ATE60597T1 - Monobasische disobutamidderivate. - Google Patents

Monobasische disobutamidderivate.

Info

Publication number
ATE60597T1
ATE60597T1 AT85108451T AT85108451T ATE60597T1 AT E60597 T1 ATE60597 T1 AT E60597T1 AT 85108451 T AT85108451 T AT 85108451T AT 85108451 T AT85108451 T AT 85108451T AT E60597 T1 ATE60597 T1 AT E60597T1
Authority
AT
Austria
Prior art keywords
lower alkyl
methylene
disobutamide
monobasic
derivatives
Prior art date
Application number
AT85108451T
Other languages
English (en)
Inventor
Bioinchandra Nanubhai Desai
Robert John Chorvat
Kurt Joachim Rorig
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE60597T1 publication Critical patent/ATE60597T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • C07D207/2632-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/272-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182Radicals derived from carboxylic acids
    • C07D295/185Radicals derived from carboxylic acids from aliphatic carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
AT85108451T 1984-07-09 1985-07-08 Monobasische disobutamidderivate. ATE60597T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/628,933 US4639524A (en) 1984-07-09 1984-07-09 Monobasic disobutamide derivatives
EP85108451A EP0170901B1 (de) 1984-07-09 1985-07-08 Monobasische Disobutamidderivate

Publications (1)

Publication Number Publication Date
ATE60597T1 true ATE60597T1 (de) 1991-02-15

Family

ID=24520909

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85108451T ATE60597T1 (de) 1984-07-09 1985-07-08 Monobasische disobutamidderivate.

Country Status (18)

Country Link
US (1) US4639524A (de)
EP (1) EP0170901B1 (de)
JP (1) JPH0645592B2 (de)
AT (1) ATE60597T1 (de)
AU (1) AU583831B2 (de)
CA (1) CA1261846A (de)
DE (1) DE3581569D1 (de)
DK (1) DK168013B1 (de)
ES (3) ES8703442A1 (de)
FI (1) FI83217C (de)
GR (1) GR851683B (de)
IE (1) IE60674B1 (de)
IL (1) IL75741A (de)
NO (1) NO166713C (de)
NZ (1) NZ212670A (de)
PH (1) PH22282A (de)
PT (1) PT80787B (de)
ZA (1) ZA855125B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
US5276155A (en) * 1991-12-20 1994-01-04 G. D. Searle & Co. Process for the resolution of (±)-α-[2-[acetyl(1-methylethyl)amino]ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide
US5432284A (en) * 1993-09-08 1995-07-11 G. D. Searle & Co. Process for the preparation of heterocyclic alkylamide derivatives
US5731435A (en) * 1995-05-03 1998-03-24 G. D. Searle & Co. Process for the preparation of heterocyclic alkylamide derivatives
US6190769B1 (en) 1999-02-19 2001-02-20 E. I. Du Pont De Nemours And Company Abrasive filaments of plasticized polyamides
KR101627503B1 (ko) 2015-02-11 2016-06-07 주식회사 썸백 고온 진공 열처리로의 이송장치

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776282A (en) * 1954-05-04 1957-01-01 Searle & Co Cyclic amides of alpha-toluic acids and derivatives thereof
GB796839A (en) * 1955-06-23 1958-06-18 Pharmacia Ab N,n-disubstituted amides of aryl acetic acids
GB964719A (en) * 1961-09-12 1964-07-22 Prodotti Schering Soc It Malonic acid derivatives
GB1008470A (en) * 1962-09-17 1965-10-27 Bellon Labor Sa Roger New cyanacetamide derivatives
BE689347A (de) * 1965-12-09 1967-04-14 Madan Ag
GB1178400A (en) * 1966-12-13 1970-01-21 Delalande Sa Nitrogen Substituted Amines and their process of Preparation.
GB1458537A (de) * 1973-12-15 1976-12-15
US4107205A (en) * 1977-03-11 1978-08-15 G. D. Searle & Co. α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]acetamides and related compounds
US4217306A (en) * 1978-05-01 1980-08-12 G. D. Searle & Co. α-Aryl-α,α-bis[ω-(disubstituted amino)alkyl]-acetamides

Also Published As

Publication number Publication date
NO852748L (no) 1986-01-10
IE60674B1 (en) 1994-08-10
GR851683B (de) 1985-11-26
IL75741A (en) 1989-06-30
US4639524A (en) 1987-01-27
IE851728L (en) 1986-01-09
CA1261846A (en) 1989-09-26
PT80787B (pt) 1987-09-18
ES544955A0 (es) 1987-02-16
JPS6136258A (ja) 1986-02-20
ES552003A0 (es) 1987-02-16
ZA855125B (en) 1986-09-24
FI83217B (fi) 1991-02-28
ES8703442A1 (es) 1987-02-16
NZ212670A (en) 1988-04-29
IL75741A0 (en) 1985-11-29
FI852693A0 (fi) 1985-07-08
DK311585A (da) 1986-01-10
DK311585D0 (da) 1985-07-08
JPH0645592B2 (ja) 1994-06-15
AU4466485A (en) 1986-01-16
AU583831B2 (en) 1989-05-11
FI852693L (fi) 1986-01-10
DK168013B1 (da) 1994-01-17
EP0170901A1 (de) 1986-02-12
ES8703443A1 (es) 1987-02-16
ES552004A0 (es) 1987-02-16
DE3581569D1 (de) 1991-03-07
NO166713C (no) 1991-09-04
NO166713B (no) 1991-05-21
EP0170901B1 (de) 1991-01-30
PH22282A (en) 1988-07-14
ES8703444A1 (es) 1987-02-16
FI83217C (fi) 1991-06-10
PT80787A (en) 1985-08-01

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