FR2532648B1 - Derives de carbostyrile, leur procede de preparation et leur application en therapeutique - Google Patents

Derives de carbostyrile, leur procede de preparation et leur application en therapeutique

Info

Publication number
FR2532648B1
FR2532648B1 FR8314115A FR8314115A FR2532648B1 FR 2532648 B1 FR2532648 B1 FR 2532648B1 FR 8314115 A FR8314115 A FR 8314115A FR 8314115 A FR8314115 A FR 8314115A FR 2532648 B1 FR2532648 B1 FR 2532648B1
Authority
FR
France
Prior art keywords
preparation process
therapeutic application
carbostyrile
derivatives
carbostyrile derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8314115A
Other languages
English (en)
Other versions
FR2532648A1 (fr
Inventor
Tatsuyoshi Tanaka
Kazuyoshi Nagami
Shigeharu Tamada
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15409082A external-priority patent/JPS5962585A/ja
Priority claimed from JP57213167A external-priority patent/JPS59104378A/ja
Priority claimed from JP58114679A external-priority patent/JPS606685A/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2532648A1 publication Critical patent/FR2532648A1/fr
Application granted granted Critical
Publication of FR2532648B1 publication Critical patent/FR2532648B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
FR8314115A 1982-09-03 1983-09-02 Derives de carbostyrile, leur procede de preparation et leur application en therapeutique Expired FR2532648B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15409082A JPS5962585A (ja) 1982-09-03 1982-09-03 カルボスチリル誘導体
JP57213167A JPS59104378A (ja) 1982-12-03 1982-12-03 カルボスチリル誘導体
JP58114679A JPS606685A (ja) 1983-06-24 1983-06-24 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
FR2532648A1 FR2532648A1 (fr) 1984-03-09
FR2532648B1 true FR2532648B1 (fr) 1989-07-21

Family

ID=27312797

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8314115A Expired FR2532648B1 (fr) 1982-09-03 1983-09-02 Derives de carbostyrile, leur procede de preparation et leur application en therapeutique

Country Status (11)

Country Link
US (1) US4564619A (fr)
KR (1) KR910000181B1 (fr)
CA (1) CA1252469A (fr)
CH (1) CH655110A5 (fr)
DE (1) DE3331808A1 (fr)
ES (4) ES525346A0 (fr)
FR (1) FR2532648B1 (fr)
GB (1) GB2127402B (fr)
IT (1) IT1193145B (fr)
NL (1) NL8303066A (fr)
SE (1) SE455503B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8608874A1 (es) * 1984-05-29 1986-09-01 Pfizer Un procedimiento para la preparacion de una 2-(1h)-quinolona
GB8529362D0 (en) * 1985-11-28 1986-01-02 Pfizer Ltd Quinolone cardiac stimulants
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR100305515B1 (ko) * 1999-02-04 2001-09-24 이순금 메주의 제조방법
NL1012886C1 (nl) 1999-08-23 2001-02-26 Rephartox 1,4-Dihydropyridine-5-carbonzuuresterderivaten en werkwijze voor de bereiding ervan.
KR100422242B1 (ko) * 2001-07-20 2004-03-12 농업회사법인(주)맛가마식품 중공봉형상 메주와 이를 이용한 간장 및 된장 제조방법과제조용 장독
US20070066619A1 (en) * 2002-10-07 2007-03-22 Artesian Therapeutics, Inc. Compounds having simultaneous ability to block L-type calcium channels and to inhibit phosphodiesterase type 3 activity
KR20050070036A (ko) * 2002-10-07 2005-07-05 아티젼 쎄라퓨틱스, 인크. Ｌ형 칼슘 채널을 차단하는 동시에 3형포스포디에스테라제의 활성을 억제할 수 있는디히드로피리딘 화합물
NL1028564C2 (nl) * 2005-03-17 2006-09-20 Rademaker Holding B V Toepassing van een coumarine-groep omvattende derivaten voor de bereiding van een antiviraal middel, coumarine-group omvattende derivaten, een werkwijze voor de bereiding daarvan, en farmaceutische preparaten die deze bevatten.
EP2258357A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse avec inhibiteur de l'acetylcholinestérase
EP2275095A3 (fr) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese par modulation des recepteurs muscariniques
EP2377530A3 (fr) 2005-10-21 2012-06-20 Braincells, Inc. Modulation de neurogénèse par inhibition PDE
EP2314289A1 (fr) 2005-10-31 2011-04-27 Braincells, Inc. Modulation de la neurogenese dont la médiation est assurée par récepteur gaba
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007223036A1 (en) * 2006-03-08 2007-09-13 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2651862A1 (fr) * 2006-05-09 2007-11-22 Braincells, Inc. Neurogenese induite par le recepteur 5ht
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134136A2 (fr) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
JP2010502722A (ja) * 2006-09-08 2010-01-28 ブレインセルス，インコーポレイティド ４−アシルアミノピリジン誘導体を含む組み合わせ
AU2007299920A1 (en) * 2006-09-19 2008-03-27 Braincells, Inc. PPAR Mediated Modulation of Neurogenesis
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
WO2013106547A1 (fr) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971797A (en) * 1973-06-15 1976-07-27 Merck & Co., Inc. S,S'-bis(pyridylmethyl)-carbonodithioates
DE2508181A1 (de) * 1975-02-26 1976-09-09 Bayer Ag 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
DE2659665A1 (de) * 1976-12-30 1978-07-13 Nattermann A & Cie Neue 1,4-dihydropyridin-derivate
JPS5387368A (en) * 1977-01-12 1978-08-01 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5390270A (en) * 1977-01-14 1978-08-08 Otsuka Pharmaceut Co Ltd Carbostryl derivs.
NZ187452A (en) * 1977-06-10 1980-05-27 Otsuka Pharma Co Ltd N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
IT1097538B (it) * 1978-07-17 1985-08-31 Medea Res Srl Processo per la preparazione del 2,6-dimetil-4-3(3-nitrofenil)-3-metossicarbonil-1,4-didropiridin-5-carbossilati di 2(n-benzil-n-metilammino)
CA1117117A (fr) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. Derives de la 2-methyl-dihydropyridine, methodes de preparation, et composition pharmaceutique de ces derives
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS57200386A (en) * 1981-06-04 1982-12-08 Yoshitomi Pharmaceut Ind Ltd Novel 1,4-dihydropyridine-3,5-dicarboxylic ester derivative and its salts

Also Published As

Publication number Publication date
ES8505998A1 (es) 1985-06-16
NL8303066A (nl) 1984-04-02
ES532537A0 (es) 1985-10-16
CH655110A5 (de) 1986-03-27
IT1193145B (it) 1988-06-02
FR2532648A1 (fr) 1984-03-09
SE8304737L (sv) 1984-03-04
ES8502686A1 (es) 1985-01-16
SE8304737D0 (sv) 1983-09-02
GB2127402A (en) 1984-04-11
ES532538A0 (es) 1985-07-16
SE455503B (sv) 1988-07-18
ES532536A0 (es) 1985-06-16
KR850000402A (ko) 1985-02-27
ES8601187A1 (es) 1985-10-16
US4564619A (en) 1986-01-14
GB8323542D0 (en) 1983-10-05
DE3331808A1 (de) 1984-03-08
IT8367922A0 (it) 1983-09-05
GB2127402B (en) 1987-01-14
CA1252469A (fr) 1989-04-11
ES525346A0 (es) 1985-01-16
KR910000181B1 (ko) 1991-01-21
ES8506697A1 (es) 1985-07-16

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Legal Events

Date Code Title Description
ST Notification of lapse