HK1159247A1 - 聚集 分子的配體 - Google Patents

聚集 分子的配體

Info

Publication number
HK1159247A1
HK1159247A1 HK11113773.3A HK11113773A HK1159247A1 HK 1159247 A1 HK1159247 A1 HK 1159247A1 HK 11113773 A HK11113773 A HK 11113773A HK 1159247 A1 HK1159247 A1 HK 1159247A1
Authority
HK
Hong Kong
Prior art keywords
tau
ligands
molecules
aggregated
aggregated tau
Prior art date
Application number
HK11113773.3A
Other languages
English (en)
Inventor
Steven John Kemp
Lynda Jane Storey
John Mervyn David Storey
Janet Rickard
Charles Robert Harrington
Claude Michel Wischik
Scott Clunas
Tobias Kerst Heinrich
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of HK1159247A1 publication Critical patent/HK1159247A1/zh

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2814Dementia; Cognitive disorders
    • G01N2800/2821Alzheimer
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/18Sulfur containing
HK11113773.3A 2008-09-23 2011-12-21 聚集 分子的配體 HK1159247A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9937608P 2008-09-23 2008-09-23
PCT/GB2009/002260 WO2010034982A1 (en) 2008-09-23 2009-09-23 Ligands for aggregated tau molecules

Publications (1)

Publication Number Publication Date
HK1159247A1 true HK1159247A1 (zh) 2012-07-27

Family

ID=41478644

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11113773.3A HK1159247A1 (zh) 2008-09-23 2011-12-21 聚集 分子的配體

Country Status (20)

Country Link
US (1) US8895313B2 (zh)
EP (1) EP2338059B1 (zh)
JP (1) JP5667058B2 (zh)
KR (1) KR101631727B1 (zh)
CN (1) CN102224423B (zh)
AU (1) AU2009295701B2 (zh)
BR (1) BRPI0919079B1 (zh)
CA (1) CA2737028C (zh)
DK (1) DK2338059T3 (zh)
ES (1) ES2540536T3 (zh)
HK (1) HK1159247A1 (zh)
HR (1) HRP20150724T1 (zh)
IL (1) IL211369A (zh)
MX (1) MX2011002647A (zh)
PL (1) PL2338059T3 (zh)
PT (1) PT2338059E (zh)
RU (1) RU2518892C2 (zh)
SI (1) SI2338059T1 (zh)
WO (1) WO2010034982A1 (zh)
ZA (1) ZA201102159B (zh)

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CN102250134B (zh) * 2010-05-21 2013-12-04 中国科学院化学研究所 一种识别氟离子的荧光探针及其制备方法和用途
WO2012094334A1 (en) * 2011-01-04 2012-07-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services One-step 18f labeling of biological substrates and uses of 18f labeled biological substrates
EP2671885A1 (en) * 2012-06-05 2013-12-11 Ares Trading S.A. Imidazo-oxadiazole and Imidazo-thiadiazole derivatives
CA2876459A1 (en) * 2012-08-14 2014-02-20 F. Hoffmann-La Roche Ag Imidazo[2,1]thiazol-3-one derivatives useful as diagnostic agents for alzheimer's disease
AU2012397435B2 (en) * 2012-12-21 2017-03-30 National Institutes For Quantum And Radiological Science And Technology Novel compound for imaging TAU protein accumulated in the brain
JP6212628B2 (ja) 2013-04-29 2017-10-11 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 2−フェニル又は2−ヘタリールイミダゾール[1,2−a]ピリジン誘導体
KR101770532B1 (ko) * 2013-09-26 2017-08-22 에프. 호프만-라 로슈 아게 이미징 수단으로서의 이미다조[1,2-a]피리딘-7-아민
HUE057702T2 (hu) * 2014-08-29 2022-05-28 Chdi Foundation Inc Szondák huntingtin fehérje képalkotáshoz
CN104557768B (zh) * 2014-12-09 2016-09-14 温州大学 一种苯并噻唑衍生物的合成方法
WO2016136727A1 (ja) * 2015-02-24 2016-09-01 国立大学法人鳥取大学 認知症の予防及び/又は治療のための医薬
WO2016148114A1 (ja) * 2015-03-13 2016-09-22 国立大学法人北海道大学 酸化ストレス誘導神経細胞死抑制化合物
WO2017031239A1 (en) * 2015-08-18 2017-02-23 The Regents Of The University Of California Nitroxide containing amyloid binding agents for imaging and therapeutic uses
RU2721845C2 (ru) * 2015-12-30 2020-05-25 Нойборон Медтех Лтд. СОЕДИНЕНИЕ ДЛЯ СПЕЦИФИЧЕСКОГО СВЯЗЫВАНИЯ С β-АМИЛОИДОМ
CN106496275A (zh) * 2016-09-07 2017-03-15 北京师范大学 与Aβ斑块具有高亲和力的N2S2类2‑芳基苯并噻唑化合物及其制备方法与应用
GB201617339D0 (en) 2016-10-12 2016-11-23 Lytix Biopharma As Therapeutic compounds
US10954216B2 (en) 2016-12-27 2021-03-23 Riken BMP-signal-inhibiting compound
KR102572014B1 (ko) * 2018-05-09 2023-08-29 아프리노이아 테라퓨틱스 리미티드 헤테로아릴 화합물 및 이의 용도
KR102215255B1 (ko) * 2019-06-12 2021-02-15 한국과학기술연구원 타우 응집체에 선택적으로 결합하는 형광 탐침자로서 유효한 신규 화합물 및 이의 제조 방법
KR102132847B1 (ko) * 2019-12-09 2020-07-13 한국과학기술연구원 타우 응집체에 높은 선택성을 가지는 화합물, 이를 포함하는 타우 표적 프로브, 및 이의 제조 방법
GB202213796D0 (en) 2022-09-21 2022-11-02 Wista Lab Ltd Tau aggregation inhibitors

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Also Published As

Publication number Publication date
CA2737028C (en) 2017-06-27
CN102224423B (zh) 2014-10-22
CA2737028A1 (en) 2010-04-01
RU2011107931A (ru) 2012-10-27
ES2540536T3 (es) 2015-07-10
US20110171739A1 (en) 2011-07-14
EP2338059A1 (en) 2011-06-29
HRP20150724T1 (hr) 2015-08-14
CN102224423A (zh) 2011-10-19
RU2518892C2 (ru) 2014-06-10
PL2338059T3 (pl) 2015-10-30
US8895313B2 (en) 2014-11-25
MX2011002647A (es) 2011-04-07
EP2338059B1 (en) 2015-04-08
AU2009295701A1 (en) 2010-04-01
IL211369A (en) 2015-07-30
BRPI0919079A2 (pt) 2020-08-18
KR20110076956A (ko) 2011-07-06
DK2338059T3 (en) 2015-06-15
JP5667058B2 (ja) 2015-02-12
AU2009295701B2 (en) 2014-07-24
WO2010034982A1 (en) 2010-04-01
JP2012502966A (ja) 2012-02-02
IL211369A0 (en) 2011-04-28
BRPI0919079B1 (pt) 2022-02-15
KR101631727B1 (ko) 2016-06-17
ZA201102159B (en) 2012-10-31
SI2338059T1 (sl) 2015-08-31
PT2338059E (pt) 2015-08-03

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