Ltd | |
DE69532817T2 (de) * | 1994-11-10 | 2005-01-13 | Millenium Pharmaceuticals, Inc., Cambridge | Verwendung von pyrazole verbindungen zur behandlung von glomerulonephritis, krebs, atherosklerose oder restenose |
US5792767A (en) * | 1995-01-27 | 1998-08-11 | Abbott Laboratories | Bicyclic substituted hexahydrobenz e! isoindole alpha-1 adrenergic antagonists |
US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
JP2002500650A (ja) * | 1997-05-23 | 2002-01-08 | バイエル、コーポレイション | Rafキナーゼ阻害剤 |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
UA60365C2 (uk) * | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
-
2000
- 2000-04-12 HN HN2000000051A patent/HN2000000051A/es unknown
- 2000-04-17 CO CO00028307A patent/CO5170417A1/es not_active Application Discontinuation
- 2000-04-17 US US09/549,893 patent/US6380214B1/en not_active Expired - Fee Related
- 2000-04-18 PA PA20008494101A patent/PA8494101A1/es unknown
- 2000-05-03 MX MXPA01011920A patent/MXPA01011920A/es active IP Right Grant
- 2000-05-03 AU AU41374/00A patent/AU4137400A/en not_active Abandoned
- 2000-05-03 JP JP2000619789A patent/JP3692041B2/ja not_active Expired - Lifetime
- 2000-05-03 AT AT00920969T patent/ATE349440T1/de not_active IP Right Cessation
- 2000-05-03 ES ES00920969T patent/ES2276681T3/es not_active Expired - Lifetime
- 2000-05-03 WO PCT/IB2000/000570 patent/WO2000071532A1/en active IP Right Grant
- 2000-05-03 BR BR0010746-8A patent/BR0010746A/pt not_active Application Discontinuation
- 2000-05-03 EP EP00920969A patent/EP1187826B1/en not_active Expired - Lifetime
- 2000-05-03 DE DE60032601T patent/DE60032601T2/de not_active Expired - Fee Related
- 2000-05-03 CA CA002374247A patent/CA2374247C/en not_active Expired - Fee Related
- 2000-05-15 UY UY26143A patent/UY26143A1/es not_active Application Discontinuation
- 2000-05-16 PE PE2000000458A patent/PE20010152A1/es not_active Application Discontinuation
- 2000-05-17 GT GT200000069A patent/GT200000069A/es unknown
- 2000-05-17 TN TNTNSN00104A patent/TNSN00104A1/fr unknown
- 2000-05-17 MA MA25977A patent/MA26733A1/fr unknown
- 2000-05-17 DZ DZ000085A patent/DZ3042A1/xx active
- 2000-05-17 AR ARP000102369A patent/AR029634A1/es not_active Application Discontinuation
-
2004
- 2004-07-20 JP JP2004211640A patent/JP2005008641A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP1187826A1 (en) | 2002-03-20 |
TNSN00104A1 (fr) | 2005-11-10 |
DZ3042A1 (fr) | 2004-03-27 |
UY26143A1 (es) | 2000-12-29 |
ATE349440T1 (de) | 2007-01-15 |
CO5170417A1 (es) | 2002-06-27 |
AU4137400A (en) | 2000-12-12 |
JP2005008641A (ja) | 2005-01-13 |
ES2276681T3 (es) | 2007-07-01 |
WO2000071532A1 (en) | 2000-11-30 |
US6380214B1 (en) | 2002-04-30 |
EP1187826B1 (en) | 2006-12-27 |
JP3692041B2 (ja) | 2005-09-07 |
MXPA01011920A (es) | 2002-05-06 |
PE20010152A1 (es) | 2001-02-08 |
DE60032601D1 (de) | 2007-02-08 |
GT200000069A (es) | 2001-11-08 |
BR0010746A (pt) | 2002-02-13 |
JP2003500401A (ja) | 2003-01-07 |
CA2374247A1 (en) | 2000-11-30 |
MA26733A1 (fr) | 2004-12-20 |
AR029634A1 (es) | 2003-07-10 |
PA8494101A1 (es) | 2003-09-05 |
DE60032601T2 (de) | 2007-11-15 |
CA2374247C (en) | 2008-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HN2000000051A (es) | Derivados heterociclicos utiles como agentes anticancerosos | |
HN2003000416A (es) | Derivados de pirrolopirimidina | |
PA8432701A1 (es) | Derivados triciclicos sustituidos con fenilamino. | |
HN2000000019A (es) | Derivados de quinolin-2-ona sustituidos con heteroarilo utiles como agentes anticancerigenos | |
GT199900070A (es) | Derivados de isotiazol, utiles como agentes anticancerosos. | |
CR7182A (es) | Benzoilsufanamidas y sulfonilbenzamidinas que se usan como agentes antitumorales | |
HN1998000132A (es) | Combinaciones terapeuticas | |
BR0211905A (pt) | Dialdeìdos de rapamicina | |
HN1998000168A (es) | Derivados de la tienapirimidina y de la tienapiridina utiles como agentes anticancerigenos. | |
ECSP045098A (es) | Procedimientos para tratar enfermedades neovasculares oculares | |
AR018705A1 (es) | Procedimientos e intermedios para preparar compuestos anticancerosos. | |
GT199900140A (es) | Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos. | |
HN2000000003A (es) | Antibioticos cetolidos | |
BRPI0411897A (pt) | pirroldihidroisoquinolinas como inibidores de pde10 | |
GT199900067A (es) | Nuevas 4-fenilpiperidinas para el tratamiento dedermatosis prurìtica. | |
UY26870A1 (es) | Antibióticos macrólidos | |
HN2003000080A (es) | Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso | |
UY26929A1 (es) | Polipéptidos antiangiogénicos y métodos para inhibir la angiogénesis | |
BR0114059A (pt) | Derivados de resorcinol | |
HN1998000088A (es) | Tratamiento de resistencia a la insulina | |
ES2190486T3 (es) | 3-acetidinilalquilpiperidinas o -pirrolidinas como antagonistas de la taquicinina. | |
HN1998000199A (es) | Agentes terapeuticos | |
BR0115139A (pt) | Compostos bis-heterocìclicos com atividade antitumor e quimiossensibilizante | |
GT200200265A (es) | Nuevas fitasas y procedimiento de produccion de dichas fitasas | |
SV2002000459A (es) | Derivados de sulfonamidas ref. x-13840 |