ES2569477T3 - Combinación de un inhibidor de HDAC y un antimetabolito - Google Patents

Combinación de un inhibidor de HDAC y un antimetabolito Download PDF

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Publication number
ES2569477T3
ES2569477T3 ES07862420.2T ES07862420T ES2569477T3 ES 2569477 T3 ES2569477 T3 ES 2569477T3 ES 07862420 T ES07862420 T ES 07862420T ES 2569477 T3 ES2569477 T3 ES 2569477T3
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ES
Spain
Prior art keywords
combination
antimetabolite
hdac inhibitor
methyl
hdai
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07862420.2T
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English (en)
Inventor
Peter Wisdom Atadja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39272127&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2569477(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2569477T3 publication Critical patent/ES2569477T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una combinación de (a) un inhibidor de desacetilasa de histona (HDAI); y (b) un anti-metabolito; en donde (a) es N-hidroxi-3-[4-[[[2-(2-metil-1H-indol-3-il)-etil]-amino]metil]fenil]-2E-2-propenamida, o una sal farmacéuticamente aceptable de la misma, y (b) es 5-azacitidina para utilizarse en el tratamiento de una enfermedad proliferativa que es síndrome mielodisplásico (MDS) o leucemia mieloblástica aguda (AML).

Description

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Claims (1)

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ES07862420.2T 2006-12-04 2007-11-30 Combinación de un inhibidor de HDAC y un antimetabolito Active ES2569477T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86838806P 2006-12-04 2006-12-04
US868388P 2006-12-04
PCT/US2007/024712 WO2008070011A2 (en) 2006-12-04 2007-11-30 Combination of an hdac inhibitor and an antimetabolite

Publications (1)

Publication Number Publication Date
ES2569477T3 true ES2569477T3 (es) 2016-05-11

Family

ID=39272127

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07862420.2T Active ES2569477T3 (es) 2006-12-04 2007-11-30 Combinación de un inhibidor de HDAC y un antimetabolito

Country Status (26)

Country Link
US (1) US8093220B2 (es)
EP (1) EP2099451B1 (es)
JP (3) JP5784274B2 (es)
KR (1) KR101475538B1 (es)
CN (1) CN101553223A (es)
AR (1) AR064072A1 (es)
AU (1) AU2007328281B2 (es)
BR (1) BRPI0719746A2 (es)
CA (1) CA2670741C (es)
CL (1) CL2007003467A1 (es)
EC (1) ECSP099483A (es)
ES (1) ES2569477T3 (es)
GT (1) GT200900148A (es)
HK (1) HK1132462A1 (es)
IL (1) IL198638A (es)
MA (1) MA30982B1 (es)
MX (1) MX2009005946A (es)
MY (1) MY148893A (es)
NO (1) NO20092473L (es)
PE (1) PE20081303A1 (es)
PL (1) PL2099451T3 (es)
RU (1) RU2469717C2 (es)
TN (1) TN2009000213A1 (es)
TW (1) TW200831075A (es)
WO (1) WO2008070011A2 (es)
ZA (1) ZA200903041B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2628726A1 (en) 2008-03-26 2013-08-21 Novartis AG Hydroxamate-based inhibitors of deacetylases b
WO2010009285A1 (en) * 2008-07-18 2010-01-21 Novartis Ag Use of hdac inhibitors for the treatment of acute myeloid leukemia and/or myelodysplastic syndrome
JP2011528662A (ja) * 2008-07-18 2011-11-24 ノバルティス アーゲー ホジキン病の治療のためのｈｄａｃ阻害剤の使用
US20110053925A1 (en) * 2009-08-28 2011-03-03 Novartis Ag Hydroxamate-Based Inhibitors of Deacetylases
SG185798A1 (en) * 2010-06-07 2013-01-30 Abraxis Bioscience Llc Combination therapy methods for treating proliferative diseases
CA2808908A1 (en) * 2010-09-01 2012-03-08 Novartis Ag Combination of hdac inhibitors with thrombocytopenia drugs
CA2903473A1 (en) 2013-03-12 2014-10-09 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
JP2016538310A (ja) * 2013-11-27 2016-12-08 オンコエシックス ゲーエムベーハー チエノトリアゾロジアゼピン化合物を含む医薬製剤を用いる白血病の治療方法
WO2016044138A1 (en) 2014-09-17 2016-03-24 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors
CN107531660A (zh) 2015-03-13 2018-01-02 福马治疗股份有限公司 作为HDAC8抑制剂的α‑肉桂酰胺化合物和组合物
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
CA2526908A1 (en) * 2003-05-21 2004-12-02 Novartis Ag Combination of histone deacetylase inhibitors with chemotherapeutic agents

Also Published As

Publication number Publication date
KR101475538B1 (ko) 2014-12-22
RU2009125439A (ru) 2011-01-20
JP2016006070A (ja) 2016-01-14
IL198638A (en) 2015-06-30
IL198638A0 (en) 2010-02-17
MY148893A (en) 2013-06-14
MA30982B1 (fr) 2009-12-01
BRPI0719746A2 (pt) 2013-12-10
ZA200903041B (en) 2010-03-31
PE20081303A1 (es) 2008-10-28
TW200831075A (en) 2008-08-01
JP5784274B2 (ja) 2015-09-24
PL2099451T3 (pl) 2016-07-29
ECSP099483A (es) 2009-08-28
CA2670741A1 (en) 2008-06-12
RU2469717C2 (ru) 2012-12-20
GT200900148A (es) 2011-08-02
KR20090087115A (ko) 2009-08-14
CN101553223A (zh) 2009-10-07
EP2099451B1 (en) 2016-02-10
AU2007328281B2 (en) 2011-03-31
EP2099451A2 (en) 2009-09-16
NO20092473L (no) 2009-09-01
US20100069318A1 (en) 2010-03-18
CL2007003467A1 (es) 2008-07-11
AR064072A1 (es) 2009-03-11
WO2008070011A3 (en) 2008-07-24
US8093220B2 (en) 2012-01-10
HK1132462A1 (zh) 2010-02-26
WO2008070011A2 (en) 2008-06-12
JP2014097992A (ja) 2014-05-29
AU2007328281A1 (en) 2008-06-12
MX2009005946A (es) 2009-06-17
CA2670741C (en) 2016-04-12
TN2009000213A1 (en) 2010-10-18
JP2010511702A (ja) 2010-04-15

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