BRPI0110184B8 - derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes - Google Patents

derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes

Info

Publication number
BRPI0110184B8
BRPI0110184B8 BRPI0110184A BR0110184A BRPI0110184B8 BR PI0110184 B8 BRPI0110184 B8 BR PI0110184B8 BR PI0110184 A BRPI0110184 A BR PI0110184A BR 0110184 A BR0110184 A BR 0110184A BR PI0110184 B8 BRPI0110184 B8 BR PI0110184B8
Authority
BR
Brazil
Prior art keywords
pyridine
oxide
transformation
pharmaceutically effective
effective compounds
Prior art date
Application number
BRPI0110184A
Other languages
English (en)
Other versions
BRPI0110184B1 (pt
BR0110184A (pt
Inventor
Szakácsné Schmidt Anikó
Reider Ferencné
Tömösközi István
Tóth József
Gruber Lajos
Ötvös László
Ürögdi László
Schneiderné Barlay Mária
Jegesné Csákai Zita
Original Assignee
Biorex Kutato Fejlesztoe Kft
Cytrx Corp
Orphazyme As
Orphazyme Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biorex Kutato Fejlesztoe Kft, Cytrx Corp, Orphazyme As, Orphazyme Aps filed Critical Biorex Kutato Fejlesztoe Kft
Publication of BR0110184A publication Critical patent/BR0110184A/pt
Publication of BRPI0110184B1 publication Critical patent/BRPI0110184B1/pt
Publication of BRPI0110184B8 publication Critical patent/BRPI0110184B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes". a presente invenção refere-se a n-[2-hidróxi-3-(1-piperidinil)propóxi] piridina-1-óxido-3-carboxamidina e os enantiômeros oticamente ativos do mesmo. (r)-(-)-n-[2-hidróxi-3- (1-piperidinil) propóxi] piridina-1-óxido-3-carboxamidina e (s)-(+)-n- [2-hidróxi-3-(1-piperidinil) propóxi] piridina-1-óxido-3-carboxamidina. ademais, a presente invenção refere-se à preparação de cloreto de n-[2-hidróxi-3-(1-piperidinil)propóxi] piridina-1-óxido-3-carboxamidina, que pode ser usado como um ingrediente ativo de medicamentos, e a preparação dos enantiômeros oticamente ativos do composto ao usar os compostos da presente invenção como substâncias intermediárias.
BRPI0110184A 2000-04-18 2001-04-17 derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes BRPI0110184B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0001583A HUP0001583A2 (hu) 2000-04-18 2000-04-18 Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké
PCT/HU2001/000046 WO2001079174A1 (en) 2000-04-18 2001-04-17 A pyridine-1-oxide derivative, and process for its transformation into pharmaceutically effective compounds

Publications (3)

Publication Number Publication Date
BR0110184A BR0110184A (pt) 2003-06-17
BRPI0110184B1 BRPI0110184B1 (pt) 2015-12-29
BRPI0110184B8 true BRPI0110184B8 (pt) 2021-05-25

Family

ID=90001563

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0110184A BRPI0110184B8 (pt) 2000-04-18 2001-04-17 derivado de piridina-1-óxido, e processo para a sua transformação em compostos farmaceuticamente eficazes

Country Status (32)

Country Link
US (1) US7126002B2 (pt)
EP (1) EP1274685B1 (pt)
JP (1) JP5066638B2 (pt)
KR (1) KR100742482B1 (pt)
CN (1) CN1216868C (pt)
AT (1) ATE332894T1 (pt)
AU (2) AU2001254997B2 (pt)
BG (1) BG65889B1 (pt)
BR (1) BRPI0110184B8 (pt)
CA (1) CA2406266C (pt)
CY (1) CY1107473T1 (pt)
CZ (1) CZ301576B6 (pt)
DE (1) DE60121431T2 (pt)
DK (1) DK1274685T3 (pt)
EE (1) EE05085B1 (pt)
ES (1) ES2267758T3 (pt)
HK (1) HK1055741A1 (pt)
HR (1) HRP20020825A2 (pt)
HU (1) HUP0001583A2 (pt)
IL (2) IL152337A0 (pt)
MX (1) MXPA02010320A (pt)
NO (1) NO323535B1 (pt)
NZ (1) NZ522017A (pt)
PL (1) PL359826A1 (pt)
PT (1) PT1274685E (pt)
RS (1) RS51003B (pt)
RU (1) RU2281282C2 (pt)
SI (1) SI1274685T1 (pt)
SK (1) SK287606B6 (pt)
UA (1) UA75353C2 (pt)
WO (1) WO2001079174A1 (pt)
ZA (1) ZA200208460B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) * 2001-09-27 2001-11-28 Biorex Kutato Fejlesztoe Kft Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
US7384936B2 (en) 2002-01-11 2008-06-10 Cytrx Corporation Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en) 2003-10-30 2009-12-28 Cytrx Corp Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) * 2006-09-26 2008-08-01 Cytrx Corp Pharmaceutical compositions and methods for treating diseases
ES2963910T3 (es) 2008-06-26 2024-04-03 Zevra Denmark As Uso de Hsp70 como regulador de la actividad enzimática
EP2646044B1 (en) 2010-11-30 2019-08-28 Orphazyme A/S Methods for increasing intracellular activity of hsp70
HUP1100534A2 (en) 2011-09-26 2013-04-29 Balazs Dr Hazay Pharmaceutical composition for the treatment of muscle atrophy
HUP1100535A2 (en) 2011-09-26 2013-04-29 Bracelia Invest Ltd Pharmaceutical composition for enhancement of stem cell treatment
AU2015317447B2 (en) 2014-09-15 2021-02-25 Zevra Denmark A/S Arimoclomol formulation
US10898476B2 (en) 2016-04-13 2021-01-26 Orphazyme A/S Heat shock proteins and cholesterol homeostasis
HUE052158T2 (hu) 2016-04-29 2021-04-28 Orphazyme As Arimoklomol a glükocerebroszidázzal társult rendellenességek kezeléséhez
HUP1800298A1 (hu) 2018-08-30 2020-05-28 N Gene Res Laboratories Inc Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
US20230226036A1 (en) 2020-06-24 2023-07-20 Orphazyme A/S Arimoclomol for treating gaucher disease
JP2024500632A (ja) 2020-11-19 2024-01-10 ゼブラ デンマーク エー／エス アリモクロモルクエン酸塩及びその中間体の調製プロセス
US20240115558A1 (en) 2020-12-24 2024-04-11 Zevra Denmark A/S Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207988B (en) * 1988-10-20 1993-07-28 Biorex Kutato Fejlesztoe Kft Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en) 1995-09-29 1995-11-28 Livigene Ltd Pharmaceutical composition
HU222994B1 (hu) * 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) * 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

Also Published As

Publication number Publication date
HRP20020825A2 (en) 2004-12-31
SI1274685T1 (sl) 2006-10-31
KR100742482B1 (ko) 2007-07-25
NO323535B1 (no) 2007-06-04
MXPA02010320A (es) 2004-09-06
HUP0001583A2 (hu) 2002-11-28
AU2001254997B2 (en) 2006-11-23
KR20030011309A (ko) 2003-02-07
CZ20023445A3 (cs) 2003-03-12
JP2004501080A (ja) 2004-01-15
NO20025015L (no) 2002-12-16
ES2267758T3 (es) 2007-03-16
CA2406266A1 (en) 2001-10-25
EE200200591A (et) 2004-04-15
RU2281282C2 (ru) 2006-08-10
BG65889B1 (bg) 2010-04-30
PL359826A1 (en) 2004-09-06
EP1274685A1 (en) 2003-01-15
AU5499701A (en) 2001-10-30
NZ522017A (en) 2004-06-25
BRPI0110184B1 (pt) 2015-12-29
WO2001079174A8 (en) 2002-12-27
CY1107473T1 (el) 2012-12-19
WO2001079174A1 (en) 2001-10-25
US7126002B2 (en) 2006-10-24
PT1274685E (pt) 2006-09-29
DE60121431D1 (de) 2006-08-24
CA2406266C (en) 2010-07-20
SK15082002A3 (sk) 2003-05-02
HK1055741A1 (en) 2004-01-21
EP1274685B1 (en) 2006-07-12
NO20025015D0 (no) 2002-10-18
YU78302A (sh) 2005-09-19
RS51003B (sr) 2010-10-31
ZA200208460B (en) 2003-10-20
DE60121431T2 (de) 2007-01-18
ATE332894T1 (de) 2006-08-15
BG107199A (bg) 2003-07-31
CN1216868C (zh) 2005-08-31
SK287606B6 (sk) 2011-03-04
IL152337A0 (en) 2003-05-29
CZ301576B6 (cs) 2010-04-21
UA75353C2 (en) 2006-04-17
CN1434800A (zh) 2003-08-06
RU2002130710A (ru) 2004-03-20
HUP0001583D0 (en) 2000-06-28
EE05085B1 (et) 2008-10-15
JP5066638B2 (ja) 2012-11-07
IL152337A (en) 2007-10-31
DK1274685T3 (da) 2006-11-06
BR0110184A (pt) 2003-06-17
US20040006232A1 (en) 2004-01-08

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: CYTRX CORPORATION (US)

Free format text: TRANSFERIDO DE: BIOREX KUTATO ES FEJLESZTO RT

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25A Requested transfer of rights approved

Owner name: ORPHAZYME APS (DK)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: PAGAR RESTAURACAO.

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE RPI 2308 DE 31/03/2014 (COD. 8.6)

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 29/12/2015, OBSERVADAS AS CONDICOES LEGAIS.

B25D Requested change of name of applicant approved
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/04/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

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