IT1250692B - Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. - Google Patents

Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Info

Publication number
IT1250692B
IT1250692B ITMI912025A ITMI912025A IT1250692B IT 1250692 B IT1250692 B IT 1250692B IT MI912025 A ITMI912025 A IT MI912025A IT MI912025 A ITMI912025 A IT MI912025A IT 1250692 B IT1250692 B IT 1250692B
Authority
IT
Italy
Prior art keywords
demetylepipodophylotoxy
glucosides
beta
procedure
preparation
Prior art date
Application number
ITMI912025A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11360401&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1250692(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Priority to ITMI912025A priority Critical patent/IT1250692B/it
Publication of ITMI912025A0 publication Critical patent/ITMI912025A0/it
Priority to EP92915482A priority patent/EP0595888B1/en
Priority to AT92915482T priority patent/ATE159026T1/de
Priority to DE69222643T priority patent/DE69222643T2/de
Priority to PCT/EP1992/001605 priority patent/WO1993002094A1/en
Priority to JP50258193A priority patent/JP3231765B2/ja
Priority to CA002113894A priority patent/CA2113894C/en
Priority to DK92915482.1T priority patent/DK0595888T3/da
Priority to ES92915482T priority patent/ES2107546T3/es
Priority to AU23265/92A priority patent/AU666322B2/en
Priority to ZA925515A priority patent/ZA925515B/xx
Priority to IL102610A priority patent/IL102610A/xx
Priority to MX9204334A priority patent/MX9204334A/es
Publication of ITMI912025A1 publication Critical patent/ITMI912025A1/it
Priority to FI940280A priority patent/FI110782B/fi
Publication of IT1250692B publication Critical patent/IT1250692B/it
Application granted granted Critical
Priority to US08/441,210 priority patent/US5688925A/en
Priority to GR970403378T priority patent/GR3025729T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Si descrive un procedimento migliorato per la produzione di DMEP-glicosidi, in particolare Etoposide e Teniposide, e relativi intermedi.
ITMI912025A 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi. IT1250692B (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
AU23265/92A AU666322B2 (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin
DK92915482.1T DK0595888T3 (da) 1991-07-23 1992-07-15 Fremgangsmåde til fremstilling af demethylepipodophyllotoxin
AT92915482T ATE159026T1 (de) 1991-07-23 1992-07-15 Verfahren zur herstellung von demethylepypodophyllotoxin
DE69222643T DE69222643T2 (de) 1991-07-23 1992-07-15 Verfahren zur herstellung von demethylepypodophyllotoxin
PCT/EP1992/001605 WO1993002094A1 (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin
JP50258193A JP3231765B2 (ja) 1991-07-23 1992-07-15 デメチルエピポドフィロトキシンの製造方法
CA002113894A CA2113894C (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin
EP92915482A EP0595888B1 (en) 1991-07-23 1992-07-15 A process for the preparation of demethylepypodophyllotoxin
ES92915482T ES2107546T3 (es) 1991-07-23 1992-07-15 Procedimiento para la preparacion de desmetilepipodofilotoxina.
IL102610A IL102610A (en) 1991-07-23 1992-07-22 Process for the preparation of demethylepipodoph- yllotoxin -b-d- glucosides and certain novel b-d- glucosides
ZA925515A ZA925515B (en) 1991-07-23 1992-07-22 A process for the preparation of demethylepypodophyllotoxin
MX9204334A MX9204334A (es) 1991-07-23 1992-07-23 Procedimiento para la preparacion de dimetil pipodo fillo toxina.
FI940280A FI110782B (fi) 1991-07-23 1994-01-20 Demetyyliepipodofyllotoksiini-beeta-D-glukosidit, menetelmä niiden valmistamiseksi, beeta-D-glukoosijohdannaiset ja menetelmät demetyyliepipodofyllotoksiini-beeta-D-glukoosin dimeerien valmistamiseksi
US08/441,210 US5688925A (en) 1991-07-23 1995-05-15 Intermediates for the preparation of demethylepipodophyllotoxin
GR970403378T GR3025729T3 (en) 1991-07-23 1997-12-22 A process for the preparation of demethylepypodophyllotoxin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Publications (3)

Publication Number Publication Date
ITMI912025A0 ITMI912025A0 (it) 1991-07-23
ITMI912025A1 ITMI912025A1 (it) 1993-01-24
IT1250692B true IT1250692B (it) 1995-04-21

Family

ID=11360401

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912025A IT1250692B (it) 1991-07-23 1991-07-23 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.

Country Status (16)

Country Link
US (1) US5688925A (it)
EP (1) EP0595888B1 (it)
JP (1) JP3231765B2 (it)
AT (1) ATE159026T1 (it)
AU (1) AU666322B2 (it)
CA (1) CA2113894C (it)
DE (1) DE69222643T2 (it)
DK (1) DK0595888T3 (it)
ES (1) ES2107546T3 (it)
FI (1) FI110782B (it)
GR (1) GR3025729T3 (it)
IL (1) IL102610A (it)
IT (1) IT1250692B (it)
MX (1) MX9204334A (it)
WO (1) WO1993002094A1 (it)
ZA (1) ZA925515B (it)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL119749A (en) * 1995-12-04 2001-03-19 Nippon Kayaku Kk Process for producing etoposide
AU728986B2 (en) * 1997-06-02 2001-01-25 Bristol-Myers Squibb Company Process for preparing etoposide
CA2343803A1 (en) 1998-09-10 2000-03-23 Ragina Naidu Synthetic method for the preparation of the antineoplastic agent etoposide
FR2791681B1 (fr) * 1999-03-29 2001-06-22 Pf Medicament Nouveau procede de preparation de l'etoposide
GB0019124D0 (en) * 2000-08-03 2000-09-27 Pfizer Novel process
KR101345002B1 (ko) 2005-01-21 2013-12-31 아스텍스 테라퓨틱스 리미티드 제약 화합물
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
AU2012319239B2 (en) 2011-10-03 2017-04-20 Mx Adjuvac Ab Nanoparticles, process for preparation and use thereof as carrier for amphipatic of hydrophobic molecules in fields of medicine including cancer treatment and food related compounds
US9907846B2 (en) 2013-04-01 2018-03-06 Mx Adjuvac Ab Nanoparticles, composed of sterol and saponin from Quillaja saponaria Molina for use in pharmaceutical compositions
EP3616688A1 (en) 2018-08-27 2020-03-04 Centre National de la Recherche Scientifique - CNRS Preparation of nanosuspension comprising nanocrystals of active pharmaceutical ingredients with little or no stabilizing agents
EP3669890A1 (en) 2018-12-18 2020-06-24 Croda International PLC Filamentous nanoparticles having vaccine adjuvant effect
CN113121618A (zh) * 2021-04-07 2021-07-16 梯尔希（南京）药物研发有限公司 两种依托泊苷杂质的制备方法
CN115197281A (zh) * 2021-04-09 2022-10-18 四川汇宇制药股份有限公司 依托泊苷中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374317D1 (en) * 1982-11-26 1987-12-10 Nippon Kayaku Kk Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
DK39886D0 (da) * 1986-01-27 1986-01-27 Hans Goeran Magnusson Hydroxybeskyttelsesgrupper
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
DE3935016A1 (de) * 1989-10-20 1991-04-25 Behringwerke Ag Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
FR2658824B1 (fr) * 1990-02-27 1992-07-03 Pf Medicament Tris acetyl-2",3",4' ethylidene-4",6" beta-d-glucopyranosides, leur preparation et leur utilisation pour la preparation d'ethylidene beta-d-glucopyranoside de demethyl-4' epipodophyllotoxine.
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
CN1025918C (zh) * 1990-06-07 1994-09-14 国家医药管理局上海医药工业研究院 抗肿瘤药表鬼臼毒吡喃糖甙的合成新工艺

Also Published As

Publication number Publication date
CA2113894C (en) 2003-12-16
AU2326592A (en) 1993-02-23
ITMI912025A1 (it) 1993-01-24
ES2107546T3 (es) 1997-12-01
AU666322B2 (en) 1996-02-08
FI940280A0 (fi) 1994-01-20
ZA925515B (en) 1993-04-28
JPH06509334A (ja) 1994-10-20
CA2113894A1 (en) 1993-02-04
ATE159026T1 (de) 1997-10-15
GR3025729T3 (en) 1998-03-31
ITMI912025A0 (it) 1991-07-23
IL102610A (en) 1997-03-18
DE69222643T2 (de) 1998-02-05
FI110782B (fi) 2003-03-31
MX9204334A (es) 1993-02-01
WO1993002094A1 (en) 1993-02-04
EP0595888A1 (en) 1994-05-11
US5688925A (en) 1997-11-18
FI940280A (fi) 1994-01-20
DK0595888T3 (da) 1998-05-18
JP3231765B2 (ja) 2001-11-26
EP0595888B1 (en) 1997-10-08
DE69222643D1 (de) 1997-11-13

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970729