HK1055741A1 - A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds - Google Patents

A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds

Info

Publication number: HK1055741A1
Authority: HK; Hong Kong
Prior art keywords: pyridine; itstransformation; mpounds; oxide; pharmaceutically effective
Prior art date: 2000-04-18

Application number

HK03108135A

Other languages

English (en)

Inventor

Laszlo Urogdi

Zita Jegesne Csakai

Lajos Gruber

Laszlo Otvos

Jozsef Toth

Istvan Tomoskozi

Aniko Szakacsne Schmidt

Ferencne Reider

Maria Schneiderne Barlay

Original Assignee

Biorex Kutato Fejlesztoe Kft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2003-11-10

Publication date

2004-01-21

2003-11-10 Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft

2004-01-21 Publication of HK1055741A1 publication Critical patent/HK1055741A1/xx

Links

ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK03108135A 2000-04-18 2003-11-10 A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds HK1055741A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0001583A HUP0001583A2 (hu)	2000-04-18	2000-04-18	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
PCT/HU2001/000046 WO2001079174A1 (en)	2000-04-18	2001-04-17	A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Publications (1)

Publication Number	Publication Date
HK1055741A1 true HK1055741A1 (en)	2004-01-21

Family

ID=90001563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK03108135A HK1055741A1 (en)	2000-04-18	2003-11-10	A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds

Country Status (32)

Country	Link
US (1)	US7126002B2 (pt)
EP (1)	EP1274685B1 (pt)
JP (1)	JP5066638B2 (pt)
KR (1)	KR100742482B1 (pt)
CN (1)	CN1216868C (pt)
AT (1)	ATE332894T1 (pt)
AU (2)	AU5499701A (pt)
BG (1)	BG65889B1 (pt)
BR (1)	BRPI0110184B8 (pt)
CA (1)	CA2406266C (pt)
CY (1)	CY1107473T1 (pt)
CZ (1)	CZ301576B6 (pt)
DE (1)	DE60121431T2 (pt)
DK (1)	DK1274685T3 (pt)
EE (1)	EE05085B1 (pt)
ES (1)	ES2267758T3 (pt)
HK (1)	HK1055741A1 (pt)
HR (1)	HRP20020825A2 (pt)
HU (1)	HUP0001583A2 (pt)
IL (2)	IL152337A0 (pt)
MX (1)	MXPA02010320A (pt)
NO (1)	NO323535B1 (pt)
NZ (1)	NZ522017A (pt)
PL (1)	PL359826A1 (pt)
PT (1)	PT1274685E (pt)
RS (1)	RS51003B (pt)
RU (1)	RU2281282C2 (pt)
SI (1)	SI1274685T1 (pt)
SK (1)	SK287606B6 (pt)
UA (1)	UA75353C2 (pt)
WO (1)	WO2001079174A1 (pt)
ZA (1)	ZA200208460B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
RU2320330C2 (ru) *	2002-01-11	2008-03-27	СиУайТиАрЭкс КОРПОРЕЙШН	Производные карбоксамидина и их использование при лечении заболеваний сосудов
HUP0303584A3 (en)	2003-10-30	2009-12-28	Cytrx Corp	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
US20080227813A1 (en) *	2006-09-26	2008-09-18	Jack Raymond Barber	Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration
CA3004867C (en)	2008-06-26	2020-09-15	Orphazyme Aps	Use of hsp70 as a regulator of enzymatic activity
WO2012072082A1 (en)	2010-11-30	2012-06-07	Orphazyme Aps	Methods for increasing intracellular activity of hsp70
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
HUP1100535A2 (en)	2011-09-26	2013-04-29	Bracelia Invest Ltd	Pharmaceutical composition for enhancement of stem cell treatment
PL3193840T3 (pl)	2014-09-15	2021-12-06	Orphazyme A/S	Preparat arimoklomolu
WO2017178029A1 (en)	2016-04-13	2017-10-19	Orphazyme Aps	Heat shock proteins and cholesterol homeostasis
PT3448382T (pt)	2016-04-29	2020-11-20	Orphazyme As C/O Cobis As	Arimoclomol para o tratamento de distúrbios associados à glucocerebrosidase
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
BR112022026396A2 (pt)	2020-06-24	2023-03-14	Kempharm Denmark As	Arimoclomol para o tratamento da doença de gaucher
MX2023005954A (es)	2020-11-19	2023-09-04	Zevra Denmark As	Procesos para preparar citrato de arimoclomol e intermediarios del mismo.
US20240115558A1 (en)	2020-12-24	2024-04-11	Zevra Denmark A/S	Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en)	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
2001
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active IP Right Cessation
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en active IP Right Grant
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
2002
- 2002-10-16 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
2003
- 2003-11-10 HK HK03108135A patent/HK1055741A1/xx not_active IP Right Cessation
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown

Also Published As

Publication number	Publication date
DE60121431D1 (de)	2006-08-24
ES2267758T3 (es)	2007-03-16
BR0110184A (pt)	2003-06-17
BG107199A (bg)	2003-07-31
BRPI0110184B1 (pt)	2015-12-29
DK1274685T3 (da)	2006-11-06
AU2001254997B2 (en)	2006-11-23
CZ301576B6 (cs)	2010-04-21
KR100742482B1 (ko)	2007-07-25
SK287606B6 (sk)	2011-03-04
PT1274685E (pt)	2006-09-29
RS51003B (sr)	2010-10-31
IL152337A0 (en)	2003-05-29
ATE332894T1 (de)	2006-08-15
UA75353C2 (en)	2006-04-17
RU2002130710A (ru)	2004-03-20
EE200200591A (et)	2004-04-15
CN1434800A (zh)	2003-08-06
NZ522017A (en)	2004-06-25
WO2001079174A1 (en)	2001-10-25
CA2406266C (en)	2010-07-20
BG65889B1 (bg)	2010-04-30
JP5066638B2 (ja)	2012-11-07
AU5499701A (en)	2001-10-30
EP1274685B1 (en)	2006-07-12
JP2004501080A (ja)	2004-01-15
ZA200208460B (en)	2003-10-20
SK15082002A3 (sk)	2003-05-02
SI1274685T1 (sl)	2006-10-31
MXPA02010320A (es)	2004-09-06
DE60121431T2 (de)	2007-01-18
CZ20023445A3 (cs)	2003-03-12
CN1216868C (zh)	2005-08-31
YU78302A (sh)	2005-09-19
CA2406266A1 (en)	2001-10-25
US7126002B2 (en)	2006-10-24
WO2001079174A8 (en)	2002-12-27
HUP0001583A2 (hu)	2002-11-28
NO20025015D0 (no)	2002-10-18
BRPI0110184B8 (pt)	2021-05-25
HRP20020825A2 (en)	2004-12-31
IL152337A (en)	2007-10-31
US20040006232A1 (en)	2004-01-08
EP1274685A1 (en)	2003-01-15
HUP0001583D0 (en)	2000-06-28
NO20025015L (no)	2002-12-16
EE05085B1 (et)	2008-10-15
KR20030011309A (ko)	2003-02-07
CY1107473T1 (el)	2012-12-19
NO323535B1 (no)	2007-06-04
PL359826A1 (en)	2004-09-06
RU2281282C2 (ru)	2006-08-10

Legal Events

Date	Code	Title	Description
2011-12-02	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20110417

Publication	Publication Date	Title
HK1055741A1 (en)	2004-01-21	A pyridine-1-oxide derivative, and process for itstransformation into pharmaceutically effective co mpounds
MY127718A (en)	2006-12-29	Dolastatin 10 derivatives.
RS50140B (sr)	2009-03-25	Postupak za dobijanje perkihinina i njegova upotreba
EE200300403A (et)	2003-12-15	N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
DK1029853T3 (da)	2004-05-24	Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
IL151172A0 (en)	2003-04-10	Amine derivatives, their preparation and use as bax modulators
TW200510375A (en)	2005-03-16	New compounds
SG128491A1 (en)	2007-01-30	Heterocyclic sulfonamide inhibitors of beta amyloid production
PT928788E (pt)	2003-04-30	Compostos farmaceuticamente activos
HRP20010969B1 (en)	2005-04-30	Novel piperazinylalkylthiopyrimidine derivatives,
IL157540A (en)	2010-11-30	Pharmaceutical compositions comprising n-(aryl)-2-arylethenesulfonamides, some such novel compounds and process for their preparation
WO2001081316A3 (en)	2002-05-23	Substituted phenyl farnesyltransferase inhibitors
DK0835868T3 (da)	2001-10-08	2-aryl-3-aminoaryloxynaphthylforbindelser, mellemprodukter, sammensætninger og fremgangsmåder
EP1019047A4 (en)	2001-06-13	ANTITHROMBOTIC AGENTS
PL350568A1 (en)	2002-12-16	N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
AU2001246999A1 (en)	2001-10-23	New neurokinin antagonists for use as medicaments
BR9502079A (pt)	1996-03-05	Composto,formulação farmaceutica e processo para preparar um composto
WO2004048381A3 (en)	2004-08-05	Pyrazoloazepine compounds as pharmaceutical agents
MY133438A (en)	2007-11-30	Morpholinobenzamide salts
AU2001244999A1 (en)	2001-10-23	Naphthamide neurokinin antagonists for use as medicaments
HUP0204149A3 (en)	2005-04-28	New sulfonyl oxazole amine derivatives, pharmaceutical compositions containing them and process for preparation the compounds
FR2786184B1 (fr)	2002-09-20	Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
NO20014889L (no)	2001-10-08	Fremgangsmåte for fremstilling av medisinske midler
ES2062940A1 (es)	1994-12-16	Agente gastrocinetico, proceso para su preparacion y composiciones farmaceuticas que lo contengan.
MXPA99003849A (es)	2003-09-23	Derivados 9a, 11b-deshidro de 9-oxima-3-ceto-6-0-metileritromicina.