ES8506313A1 - Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno. - Google Patents

Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno.

Info

Publication number
ES8506313A1
ES8506313A1 ES524316A ES524316A ES8506313A1 ES 8506313 A1 ES8506313 A1 ES 8506313A1 ES 524316 A ES524316 A ES 524316A ES 524316 A ES524316 A ES 524316A ES 8506313 A1 ES8506313 A1 ES 8506313A1
Authority
ES
Spain
Prior art keywords
antibiotics
preparation
hydrogen
hydrocarbylcarbonylamino
hydrocarbylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524316A
Other languages
English (en)
Other versions
ES524316A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES524316A0 publication Critical patent/ES524316A0/es
Publication of ES8506313A1 publication Critical patent/ES8506313A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE 7-OXO-1-AZABICILO 3.2.0 HEPTENO.CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) O UN DERIVADO REACTIVO DEL MISMO, CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UN ACEPTADOR DE ACIDOS (CARBONATOS O BICARBONATOS), PARA DAR UN COMPUESTO DE FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE POLAR SECO TAL COMO DIMETILFORMAMIDA A TEMPERATURA AMBIENTE. DONDE R1 ES HIDROGENO, CHO O SO3H O UNA SAL DEL MISMO; R2 Y R3 SON HIDROGENO, HIDROCARBILO, HIDROCARBILCARBONILO O HIDROCARBILCARBONILAMINO; O R2 Y R3 UNIDOS FORMAN UN ATOMO DE NITROGENO. OPCIONALMENTE DESPUES SE PUEDE: 1) SI EN EL COMPUESTO DE FORMULA (I) R1 ES -CHO, CONVERTIRLO EN HIDROGENO; 2) SEPARAR CUALQUIER GRUPO DE BLOQUEO DEL CARBOXI O SEPARAR CUALQUIER GRUPO PROTECTOR; 3) CONVERTIR EL PRODUCTO EN UNA SAL O ESTER FARMACEUTICAMENTE ACEPTABLE.SE UTILIZA EN FARMACIA PARA EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES524316A 1981-12-09 1983-07-20 Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno. Expired ES8506313A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8137148 1981-12-09

Publications (2)

Publication Number Publication Date
ES524316A0 ES524316A0 (es) 1984-11-16
ES8506313A1 true ES8506313A1 (es) 1984-11-16

Family

ID=10526490

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518014A Expired ES8402303A1 (es) 1981-12-09 1982-12-07 Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo (3.2.0) hepteno.
ES524316A Expired ES8506313A1 (es) 1981-12-09 1983-07-20 Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo(3.2.0)hepteno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES518014A Expired ES8402303A1 (es) 1981-12-09 1982-12-07 Un procedimiento para la preparacion de nuevos derivados de 7-oxo-1-azabiciclo (3.2.0) hepteno.

Country Status (5)

Country Link
EP (1) EP0081312A2 (es)
JP (1) JPS58109488A (es)
AU (1) AU9119282A (es)
ES (2) ES8402303A1 (es)
ZA (1) ZA829006B (es)

Also Published As

Publication number Publication date
JPS58109488A (ja) 1983-06-29
ES524316A0 (es) 1984-11-16
EP0081312A2 (en) 1983-06-15
ES518014A0 (es) 1984-01-16
ES8402303A1 (es) 1984-01-16
AU9119282A (en) 1983-06-16
ZA829006B (en) 1983-09-28

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