ES8200673A1 - Un procedimiento para la preparacion del derivado de furano - Google Patents

Un procedimiento para la preparacion del derivado de furano

Info

Publication number
ES8200673A1
ES8200673A1 ES498389A ES498389A ES8200673A1 ES 8200673 A1 ES8200673 A1 ES 8200673A1 ES 498389 A ES498389 A ES 498389A ES 498389 A ES498389 A ES 498389A ES 8200673 A1 ES8200673 A1 ES 8200673A1
Authority
ES
Spain
Prior art keywords
production
formula
image
aziridine derivative
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498389A
Other languages
English (en)
Other versions
ES498389A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES498389A0 publication Critical patent/ES498389A0/es
Publication of ES8200673A1 publication Critical patent/ES8200673A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/12Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE "RANITIDA" DE FORMULA (I), DERIVADA DEL FURANO. SE HACE REACCIONAR UN TIOL DE FORMULA (II) CON UN AGENTE ALQUILANTE DE FORMULA (III), EN QUE R1 ES UN GRUPO DE FORMULA (IV), L ES UN GRUPO ELIMINABLE, TAL COMO HALOGENO, Y R2 ES HIDROGENO. LA REACCION SE LLEVA EN UN DISOLVENTE Y EN PRESENCIA DE UNA BASE, A TEMPERATURA DE 10-80 C., O BIEN EN UN SISTEMA BIFASICO DE CLOROFORMO Y AGUA, CON UN CATALIZADOR DE TRANSFERENCIA DE FASE Y UNA BASE. CASO DE FORMAR R1 Y R2 UN GRUPO ETILENIMINO CON EL ATOMO DE NITROGENO ADYACENTE, LA REACCION SE LLEVA A CABO CON CALENTAMIENTO Y BAJO ATMOSFERA INERTE DE NITROGENO.
ES498389A 1980-01-08 1981-01-08 Un procedimiento para la preparacion del derivado de furano Expired ES8200673A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8000580 1980-01-08
GB8000581 1980-01-08
GB8039336 1980-12-08

Publications (2)

Publication Number Publication Date
ES498389A0 ES498389A0 (es) 1981-11-16
ES8200673A1 true ES8200673A1 (es) 1981-11-16

Family

ID=27260837

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498389A Expired ES8200673A1 (es) 1980-01-08 1981-01-08 Un procedimiento para la preparacion del derivado de furano

Country Status (14)

Country Link
JP (1) JPH02167259A (es)
AR (1) AR225940A1 (es)
AT (1) AT376966B (es)
CH (1) CH650257A5 (es)
DE (1) DE3100364A1 (es)
DK (1) DK157865C (es)
ES (1) ES8200673A1 (es)
FI (1) FI80450C (es)
FR (1) FR2473044A1 (es)
HU (1) HU182272B (es)
NL (1) NL8100068A (es)
PT (1) PT72320B (es)
SE (2) SE449747B (es)
YU (1) YU42372B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213509A1 (de) * 1982-04-10 1983-10-20 Basf Ag, 6700 Ludwigshafen N-substituierte imidazol-derivate, ihre herstellung, diese enthaltende arzneimittel und ihre verwendung
YU42819B (en) * 1982-11-22 1988-12-31 Lek Tovarna Farmacevtskih Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
NL8303965A (nl) * 1982-12-08 1984-07-02 Degussa Nieuwe etheendiamine- en guanidine-derivaten; werkwijze voor het bereiden daarvan; geneesmiddelen die ze bevatten; werkwijze voor het bereiden van dergelijke geneesmiddelen; toepassing van de verbindingen voor het bereiden van geneesmiddelen en in de geneeskunde.
DE3343884A1 (de) * 1982-12-08 1984-06-14 Degussa Ag, 6000 Frankfurt Neue ethendiamin- und guanidin-derivate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
IL56265A (en) 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
NO784350L (no) * 1977-12-30 1979-07-03 Crc Ricerca Chim Fremgangsmaate til alkylering av 4(5)-merkaptometyl-imidazoler med aziridinderivater
IL57416A (en) * 1978-05-30 1983-03-31 Smith Kline French Lab Nitro compounds,processes for preparing them and compositions containing them
FI811376L (fi) * 1980-05-13 1981-11-14 Crc Ricerca Chim Foerfarande foer framstaellning av n-/2-///5-(dialkylamino)-metyl-2-furanyl/-metyl/-tio/etyl/-n'-alkyl-2-nitro-1,1-etendiaminer och deras mellanprodukter

Also Published As

Publication number Publication date
FI80450B (fi) 1990-02-28
ES498389A0 (es) 1981-11-16
ATA3781A (de) 1984-06-15
JPH0346465B2 (es) 1991-07-16
SE8502780L (sv) 1985-06-05
AT376966B (de) 1985-01-25
SE8502780D0 (sv) 1985-06-05
YU2781A (en) 1983-06-30
SE8100074L (sv) 1981-07-09
DK157865B (da) 1990-02-26
SE449747B (sv) 1987-05-18
PT72320A (en) 1981-02-01
AR225940A1 (es) 1982-05-14
FR2473044B1 (es) 1984-04-13
NL8100068A (nl) 1981-08-03
HU182272B (en) 1983-12-28
CH650257A5 (fr) 1985-07-15
FI80450C (fi) 1990-06-11
DK157865C (da) 1990-07-30
JPH02167259A (ja) 1990-06-27
PT72320B (en) 1982-07-23
SE460604B (sv) 1989-10-30
DE3100364C2 (es) 1989-12-28
YU42372B (en) 1988-08-31
FR2473044A1 (fr) 1981-07-10
FI810039L (fi) 1981-07-09
DE3100364A1 (de) 1981-11-19
DK7181A (da) 1981-07-09

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