ES2132245T3 - Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht. - Google Patents
Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht.Info
- Publication number
- ES2132245T3 ES2132245T3 ES93916671T ES93916671T ES2132245T3 ES 2132245 T3 ES2132245 T3 ES 2132245T3 ES 93916671 T ES93916671 T ES 93916671T ES 93916671 T ES93916671 T ES 93916671T ES 2132245 T3 ES2132245 T3 ES 2132245T3
- Authority
- ES
- Spain
- Prior art keywords
- azaadamanthane
- agonists
- antagonists
- derivatives
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
ESTA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I) O A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE LOS MISMOS, EN DONDE Z SE SELECCIONA DEL GRUPO QUE CONSISTE EN (A) Y (B), R1 ES ALCOXI DE UNO A SEIS ATOMOS DE CARBONO; R2, R3, R4 Y R5 SON IGUALES O DIFERENTES Y SE SELECCIONAN DEL GRUPO QUE CONSISTE EN HIDROGENO, HALOGENO, CF3, HIDROXI, ALCOXI DE UNO A SEIS ATOMOS DE CARBONO, ACILO DE DOS A SIETE ATOMOS DE CARBONO, AMINO, AMINO SUSTITUIDO POR UNO O DOS GRUPOS ALQUILO DE UNO A SEIS ATOMOS DE CARBONO, ACILAMINO C2-C7, AMINOCARBONILO, AMINOSULFONA OPCIONALMENTE SUSTITUIDA POR UNO O DOS GRUPOS ALQUILO DE UNO A SEIS ATOMOS DE CARBONO, ALQUILSULFONA C1-C6 Y NITRO; M ES 1 O 2; X ES 0 O NR7; Y R7 ES HIDROGENO O ALQUILO DE 1 A 6 ATOMOS DE CARBONO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/919,679 US5840903A (en) | 1992-07-27 | 1992-07-27 | 4-aminomethyl-1-azaadamantane derived benzamides |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2132245T3 true ES2132245T3 (es) | 1999-08-16 |
Family
ID=25442463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93916671T Expired - Lifetime ES2132245T3 (es) | 1992-07-27 | 1993-06-25 | Derivados de 1-azaadamantano como agonistas o antagonistas de 5-ht. |
Country Status (11)
Country | Link |
---|---|
US (2) | US5840903A (es) |
EP (1) | EP0652879B1 (es) |
JP (1) | JP3383668B2 (es) |
AT (1) | ATE178900T1 (es) |
AU (1) | AU4644893A (es) |
CA (1) | CA2136837A1 (es) |
DE (1) | DE69324492T2 (es) |
DK (1) | DK0652879T3 (es) |
ES (1) | ES2132245T3 (es) |
GR (1) | GR3030506T3 (es) |
WO (1) | WO1994002482A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60107393T2 (de) | 2000-03-01 | 2005-12-01 | Euro-Celtique S.A. | Verwendung von tramadol zur herstellung eines arzneimittels zur behandlung von funktionelle gastrointestinale krankenheiten |
US7897766B2 (en) * | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
WO2008112205A1 (en) | 2007-03-09 | 2008-09-18 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
MX2009010174A (es) * | 2007-03-23 | 2009-10-12 | Abbott Lab | Derivados de aza-adamantano ester y carbamato y metodos de uso de los mismos. |
WO2008118743A1 (en) * | 2007-03-23 | 2008-10-02 | Abbott Laboratories | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof |
WO2008118745A1 (en) * | 2007-03-23 | 2008-10-02 | Abbott Laboratories | 4-substituted azaadamantane derivatives and methods of use thereof |
MX2009010173A (es) | 2007-03-23 | 2009-10-12 | Abbott Lab | Derivados de aminometil aza-adamantano y uso de los mismos como moduladores selectivos del receptor de acetilcolina nicotinico alfa-7 neuronal (nnrs). |
CN106074548A (zh) | 2010-09-23 | 2016-11-09 | 艾伯维巴哈马有限公司 | 氮杂金刚烷衍生物的一水合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2514006A1 (fr) * | 1981-10-05 | 1983-04-08 | Nativelle Sa Ets | Acylamino-4 aza-1 adamantanes, procede pour leur preparation, et application en therapeutique |
FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
DE3587151T2 (de) * | 1984-12-20 | 1993-07-15 | Sandoz Ag | Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten. |
GB8523211D0 (en) * | 1985-09-19 | 1985-10-23 | Beecham Group Plc | Compounds |
GB8525844D0 (en) * | 1985-10-19 | 1985-11-20 | Beecham Group Plc | Compounds |
US4910193A (en) * | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
US4950759A (en) * | 1988-07-07 | 1990-08-21 | Duphar International Research B.V. | Substituted 1,7-annelated 1H-indazoles |
US4992461A (en) * | 1989-09-11 | 1991-02-12 | G. D. Searle & Co. | N-azabicyclo(3.3.0)octane amides of aromatic acids, compositions, and methods of use thereof |
US5140023A (en) * | 1990-04-27 | 1992-08-18 | G. D. Searle & Co. | Azatetracycle compounds |
-
1992
- 1992-07-27 US US07/919,679 patent/US5840903A/en not_active Expired - Fee Related
-
1993
- 1993-06-25 AT AT93916671T patent/ATE178900T1/de not_active IP Right Cessation
- 1993-06-25 CA CA002136837A patent/CA2136837A1/en not_active Abandoned
- 1993-06-25 AU AU46448/93A patent/AU4644893A/en not_active Abandoned
- 1993-06-25 WO PCT/US1993/005945 patent/WO1994002482A1/en active IP Right Grant
- 1993-06-25 DK DK93916671T patent/DK0652879T3/da active
- 1993-06-25 ES ES93916671T patent/ES2132245T3/es not_active Expired - Lifetime
- 1993-06-25 DE DE69324492T patent/DE69324492T2/de not_active Expired - Fee Related
- 1993-06-25 EP EP93916671A patent/EP0652879B1/en not_active Expired - Lifetime
- 1993-06-25 JP JP50446094A patent/JP3383668B2/ja not_active Expired - Fee Related
-
1995
- 1995-05-18 US US08/443,545 patent/US5643917A/en not_active Expired - Fee Related
-
1999
- 1999-06-15 GR GR990401581T patent/GR3030506T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE178900T1 (de) | 1999-04-15 |
EP0652879A1 (en) | 1995-05-17 |
GR3030506T3 (en) | 1999-10-29 |
DK0652879T3 (da) | 1999-10-25 |
US5840903A (en) | 1998-11-24 |
AU4644893A (en) | 1994-02-14 |
JP3383668B2 (ja) | 2003-03-04 |
JPH07509242A (ja) | 1995-10-12 |
US5643917A (en) | 1997-07-01 |
CA2136837A1 (en) | 1994-02-03 |
EP0652879B1 (en) | 1999-04-14 |
WO1994002482A1 (en) | 1994-02-03 |
DE69324492T2 (de) | 1999-09-02 |
DE69324492D1 (de) | 1999-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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