FI942095A - Renade heparinfraktioner, förfarande för framställning av dessa och farmaceutiska kompositioner som innehåller dessa - Google Patents

Renade heparinfraktioner, förfarande för framställning av dessa och farmaceutiska kompositioner som innehåller dessa Download PDF

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Publication number
FI942095A
FI942095A FI942095A FI942095A FI942095A FI 942095 A FI942095 A FI 942095A FI 942095 A FI942095 A FI 942095A FI 942095 A FI942095 A FI 942095A FI 942095 A FI942095 A FI 942095A
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FI
Finland
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
heparin fractions
purified heparin
Prior art date
Application number
FI942095A
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English (en)
Finnish (fi)
Other versions
FI942095A0 (sv
FI107388B (sv
Inventor
Jean-Francois Branellec
Jose Espejo
Philippe Picart
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Choay Sa filed Critical Choay Sa
Publication of FI942095A0 publication Critical patent/FI942095A0/sv
Publication of FI942095A publication Critical patent/FI942095A/sv
Application granted granted Critical
Publication of FI107388B publication Critical patent/FI107388B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI942095A 1993-05-07 1994-05-06 Förfarande för framställning av renade heparinfraktioner, som inte innehåller nitrosoföreningar FI107388B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9305534 1993-05-07
FR9305534A FR2704861B1 (fr) 1993-05-07 1993-05-07 Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.

Publications (3)

Publication Number Publication Date
FI942095A0 FI942095A0 (sv) 1994-05-06
FI942095A true FI942095A (sv) 1994-11-08
FI107388B FI107388B (sv) 2001-07-31

Family

ID=9446915

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942095A FI107388B (sv) 1993-05-07 1994-05-06 Förfarande för framställning av renade heparinfraktioner, som inte innehåller nitrosoföreningar

Country Status (26)

Country Link
US (1) US5599801A (sv)
EP (1) EP0623629B1 (sv)
JP (1) JP3529835B2 (sv)
KR (1) KR100328095B1 (sv)
CN (1) CN1066155C (sv)
AT (1) ATE141618T1 (sv)
AU (1) AU672291B2 (sv)
BR (1) BR9401920A (sv)
CA (1) CA2122930C (sv)
CZ (1) CZ287889B6 (sv)
DE (1) DE69400385T2 (sv)
DK (1) DK0623629T3 (sv)
ES (1) ES2093494T3 (sv)
FI (1) FI107388B (sv)
FR (1) FR2704861B1 (sv)
GR (1) GR3021648T3 (sv)
HK (1) HK1007432A1 (sv)
HU (1) HU221595B (sv)
IL (1) IL109587A (sv)
MY (1) MY110862A (sv)
NO (1) NO306952B1 (sv)
NZ (1) NZ260460A (sv)
PL (1) PL178294B1 (sv)
RU (1) RU2133253C1 (sv)
TW (1) TW438812B (sv)
ZA (1) ZA943152B (sv)

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US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5980865A (en) * 1995-08-18 1999-11-09 Baker Norton Pharmaceuticals, Inc. Method for treating late phase allergic reactions and inflammatory diseases
WO1997016556A1 (en) 1995-10-30 1997-05-09 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase i
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
EP1109919A2 (en) * 1998-08-27 2001-06-27 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase i and ii
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
US7412332B1 (en) * 1999-04-23 2008-08-12 Massachusetts Institute Of Technology Method for analyzing polysaccharides
AU2001243512C1 (en) 2000-03-08 2008-04-17 Massachusetts Institute Of Technology Heparinase III and uses thereof
US8227449B2 (en) * 2000-03-30 2012-07-24 Glycores 2000 S.R.L. Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
IT1318432B1 (it) * 2000-03-30 2003-08-25 Inalco Spa Glicosaminoglicani derivati dal polisaccaride k5 aventi elevataattivita' anticoagulante ed antitrombotica e processo per la loro
DE60138115D1 (de) * 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
WO2002032406A2 (en) * 2000-10-18 2002-04-25 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US20050027117A1 (en) * 2000-12-18 2005-02-03 Pasqua Oreste Anticoagulant and antithrombotic LMW-glycosaminoglycans derived from K5 polysaccharide and process for their preparation
JP2002293804A (ja) * 2001-03-28 2002-10-09 Itoham Foods Inc 低分子量ヘパリンの製造法
AU2003225724A1 (en) * 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ITMO20040199A1 (it) * 2004-07-29 2004-10-29 Biofer Spa Procedimento per la purificazione da gruppi e n no rsidui di eparine a basso peso molecolare ottentite tramite nitrosazione.
JP2006291028A (ja) * 2005-04-11 2006-10-26 Q P Corp 低分子ヘパリンまたはその塩、ならびにその製造方法
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
KR101794877B1 (ko) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102633905B (zh) * 2011-04-11 2014-10-08 南通天龙畜产品有限公司 一种肝素钠中不被亚硝酸降解且在肝素钠保留时间附近出峰的物质的去除方法
CN104045744B (zh) * 2014-06-26 2016-01-06 常州千红生化制药股份有限公司 达肝素钠的制备方法
CN104098716B (zh) * 2014-07-16 2015-04-22 南京健友生化制药股份有限公司 一种达肝素钠精品的生产方法
US10688249B2 (en) * 2015-06-11 2020-06-23 Virchow Biotech Pvt. Ltd. Multiple dose pharmaceutical compositions containing heparin and/or heparin-like compounds and devices and methods for delivering the same
CN105294885A (zh) * 2015-11-23 2016-02-03 山东大学 一种新来源亚硝酸降解低分子肝素的制备方法
US11492421B2 (en) * 2018-02-14 2022-11-08 Biological E Limited Process for the preparation of Dalteparin sodium
RU186728U1 (ru) * 2018-10-19 2019-01-30 Федеральное государственное бюджетное образовательное учреждение высшего образования "МИРЭА - Российский технологический университет" Лабораторное устройство для отмывки порошковых продуктов химических реакций от посторонних примесей
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
EP3997238A1 (en) 2019-07-09 2022-05-18 Optimvia, LLC Methods for synthesizing anticoagulant polysaccharides
CN110845641A (zh) * 2019-11-07 2020-02-28 中国药科大学 一种肝素寡糖及其在制备抗血管生成药物中的应用
CN110787489A (zh) * 2019-11-20 2020-02-14 江苏千牧生物科技股份有限公司 一种肝素钠加工使用的分离装置及加工的工艺
CN115304688A (zh) * 2022-08-25 2022-11-08 湖北亿诺瑞生物制药有限公司 一种达肝素钠的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4438261A (en) * 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
US5094815A (en) * 1988-05-18 1992-03-10 Cornell Research Foundation, Inc. Photolytic interface for HPLC-chemiluminescence detection of non volatile N-nitroso compounds
US5032679A (en) * 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
IT1243300B (it) * 1990-12-20 1994-05-26 Fidia Spa Derivati dell'eparina
US5385937A (en) * 1991-04-10 1995-01-31 Brigham & Women's Hospital Nitrosation of homocysteine as a method for treating homocysteinemia

Also Published As

Publication number Publication date
HK1007432A1 (en) 1999-04-09
HUT70553A (en) 1995-10-30
NO306952B1 (no) 2000-01-17
MY110862A (en) 1999-05-31
NO941686L (no) 1994-11-08
NZ260460A (en) 1996-02-27
DE69400385D1 (de) 1996-09-26
CZ287889B6 (cs) 2001-03-14
RU94015595A (ru) 1996-09-27
IL109587A (en) 1997-04-15
FI942095A0 (sv) 1994-05-06
HU9401446D0 (en) 1994-08-29
GR3021648T3 (en) 1997-02-28
AU672291B2 (en) 1996-09-26
AU6191294A (en) 1994-11-10
ES2093494T3 (es) 1996-12-16
JP3529835B2 (ja) 2004-05-24
CN1066155C (zh) 2001-05-23
EP0623629B1 (fr) 1996-08-21
KR100328095B1 (ko) 2002-06-20
TW438812B (en) 2001-06-07
NO941686D0 (no) 1994-05-06
CA2122930A1 (en) 1994-11-08
CA2122930C (en) 2000-10-24
DK0623629T3 (da) 1996-12-23
FI107388B (sv) 2001-07-31
PL178294B1 (pl) 2000-04-28
CZ113294A3 (en) 1994-12-15
RU2133253C1 (ru) 1999-07-20
FR2704861A1 (fr) 1994-11-10
ZA943152B (en) 1995-01-09
IL109587A0 (en) 1994-08-26
HU221595B (hu) 2002-11-28
JPH07126302A (ja) 1995-05-16
EP0623629A1 (fr) 1994-11-09
BR9401920A (pt) 1994-11-29
CN1096034A (zh) 1994-12-07
US5599801A (en) 1997-02-04
FR2704861B1 (fr) 1995-07-28
ATE141618T1 (de) 1996-09-15
DE69400385T2 (de) 1996-12-19

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