ES8506324A1 - Procedimiento para la fabricacion de 4'-demetil-epipodofilotoxin-b-d-etiliden-glucosido y derivado acilico del mismo - Google Patents
Procedimiento para la fabricacion de 4'-demetil-epipodofilotoxin-b-d-etiliden-glucosido y derivado acilico del mismoInfo
- Publication number
- ES8506324A1 ES8506324A1 ES525743A ES525743A ES8506324A1 ES 8506324 A1 ES8506324 A1 ES 8506324A1 ES 525743 A ES525743 A ES 525743A ES 525743 A ES525743 A ES 525743A ES 8506324 A1 ES8506324 A1 ES 8506324A1
- Authority
- ES
- Spain
- Prior art keywords
- acyl
- derivative
- epipodophyllotoxin
- demethyl
- glucoside
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE FABRICACION DE 4-DEMETIL-EPIPOFILOTOXIN-B-D-ETILIDEN-GLUCOSIDO Y DERIVADO ACILICO DEL MISMO.COMPRENDE EL SOMETER EL 4-HALOGENOACETIL-4-DEMETIL-EPIPODOFILOTOXIN-B-D-2,3-DI-0-HALOGENOACETIL-4,6-0-ETILIDEN-GLUCOSIDO DE FORMULA (II), A ALCOHOLISIS EN PRESENCIA DE UN CATALIZADOR COMO ETANOL, PROPANOL O METANOL, REALIZADA A TEMPERATURA ENTRE 40 Y 100JC, PARA ELIMINAR LOS GRUPOS HALOGENOACETILO, OBTENIENDOSE EL 4-DEMETIL-EPIPODOFILOTOXIN-B-D-ETILIDEN-GLUCOSIDO DE FORMULA (I).TIENE APLICACIONES MEDICAS POR SU ACTIVIDAD ANTITUMORAL Y COMO SUSTANCIA ANTICANCEROSA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20618882A JPS5998098A (ja) | 1982-11-26 | 1982-11-26 | 4′―デメチル―エピポドフィロトキシン―β―D―エチリデングルコシドの新規製造法 |
JP8586883A JPS59212500A (ja) | 1983-05-18 | 1983-05-18 | 4′−デメチル−エピポドフイロトキシン−β−D−エチリデングルコシドの新規製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES525743A0 ES525743A0 (es) | 1985-07-01 |
ES8506324A1 true ES8506324A1 (es) | 1985-07-01 |
Family
ID=26426870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES525743A Expired ES8506324A1 (es) | 1982-11-26 | 1983-09-19 | Procedimiento para la fabricacion de 4'-demetil-epipodofilotoxin-b-d-etiliden-glucosido y derivado acilico del mismo |
Country Status (7)
Country | Link |
---|---|
US (1) | US4564675A (es) |
EP (1) | EP0111058B1 (es) |
KR (1) | KR890000763B1 (es) |
DE (1) | DE3374317D1 (es) |
DK (1) | DK157031C (es) |
ES (1) | ES8506324A1 (es) |
FI (1) | FI71942C (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60246393A (ja) * | 1984-05-22 | 1985-12-06 | Nippon Kayaku Co Ltd | エトポシドの新規製造法 |
AU582758B2 (en) * | 1984-06-28 | 1989-04-13 | Mect Corporation | Sialic acid derivatives, galactose derivatives and method for producing the same |
US4895727A (en) * | 1985-05-03 | 1990-01-23 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for exhancing penetration and retention in the skin |
IL77334A (en) * | 1985-12-16 | 1991-04-15 | Univ Bar Ilan | Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor |
WO1988003799A1 (en) * | 1986-11-19 | 1988-06-02 | Chemex Pharmaceuticals, Inc. | Pharmaceutical vehicles for reducing transdermal flux |
US4916217A (en) * | 1987-01-08 | 1990-04-10 | Bristol-Myers Company | Phosphorus containing derivatives of epipodophyllotoxin |
US5716990A (en) * | 1987-03-09 | 1998-02-10 | Cancer Research Campaign Technology Limited | Drug delivery systems |
US4874851A (en) * | 1987-07-01 | 1989-10-17 | Bristol-Meyers Company | 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives |
US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
US4904768A (en) * | 1987-08-04 | 1990-02-27 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-phosphate derivatives |
US4868291A (en) * | 1987-08-20 | 1989-09-19 | Bristol-Myers Company | 4'-deshydroxyepipodophyllotoxin glucosides: synthesis and use |
ZA886810B (en) * | 1987-12-18 | 1989-08-30 | Bristol Myers Co | Epipodophyllotoxin glucoside 4'-acyl derivatives |
US4935504A (en) * | 1987-12-18 | 1990-06-19 | Bristol-Myers Company | Epipodophyllotoxin glucoside 4'-acyl derivatives |
US4958010A (en) * | 1988-02-16 | 1990-09-18 | Bristol-Myers Company | Epipodophyllotoxin glucoside lactam derivatives |
US5632990A (en) * | 1988-04-22 | 1997-05-27 | Cancer Research Campaign Tech. Ltd. | Treatment for tumors comprising conjugated antibody A5B7 and a prodrug |
US4912204A (en) * | 1988-09-06 | 1990-03-27 | Bristol-Myers Company | Fluoro-substituted epipodophyllotoxin glucosides |
US5061791A (en) * | 1988-12-21 | 1991-10-29 | Warner-Lambert Company | 4-bromo-4'-demethylepipodophyllotoxin derivatives |
DE3913326A1 (de) * | 1989-04-22 | 1990-11-08 | Behringwerke Ag | Verfahren zur herstellung von etoposiden |
US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
US5066645A (en) * | 1989-09-01 | 1991-11-19 | Bristol-Myers Company | Epipodophyllotoxin altroside derivatives |
FR2658824B1 (fr) * | 1990-02-27 | 1992-07-03 | Pf Medicament | Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine. |
US5081234A (en) * | 1990-04-30 | 1992-01-14 | Bristol-Myers Squibb Co. | 4'-demethylepipodophyllotoxin glycosides |
IT1250692B (it) * | 1991-07-23 | 1995-04-21 | Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. | |
JP3061476B2 (ja) * | 1992-04-24 | 2000-07-10 | 日本化薬株式会社 | エトポシド燐酸エステルの製造法 |
US5459248A (en) * | 1993-11-04 | 1995-10-17 | Bristol-Myers Squibb Company | Process of preparing etoposide phosphate and etoposide |
US5463040A (en) * | 1994-06-28 | 1995-10-31 | Teva Pharmaceutical Industries, Ltd. | Method of preparing etoposide |
US6207673B1 (en) | 1997-03-12 | 2001-03-27 | The University Of North Carolina At Chapel Hill | Covalent conjugates of topoisomerase I and topoisomerase II inhibitors |
US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
WO2000015647A2 (en) | 1998-09-10 | 2000-03-23 | Phytogen Life Sciences Inc. | Synthetic method for the preparation of the antineoplastic agent etoposide |
US6756063B2 (en) | 2001-03-29 | 2004-06-29 | Zoltan Laboratories, Llc | Methods and compositions for the treatment of human and animal cancers |
US7200207B2 (en) * | 2004-03-13 | 2007-04-03 | Intrado Inc. | Communication network for providing emergency services |
BRPI0606480A (pt) | 2005-01-21 | 2008-03-11 | Astex Therapeutics Ltd | compostos farmacêuticos |
WO2008044045A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
WO2008044041A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
KR102090740B1 (ko) | 2011-10-03 | 2020-03-18 | 엠엑스 아쥬바크 에이비 | 암 치료 및 식품 관련 화합물을 포함하는 의학 분야에서 양친매성 또는 소수성 분자를 위한 나노입자, 제조 방법 및 담체로의 용도 |
CN102603762A (zh) * | 2012-02-14 | 2012-07-25 | 上海金和生物技术有限公司 | 一种依托泊甙中间体的制备方法 |
WO2014163558A1 (en) | 2013-04-01 | 2014-10-09 | Moreinx Ab | Nanoparticles, composed of sterol and saponin from quillaja saponaria molina process for preparation and use thereof as carrier for amphipatic of hydrphobic molecules in fields of medicine including cancer treatment and food related compounds |
CN108129525B (zh) * | 2017-12-28 | 2019-11-22 | 山东铂源药业有限公司 | 一种依托泊苷中间体的制备方法 |
EP3616688A1 (en) | 2018-08-27 | 2020-03-04 | Centre National de la Recherche Scientifique - CNRS | Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents |
EP3669890A1 (en) | 2018-12-18 | 2020-06-24 | Croda International PLC | Filamentous nanoparticles having vaccine adjuvant effect |
CN115141208B (zh) * | 2022-08-05 | 2024-03-08 | 贵州大学 | 一种含各类酯基结构的鬼臼毒素类化合物及其制备方法和应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL6613143A (es) * | 1965-09-21 | 1967-03-22 | ||
CH514578A (de) * | 1968-02-27 | 1971-10-31 | Sandoz Ag | Verfahren zur Herstellung von Glucosiden |
US4147860A (en) * | 1976-07-13 | 1979-04-03 | E. I. Du Pont De Nemours And Company | Process for preparing nitroaromatic glycosides |
-
1983
- 1983-09-03 DE DE8383108701T patent/DE3374317D1/de not_active Expired
- 1983-09-03 EP EP83108701A patent/EP0111058B1/en not_active Expired
- 1983-09-06 US US06/529,749 patent/US4564675A/en not_active Expired - Lifetime
- 1983-09-12 KR KR1019830004276A patent/KR890000763B1/ko not_active IP Right Cessation
- 1983-09-19 FI FI833334A patent/FI71942C/fi not_active IP Right Cessation
- 1983-09-19 ES ES525743A patent/ES8506324A1/es not_active Expired
- 1983-09-19 DK DK425583A patent/DK157031C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI71942C (fi) | 1987-03-09 |
ES525743A0 (es) | 1985-07-01 |
FI833334A (fi) | 1984-05-27 |
DK157031B (da) | 1989-10-30 |
EP0111058B1 (en) | 1987-11-04 |
KR890000763B1 (ko) | 1989-04-05 |
FI71942B (fi) | 1986-11-28 |
DK157031C (da) | 1990-03-26 |
FI833334A0 (fi) | 1983-09-19 |
DE3374317D1 (en) | 1987-12-10 |
DK425583D0 (da) | 1983-09-19 |
EP0111058A1 (en) | 1984-06-20 |
KR840006672A (ko) | 1984-12-01 |
DK425583A (da) | 1984-05-27 |
US4564675A (en) | 1986-01-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20041102 |