FR21C1031I2 - Derives de la n4-phenyl-quinazoline-4-amine et composes similaires en tant que inhibiteurs de la kinase tyrosine erbb type i pour le traitement de maladies hyperproliferatives - Google Patents

Derives de la n4-phenyl-quinazoline-4-amine et composes similaires en tant que inhibiteurs de la kinase tyrosine erbb type i pour le traitement de maladies hyperproliferatives

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Publication number
FR21C1031I2
FR21C1031I2 FR21C1031C FR21C1031C FR21C1031I2 FR 21C1031 I2 FR21C1031 I2 FR 21C1031I2 FR 21C1031 C FR21C1031 C FR 21C1031C FR 21C1031 C FR21C1031 C FR 21C1031C FR 21C1031 I2 FR21C1031 I2 FR 21C1031I2
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Prior art keywords
treatment
inhibitors
quinazolin
phenyl
similar compounds
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FR21C1031C
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English (en)
French (fr)
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Array Biopharma Inc
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Array Biopharma Inc
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Publication of FR21C1031I1 publication Critical patent/FR21C1031I1/fr
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Publication of FR21C1031I2 publication Critical patent/FR21C1031I2/fr
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
FR21C1031C 2005-11-15 2021-07-20 Derives de la n4-phenyl-quinazoline-4-amine et composes similaires en tant que inhibiteurs de la kinase tyrosine erbb type i pour le traitement de maladies hyperproliferatives Active FR21C1031I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US73628905P 2005-11-15 2005-11-15
US81701906P 2006-06-28 2006-06-28
PCT/US2006/044431 WO2007059257A2 (en) 2005-11-15 2006-11-15 N4-phenyl-quinaz0line-4 -amine derivatives and related compounds as erbb type i receptor tyrosine kinase inhibitors for the treatment of hyperproliferative diseases

Publications (2)

Publication Number Publication Date
FR21C1031I1 FR21C1031I1 (zh) 2021-08-27
FR21C1031I2 true FR21C1031I2 (fr) 2022-07-15

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FR21C1031C Active FR21C1031I2 (fr) 2005-11-15 2021-07-20 Derives de la n4-phenyl-quinazoline-4-amine et composes similaires en tant que inhibiteurs de la kinase tyrosine erbb type i pour le traitement de maladies hyperproliferatives

Country Status (29)

Country Link
US (6) US8648087B2 (zh)
EP (2) EP1971601B1 (zh)
JP (2) JP5134548B2 (zh)
KR (1) KR101086967B1 (zh)
CN (2) CN101356171A (zh)
AT (2) ATE507224T1 (zh)
AU (2) AU2006315383B2 (zh)
BR (2) BRPI0618668B1 (zh)
CA (2) CA2632194C (zh)
CY (2) CY1110583T1 (zh)
DE (2) DE602006021645D1 (zh)
DK (2) DK1971601T3 (zh)
ES (2) ES2335535T3 (zh)
FI (1) FIC20210022I1 (zh)
FR (1) FR21C1031I2 (zh)
HK (2) HK1119174A1 (zh)
HU (1) HUS2100028I1 (zh)
IL (2) IL239149A (zh)
LT (1) LTC1971601I2 (zh)
LU (1) LUC00217I2 (zh)
NL (1) NL301113I2 (zh)
NO (1) NO342413B1 (zh)
PL (2) PL2090575T3 (zh)
PT (2) PT1971601E (zh)
RU (2) RU2428421C2 (zh)
SG (1) SG152230A1 (zh)
SI (2) SI1971601T1 (zh)
WO (1) WO2007059257A2 (zh)
ZA (1) ZA200804498B (zh)

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