FI118589B - Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkeaineina - Google Patents

Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkeaineina Download PDF

Info

Publication number: FI118589B
Authority: FI; Finland
Prior art keywords: phenyl; alkyl; alkoxy; methyl; alkylthio
Prior art date: 1994-03-31

Application number

FI963885A

Other languages

English (en)

Finnish (fi)

Swedish (sv)

Other versions

FI963885A (fi

FI963885A0 (fi

Inventor

Manfred Raschack

Liliane Unger

Siegfried Bialojan

Hartmut Riechers

Dagmar Klinge

Ernst Baumann

Joachim Rheinheimer

Uwe Josef Vogelbacher

Wolfgang Wernet

Claus Bollschweiler

Burkhard Kroeger

Original Assignee

Abbott Gmbh & Co Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-31

Filing date

1996-09-27

Publication date

2008-01-15

1996-09-27 Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg

1996-09-27 Publication of FI963885A0 publication Critical patent/FI963885A0/fi

1996-11-26 Publication of FI963885A publication Critical patent/FI963885A/fi

2008-01-15 Application granted granted Critical

2008-01-15 Publication of FI118589B publication Critical patent/FI118589B/fi

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

FI963885A 1994-03-31 1996-09-27 Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkeaineina FI118589B (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
DE4411225A DE4411225A1 (de)	1994-03-31	1994-03-31	Verwendung von Carbonsäurederivaten als Arzneimittel
DE4411225		1994-03-31
PCT/EP1995/001099 WO1995026716A1 (de)	1994-03-31	1995-03-23	Pyrimidin- oder triazincarbonsäurederivate zur verwendung als arzneimittel
EP9501099		1995-03-23

Publications (3)

Publication Number	Publication Date
FI963885A0 FI963885A0 (fi)	1996-09-27
FI963885A FI963885A (fi)	1996-11-26
FI118589B true FI118589B (fi)	2008-01-15

Family

ID=6514334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI963885A FI118589B (fi)	1994-03-31	1996-09-27	Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkeaineina

Country Status (28)

Country	Link
US (1)	US5840722A (pl)
EP (1)	EP0752854B1 (pl)
JP (2)	JP4001622B2 (pl)
KR (1)	KR100365629B1 (pl)
CN (1)	CN1070701C (pl)
AT (1)	ATE204471T1 (pl)
AU (1)	AU695193B2 (pl)
BR (1)	BR9507231A (pl)
CA (1)	CA2186784C (pl)
CZ (1)	CZ290684B6 (pl)
DE (2)	DE4411225A1 (pl)
DK (1)	DK0752854T3 (pl)
ES (1)	ES2162916T3 (pl)
FI (1)	FI118589B (pl)
GR (1)	GR3036606T3 (pl)
HR (1)	HRP950115B1 (pl)
HU (1)	HU228063B1 (pl)
IL (1)	IL113137A (pl)
NO (1)	NO310497B1 (pl)
NZ (1)	NZ283333A (pl)
PL (1)	PL179580B1 (pl)
PT (1)	PT752854E (pl)
RU (1)	RU2163808C2 (pl)
SI (1)	SI9520048A (pl)
TW (1)	TW382594B (pl)
UA (1)	UA44734C2 (pl)
WO (1)	WO1995026716A1 (pl)
ZA (1)	ZA952614B (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4411225A1 (de) *	1994-03-31	1995-10-05	Basf Ag	Verwendung von Carbonsäurederivaten als Arzneimittel
DE19533023B4 (de)	1994-10-14	2007-05-16	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19536891A1 (de) *	1995-10-04	1997-04-10	Basf Ag	Neue Aminosäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de)	1996-04-12	1997-10-16	Basf Ag	Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
DE19636046A1 (de)	1996-09-05	1998-03-12	Basf Ag	Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
US6030975A (en) *	1997-03-14	2000-02-29	Basf Aktiengesellschaft	Carboxylic acid derivatives, their preparation and use in treating cancer
DE19726146A1 (de) *	1997-06-19	1998-12-24	Basf Ag	Neue ß-Amino und ß-Azidopcarbonsäurederivate, ihre Herstellung und Verwendung als Endothelinrezeptorantagonisten
BR9811631A (pt) *	1997-09-04	2000-09-26	Basf Ag	Derivado de ácido carboxìlico e uso do mesmo
TR200001182T2 (tr)	1997-10-31	2000-11-21	Basf Aktiengesellschaft	Yeni karbonik asit türevleri, üretimleri ve kullanımları.
DE19806438A1 (de) *	1998-02-17	1999-08-19	Basf Ag	Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung
DE19809144A1 (de) *	1998-03-04	1999-09-09	Basf Ag	Neue unsymmetrisch substituierte Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶LAMBDA¶/ET¶B¶-Rezeptorantagonisten
DE19809635A1 (de)	1998-03-06	1999-09-09	Basf Ag	Verfahren zur Darstellung von Endothelinrezeptorantagonisten vom Sulfanyltyp
US7566452B1 (en)	1999-05-04	2009-07-28	New York University	Cancer treatment with endothelin receptor antagonists
WO2002064573A1 (de) *	2001-02-14	2002-08-22	Abbott Gmbh & Co. Kg	Neue carbonsäurederivate mit alkylsubstituierten triazinen, ihre herstellung und verwendung als endothelin-rezeptorantagonisten
US20040204422A1 (en) *	2003-04-14	2004-10-14	Abbott Gmbh & Co. Kg.	N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
EP2118073A2 (en) *	2007-02-02	2009-11-18	Concert Pharmaceuticals Inc.	Selective endothelin type-a antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69226813T2 (de) *	1991-06-07	1999-02-18	Ube Industries	Pyrimidin- oder Triazin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Herbizide
DE4313412A1 (de) *	1993-04-23	1994-10-27	Basf Ag	3-(Het)aryl-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung
DE4411225A1 (de) *	1994-03-31	1995-10-05	Basf Ag	Verwendung von Carbonsäurederivaten als Arzneimittel

1994
- 1994-03-31 DE DE4411225A patent/DE4411225A1/de not_active Withdrawn
1995
- 1995-03-09 HR HR950115A patent/HRP950115B1/xx not_active IP Right Cessation
- 1995-03-23 CA CA002186784A patent/CA2186784C/en not_active Expired - Lifetime
- 1995-03-23 SI SI9520048A patent/SI9520048A/sl unknown
- 1995-03-23 PT PT95914301T patent/PT752854E/pt unknown
- 1995-03-23 EP EP95914301A patent/EP0752854B1/de not_active Expired - Lifetime
- 1995-03-23 PL PL95316563A patent/PL179580B1/pl unknown
- 1995-03-23 DE DE59509537T patent/DE59509537D1/de not_active Expired - Lifetime
- 1995-03-23 AU AU21356/95A patent/AU695193B2/en not_active Expired
- 1995-03-23 KR KR1019960705420A patent/KR100365629B1/ko not_active IP Right Cessation
- 1995-03-23 DK DK95914301T patent/DK0752854T3/da active
- 1995-03-23 JP JP52539195A patent/JP4001622B2/ja not_active Expired - Lifetime
- 1995-03-23 US US08/718,377 patent/US5840722A/en not_active Expired - Lifetime
- 1995-03-23 RU RU96121628/14A patent/RU2163808C2/ru active
- 1995-03-23 BR BR9507231A patent/BR9507231A/pt not_active Application Discontinuation
- 1995-03-23 ES ES95914301T patent/ES2162916T3/es not_active Expired - Lifetime
- 1995-03-23 CZ CZ19962873A patent/CZ290684B6/cs not_active IP Right Cessation
- 1995-03-23 WO PCT/EP1995/001099 patent/WO1995026716A1/de active IP Right Grant
- 1995-03-23 NZ NZ283333A patent/NZ283333A/en not_active IP Right Cessation
- 1995-03-23 UA UA96104109A patent/UA44734C2/uk unknown
- 1995-03-23 AT AT95914301T patent/ATE204471T1/de active
- 1995-03-23 HU HU9602695A patent/HU228063B1/hu unknown
- 1995-03-23 CN CN95193167A patent/CN1070701C/zh not_active Expired - Lifetime
- 1995-03-27 IL IL11313795A patent/IL113137A/xx not_active IP Right Cessation
- 1995-03-28 TW TW084103012A patent/TW382594B/zh not_active IP Right Cessation
- 1995-03-30 ZA ZA952614A patent/ZA952614B/xx unknown
1996
- 1996-09-27 FI FI963885A patent/FI118589B/fi not_active IP Right Cessation
- 1996-09-27 NO NO19964121A patent/NO310497B1/no not_active IP Right Cessation
2001
- 2001-09-12 GR GR20010401467T patent/GR3036606T3/el unknown
2007
- 2007-02-15 JP JP2007034659A patent/JP4769742B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH09510984A (ja)	1997-11-04
CZ287396A3 (en)	1997-04-16
DE4411225A1 (de)	1995-10-05
BR9507231A (pt)	1997-09-16
IL113137A (en)	1999-10-28
FI963885A (fi)	1996-11-26
CA2186784A1 (en)	1995-10-12
NO964121D0 (no)	1996-09-27
HRP950115A2 (en)	1997-10-31
NO310497B1 (no)	2001-07-16
UA44734C2 (uk)	2002-03-15
PT752854E (pt)	2002-02-28
CN1148807A (zh)	1997-04-30
HRP950115B1 (en)	2001-12-31
FI963885A0 (fi)	1996-09-27
KR970702042A (ko)	1997-05-13
DK0752854T3 (da)	2001-10-08
KR100365629B1 (ko)	2003-04-10
MX9604448A (es)	1997-07-31
HU9602695D0 (en)	1996-11-28
ATE204471T1 (de)	2001-09-15
SI9520048A (en)	1997-02-28
ES2162916T3 (es)	2002-01-16
IL113137A0 (en)	1995-06-29
JP4001622B2 (ja)	2007-10-31
NO964121L (no)	1996-11-26
CZ290684B6 (cs)	2002-09-11
ZA952614B (en)	1996-09-30
AU2135695A (en)	1995-10-23
DE59509537D1 (de)	2001-09-27
HU228063B1 (en)	2012-09-28
WO1995026716A1 (de)	1995-10-12
NZ283333A (en)	1997-02-24
JP4769742B2 (ja)	2011-09-07
EP0752854B1 (de)	2001-08-22
EP0752854A1 (de)	1997-01-15
GR3036606T3 (en)	2001-12-31
AU695193B2 (en)	1998-08-06
US5840722A (en)	1998-11-24
HUT75305A (en)	1997-05-28
RU2163808C2 (ru)	2001-03-10
PL316563A1 (en)	1997-01-20
PL179580B1 (pl)	2000-09-29
CN1070701C (zh)	2001-09-12
CA2186784C (en)	2007-02-20
TW382594B (en)	2000-02-21
JP2007131645A (ja)	2007-05-31

Legal Events

Date

Code

Title

Description

2008-01-15

FG

Patent granted

Ref document number: 118589

Country of ref document: FI

2014-03-04

PC

Transfer of assignment of patent

Owner name: ABBVIE DEUTSCHLAND GMBH & CO KG

2015-04-22

MA

Patent expired

Publication	Publication Date	Title
FI118589B (fi)	2008-01-15	Pyrimidiini- tai triatsiinikarboksyylihappojohdannaiset käytettäväksi lääkeaineina
EP0785926B1 (de)	2001-08-22	Carbonsäurederivate, ihre herstellung und verwendung als arzneimittel
JP6648137B2 (ja)	2020-02-14	ヘテロ環式誘導体およびその使用
EP0892786B1 (de)	2004-06-09	Neue carbonsäurederivate, ihre herstellung und verwendung
NZ337557A (en)	2001-08-31	Novel carboxylic acid derivatives, their preparation and use in treating cancer
CN112538038A (zh)	2021-03-23	2-吲哚酮类ERRα反向激动剂及其药物组合物和应用
DE19533025A1 (de)	1997-03-13	Neue Carbonsäurederivate, ihre Herstellung und Verwendung
BG104577A (bg)	2001-03-30	Производни на 5-заместени пиримидин-2-илокси-карбоксилни киселини, тяхното получаване и използване като ендотелин-антагонисти
AU1487899A (en)	1999-06-07	Novel heterocyclically substituted alpha-hydroxycarboxlic acid derivatives, method for producing the same and their use as endothelin receptor antagonists
JP2002533330A (ja)	2002-10-08	新規のβ−アミドおよびβ−スルホンアミドカルボン酸誘導体、これらの製造およびエンドセリン受容体アンタゴニストとしてのこれらの使用
CZ324199A3 (cs)	2000-07-12	Léčivo k zabránění růstu solidního tumoru u člověka a způsob jeho výroby
JP2002505324A (ja)	2002-02-19	不斉に置換された新規のカルボン酸誘導体、その製造方法ならびに混合ｅｔａ／ｅｔｂ受容体アンタゴニストとしての使用
CZ20014312A3 (cs)	2003-02-12	Nové deriváty karboxylových kyselin obsahující dusíkaté heterocyklické kruhy substituované arylovou skupinou, způsob jejich přípravy a použití jako antagonistů receptorů endothelinu
DE19836044A1 (de)	2000-02-17	Neue Carbonsäurederivate, die Ketoseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten
CZ20003219A3 (cs)	2000-12-13	Nové nesymetricky subtituované deriváty karboxylových kyselin, jejich přípravy a použití jako smíšených antagonistů ETA/ETB receptorů
DE19752904A1 (de)	1999-07-15	Neue Carbonsäurederivate, die Amidseitenketten tragen, ihre Herstellung und Verwendung als Endothelin-Rezeptorantagonisten