HK1023571A1 - Thienotriazolodiazepine compounds and medicinal use thereof - Google Patents
Thienotriazolodiazepine compounds and medicinal use thereofInfo
- Publication number
- HK1023571A1 HK1023571A1 HK00102681A HK00102681A HK1023571A1 HK 1023571 A1 HK1023571 A1 HK 1023571A1 HK 00102681 A HK00102681 A HK 00102681A HK 00102681 A HK00102681 A HK 00102681A HK 1023571 A1 HK1023571 A1 HK 1023571A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- compound
- inventive compound
- useful
- pharmaceutically acceptable
- thienotriazolodiazepine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP24379396 | 1996-09-13 | ||
PCT/JP1997/002817 WO1998011111A1 (fr) | 1996-09-13 | 1997-08-11 | Composes de thienotriazolodiazepine et leurs utilisations a des fins medicinales |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1023571A1 true HK1023571A1 (en) | 2000-09-15 |
Family
ID=17109041
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00102681A HK1023571A1 (en) | 1996-09-13 | 2000-05-03 | Thienotriazolodiazepine compounds and medicinal use thereof |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0989131B1 (fr) |
JP (1) | JP3094453B2 (fr) |
KR (1) | KR100338144B1 (fr) |
CN (1) | CN1109037C (fr) |
AT (1) | ATE227727T1 (fr) |
AU (1) | AU716490B2 (fr) |
CA (1) | CA2265645C (fr) |
DE (1) | DE69717160T2 (fr) |
DK (1) | DK0989131T3 (fr) |
EA (1) | EA001732B1 (fr) |
ES (1) | ES2182108T3 (fr) |
HK (1) | HK1023571A1 (fr) |
NO (1) | NO323892B1 (fr) |
PT (1) | PT989131E (fr) |
WO (1) | WO1998011111A1 (fr) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100838686B1 (ko) | 2000-06-16 | 2008-06-16 | 미쯔비시 웰 파마 가부시키가이샤 | 방출 pH 범위 및/또는 속도 제어 조성물 |
JP5159305B2 (ja) * | 2005-05-30 | 2013-03-06 | 田辺三菱製薬株式会社 | チエノトリアゾロジアゼピン化合物及びその医薬としての用途 |
WO2009084693A1 (fr) | 2007-12-28 | 2009-07-09 | Mitsubishi Tanabe Pharma Corporation | Agent antitumoral |
GB0919432D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
JP5524343B2 (ja) | 2009-11-05 | 2014-06-18 | グラクソスミスクライン エルエルシー | ベンゾジアゼピンブロモドメイン阻害剤 |
ME02356B (fr) | 2009-11-05 | 2016-06-20 | Glaxosmithkline Llc | Inhibiteur de bromodomaines vis-à-vis de la benzodiazépine |
MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
BR122014024883A2 (pt) * | 2010-05-14 | 2019-08-20 | Dana-Farber Cancer Institute, Inc. | Compostos no tratamento de neoplasia |
CN103180318B (zh) | 2010-05-14 | 2017-05-10 | 达那-法伯癌症研究所 | 雄性避孕组合物以及使用方法 |
US9085582B2 (en) | 2010-06-22 | 2015-07-21 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
GB201020015D0 (en) * | 2010-11-25 | 2011-01-12 | Glaxo Group Ltd | Method of treatment |
AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
WO2012075456A1 (fr) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Inhibiteurs de bromodomaines et leurs utilisations |
WO2012151512A2 (fr) | 2011-05-04 | 2012-11-08 | Constellation Pharmaceuticals, Inc. | Inhibiteurs de bromodomaines et leurs utilisations |
EP2721031B1 (fr) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Inhibiteurs à bromodomaine et leurs utilisations |
DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
WO2013097052A1 (fr) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Inhibiteurs de bromodomaine |
EP2838881B1 (fr) | 2012-04-20 | 2018-08-08 | AbbVie Inc. | Dérivés d'iso-indolone |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
WO2013184878A1 (fr) | 2012-06-06 | 2013-12-12 | Constellation Pharmaceuticals, Inc. | Inhibiteurs de bromo-domaine de benzo [b] isoxazoloazépines et applications associées |
CN104718201A (zh) | 2012-06-12 | 2015-06-17 | 艾伯维公司 | 吡啶酮和哒嗪酮衍生物 |
MX2014015986A (es) * | 2012-06-25 | 2016-02-11 | Oncoethix Gmbh | Metodo para tratar linfoma utilizando compuestos de tienotriazolodiazepina. |
MX2015001880A (es) | 2012-08-16 | 2015-05-11 | Bayer Pharma AG | 2,3-benzodiacepinas. |
US20140107107A1 (en) * | 2012-09-28 | 2014-04-17 | Oncoethix Sa | Pharmaceutical formulation containing thienotriazolodiazepine compounds |
ES2625959T3 (es) | 2012-09-28 | 2017-07-21 | Bayer Pharma Aktiengesellschaft | 5-Aril-triazolo-azepinas inhibidoras de la proteína BET |
AU2014249192B2 (en) | 2013-03-11 | 2017-12-21 | The Regents Of The University Of Michigan | BET bromodomain inhibitors and therapeutic methods using the same |
WO2014159392A1 (fr) * | 2013-03-14 | 2014-10-02 | Dana-Farber Cancer Institute, Inc. | Réactifs de liaison à des bromodomaines et leurs utilisations |
WO2015013635A2 (fr) | 2013-07-25 | 2015-01-29 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs des facteurs de transcription et leurs utilisations |
EP3027194A1 (fr) * | 2013-08-01 | 2016-06-08 | Oncoethix GmbH | Préparation pharmaceutique contenant des composés de thiénotriazolodiazépine |
CN103694253A (zh) * | 2013-11-04 | 2014-04-02 | 湖南华腾制药有限公司 | 一种噻吩并***并[4,3-a][1,4]二氮杂卓类化合物的制备方法 |
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JP2017504650A (ja) | 2014-01-31 | 2017-02-09 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | ジアゼパン誘導体およびその使用 |
EP3099677A4 (fr) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Dérivés de diaminopyrimidine benzènesulfone et leurs utilisations |
WO2015117087A1 (fr) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Utilisations des dérivés de diazépane |
CN106456653A (zh) | 2014-02-28 | 2017-02-22 | 腾沙治疗公司 | 高胰岛素血症相关病症的治疗 |
CN107074861A (zh) | 2014-02-28 | 2017-08-18 | 密执安大学评议会 | 作为bet溴结构域抑制剂的9h嘧啶并[4,5‑b]吲哚和相关类似物 |
US9969747B2 (en) | 2014-06-20 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Crystalline forms of 2-((4S)-6-(4-chlorophenyl)-1-methyl-4H-benzo[C]isoxazolo[4,5-e]azepin-4-yl)acetamide |
CA2955077A1 (fr) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Derives de dihydropteridinone et leurs utilisations |
BR112017002369A2 (pt) | 2014-08-08 | 2017-12-05 | Dana Farber Cancer Inst Inc | derivados de diazepana e usos dos mesmos |
EA033325B1 (ru) | 2014-10-27 | 2019-09-30 | Тэнша Терапеутикс, Инк. | Ингибиторы бромодомена |
CN107257800B (zh) | 2014-12-23 | 2020-06-30 | 达纳-法伯癌症研究所股份有限公司 | 通过双功能分子诱导靶蛋白降解的方法 |
US9694084B2 (en) | 2014-12-23 | 2017-07-04 | Dana-Farber Cancer Institute, Inc. | Methods to induce targeted protein degradation through bifunctional molecules |
US10307407B2 (en) | 2015-02-27 | 2019-06-04 | The Regents Of The University Of Michigan | 9H-pyrimido [4,5-B] indoles as BET bromodomain inhibitors |
WO2016176335A1 (fr) | 2015-04-27 | 2016-11-03 | Concert Pharmaceuticals, Inc. | Otx-015 deutéré |
WO2016196065A1 (fr) | 2015-05-29 | 2016-12-08 | Genentech, Inc. | Procédés et compositions pour évaluer la réponse de cancers aux inhibiteurs bet |
WO2016201370A1 (fr) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Thérapie d'association utilisant des inhibiteurs de transcription et des inhibiteurs de kinases |
WO2017007612A1 (fr) | 2015-07-07 | 2017-01-12 | Dana-Farber Cancer Institute, Inc. | Procédés pour induire la dégradation ciblée de protéines par des molécules bifonctionnelles |
BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
WO2017044792A1 (fr) | 2015-09-11 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Acétamide thiénotriazoldiazépines et leurs utilisations |
SG10201913450PA (en) | 2015-11-25 | 2020-03-30 | Dana Farber Cancer Inst Inc | Bivalent bromodomain inhibitors and uses thereof |
US11548899B2 (en) | 2016-02-15 | 2023-01-10 | The Regents Of The University Of Michigan | Fused 1,4-oxazepines and related analogs as BET bromodomain inhibitors |
US11192898B2 (en) | 2016-04-06 | 2021-12-07 | The Regents Of The University Of Michigan | MDM2 protein degraders |
CA3020281A1 (fr) | 2016-04-06 | 2017-10-12 | The Regents Of The University Of Michigan | Intermediaires monofonctionnels pour la degradation d'une proteine cible dependante du ligand |
AU2017250076B2 (en) | 2016-04-12 | 2021-07-22 | The Regents Of The University Of Michigan | Bet protein degraders |
PL3442972T3 (pl) | 2016-04-15 | 2020-07-27 | Abbvie Inc. | Inhibitory bromodomeny |
EP3455218A4 (fr) | 2016-05-10 | 2019-12-18 | C4 Therapeutics, Inc. | Dégronimères de type glutarimide liés au carbone c3 pour la dégradation de protéines cibles |
WO2017197055A1 (fr) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Dégronimères hétérocycliques pour la dégradation de protéines cibles |
WO2017197036A1 (fr) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Dégronimères spirocycliques pour la dégradation de protéines cibles |
JP6961684B2 (ja) | 2016-09-13 | 2021-11-05 | ザ リージェンツ オブ ザ ユニヴァシティ オブ ミシガン | Betタンパク質分解物質としての縮合1,4−オキサゼピン |
ES2857743T3 (es) | 2016-09-13 | 2021-09-29 | Univ Michigan Regents | 1,4-diazepinas fusionadas como degradadores de proteína BET |
WO2018064589A1 (fr) | 2016-09-29 | 2018-04-05 | Dana-Farber Cancer Institute, Inc. | Dégradation ciblée de protéines à l'aide d'une ubiquitine ligase e3 mutante |
JP2020502148A (ja) | 2016-12-16 | 2020-01-23 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ジアゼピン誘導体の製造のための方法 |
WO2018144789A1 (fr) | 2017-02-03 | 2018-08-09 | The Regents Of The University Of Michigan | 1,4-diazépines fusionnées utilisées en tant qu'inhibiteurs de bromodomaines bet |
EP3640253A4 (fr) * | 2017-05-31 | 2021-01-13 | AYUMI Pharmaceutical Corporation | Dérivé de 6h-thiéno[2,3-e][1,2,4]triazolo[3,4-c][1,2,4]triazépine |
CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
CN111278815B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 戊二酰亚胺 |
WO2019043208A1 (fr) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | Dihydroquinolinones |
CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
WO2019055444A1 (fr) | 2017-09-13 | 2019-03-21 | The Regents Of The University Of Michigan | Agents de dégradation de protéine de bromodomaine bet avec des lieurs clivables |
EP3710002A4 (fr) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | Agents de dégradation et dégrons pour dégradation protéique ciblée |
KR20210018199A (ko) | 2018-03-26 | 2021-02-17 | 씨4 테라퓨틱스, 인코포레이티드 | 이카로스의 분해를 위한 세레블론 결합제 |
WO2019204354A1 (fr) | 2018-04-16 | 2019-10-24 | C4 Therapeutics, Inc. | Composés spirocycliques |
EA202092635A1 (ru) | 2018-06-13 | 2021-03-23 | Дибли Аг | Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet |
TW202019946A (zh) | 2018-07-04 | 2020-06-01 | 日商田邊三菱製藥股份有限公司 | 具有bet蛋白質分解誘導作用的醯胺化合物及其作為醫藥的用途 |
EP3936507A4 (fr) * | 2019-03-07 | 2022-11-23 | Medshine Discovery Inc. | Composés ayant à la fois des effets d'inhibition de protéine de bromodomaine bet et de régulation de gène pd-l1 |
JP7419406B2 (ja) | 2020-02-06 | 2024-01-22 | 田辺三菱製薬株式会社 | Brd4蛋白質分解誘導作用を有するスルホンアミドあるいはスルフィンアミド化合物及びその医薬としての用途 |
WO2022048685A1 (fr) * | 2020-09-07 | 2022-03-10 | 南京明德新药研发有限公司 | Forme cristalline d'un composé d'oxime de benzotétrahydrofurane et son procédé de préparation |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE870123L (en) * | 1986-01-21 | 1987-07-21 | Boehringer Ingelheim Int | Thieno-1,4-diazepines |
EP0368175A1 (fr) * | 1988-11-06 | 1990-05-16 | Boehringer Ingelheim Kg | 3S,7S-3-(Morpholinocarbonyle)-5-(2-chlorophényle)-7,10-diméthyle-3,4-dihydro-2H,7H-cyclopenta[4,5]thiéno[3,4-f][1,2,4]triazolo[4,3-a][1,4]diazépine. |
EP0387613A1 (fr) * | 1989-03-03 | 1990-09-19 | Boehringer Ingelheim Kg | Thiénodiazépines |
YU133090A (sh) * | 1989-07-12 | 1993-10-20 | Boehringer Ingelheim Kg. | Novi heteroazepini s paf-antaganostičnim učinkom in postopek za njihovo pripravo |
WO1994006801A1 (fr) * | 1990-05-23 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation comme medicament |
DE4027470A1 (de) * | 1990-08-30 | 1992-03-05 | Boehringer Ingelheim Kg | Neue hetrazepinoide amide |
JP3239364B2 (ja) * | 1991-10-11 | 2001-12-17 | ウェルファイド株式会社 | 骨粗鬆症治療薬およびジアゼピン化合物 |
DE69230891T2 (de) * | 1991-12-11 | 2000-10-05 | Yoshitomi Pharmaceutical | Arzneimittel zur Behandlung von Autoimmunerkrankungen |
JP3215489B2 (ja) * | 1992-04-23 | 2001-10-09 | 日本電信電話株式会社 | 燃料電池排熱利用システムとその制御方法 |
EP0661284A1 (fr) * | 1992-09-18 | 1995-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation medicinale |
EP0692483A1 (fr) * | 1993-03-30 | 1996-01-17 | Yoshitomi Pharmaceutical Industries, Ltd. | Inhibiteur d'adhesion cellulaire et compose a base de thienotriazolodiazepine |
JP3633008B2 (ja) * | 1993-11-15 | 2005-03-30 | 三菱ウェルファーマ株式会社 | チエノトリアゾロジアゼピン化合物 |
JPH0879471A (ja) * | 1994-09-01 | 1996-03-22 | Konica Corp | 画像形成装置 |
-
1997
- 1997-08-11 WO PCT/JP1997/002817 patent/WO1998011111A1/fr active IP Right Grant
- 1997-08-11 AU AU37860/97A patent/AU716490B2/en not_active Expired
- 1997-08-11 DE DE69717160T patent/DE69717160T2/de not_active Expired - Lifetime
- 1997-08-11 CA CA002265645A patent/CA2265645C/fr not_active Expired - Lifetime
- 1997-08-11 CN CN97199667A patent/CN1109037C/zh not_active Expired - Lifetime
- 1997-08-11 PT PT97934774T patent/PT989131E/pt unknown
- 1997-08-11 KR KR1019997002057A patent/KR100338144B1/ko not_active IP Right Cessation
- 1997-08-11 DK DK97934774T patent/DK0989131T3/da active
- 1997-08-11 EA EA199900287A patent/EA001732B1/ru not_active IP Right Cessation
- 1997-08-11 AT AT97934774T patent/ATE227727T1/de active
- 1997-08-11 JP JP10513480A patent/JP3094453B2/ja not_active Expired - Lifetime
- 1997-08-11 ES ES97934774T patent/ES2182108T3/es not_active Expired - Lifetime
- 1997-08-11 EP EP97934774A patent/EP0989131B1/fr not_active Expired - Lifetime
-
1999
- 1999-03-11 NO NO19991191A patent/NO323892B1/no not_active IP Right Cessation
-
2000
- 2000-05-03 HK HK00102681A patent/HK1023571A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0989131A1 (fr) | 2000-03-29 |
AU716490B2 (en) | 2000-02-24 |
DE69717160D1 (de) | 2002-12-19 |
DK0989131T3 (da) | 2003-03-03 |
CA2265645A1 (fr) | 1998-03-19 |
JP3094453B2 (ja) | 2000-10-03 |
NO323892B1 (no) | 2007-07-16 |
CN1109037C (zh) | 2003-05-21 |
ATE227727T1 (de) | 2002-11-15 |
EP0989131B1 (fr) | 2002-11-13 |
NO991191L (no) | 1999-04-23 |
ES2182108T3 (es) | 2003-03-01 |
CA2265645C (fr) | 2007-01-23 |
KR20000036057A (ko) | 2000-06-26 |
WO1998011111A1 (fr) | 1998-03-19 |
NO991191D0 (no) | 1999-03-11 |
EA001732B1 (ru) | 2001-08-27 |
CN1237180A (zh) | 1999-12-01 |
DE69717160T2 (de) | 2003-05-08 |
EA199900287A1 (ru) | 1999-08-26 |
PT989131E (pt) | 2003-03-31 |
AU3786097A (en) | 1998-04-02 |
KR100338144B1 (ko) | 2002-05-24 |
EP0989131A4 (fr) | 2000-03-29 |
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