FI940903A - Steroidsulfatasinhibitorer - Google Patents

Steroidsulfatasinhibitorer Download PDF

Info

Publication number
FI940903A
FI940903A FI940903A FI940903A FI940903A FI 940903 A FI940903 A FI 940903A FI 940903 A FI940903 A FI 940903A FI 940903 A FI940903 A FI 940903A FI 940903 A FI940903 A FI 940903A
Authority
FI
Finland
Prior art keywords
sub
compound
steroid sulphatase
enzyme
sulphate
Prior art date
Application number
FI940903A
Other languages
English (en)
Finnish (fi)
Other versions
FI940903A0 (sv
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Imperial College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College filed Critical Imperial College
Publication of FI940903A0 publication Critical patent/FI940903A0/sv
Publication of FI940903A publication Critical patent/FI940903A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI940903A 1991-08-29 1994-02-25 Steroidsulfatasinhibitorer FI940903A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
PCT/GB1992/001587 WO1993005064A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Publications (2)

Publication Number Publication Date
FI940903A0 FI940903A0 (sv) 1994-02-25
FI940903A true FI940903A (sv) 1994-04-20

Family

ID=10700604

Family Applications (5)

Application Number Title Priority Date Filing Date
FI940903A FI940903A (sv) 1991-08-29 1994-02-25 Steroidsulfatasinhibitorer
FI20002260A FI20002260A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av farmaceutiska kompositioner, som innehåller steroidsulfatasinhibitorer
FI20002261A FI20002261A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av läkemedel, som innehåller steroidsulfatasinhibitorer
FI20002259A FI20002259A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av steroidsulfatasinhibitorer
FI20050991A FI20050991A (sv) 1991-08-29 2005-10-03 Användningen av föreningar med sulfamatgrupp för framställningen av streroidsulfatasinhibitorer

Family Applications After (4)

Application Number Title Priority Date Filing Date
FI20002260A FI20002260A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av farmaceutiska kompositioner, som innehåller steroidsulfatasinhibitorer
FI20002261A FI20002261A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av läkemedel, som innehåller steroidsulfatasinhibitorer
FI20002259A FI20002259A (sv) 1991-08-29 2000-10-13 Förfarande för framställning av steroidsulfatasinhibitorer
FI20050991A FI20050991A (sv) 1991-08-29 2005-10-03 Användningen av föreningar med sulfamatgrupp för framställningen av streroidsulfatasinhibitorer

Country Status (26)

Country Link
US (3) US5616574A (sv)
EP (6) EP0982032B1 (sv)
JP (6) JP3219408B2 (sv)
KR (4) KR100258396B1 (sv)
AT (5) ATE194843T1 (sv)
AU (2) AU689043B2 (sv)
BR (1) BR9206434A (sv)
CA (4) CA2305758A1 (sv)
CY (4) CY2253B1 (sv)
CZ (1) CZ295939B6 (sv)
DE (5) DE69233020T2 (sv)
DK (4) DK0928609T3 (sv)
ES (4) ES2148178T3 (sv)
FI (5) FI940903A (sv)
GB (1) GB9118478D0 (sv)
GE (6) GEP20022637B (sv)
GR (1) GR3034579T3 (sv)
HK (3) HK1019753A1 (sv)
HU (1) HUT66097A (sv)
LV (1) LV12618B (sv)
NO (6) NO307301B1 (sv)
RU (4) RU2182152C2 (sv)
SG (7) SG103374A1 (sv)
SK (4) SK282189B6 (sv)
UA (4) UA41875C2 (sv)
WO (1) WO1993005064A1 (sv)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9604709D0 (en) * 1996-03-05 1996-05-01 Imperial College A compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
DE69531048T2 (de) * 1994-04-05 2004-05-06 Celltech Therapeutics Ltd., Slough Verwendung von steroidsulphatase-hemmern
DE4447715C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB9422777D0 (en) * 1994-11-11 1995-01-04 Imperial College Assay
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
US5705495A (en) * 1995-10-19 1998-01-06 Jenapharm Gmbh & Co. Kg. Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
KR20000035979A (ko) * 1996-09-12 2000-06-26 야마구찌 다까시 3-치환-ｄ-호모-1,3,5(10)-에스트라트리엔 유도체
WO1999064013A1 (en) 1998-06-10 1999-12-16 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
US6642220B1 (en) 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6288050B1 (en) * 1997-07-18 2001-09-11 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
GB2331987B (en) 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
GB9807779D0 (en) 1998-04-09 1998-06-10 Ciba Geigy Ag Organic compounds
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
IL145995A0 (en) 1999-04-30 2002-07-25 Sterix Ltd Use
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
US6583130B1 (en) 1999-09-13 2003-06-24 Schering Ag C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds
ES2250224T3 (es) * 1999-12-13 2006-04-16 Sterix Limited Compuestos halogenos de sulfamato, fosfonato, tiofosfonato, sulfonato y sulfonamida como inhibidores de sulfatasa esteoride.
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
JPWO2001081364A1 (ja) * 2000-04-24 2004-01-08 協和醗酵工業株式会社 エストラ−１，３，５（１０）−トリエン誘導体
DE10027887A1 (de) * 2000-05-31 2001-12-13 Jenapharm Gmbh Verbindungen mit einer Sulfonamidgruppe und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
EP1406634A1 (en) 2001-07-13 2004-04-14 Schering Aktiengesellschaft Combination of drospirenone and an estrogen sulphamate for hrt
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10139494A1 (de) * 2001-08-13 2003-03-06 Jenapharm Gmbh Antitumor wirksame 2-Alkoxyestradiolsulfamate
ATE408615T1 (de) 2001-10-18 2008-10-15 Sterix Ltd Steroidale verbindungen zur hemmung von steroid sulfotase
EP1448592B1 (en) * 2001-10-18 2006-03-08 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
US20040254241A1 (en) * 2002-08-28 2004-12-16 Yoji Ino Aryl sulfamate derivatives
WO2004035089A1 (ja) * 2002-10-09 2004-04-29 Kyowa Hakko Kogyo Co., Ltd. ホルモン依存性癌の治療剤
DE10307104A1 (de) 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
DK1644350T3 (da) * 2003-05-16 2009-11-23 Theramex Sullfamatbenzothiophenderivater som steroidsulfataseinhibitorer
ATE464293T1 (de) 2003-05-21 2010-04-15 Aska Pharm Co Ltd Cyclisches aminophenylsulfamatderivativ
US7534780B2 (en) 2004-05-21 2009-05-19 Bayer Schering Pharma Aktiengesellschaft Estradiol prodrugs
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
KR20100068287A (ko) 2007-09-17 2010-06-22 쁘레글렘 에스.아. 폐경기 전 여성의 에스트로겐 의존성 질환의 치료
EP2149371A1 (en) * 2008-07-28 2010-02-03 PregLem S.A. Use of steroid sulfatase inhibitors for the treatment of preterm labor
PL2398500T3 (pl) 2009-02-20 2019-09-30 2-Bbb Medicines B.V. System dostarczania leków na bazie glutationu
KR101741629B1 (ko) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CN110974840A (zh) * 2019-12-27 2020-04-10 天津市肿瘤医院 一种类固醇硫酸酯酶抑制剂及其药物用途

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE114806C (sv) *
DE1593846A1 (de) * 1967-01-28 1971-02-25 Hoechst Ag Verfahren zur Herstellung von Sulfamidsaeure-arylestern
US3647738A (en) * 1970-11-03 1972-03-07 Union Carbide Corp Alpha-olefin polymer compositions
GB1398026A (en) * 1972-11-10 1975-06-18 Jenapharm Veb Steroid esters
DE2418217A1 (de) * 1974-04-13 1975-11-06 Hoechst Ag Sulfamidsaeureester und verfahren zu ihrer herstellung
DD114806A1 (sv) * 1974-10-11 1975-08-20
US4937237A (en) * 1988-12-23 1990-06-26 Smithkline Beckman Corporation Phosphinic acid substituted aromatic steroids as inhibitors of steroid 5-60 -reductase
PT94305B (pt) * 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
GB9625334D0 (en) * 1996-12-05 1997-01-22 Imperial College Compound
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9118465D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
JP2000506161A (ja) * 1996-03-05 2000-05-23 インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン スルファメート基を有する化合物
US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same

Also Published As

Publication number Publication date
FI20002259A (sv) 2000-10-13
SG73391A1 (en) 2006-08-30
CY2398B1 (en) 2004-09-10
AU689043B2 (en) 1998-03-19
CY2397B1 (en) 2004-09-10
EP0928609A3 (en) 2001-11-07
NO20025725D0 (no) 2002-11-28
DK0982032T3 (da) 2003-11-03
SG88783A1 (en) 2002-05-21
NO940635D0 (no) 1994-02-24
SK24694A3 (en) 1994-11-09
NO995076D0 (no) 1999-10-18
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
ES2196483T3 (es) 2003-12-16
GEP20022803B (en) 2002-09-25
RU2210574C2 (ru) 2003-08-20
DK0921130T3 (da) 2003-07-21
DE69233149T2 (de) 2004-06-24
CA2305749A1 (en) 1993-03-18
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
JP3581820B2 (ja) 2004-10-27
NO308903B1 (no) 2000-11-13
SK282186B6 (sk) 2001-12-03
NO2595A (no) 1994-04-29
KR100322650B1 (ko) 2002-03-20
CA2305767A1 (en) 1993-03-18
DE69233020D1 (de) 2003-05-22
EP0982032A2 (en) 2000-03-01
SK282188B6 (sk) 2001-12-03
HK1020672A1 (en) 2000-05-19
EP0921130A2 (en) 1999-06-09
NO995076L (no) 1994-04-29
ATE278704T1 (de) 2004-10-15
AU717116B2 (en) 2000-03-16
NO20025725L (no) 1994-04-29
NO307301B1 (no) 2000-03-13
LV12618B (en) 2001-07-20
FI20050991A (sv) 2005-10-03
CY2253B1 (en) 2003-07-04
FI20002261A (sv) 2000-10-13
US5830886A (en) 1998-11-03
NO995075L (no) 1994-04-29
KR100321018B1 (ko) 2002-03-20
EP0928609A2 (en) 1999-07-14
SG115508A1 (en) 2005-10-28
NO940635L (sv) 1994-04-29
DE69233053D1 (de) 2003-06-12
GEP20063773B (en) 2006-03-27
EP0982032A3 (en) 2002-03-20
JP3219408B2 (ja) 2001-10-15
JP3581821B2 (ja) 2004-10-27
SK282187B6 (sk) 2001-12-03
AU668882B2 (en) 1996-05-23
CA2114630C (en) 2003-09-30
FI940903A0 (sv) 1994-02-25
NO318009B1 (no) 2005-01-17
UA70957C2 (uk) 2004-11-15
SG88782A1 (en) 2002-05-21
ATE237333T1 (de) 2003-05-15
JP2000355542A (ja) 2000-12-26
KR100258396B1 (ko) 2000-08-01
CA2305758A1 (en) 1993-03-18
AU1007799A (en) 1999-03-04
GB9118478D0 (en) 1991-10-16
GEP20022802B (en) 2002-09-25
NO995075D0 (no) 1999-10-18
EP0921130A3 (en) 2001-09-05
ES2193475T3 (es) 2003-11-01
NO20002595D0 (no) 2000-05-19
ATE194843T1 (de) 2000-08-15
SG103374A1 (en) 2004-04-29
HUT66097A (en) 1994-09-28
DE69231280D1 (de) 2000-08-24
KR100321019B1 (ko) 2002-03-20
DK0928609T3 (da) 2003-07-21
JP3581802B2 (ja) 2004-10-27
AU5837396A (en) 1996-09-05
JP2000038341A (ja) 2000-02-08
EP0641355A1 (en) 1995-03-08
DE69233053T2 (de) 2003-11-20
NO20044458L (no) 1994-04-29
EP0921130B1 (en) 2003-05-07
UA70956C2 (uk) 2004-11-15
SK282189B6 (sk) 2001-12-03
UA41875C2 (uk) 2001-10-15
NO314287B1 (no) 2003-03-03
RU2182152C2 (ru) 2002-05-10
LV12618A (en) 2001-02-20
SG103820A1 (en) 2004-05-26
NO308774B1 (no) 2000-10-30
CZ295939B6 (cs) 2005-12-14
RU2207134C2 (ru) 2003-06-27
JPH07501515A (ja) 1995-02-16
GEP20022766B (en) 2002-08-26
EP0982032B1 (en) 2003-08-06
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