DK1268472T3 - 3-aminopyrazolinhibitorer af cyclinafhængige kinaser - Google Patents

3-aminopyrazolinhibitorer af cyclinafhængige kinaser

Info

Publication number
DK1268472T3
DK1268472T3 DK01948983T DK01948983T DK1268472T3 DK 1268472 T3 DK1268472 T3 DK 1268472T3 DK 01948983 T DK01948983 T DK 01948983T DK 01948983 T DK01948983 T DK 01948983T DK 1268472 T3 DK1268472 T3 DK 1268472T3
Authority
DK
Denmark
Prior art keywords
inhibitors
aminopyrazoline
cyclin
dependent kinases
useful
Prior art date
Application number
DK01948983T
Other languages
English (en)
Inventor
Mark E Salvati
Spencer David Kimball
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DK1268472T3 publication Critical patent/DK1268472T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DK01948983T 2000-02-07 2001-01-23 3-aminopyrazolinhibitorer af cyclinafhængige kinaser DK1268472T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18060900P 2000-02-07 2000-02-07
PCT/US2001/002208 WO2001057034A1 (en) 2000-02-07 2001-01-23 3-aminopyrazole inhibitors of cyclin dependent kinases

Publications (1)

Publication Number Publication Date
DK1268472T3 true DK1268472T3 (da) 2004-12-06

Family

ID=22661092

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01948983T DK1268472T3 (da) 2000-02-07 2001-01-23 3-aminopyrazolinhibitorer af cyclinafhængige kinaser

Country Status (11)

Country Link
US (2) US6482842B2 (da)
EP (1) EP1268472B1 (da)
JP (1) JP2003522174A (da)
AT (1) ATE279410T1 (da)
AU (2) AU2972701A (da)
CA (1) CA2399274A1 (da)
DE (1) DE60106409T2 (da)
DK (1) DK1268472T3 (da)
ES (1) ES2228905T3 (da)
PT (1) PT1268472E (da)
WO (1) WO2001057034A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1939203T3 (da) 2000-04-25 2015-02-23 Icos Corp Hæmmere af human phosphatidyl-inositol 3-kinase delta isoform
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
AU2003287692A1 (en) * 2002-11-12 2004-06-03 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor supression and regression
JP2006526015A (ja) * 2003-05-02 2006-11-16 エラン ファーマシューティカルズ，インコーポレイテッド 炎症疾患治療のためのブラジキニンｂ１受容体アンタゴニストとしての４−ブロモ−５−（２−クロロ−ベンゾイルアミノ）−１ｈ−ピラゾール−３−カルボン酸アミド誘導体および関連化合物
WO2005016888A1 (ja) * 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
WO2005047504A1 (en) * 2003-11-07 2005-05-26 The Board Of Trustees Of The University Of Illinois Induction of cellular senescence by cdk4 disruption for tumor suppression and regression
CN102229609A (zh) 2004-05-13 2011-11-02 艾科斯有限公司 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮
EP1899304A1 (en) * 2005-05-23 2008-03-19 Arena Pharmaceuticals, Inc. 5-amino-1h-pyrazole-3-carboxylic acid derivatives as agonists for the g-protein coupled receptor (gpcr) rup38 for the treatment of metabolic-related disorders thereof
US9492449B2 (en) 2008-11-13 2016-11-15 Gilead Calistoga Llc Therapies for hematologic malignancies
SG195655A1 (en) 2008-11-13 2013-12-30 Gilead Calistoga Llc Therapies for hematologic malignancies
BR112012001325A2 (pt) 2009-07-21 2017-05-02 Gilead Calistoga Llc tratamento de distúrbios do fígado com inibidaores de pi3k
SI2834241T1 (sl) 2012-03-05 2021-06-30 Gilead Calistoga Llc Polimorfne oblike (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilkinazolin-4(3H)-ONA
JP2017500319A (ja) 2013-12-20 2017-01-05 ギリアード カリストガ エルエルシー （ｓ）−２−（１−（９ｈ−プリン−６−イルアミノ）プロピル）−５−フルオロ−３−フェニルキナゾリン−４（３ｈ）−オンの塩酸塩の多形形態
AU2014364410B2 (en) 2013-12-20 2017-11-16 Gilead Calistoga Llc Process methods for phosphatidylinositol 3-kinase inhibitors
CA2952012A1 (en) 2014-06-13 2015-12-17 Gilead Sciences, Inc. Phosphatidylinositol 3-kinase inhibitors

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US4416683A (en) * 1980-09-16 1983-11-22 Eli Lilly And Company Benzamides, compositions and agricultural method
JPS6033552A (ja) * 1983-08-04 1985-02-20 Fuji Photo Film Co Ltd カラ−画像形成方法
ATE49198T1 (de) * 1984-05-12 1990-01-15 Fisons Plc Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung.
JPH0743522B2 (ja) * 1985-07-05 1995-05-15 コニカ株式会社 ５―アミノ―１ｈ―ピラゾール系化合物を用いる写真用マゼンタカプラーの合成方法
JPH01258695A (ja) * 1988-04-07 1989-10-16 Yamanouchi Pharmaceut Co Ltd （ピラゾリルアミノ）メチレンビス（ホスホン酸）誘導体及びその医薬
EP0646584A1 (en) * 1991-09-03 1995-04-05 Yamanouchi Pharmaceutical Co. Ltd. Pyrazolotriazole derivative
JPH06210063A (ja) * 1993-01-14 1994-08-02 Kousaku Ishikawa パチンコゲーム機における持ち玉返却機構
AU700964B2 (en) * 1994-11-10 1999-01-14 Cor Therapeutics, Inc. Pharmaceutical pyrazole compositions useful as inhibitors of protein kinases
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
DE19744676A1 (de) 1997-10-10 1999-04-15 Forschungszentrum Borstel Zent Kombinationspräparate für die Therapie von Tumoren
GB9904932D0 (en) 1999-03-04 1999-04-28 Glaxo Group Ltd Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
HN2000000051A (es) 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
ES2251395T3 (es) 1999-07-26 2006-05-01 Banyu Pharmaceutical Co., Ltd. Derivados de biarilureas.
US6387900B1 (en) * 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
EA005373B1 (ru) 1999-08-12 2005-02-24 Фармация Италия С.П.А. Производные 3(5)-аминопиразола, способ их получения и их применение в качестве противоопухолевых средств

Also Published As

Publication number Publication date
US20010047019A1 (en) 2001-11-29
JP2003522174A (ja) 2003-07-22
US6482842B2 (en) 2002-11-19
AU2001229727B2 (en) 2004-10-14
DE60106409T2 (de) 2006-02-02
ATE279410T1 (de) 2004-10-15
EP1268472B1 (en) 2004-10-13
DE60106409D1 (de) 2004-11-18
ES2228905T3 (es) 2005-04-16
US6610724B2 (en) 2003-08-26
CA2399274A1 (en) 2001-08-09
AU2972701A (en) 2001-08-14
WO2001057034A1 (en) 2001-08-09
EP1268472A1 (en) 2003-01-02
PT1268472E (pt) 2005-01-31
US20030018058A1 (en) 2003-01-23

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