FR2399242A1 - Procede de preparation de liposomes en solution aqueuse - Google Patents

Procede de preparation de liposomes en solution aqueuse

Info

Publication number
FR2399242A1
FR2399242A1 FR7822985A FR7822985A FR2399242A1 FR 2399242 A1 FR2399242 A1 FR 2399242A1 FR 7822985 A FR7822985 A FR 7822985A FR 7822985 A FR7822985 A FR 7822985A FR 2399242 A1 FR2399242 A1 FR 2399242A1
Authority
FR
France
Prior art keywords
aqueous solution
preparing liposomes
lipid
solvent
vesicles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7822985A
Other languages
English (en)
Other versions
FR2399242B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Battelle Memorial Institute Inc
Original Assignee
Battelle Memorial Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute Inc filed Critical Battelle Memorial Institute Inc
Publication of FR2399242A1 publication Critical patent/FR2399242A1/fr
Application granted granted Critical
Publication of FR2399242B1 publication Critical patent/FR2399242B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/929—Specified combination of agitation steps, e.g. mixing to make subcombination composition followed by homogenization

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé de préparation de liposomes en solution aqueuse. Suivant ce procédé, on disperse une solution aqueuse à encapsuler dans un solvant, insoluble dans l'eau, contenant au moins un lipide de manière à former des vésicules de cette solution entourée d'une pellicule de ce lipide, puis on émulsionne ces vésicules dans un mileu aqueux, ledit solvant étant éliminé avant ou après ladite opération d'émulsion. L'invention s'applique notamment à l'encapsulation de colorants, parfums, arômes, médicaments, enzymes, polypeptides, chélatants.
FR7822985A 1977-08-05 1978-08-03 Procede de preparation de liposomes en solution aqueuse Granted FR2399242A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH961677A CH624011A5 (fr) 1977-08-05 1977-08-05

Publications (2)

Publication Number Publication Date
FR2399242A1 true FR2399242A1 (fr) 1979-03-02
FR2399242B1 FR2399242B1 (fr) 1983-01-07

Family

ID=4353843

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7822985A Granted FR2399242A1 (fr) 1977-08-05 1978-08-03 Procede de preparation de liposomes en solution aqueuse

Country Status (20)

Country Link
US (1) US4224179A (fr)
JP (1) JPS5441279A (fr)
AU (1) AU520916B2 (fr)
BE (1) BE869490A (fr)
CA (1) CA1098410A (fr)
CH (1) CH624011A5 (fr)
DE (1) DE2834307A1 (fr)
DK (1) DK155036C (fr)
ES (1) ES472326A1 (fr)
FR (1) FR2399242A1 (fr)
GB (1) GB2001929B (fr)
HU (1) HU179672B (fr)
IE (1) IE47067B1 (fr)
IL (1) IL55154A (fr)
IT (1) IT1097928B (fr)
LU (1) LU80071A1 (fr)
NL (1) NL7808167A (fr)
SE (1) SE433169B (fr)
SU (1) SU1158031A3 (fr)
ZA (1) ZA784407B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
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EP0047480A2 (fr) * 1980-09-05 1982-03-17 Institut Armand Frappier Formation d'un immunosome préparé exclusivement d'antigènes viraux reconstitués sur une membrane artificielle
EP0072234A1 (fr) * 1981-08-10 1983-02-16 The Wellcome Foundation Limited Formulations pharmaceutiques contenant de l'antimoine
EP0100964A2 (fr) * 1982-07-31 1984-02-22 Reifenrath, Rainer, Dr. Produit pharmaceutique pour le traitement et la prophylaxie d'infections, de la toux et d'affections obstructives des voies respiratoires, ainsi que son procédé de préparation
FR2540381A1 (fr) * 1983-02-08 1984-08-10 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
FR2561101A1 (fr) * 1984-03-13 1985-09-20 Paris Sud Universite Procede de preparation de liposomes et liposomes ainsi obtenus
DE3713493A1 (de) * 1986-04-22 1987-10-29 Oreal Kosmetisches oder pharmazeutisches mittel auf basis einer waessrigen dispersion von lipidkuegelchen
EP0280503A2 (fr) * 1987-02-23 1988-08-31 Research Development Foundation Liposomes multivésiculaires contenant une substance biologiquement active en présence d'un chlorhydrate
EP0472225A2 (fr) 1985-12-11 1992-02-26 L V M H Recherche Liposomes ou phases lamellaires lipidiques hydratées contenant de la trétinoine

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EP0100964A3 (fr) * 1982-07-31 1984-06-13 Reifenrath, Rainer, Dr. Produit pharmaceutique pour le traitement et la prophylaxie d'infections, de la toux et d'affections obstructives des voies respiratoires, ainsi que son procédé de préparation
FR2540381A1 (fr) * 1983-02-08 1984-08-10 Dior Sa Parfums Christian Procede pour stimuler la croissance des cellules; composition cosmetique, pharmaceutique et composition complementaire pour milieu de culture cellulaire appliquant ce procede
EP0120722A1 (fr) * 1983-02-08 1984-10-03 Parfums Christian Dior Procédé pour stimuler la multiplication des cellules, composition cosmétique, pharmaceutique et composition complémentaire pour milieu de culture cellulaire appliquant ce procédé
FR2561101A1 (fr) * 1984-03-13 1985-09-20 Paris Sud Universite Procede de preparation de liposomes et liposomes ainsi obtenus
EP0472225A2 (fr) 1985-12-11 1992-02-26 L V M H Recherche Liposomes ou phases lamellaires lipidiques hydratées contenant de la trétinoine
DE3713493A1 (de) * 1986-04-22 1987-10-29 Oreal Kosmetisches oder pharmazeutisches mittel auf basis einer waessrigen dispersion von lipidkuegelchen
EP0280503A2 (fr) * 1987-02-23 1988-08-31 Research Development Foundation Liposomes multivésiculaires contenant une substance biologiquement active en présence d'un chlorhydrate
EP0280503A3 (en) * 1987-02-23 1989-10-11 Clayton Foundation For Research Multivesicular liposomes having a biologically active substance encapsulated therein in the presence of a hydrochloride

Also Published As

Publication number Publication date
AU520916B2 (en) 1982-03-04
GB2001929B (en) 1982-07-28
AU3866678A (en) 1980-02-07
JPS6355978B2 (fr) 1988-11-07
IE781574L (en) 1979-02-05
FR2399242B1 (fr) 1983-01-07
HU179672B (en) 1982-11-29
ZA784407B (en) 1979-07-25
DE2834307A1 (de) 1979-02-15
US4224179A (en) 1980-09-23
SU1158031A3 (ru) 1985-05-23
JPS5441279A (en) 1979-04-02
SE7808356L (sv) 1979-02-06
DK155036C (da) 1989-06-26
IT7826441A0 (it) 1978-08-03
IL55154A0 (en) 1978-09-29
DK344478A (da) 1979-02-06
IT1097928B (it) 1985-08-31
LU80071A1 (fr) 1979-05-15
DK155036B (da) 1989-01-30
IE47067B1 (en) 1983-12-14
GB2001929A (en) 1979-02-14
IL55154A (en) 1981-09-13
SE433169B (sv) 1984-05-14
CH624011A5 (fr) 1981-07-15
ES472326A1 (es) 1979-02-16
NL7808167A (nl) 1979-02-07
BE869490A (fr) 1979-02-05
CA1098410A (fr) 1981-03-31

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