ES8502704A1 - Un procedimiento para la preparacion de antibioticos b-lactamicos. - Google Patents

Un procedimiento para la preparacion de antibioticos b-lactamicos.

Info

Publication number
ES8502704A1
ES8502704A1 ES520971A ES520971A ES8502704A1 ES 8502704 A1 ES8502704 A1 ES 8502704A1 ES 520971 A ES520971 A ES 520971A ES 520971 A ES520971 A ES 520971A ES 8502704 A1 ES8502704 A1 ES 8502704A1
Authority
ES
Spain
Prior art keywords
carbon atom
bonded via
organic group
group bonded
atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520971A
Other languages
English (en)
Other versions
ES520971A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8502704A1 publication Critical patent/ES8502704A1/es
Publication of ES520971A0 publication Critical patent/ES520971A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ANTIBIOTICOS BBB-LACTAMICOS, DE FORMULA (I) EN LA QUE R Y R REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO ORGAMICO UNIDO A TRAVES DE UN ATOMO DE CARBONO AL ANILLO DE AZABICICLOHEPTENO; Y R Y R REPRESENTAN CADA UNO DE ELLOS UN GRUPO ORGANICO UNIDO A TRAVES DE UN ATOMO DE CARBONO AL ANILLO DE AZABICICLOHEPTENO, Y SUS SALES Y ESTERES FARMACEUTICAMENTE ACEPTABLES.CONSISTE EN SOMETER A UNA REACCION DE ELIMINACION DE LA MOLECULA: RRRPFO DE UN ESTER DE UN COMPUESTO DE FORMULA (II), Y A CONTINUACION SEPARAR CUALQUIER GRUPO BLOQUEANTE DE CARBOXI O CONVERTIR EL PRODUCTO EN UNA SAL O EN UN ESTER, FARMACEUTICAMENTE ACEPTABLES.DE APLICACION COMO AGENTES ANTIBACTERIANOS.
ES520971A 1981-03-04 1983-03-24 Un procedimiento para la preparacion de antibioticos b-lactamicos. Granted ES520971A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8106762 1981-03-04

Publications (2)

Publication Number Publication Date
ES8502704A1 true ES8502704A1 (es) 1984-05-16
ES520971A0 ES520971A0 (es) 1984-05-16

Family

ID=10520128

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510117A Expired ES8403488A1 (es) 1981-03-04 1982-03-03 Un procedimiento para la preparacion de antibioticos b-lactamicos.
ES520971A Granted ES520971A0 (es) 1981-03-04 1983-03-24 Un procedimiento para la preparacion de antibioticos b-lactamicos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510117A Expired ES8403488A1 (es) 1981-03-04 1982-03-03 Un procedimiento para la preparacion de antibioticos b-lactamicos.

Country Status (5)

Country Link
EP (1) EP0060077A1 (es)
JP (1) JPS57158786A (es)
AU (1) AU8113282A (es)
ES (2) ES8403488A1 (es)
ZA (1) ZA821361B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES514240A0 (es) * 1981-08-03 1984-04-16 Merck & Co Inc Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
EP0093485A3 (en) * 1982-03-16 1985-04-10 Beecham Group Plc Process for the preparation of substituted 3-oxa-1-aza-bicyclo(4.2.0)octan-8-ones, and intermediates obtained thereby
KR900006449B1 (ko) * 1982-08-24 1990-08-31 상꾜 가부시끼가이샤 아제티디논 화합물의 제조방법
EP0113101A1 (en) * 1982-12-30 1984-07-11 Merck & Co. Inc. 6-(1-Hydroxyethyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carboxylic acid esters
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
IE51861B1 (en) * 1978-10-24 1987-04-15 Merck & Co Inc 6-,1-and 2-substituted-1-carbapen-2-em-3-carboxylic acids,processes for the preparation of such compounds and pharmaceutical compositions comprising such compounds
GR72296B (es) * 1979-12-03 1983-10-18 Merck & Co Inc
US4262010A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
DK329381A (da) * 1980-07-24 1982-01-25 Takeda Chemical Industries Ltd Fremgangsmaade til frmstilling af 1,1-disubstitueret carba-z -penem samt salte og estere deraf

Also Published As

Publication number Publication date
ES510117A0 (es) 1983-08-01
JPS57158786A (en) 1982-09-30
EP0060077A1 (en) 1982-09-15
AU8113282A (en) 1982-09-09
ZA821361B (en) 1983-01-26
ES520971A0 (es) 1984-05-16
ES8403488A1 (es) 1983-08-01

Similar Documents

Publication Publication Date Title
AU7493187A (en) Cephalosporin compounds, processes for their preparation and antibacterial agents
AU686222B2 (en) Cyclodepsipeptide compound
DE69020676D1 (de) Tricyclische Carbapenemverbindungen.
ES8405390A1 (es) Un procedimiento para preparar compuestos de quinolona.
EP0612751A3 (en) Compounds for the preparation of cephem derivatives.
ES8609338A1 (es) Un procedimiento para la preparacion de nuevos derivados pe-nem
ES2121585T3 (es) Compuestos antibioticos de carbapenem.
ES8403488A1 (es) Un procedimiento para la preparacion de antibioticos b-lactamicos.
ES2133358T3 (es) Compuestos de carbapenem como antibioticos.
DE69423339D1 (de) Epoxycyclohexendionderivat
ES2132245T3 (es) Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.
DE3166235D1 (en) Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
ES2121058T3 (es) Compuestos antibioticos de carbapenem.
ES8304973A1 (es) Un procedimiento para la preparacion de nuevos derivados de tiocarbapenem 3-sustituidos.
ES8405399A1 (es) Un procedimiento para la preparacion de nuevos derivados de carbapenem.
ES8700859A1 (es) Un procedimiento para la preparacion de nuevos derivados pe-nem
ES2140445T3 (es) Derivados de pirrolidinil-tio-penem con propiedades antibioticas.
ATE172462T1 (de) Antibiotische carbapenemverbindungen
ES8506313A1 (es) Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno.
ES8307812A1 (es) Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.
CA1270833C (en) 2,5-PYRROLIDINEDIONE DERIVATIVES USEFUL AS ANTI-ARHYTMIZING AGENTS
ES8203379A1 (es) Un procedimiento para la preparacion de carbapenemas
TH13040EX (th) คาร์บาพีเนม ซึ่งมีหมู่เฟนิลที่ถูกแทนที่ด้วย หมู่คาร์บอกซิ, กรรมวิธีสำหรับเตรียมสารเหล่านั้น สารขั้นกลางการใช้เป็นสารปฏิชีวนะ