ES8203379A1 - Un procedimiento para la preparacion de carbapenemas - Google Patents
Un procedimiento para la preparacion de carbapenemasInfo
- Publication number
- ES8203379A1 ES8203379A1 ES503680A ES503680A ES8203379A1 ES 8203379 A1 ES8203379 A1 ES 8203379A1 ES 503680 A ES503680 A ES 503680A ES 503680 A ES503680 A ES 503680A ES 8203379 A1 ES8203379 A1 ES 8203379A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- optionally substituted
- beta
- lactam antibiotics
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE CARBAPENEMAS. CONSISTE EN LA REACCION DE UN COMPUESTO (I) O DE UN DERIVADO REACTIVO DEL MISMO CON UN DERIVADO DE AZIRIDINA (II), EN EL QUE PUEDE PROTEGERSE CUALQUIER GRUPO REACTIVO. SE OBTIENE EL COMPUESTO (III) Y A CONTINUACION SE PUEDEN EFECTUAR LAS SIGUIENTES OPERACIONES: A) SEPARAR CUALQUIER GRUPO PROTECTOR DE LOS RADICALES R1, R2 Y R3; B) SEPARAR CUALQUIER GRUPO DE BLOQUEO DEL CARBOXILO; C) CONVERTIR EL PRODUCTO EN UN ESTER, SAL O CACIDO. LA REACCION TIENE LUGAR EN PRESENCIA DE UN CARBONATO O BICARBONATO DE POTASIO, CALCIO, SODIO, MAGNESIO O LITIO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8021782 | 1980-07-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES503680A0 ES503680A0 (es) | 1982-04-01 |
ES8203379A1 true ES8203379A1 (es) | 1982-04-01 |
Family
ID=10514499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES503680A Expired ES8203379A1 (es) | 1980-07-03 | 1981-07-03 | Un procedimiento para la preparacion de carbapenemas |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0044142A1 (es) |
JP (1) | JPS5740486A (es) |
AU (1) | AU7249581A (es) |
ES (1) | ES8203379A1 (es) |
GR (1) | GR74599B (es) |
PT (1) | PT73313B (es) |
ZA (1) | ZA814342B (es) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK523276A (da) * | 1975-11-21 | 1977-05-22 | Merck & Co Inc | Fremgangsmade til fremstilling af n-acylderivater af thienamycin |
CH633554A5 (en) * | 1975-11-21 | 1982-12-15 | Merck & Co Inc | Process for the preparation of novel thienamycin derivatives. |
GB1531141A (en) * | 1976-08-17 | 1978-11-01 | Beecham Group Ltd | Beta-lactam antibiotics |
-
1981
- 1981-06-17 EP EP81302738A patent/EP0044142A1/en not_active Withdrawn
- 1981-06-26 ZA ZA814342A patent/ZA814342B/xx unknown
- 1981-07-01 GR GR65400A patent/GR74599B/el unknown
- 1981-07-02 PT PT73313A patent/PT73313B/pt unknown
- 1981-07-02 JP JP56103882A patent/JPS5740486A/ja active Pending
- 1981-07-02 AU AU72495/81A patent/AU7249581A/en not_active Abandoned
- 1981-07-03 ES ES503680A patent/ES8203379A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ZA814342B (en) | 1982-07-28 |
PT73313A (en) | 1981-08-01 |
AU7249581A (en) | 1982-01-07 |
GR74599B (es) | 1984-06-29 |
ES503680A0 (es) | 1982-04-01 |
JPS5740486A (en) | 1982-03-06 |
EP0044142A1 (en) | 1982-01-20 |
PT73313B (en) | 1982-07-30 |
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