ES8703444A1 - Procedimiento para preparar derivados monobasicos de disobutamida. - Google Patents
Procedimiento para preparar derivados monobasicos de disobutamida.Info
- Publication number
- ES8703444A1 ES8703444A1 ES552004A ES552004A ES8703444A1 ES 8703444 A1 ES8703444 A1 ES 8703444A1 ES 552004 A ES552004 A ES 552004A ES 552004 A ES552004 A ES 552004A ES 8703444 A1 ES8703444 A1 ES 8703444A1
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- methylene
- disobutamide
- monobasic
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
PROCEDIMIENTO PARA PREPARAR DERIVADOS MONOBASICOS DE DISOBUTAMIDA, DE FORMULA (I), Y DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II) CON 1-(CLOROACETIL)PIPERIDINA PARA FORMAR UN COMPUESTO DE FORMULA (I) EN LA QUE R2 Y R3 REPRESENTAN ALQUILO INFERIOR, X E Y PUEDEN SER VARIOS TIPOS DE RADICALES, Y N VALE 1 A 3. LA REACCION SE LLEVA A CABO EN N,N-DIMETILFORMAMIDA, EN PRESENCIA DE HIDRURO SODICO, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIARRITMICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/628,933 US4639524A (en) | 1984-07-09 | 1984-07-09 | Monobasic disobutamide derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES552004A0 ES552004A0 (es) | 1987-02-16 |
ES8703444A1 true ES8703444A1 (es) | 1987-02-16 |
Family
ID=24520909
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544955A Expired ES8703442A1 (es) | 1984-07-09 | 1985-07-08 | Procedimiento para preparar derivados monobasicos de disobu-tamida |
ES552004A Expired ES8703444A1 (es) | 1984-07-09 | 1986-02-14 | Procedimiento para preparar derivados monobasicos de disobutamida. |
ES552003A Expired ES8703443A1 (es) | 1984-07-09 | 1986-02-14 | Procedimiento para preparar derivados monobasicos de disobutamida. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES544955A Expired ES8703442A1 (es) | 1984-07-09 | 1985-07-08 | Procedimiento para preparar derivados monobasicos de disobu-tamida |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552003A Expired ES8703443A1 (es) | 1984-07-09 | 1986-02-14 | Procedimiento para preparar derivados monobasicos de disobutamida. |
Country Status (18)
Country | Link |
---|---|
US (1) | US4639524A (es) |
EP (1) | EP0170901B1 (es) |
JP (1) | JPH0645592B2 (es) |
AT (1) | ATE60597T1 (es) |
AU (1) | AU583831B2 (es) |
CA (1) | CA1261846A (es) |
DE (1) | DE3581569D1 (es) |
DK (1) | DK168013B1 (es) |
ES (3) | ES8703442A1 (es) |
FI (1) | FI83217C (es) |
GR (1) | GR851683B (es) |
IE (1) | IE60674B1 (es) |
IL (1) | IL75741A (es) |
NO (1) | NO166713C (es) |
NZ (1) | NZ212670A (es) |
PH (1) | PH22282A (es) |
PT (1) | PT80787B (es) |
ZA (1) | ZA855125B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8609630D0 (en) * | 1986-04-19 | 1986-05-21 | Pfizer Ltd | Anti-arrhythmia agents |
US5276155A (en) * | 1991-12-20 | 1994-01-04 | G. D. Searle & Co. | Process for the resolution of (±)-α-[2-[acetyl(1-methylethyl)amino]ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide |
US5432284A (en) * | 1993-09-08 | 1995-07-11 | G. D. Searle & Co. | Process for the preparation of heterocyclic alkylamide derivatives |
US5731435A (en) * | 1995-05-03 | 1998-03-24 | G. D. Searle & Co. | Process for the preparation of heterocyclic alkylamide derivatives |
US6190769B1 (en) | 1999-02-19 | 2001-02-20 | E. I. Du Pont De Nemours And Company | Abrasive filaments of plasticized polyamides |
KR101627503B1 (ko) | 2015-02-11 | 2016-06-07 | 주식회사 썸백 | 고온 진공 열처리로의 이송장치 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2776282A (en) * | 1954-05-04 | 1957-01-01 | Searle & Co | Cyclic amides of alpha-toluic acids and derivatives thereof |
GB796839A (en) * | 1955-06-23 | 1958-06-18 | Pharmacia Ab | N,n-disubstituted amides of aryl acetic acids |
GB964719A (en) * | 1961-09-12 | 1964-07-22 | Prodotti Schering Soc It | Malonic acid derivatives |
GB1008470A (en) * | 1962-09-17 | 1965-10-27 | Bellon Labor Sa Roger | New cyanacetamide derivatives |
BE689347A (es) * | 1965-12-09 | 1967-04-14 | Madan Ag | |
GB1178400A (en) * | 1966-12-13 | 1970-01-21 | Delalande Sa | Nitrogen Substituted Amines and their process of Preparation. |
GB1458537A (es) * | 1973-12-15 | 1976-12-15 | ||
US4107205A (en) * | 1977-03-11 | 1978-08-15 | G. D. Searle & Co. | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds |
US4217306A (en) * | 1978-05-01 | 1980-08-12 | G. D. Searle & Co. | α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides |
-
1984
- 1984-07-09 US US06/628,933 patent/US4639524A/en not_active Expired - Fee Related
-
1985
- 1985-07-08 IL IL75741A patent/IL75741A/xx not_active IP Right Cessation
- 1985-07-08 DK DK311585A patent/DK168013B1/da not_active IP Right Cessation
- 1985-07-08 ES ES544955A patent/ES8703442A1/es not_active Expired
- 1985-07-08 ZA ZA855125A patent/ZA855125B/xx unknown
- 1985-07-08 FI FI852693A patent/FI83217C/fi not_active IP Right Cessation
- 1985-07-08 DE DE8585108451T patent/DE3581569D1/de not_active Expired - Fee Related
- 1985-07-08 EP EP85108451A patent/EP0170901B1/en not_active Expired - Lifetime
- 1985-07-08 NZ NZ212670A patent/NZ212670A/en unknown
- 1985-07-08 GR GR851683A patent/GR851683B/el unknown
- 1985-07-08 PT PT80787A patent/PT80787B/pt not_active IP Right Cessation
- 1985-07-08 CA CA000486464A patent/CA1261846A/en not_active Expired
- 1985-07-08 NO NO852748A patent/NO166713C/no unknown
- 1985-07-08 JP JP60149870A patent/JPH0645592B2/ja not_active Expired - Lifetime
- 1985-07-08 AU AU44664/85A patent/AU583831B2/en not_active Ceased
- 1985-07-08 AT AT85108451T patent/ATE60597T1/de active
- 1985-07-09 IE IE172885A patent/IE60674B1/en not_active IP Right Cessation
- 1985-07-09 PH PH32502A patent/PH22282A/en unknown
-
1986
- 1986-02-14 ES ES552004A patent/ES8703444A1/es not_active Expired
- 1986-02-14 ES ES552003A patent/ES8703443A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NO852748L (no) | 1986-01-10 |
IE60674B1 (en) | 1994-08-10 |
GR851683B (es) | 1985-11-26 |
IL75741A (en) | 1989-06-30 |
US4639524A (en) | 1987-01-27 |
IE851728L (en) | 1986-01-09 |
CA1261846A (en) | 1989-09-26 |
PT80787B (pt) | 1987-09-18 |
ES544955A0 (es) | 1987-02-16 |
JPS6136258A (ja) | 1986-02-20 |
ES552003A0 (es) | 1987-02-16 |
ZA855125B (en) | 1986-09-24 |
FI83217B (fi) | 1991-02-28 |
ES8703442A1 (es) | 1987-02-16 |
NZ212670A (en) | 1988-04-29 |
ATE60597T1 (de) | 1991-02-15 |
IL75741A0 (en) | 1985-11-29 |
FI852693A0 (fi) | 1985-07-08 |
DK311585A (da) | 1986-01-10 |
DK311585D0 (da) | 1985-07-08 |
JPH0645592B2 (ja) | 1994-06-15 |
AU4466485A (en) | 1986-01-16 |
AU583831B2 (en) | 1989-05-11 |
FI852693L (fi) | 1986-01-10 |
DK168013B1 (da) | 1994-01-17 |
EP0170901A1 (en) | 1986-02-12 |
ES8703443A1 (es) | 1987-02-16 |
ES552004A0 (es) | 1987-02-16 |
DE3581569D1 (de) | 1991-03-07 |
NO166713C (no) | 1991-09-04 |
NO166713B (no) | 1991-05-21 |
EP0170901B1 (en) | 1991-01-30 |
PH22282A (en) | 1988-07-14 |
FI83217C (fi) | 1991-06-10 |
PT80787A (en) | 1985-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH23739A (en) | Piperidine derivative and pharmaceutical composition | |
ATE23716T1 (de) | 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. | |
ES482112A1 (es) | Procedimiento de preparacion de nuevos derivados de 3,20- dioxo-4,9-dieno-21-hidroxilo-esteroides. | |
ES8205791A1 (es) | Procedimiento para la preparacion de derivados de imidazol del sistema de 1,4-benzodioxan-2-ilo | |
ES8703444A1 (es) | Procedimiento para preparar derivados monobasicos de disobutamida. | |
FI823465A0 (fi) | Foerfarande foer framstaellning av nya alkan- och alkenderivat | |
ES8104241A1 (es) | Un procedimiento para la preparacion de compuestos derivadosde 1-((naftil substituido)etil)imidazol | |
ES8506011A1 (es) | Procedimiento para la obtencion de un derivado de tetrahidrobenzotiazol | |
ES8307233A1 (es) | Procedimiento para preparar derivados del acido 1,4-tiazan-3-carboxilico. | |
ES8407482A1 (es) | Un procedimiento para la preparacion de nuevos derivados de acidos alquiloxazolilaceticos. | |
ES481057A1 (es) | Procedimiento para preparar una composicion protectora de - plantas que comprende como antidoto un derivado de 1,4-oxa- za-spirohidrocarburo. | |
ES8705426A1 (es) | Un procedimiento para la preparacion de un derivado de piperazina. | |
GR3005900T3 (es) | ||
ES8602789A1 (es) | Procedimiento para preparar derivados de 14-hidroxiimino- eburnano racemicos y opticamente activos |