ES8700859A1 - Un procedimiento para la preparacion de nuevos derivados pe-nem - Google Patents

Un procedimiento para la preparacion de nuevos derivados pe-nem

Info

Publication number
ES8700859A1
ES8700859A1 ES548147A ES548147A ES8700859A1 ES 8700859 A1 ES8700859 A1 ES 8700859A1 ES 548147 A ES548147 A ES 548147A ES 548147 A ES548147 A ES 548147A ES 8700859 A1 ES8700859 A1 ES 8700859A1
Authority
ES
Spain
Prior art keywords
pemens
alkylidene
intermediates
preparation
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES548147A
Other languages
English (en)
Other versions
ES548147A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8700859A1 publication Critical patent/ES8700859A1/es
Publication of ES548147A0 publication Critical patent/ES548147A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE NUEVOS DERIVADOS PENEM DE FORMULA GENERAL (II), SUS SALES FARMACEUTICAMENTE ACEPTABLES O UN ESTER HIDROLIZABLE <IN VIVO>. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (XIII), CON UN TIOL DE FORMULA GENERAL R4-SH, O UN DERIVADO DEL MISMO Y DESPUES SEPARAR CUALQUIER GRUPO BLOQUEANTE DEL CARBOXILO O CONVERTIR EL PRODUCTO EN EL ACIDO LIBRE O EN LA SAL O EL ESTER HIDROLIZABLE. ESTOS COMPUESTOS B-LACTAMICOS Y EN ESPECIAL LOS PERTENECIENTES A LA CLASE 6-ALQUILIDEN-PENEM, POSEEN PROPIEDADES ANTIBACTERIANAS E INHINBIDORAS DE B-LACTAMASAS Y PUEDEN EMPLEARSE EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS EN EL HOMBRE Y ANIMALES.
ES548147A 1984-01-26 1985-10-23 Un procedimiento para la preparacion de nuevos derivados pe-nem Expired ES8700859A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848402086A GB8402086D0 (en) 1984-01-26 1984-01-26 Compounds

Publications (2)

Publication Number Publication Date
ES8700859A1 true ES8700859A1 (es) 1986-11-16
ES548147A0 ES548147A0 (es) 1986-11-16

Family

ID=10555586

Family Applications (2)

Application Number Title Priority Date Filing Date
ES539854A Expired ES8704951A1 (es) 1984-01-26 1985-01-25 Un procedimiento para la preparacion de nuevos derivados penem.
ES548147A Expired ES8700859A1 (es) 1984-01-26 1985-10-23 Un procedimiento para la preparacion de nuevos derivados pe-nem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES539854A Expired ES8704951A1 (es) 1984-01-26 1985-01-25 Un procedimiento para la preparacion de nuevos derivados penem.

Country Status (8)

Country Link
EP (1) EP0150781A1 (es)
JP (1) JPS60197691A (es)
AU (1) AU3806185A (es)
ES (2) ES8704951A1 (es)
GB (1) GB8402086D0 (es)
GR (1) GR850207B (es)
IE (1) IE850161L (es)
ZA (1) ZA85564B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518416D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
DE3752124T2 (de) * 1986-01-17 1998-03-26 Beecham Group Plc Verfahren zur Herstellung von Penem Derivaten und Zwischenprodukte zu dieser Herstellung
GB8711391D0 (en) * 1987-05-14 1987-06-17 Beecham Group Plc Process
AR039774A1 (es) 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039475A1 (es) 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use

Also Published As

Publication number Publication date
ES548147A0 (es) 1986-11-16
JPS60197691A (ja) 1985-10-07
ES539854A0 (es) 1987-04-16
EP0150781A1 (en) 1985-08-07
GB8402086D0 (en) 1984-02-29
IE850161L (en) 1985-07-26
AU3806185A (en) 1985-08-01
GR850207B (es) 1985-05-23
ES8704951A1 (es) 1987-04-16
ZA85564B (en) 1986-08-27

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