BRPI0408274B8 - compostos de ligação de amiloide e composição farmacêutica - Google Patents
compostos de ligação de amiloide e composição farmacêuticaInfo
- Publication number
- BRPI0408274B8 BRPI0408274B8 BRPI0408274A BRPI0408274A BRPI0408274B8 BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8 BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 A BRPI0408274 A BR PI0408274A BR PI0408274 B8 BRPI0408274 B8 BR PI0408274B8
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- disease
- pharmaceutical composition
- deposit
- amyloid
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
compostos de ligação de amilóide, composição farmacêutica e método de detecção de depósito de amilóide in vivo a invenção proporciona compostos derivados do benzotiazol, composições que compreendem esses compostos, métodos de preparação desses compostos e métodos de uso desses compostos para detectar depósito(s) de amilóides e para diagnose de uma doença, desordem ou condição caracterizada por depósito(s) de amilóides. os compostos encontram uso particular no diagnóstico e tratamento de pacientes com doenças onde a acumulação de placas neuríticas é prevalente. os estados doentios ou doenças incluem, mas, sem limitação, a doença de alzheimer, a doença familiar de alzheimer, a síndrome de down e homozigotos para o alelo e4 da apolipoproteína.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/388,173 US7270800B2 (en) | 2000-08-24 | 2003-03-14 | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
US10/388,173 | 2003-03-14 | ||
US10/645,847 | 2003-08-22 | ||
US10/645,847 US20050043523A1 (en) | 2003-08-22 | 2003-08-22 | Benzothiazole derivative compounds, compositions and uses |
PCT/US2004/007797 WO2004083195A1 (en) | 2003-03-14 | 2004-03-15 | Benzothiazole derivative compounds, compositions and uses |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0408274A BRPI0408274A (pt) | 2006-03-21 |
BRPI0408274B1 BRPI0408274B1 (pt) | 2019-02-26 |
BRPI0408274B8 true BRPI0408274B8 (pt) | 2021-05-25 |
Family
ID=35057877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408274A BRPI0408274B8 (pt) | 2003-03-14 | 2004-03-15 | compostos de ligação de amiloide e composição farmacêutica |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1611115B1 (pt) |
JP (1) | JP4875487B2 (pt) |
CN (2) | CN102532055B (pt) |
AU (2) | AU2004221897B2 (pt) |
BE (1) | BE2015C005I2 (pt) |
BR (1) | BRPI0408274B8 (pt) |
CY (2) | CY1113334T1 (pt) |
DK (1) | DK1611115T3 (pt) |
ES (1) | ES2393921T3 (pt) |
HK (1) | HK1086270A1 (pt) |
HU (1) | HUS1500006I1 (pt) |
NO (3) | NO330861B1 (pt) |
PL (1) | PL1611115T3 (pt) |
PT (1) | PT1611115E (pt) |
RU (1) | RU2440995C2 (pt) |
SI (1) | SI1611115T1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020133019A1 (en) * | 2000-08-24 | 2002-09-19 | Klunk William E. | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and vivo imaging and prevention of amyloid deposition |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
AU2005245470A1 (en) * | 2004-05-20 | 2005-12-01 | Foldrx Pharmaceuticals, Inc. | 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
GB0516564D0 (en) * | 2005-08-12 | 2005-09-21 | Ge Healthcare Ltd | Fluorination process |
KR101503940B1 (ko) * | 2007-01-30 | 2015-03-18 | 지이 헬쓰케어 리미티드 | 신경퇴행성 질환의 진단을 돕는 수단 |
CN101293878B (zh) * | 2007-04-25 | 2010-12-15 | 中国科学院上海应用物理研究所 | 苯并噻唑苯胺类化合物及其制备方法和应用 |
WO2010011964A2 (en) * | 2008-07-24 | 2010-01-28 | Siemens Medical Solutions Usa, Inc. | Imaging agents useful for identifying ad pathology |
PT2338059E (pt) * | 2008-09-23 | 2015-08-03 | Wista Lab Ltd | Ligandos para moléculas de tau agregada |
MX2016003422A (es) * | 2013-09-26 | 2016-06-28 | Hoffmann La Roche | Imidazo[1,2-a]piridina-7-aminas como herramientas de imagen. |
JP6260967B2 (ja) * | 2013-11-06 | 2018-01-17 | 国立大学法人京都大学 | 放射性ヨウ素標識化合物、及び、これを含む放射性医薬 |
CN103613589B (zh) * | 2013-11-29 | 2016-03-30 | 江苏华益科技有限公司 | 一种用于神经退行性疾病领域的新型pet显像剂前体及标准品的合成方法 |
MX2017002705A (es) * | 2014-08-29 | 2017-12-20 | Chdi Foundation Inc | Sondas para la proyección de imagen de la proteína huntingtina. |
CN109400615B (zh) * | 2017-08-18 | 2021-07-16 | 上海交通大学医学院附属新华医院 | 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用 |
GR1009516B (el) * | 2018-03-22 | 2019-05-02 | Εκεφε Δημοκριτος | Τρικαρβονυλο-συμπλοκα μεταλλων μεταπτωσεως με βενζο-ετεροκυκλικο παραγωγο του κυκλοπενταδιενυλικου ανιοντος με υψηλη διαπερατοτητα του αιματοεγκεφαλικου φραγμου για εφαρμογες στη διαγνωση και θεραπεια νοσων του κνς |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ID22275A (id) * | 1996-11-22 | 1999-09-23 | Elan Pharm Inc | Komposisi farmasi yang terdiri dari derivat asam amino n-(aril atau heteroaril) dan metode untuk menghambat pelepasan b-amiloid peptida dan atau sintesisnya dengan menggunakan senyawa tersebut |
GB9919673D0 (en) * | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
US20020133019A1 (en) * | 2000-08-24 | 2002-09-19 | Klunk William E. | Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and vivo imaging and prevention of amyloid deposition |
JP2004524289A (ja) * | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
ES2274973T3 (es) * | 2001-04-23 | 2007-06-01 | The Trustees Of The University Of Pennsylvania | Inhibidores de la agregacion de placas amiloides y agentes de obtencion de imagenes diagnosticas. |
GB0229686D0 (en) * | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
-
2004
- 2004-03-15 EP EP04720788A patent/EP1611115B1/en not_active Expired - Lifetime
- 2004-03-15 SI SI200431952T patent/SI1611115T1/sl unknown
- 2004-03-15 RU RU2005131872/04A patent/RU2440995C2/ru not_active Application Discontinuation
- 2004-03-15 BR BRPI0408274A patent/BRPI0408274B8/pt active IP Right Grant
- 2004-03-15 CN CN201110437182.5A patent/CN102532055B/zh not_active Expired - Lifetime
- 2004-03-15 CN CNA2004800125035A patent/CN1784392A/zh active Pending
- 2004-03-15 DK DK04720788.1T patent/DK1611115T3/da active
- 2004-03-15 JP JP2006507179A patent/JP4875487B2/ja not_active Expired - Lifetime
- 2004-03-15 PT PT47207881T patent/PT1611115E/pt unknown
- 2004-03-15 ES ES04720788T patent/ES2393921T3/es not_active Expired - Lifetime
- 2004-03-15 PL PL04720788T patent/PL1611115T3/pl unknown
- 2004-03-15 AU AU2004221897A patent/AU2004221897B2/en not_active Expired
-
2005
- 2005-10-11 NO NO20054674A patent/NO330861B1/no active Protection Beyond IP Right Term
-
2006
- 2006-07-04 HK HK06107502.0A patent/HK1086270A1/xx not_active IP Right Cessation
-
2011
- 2011-02-16 AU AU2011200667A patent/AU2011200667B2/en not_active Expired
- 2011-07-06 NO NO20110980A patent/NO20110980L/no not_active Application Discontinuation
-
2012
- 2012-11-16 CY CY20121101106T patent/CY1113334T1/el unknown
-
2015
- 2015-01-27 BE BE2015C005C patent/BE2015C005I2/fr unknown
- 2015-02-18 HU HUS1500006C patent/HUS1500006I1/hu unknown
- 2015-02-18 NO NO2015005C patent/NO2015005I1/no not_active IP Right Cessation
- 2015-03-04 CY CY2015007C patent/CY2015007I1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004221897A2 (en) | 2004-09-30 |
CN102532055A (zh) | 2012-07-04 |
PL1611115T3 (pl) | 2013-01-31 |
AU2004221897A9 (en) | 2009-08-20 |
AU2011200667B2 (en) | 2011-12-22 |
AU2011200667A1 (en) | 2011-03-10 |
BE2015C005I2 (pt) | 2023-03-07 |
EP1611115A1 (en) | 2006-01-04 |
JP4875487B2 (ja) | 2012-02-15 |
PT1611115E (pt) | 2012-12-07 |
CN1784392A (zh) | 2006-06-07 |
AU2004221897B2 (en) | 2010-11-18 |
NO20110980L (no) | 2005-12-13 |
NO2015005I2 (no) | 2015-02-18 |
CY2015007I1 (el) | 2015-12-09 |
HK1086270A1 (en) | 2006-09-15 |
AU2004221897A1 (en) | 2004-09-30 |
DK1611115T3 (da) | 2012-11-26 |
BRPI0408274B1 (pt) | 2019-02-26 |
NO20054674D0 (no) | 2005-10-11 |
RU2440995C2 (ru) | 2012-01-27 |
NO2015005I1 (no) | 2015-03-02 |
RU2005131872A (ru) | 2006-02-27 |
NO330861B1 (no) | 2011-08-01 |
EP1611115B1 (en) | 2012-08-22 |
HUS1500006I1 (hu) | 2015-02-18 |
BRPI0408274A (pt) | 2006-03-21 |
CN102532055B (zh) | 2016-05-11 |
NO20054674L (no) | 2005-12-13 |
CY1113334T1 (el) | 2015-12-09 |
ES2393921T3 (es) | 2013-01-02 |
JP2006522104A (ja) | 2006-09-28 |
SI1611115T1 (sl) | 2012-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS |
|
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/02/2019, OBSERVADAS AS CONDICOES LEGAIS. |
|
B25G | Requested change of headquarter approved |
Owner name: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYS |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |