HK1091819A1 - Substitued pyridines and pyridazines with angiogenesis inhibiting activity - Google Patents

Substitued pyridines and pyridazines with angiogenesis inhibiting activity

Info

Publication number: HK1091819A1
Authority: HK; Hong Kong
Prior art keywords: pyridazines; substitued; pyridines; inhibiting activity; angiogenesis inhibiting
Prior art date: 1999-09-28

Application number

HK06112290.6A

Other languages

English (en)

Inventor

Jacques P Dumas

Teddy Kite Joe

Harold C Kluender

Wendy Lee

Dhanapalan Nagarathnam

Robert N Sibley

Ning Su

Stephen James Boyer

Julie A Dixon

Original Assignee

Bayer Pharmaceuticals Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-09-28

Filing date

2006-11-08

Publication date

2007-01-26

2006-11-08 Application filed by Bayer Pharmaceuticals Corp filed Critical Bayer Pharmaceuticals Corp

2007-01-26 Publication of HK1091819A1 publication Critical patent/HK1091819A1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyridine Compounds (AREA)

HK06112290.6A 1999-09-28 2006-11-08 Substitued pyridines and pyridazines with angiogenesis inhibiting activity HK1091819A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40760099A	1999-09-28	1999-09-28

Publications (1)

Publication Number	Publication Date
HK1091819A1 true HK1091819A1 (en)	2007-01-26

Family

ID=23612752

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
HK06112290.6A HK1091819A1 (en)	1999-09-28	2006-11-08	Substitued pyridines and pyridazines with angiogenesis inhibiting activity
HK06112289.9A HK1091818A1 (en)	1999-09-28	2006-11-08	Substitued pyridines and pyridazines with angiogenesis inhibiting activity

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
HK06112289.9A HK1091818A1 (en)	1999-09-28	2006-11-08	Substitued pyridines and pyridazines with angiogenesis inhibiting activity

Country Status (36)

Country	Link
EP (1)	EP1228063B1 (no)
JP (1)	JP4919567B2 (no)
KR (3)	KR100895571B1 (no)
CN (3)	CN100374435C (no)
AR (3)	AR025752A1 (no)
AT (1)	ATE422494T1 (no)
AU (1)	AU782820B2 (no)
BG (1)	BG65860B1 (no)
BR (1)	BRPI0014382B8 (no)
CA (1)	CA2385817C (no)
CO (1)	CO5200835A1 (no)
CZ (1)	CZ304767B6 (no)
DE (1)	DE60041548D1 (no)
DO (1)	DOP2000000070A (no)
EE (1)	EE05258B1 (no)
ES (1)	ES2320525T3 (no)
GT (1)	GT200000158A (no)
HK (2)	HK1091819A1 (no)
HR (1)	HRP20020308A2 (no)
HU (1)	HU230223B1 (no)
IL (3)	IL148880A0 (no)
MA (1)	MA25563A1 (no)
MX (1)	MXPA02003156A (no)
MY (3)	MY143377A (no)
NO (1)	NO20021520L (no)
NZ (1)	NZ518589A (no)
PA (1)	PA8503201A1 (no)
PE (1)	PE20010607A1 (no)
PL (1)	PL205957B1 (no)
RS (1)	RS50369B (no)
RU (1)	RU2260008C2 (no)
SK (1)	SK287417B6 (no)
TW (1)	TW593315B (no)
UA (1)	UA75053C2 (no)
WO (1)	WO2001023375A2 (no)
ZA (1)	ZA200202760B (no)

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IL154034A0 (en) *	2000-08-09	2003-07-31	Astrazeneca Ab	Indole, azaindole and indazole derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals
ATE399766T1 (de)	2000-10-20	2008-07-15	Eisai R&D Man Co Ltd	Stickstoff enthaltende aromatische heterozyklen
AU2002364102A1 (en) *	2001-12-21	2003-07-30	Bayer Pharmaceuticals Corporation	Anti-angiogenesis combination therapies comprising pyridazine or pyridine derivatives
TWI299664B (en)	2003-01-06	2008-08-11	Osi Pharm Inc	(2-carboxamido)(3-amino)thiophene compounds
CA2518530A1 (en) *	2003-03-11	2004-09-23	Novartis Ag	Use of isoquinoline derivatives for treating cancer and map kinase related diseases
US20070082910A1 (en) *	2003-04-08	2007-04-12	Mitsubishi Pharma Corporation	Specific nad(p)h oxidase inhibitor
US7683172B2 (en)	2003-11-11	2010-03-23	Eisai R&D Management Co., Ltd.	Urea derivative and process for preparing the same
KR100553398B1 (ko) *	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
US8772269B2 (en)	2004-09-13	2014-07-08	Eisai R&D Management Co., Ltd.	Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030941A1 (ja)	2004-09-13	2006-03-23	Eisai R & D Management Co., Ltd.	スルホンアミド含有化合物の血管新生阻害物質との併用
KR20070053205A (ko)	2004-09-17	2007-05-23	에자이 알앤드디 매니지먼트 가부시키가이샤	의약 조성물
EP1925676A4 (en)	2005-08-02	2010-11-10	Eisai R&D Man Co Ltd	TEST METHOD FOR THE EFFECT OF A VASCULARIZATION INHIBITOR
US8304406B2 (en)	2006-04-15	2012-11-06	Bayer Intellectual Property Gmbh	Compounds for treating pulmonary hypertension
EP2036557B1 (en)	2006-05-18	2015-10-21	Eisai R&D Management Co., Ltd.	Antitumor agent for thyroid cancer
WO2008026748A1 (fr)	2006-08-28	2008-03-06	Eisai R & D Management Co., Ltd.	Agent antitumoral pour cancer gastrique non différencié
US8962655B2 (en)	2007-01-29	2015-02-24	Eisai R&D Management Co., Ltd.	Composition for treatment of undifferentiated gastric cancer
AU2008325608B2 (en)	2007-11-09	2013-03-14	Eisai R & D Management Co., Ltd.	Combination of anti-angiogenic substance and anti-tumor platinum complex
CN101481380B (zh)	2008-01-08	2012-10-17	浙江医药股份有限公司新昌制药厂	噻吩并哒嗪类化合物及其制备方法、药物组合物及其用途
ES2573515T3 (es)	2010-06-25	2016-06-08	Eisai R&D Management Co., Ltd.	Agente antitumoral que emplea compuestos con efecto inhibitorio de cinasas combinados
RU2580609C2 (ru)	2011-04-18	2016-04-10	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Противоопухолевое терапевтическое средство
ES2705950T3 (es)	2011-06-03	2019-03-27	Eisai R&D Man Co Ltd	Biomarcadores para predecir y valorar la capacidad de respuesta de sujetos con cáncer de tiroides y de riñón a compuestos de lenvatinib
EP2937337A4 (en)	2012-12-21	2016-06-22	Eisai R&D Man Co Ltd	AMORPHIC FORM OF CHINOLINE DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
NZ714049A (en)	2013-05-14	2020-05-29	Eisai R&D Man Co Ltd	Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds
CN103396361B (zh) *	2013-07-24	2016-05-04	中国人民解放军第二军医大学	3,4-二氢异喹啉类抗肿瘤化合物及其制备方法与应用
TWI721954B (zh)	2014-08-28	2021-03-21	日商衛材R&D企管股份有限公司	高純度喹啉衍生物及其生產方法
RU2017128583A (ru)	2015-02-25	2019-03-25	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Способ ослабления горечи хинолинового производного
CA2978226A1 (en)	2015-03-04	2016-09-09	Merck Sharpe & Dohme Corp.	Combination of a pd-1 antagonist and a vegfr/fgfr/ret tyrosine kinase inhibitor for treating cancer
CN104804008B (zh) *	2015-03-27	2016-03-23	亿腾药业（泰州）有限公司	一种工业化生产甲磺酸特拉替尼的方法
AU2016279474B2 (en)	2015-06-16	2021-09-09	Eisai R&D Management Co., Ltd.	Anticancer agent
CN107129502B (zh)	2017-04-13	2022-08-05	泰州亿腾景昂药业股份有限公司	EOC315 Mod.I晶型化合物及其制备方法
CN112830932B (zh) *	2020-12-25	2022-04-08	泰州亿腾景昂药业股份有限公司	特拉替尼的游离碱晶型及其制备方法与用途
CA3237696A1 (en)	2021-11-08	2023-05-11	Progentos Therapeutics, Inc.	Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof

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FR1453897A (fr) *	1965-06-16	1966-07-22		Dérivés du thiophène et de thiéno pyridazines
GB1094044A (en) *	1965-07-12	1967-12-06	Vantorex Ltd	Phthalazine derivatives
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
GB1293565A (en) *	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
JPH03106875A (ja) *	1989-09-20	1991-05-07	Morishita Pharmaceut Co Ltd	１―（３―ピリジルメチル）フタラジン誘導体
ES2224130T3 (es) *	1994-08-09	2005-03-01	Eisai Co., Ltd.	Compuesto de piridazina condensada.
CO4950519A1 (es) *	1997-02-13	2000-09-01	Novartis Ag	Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
ES2342240T3 (es) *	1998-08-11	2010-07-02	Novartis Ag	Derivados de isoquinolina con actividad que inhibe la angiogenia.
BR0009507A (pt) *	1999-03-30	2002-01-15	Novartis Ag	Derivados de ftalazina para o tratamento de doenças inflamatórias
AR025068A1 (es) *	1999-08-10	2002-11-06	Bayer Corp	Pirazinas sustituidas y piridazinas fusionadas, composicion farmaceutica que las comprenden, uso de dichos compuestos para la manufactura de un medicamentocon actividad inhibidora de angiogenesis
US6706731B2 (en) *	2000-02-09	2004-03-16	Novartis Ag	Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase

2000
- 2000-09-22 AR ARP000104981A patent/AR025752A1/es not_active Application Discontinuation
- 2000-09-22 GT GT200000158A patent/GT200000158A/es unknown
- 2000-09-22 DO DO2000000070A patent/DOP2000000070A/es unknown
- 2000-09-22 CO CO00072226A patent/CO5200835A1/es active IP Right Grant
- 2000-09-25 MY MYPI20051064A patent/MY143377A/en unknown
- 2000-09-25 TW TW089119700A patent/TW593315B/zh not_active IP Right Cessation
- 2000-09-25 PE PE2000001004A patent/PE20010607A1/es not_active Application Discontinuation
- 2000-09-25 MY MYPI20051063A patent/MY143580A/en unknown
- 2000-09-25 PA PA20008503201A patent/PA8503201A1/es unknown
- 2000-09-25 MY MYPI20004467A patent/MY135058A/en unknown
- 2000-09-26 HU HU0202704A patent/HU230223B1/hu not_active IP Right Cessation
- 2000-09-26 AU AU15696/01A patent/AU782820B2/en not_active Expired
- 2000-09-26 JP JP2001526527A patent/JP4919567B2/ja not_active Expired - Lifetime
- 2000-09-26 CN CNB008163693A patent/CN100374435C/zh not_active Expired - Lifetime
- 2000-09-26 NZ NZ518589A patent/NZ518589A/en not_active IP Right Cessation
- 2000-09-26 MX MXPA02003156A patent/MXPA02003156A/es active IP Right Grant
- 2000-09-26 WO PCT/US2000/026500 patent/WO2001023375A2/en active Application Filing
- 2000-09-26 KR KR1020087021379A patent/KR100895571B1/ko active IP Right Grant
- 2000-09-26 KR KR1020087021380A patent/KR100895572B1/ko active IP Right Grant
- 2000-09-26 EE EEP200200161A patent/EE05258B1/xx not_active IP Right Cessation
- 2000-09-26 DE DE60041548T patent/DE60041548D1/de not_active Expired - Lifetime
- 2000-09-26 RS YUP-229/02A patent/RS50369B/sr unknown
- 2000-09-26 CN CNB2005101271105A patent/CN100422173C/zh not_active Expired - Lifetime
- 2000-09-26 CA CA2385817A patent/CA2385817C/en not_active Expired - Lifetime
- 2000-09-26 IL IL14888000A patent/IL148880A0/xx active IP Right Grant
- 2000-09-26 ES ES00978215T patent/ES2320525T3/es not_active Expired - Lifetime
- 2000-09-26 RU RU2002111414/04A patent/RU2260008C2/ru active
- 2000-09-26 KR KR1020027003972A patent/KR100890473B1/ko active IP Right Grant
- 2000-09-26 EP EP00978215A patent/EP1228063B1/en not_active Expired - Lifetime
- 2000-09-26 UA UA2002043504A patent/UA75053C2/uk unknown
- 2000-09-26 PL PL366342A patent/PL205957B1/pl unknown
- 2000-09-26 SK SK591-2002A patent/SK287417B6/sk not_active IP Right Cessation
- 2000-09-26 CN CNB2005101271092A patent/CN100422172C/zh not_active Expired - Lifetime
- 2000-09-26 CZ CZ2002-1444A patent/CZ304767B6/cs not_active IP Right Cessation
- 2000-09-26 BR BRPI0014382A patent/BRPI0014382B8/pt not_active IP Right Cessation
- 2000-09-26 AT AT00978215T patent/ATE422494T1/de not_active IP Right Cessation
2002
- 2002-03-26 NO NO20021520A patent/NO20021520L/no unknown
- 2002-04-09 ZA ZA200202760A patent/ZA200202760B/xx unknown
- 2002-04-10 HR HR20020308A patent/HRP20020308A2/xx not_active IP Right Cessation
- 2002-04-23 BG BG106637A patent/BG65860B1/bg unknown
- 2002-04-26 MA MA26619A patent/MA25563A1/fr unknown
2006
- 2006-11-08 HK HK06112290.6A patent/HK1091819A1/xx unknown
- 2006-11-08 HK HK06112289.9A patent/HK1091818A1/xx not_active IP Right Cessation
2008
- 2008-08-11 IL IL193367A patent/IL193367A/en active IP Right Grant
- 2008-08-11 IL IL193368A patent/IL193368A/en active IP Right Grant
2011
- 2011-07-15 AR ARP110102558A patent/AR082231A2/es unknown
- 2011-07-15 AR ARP110102559A patent/AR082232A2/es unknown

Also Published As

Publication number	Publication date
MY135058A (en)	2008-01-31
BG106637A (bg)	2003-02-28
AU782820B2 (en)	2005-09-01
KR20020038775A (ko)	2002-05-23
IL193367A0 (en)	2009-02-11
CN100374435C (zh)	2008-03-12
HUP0202704A2 (hu)	2002-12-28
KR100895572B1 (ko)	2009-04-29
BRPI0014382B8 (pt)	2021-05-25
EP1228063A2 (en)	2002-08-07
EP1228063B1 (en)	2009-02-11
CO5200835A1 (es)	2002-09-27
NZ518589A (en)	2005-03-24
IL193368A (en)	2011-05-31
AR082232A2 (es)	2012-11-21
EE200200161A (et)	2003-08-15
HRP20020308A2 (en)	2004-06-30
HUP0202704A3 (en)	2003-12-29
AU1569601A (en)	2001-04-30
JP4919567B2 (ja)	2012-04-18
PL205957B1 (pl)	2010-06-30
NO20021520D0 (no)	2002-03-26
IL148880A0 (en)	2002-09-12
HRP20020308B1 (no)	2013-01-31
SK287417B6 (sk)	2010-09-07
IL193368A0 (en)	2009-02-11
MY143580A (en)	2011-05-31
PE20010607A1 (es)	2001-07-12
HU230223B1 (en)	2015-10-28
AR082231A2 (es)	2012-11-21
HK1091818A1 (en)	2007-01-26
YU22902A (sh)	2004-12-31
KR20080091505A (ko)	2008-10-13
TW593315B (en)	2004-06-21
IL193367A (en)	2011-03-31
BG65860B1 (bg)	2010-03-31
CN100422172C (zh)	2008-10-01
CZ304767B6 (cs)	2014-10-08
CN1769282A (zh)	2006-05-10
CA2385817C (en)	2010-05-04
CA2385817A1 (en)	2001-04-05
NO20021520L (no)	2002-05-23
BR0014382A (pt)	2003-06-24
AR025752A1 (es)	2002-12-11
MA25563A1 (fr)	2002-10-01
MY143377A (en)	2011-05-13
RU2260008C2 (ru)	2005-09-10
WO2001023375A3 (en)	2002-05-02
DE60041548D1 (de)	2009-03-26
CN1420879A (zh)	2003-05-28
KR100895571B1 (ko)	2009-04-29
ATE422494T1 (de)	2009-02-15
PL366342A1 (en)	2005-01-24
JP2003526632A (ja)	2003-09-09
DOP2000000070A (es)	2002-02-28
GT200000158A (es)	2002-03-16
CN1769283A (zh)	2006-05-10
PA8503201A1 (es)	2002-08-26
MXPA02003156A (es)	2002-09-30
KR100890473B1 (ko)	2009-03-26
CN100422173C (zh)	2008-10-01
SK5912002A3 (en)	2003-01-09
RS50369B (sr)	2009-11-10
EE05258B1 (et)	2010-02-15
KR20080086547A (ko)	2008-09-25
CZ20021444A3 (cs)	2002-08-14
ZA200202760B (en)	2003-10-29
WO2001023375A2 (en)	2001-04-05
UA75053C2 (en)	2006-03-15
ES2320525T3 (es)	2009-05-25
BR0014382B1 (pt)	2014-04-01

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