ES2552320T3 - Nuevas piridín-2-onas y piridazín-3-onas sustituidas - Google Patents

Nuevas piridín-2-onas y piridazín-3-onas sustituidas Download PDF

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ES2552320T3
ES2552320T3 ES09769133.1T ES09769133T ES2552320T3 ES 2552320 T3 ES2552320 T3 ES 2552320T3 ES 09769133 T ES09769133 T ES 09769133T ES 2552320 T3 ES2552320 T3 ES 2552320T3
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alkyl
halogen
alkoxy
hydroxy
optionally substituted
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Nolan James Dewdney
Rama K. Kondru
Bradley E. Loe
Yan Lou
Joel Mcintosh
Timothy D. Owens
Michael Soth
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F Hoffmann La Roche AG
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compuesto según la fórmula III o IV:**Fórmula** en las que: R es H, -R1, -R1-R2-R3 , -R1-R3 o -R2-R3; en el que R1 es arilo, heteroarilo, cicloalquilo o heterocicloalquilo, y se sustituye opcionalmente con R1', en el que R1' es alquilo C1-6, hidroxi, hidroxialquilo C1-6, alcoxi C1-6, halógeno, nitro, amino, cicloalquilo, heterocicloalquilo, ciano o haloalquilo C1-6, R2 es -C(>=O), -C(>=O)O, -C(>=O)N(R2'), -(CH2)q o -S(>=O)2; en el que R2' es H o alquilo C1-6; y q es 1, 2 o 3, R3 es H o R4; en el que R4 es alquilo C1-6, alcoxi C1-6, heteroalquilo C1-6, arilo, ariloalquilo, alquiloarilo, heteroarilo, alquilheteroarilo, heteroaril-alquilo, cicloalquilo, alquil-cicloalquilo, cicloalquil-alquilo, heterocicloalquilo, alquil-heterocicloalquilo o heterocicloalquil-alquilo, y se sustituye opcionalmente con uno o más de entre alquilo C1-6, hidroxi, oxo, hidroxialquilo C1-6, alcoxi C1-6, halógeno, nitro, amino, ciano, alquilsulfonilo C1-6 o haloalquilo C1-6, X es CH o N, Y1 es H o alquilo C1-6, Y2 es Y2a o Y2b, en el que Y2a es H o halógeno, e Y2b es alquilo C1-6, sustituido opcionalmente con uno o más Y2b', e Y2b' es hidroxi, alcoxi C1-6 o halógeno, cada Y2' es, independientemente, Y2'a o Y2'b, en el que Y2'a es halógeno, e Y2'b es alquilo C1-6, sustituido opcionalmente con uno o más Y2'b', e Y2'b' es hidroxi, alcoxi C1-6 o halógeno, n es 0, 1, 2 ó 3, Y3 es H, halógeno o alquilo C1-6,en el que alquilo C1-6 se encuentra sustituido opcionalmente con uno o más sustituyentes seleccionados de entre el grupo que consiste de hidroxi, alcoxi C1-6, amino y halógeno, m es 0 ó 1; Y4 es Y4a, Y4b, Y4c o Y4d, en el que Y4a es H o halógeno, Y4b es alquilo C1-6, sustituido opcionalmente con uno o más sustituyentes seleccionados de entre el grupo que consiste de haloalquilo C1-6, halógeno, hidroxi, amino, ciano y alcoxi C1-6, Y4c es cicloalquilo C3-7, sustituido opcionalmente con uno o más sustituyentes seleccionados de entre el grupo que consiste de alquilo C1-6, haloalquilo C1-6, halógeno, hidroxi, amino y alcoxi C1-6, y Y4d es amino, sustituido opcionalmente con uno o más alquilos C1-6, o una sal farmacéuticamente aceptable del mismo.
ES09769133.1T 2008-06-24 2009-06-15 Nuevas piridín-2-onas y piridazín-3-onas sustituidas Active ES2552320T3 (es)

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US7527708P 2008-06-24 2008-06-24
US75277P 2008-06-24
PCT/EP2009/057320 WO2009156284A1 (en) 2008-06-24 2009-06-15 Novel substituted pyridin-2-ones and pyridazin-3-ones

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ES2552320T3 true ES2552320T3 (es) 2015-11-27

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US (4) US7902194B2 (es)
EP (1) EP2297142B1 (es)
JP (1) JP5536049B2 (es)
KR (1) KR101299867B1 (es)
CN (3) CN103709148B (es)
AR (1) AR072272A1 (es)
AU (1) AU2009264400B2 (es)
BR (1) BRPI0914657A2 (es)
CA (1) CA2728016C (es)
CL (1) CL2010001483A1 (es)
CO (1) CO6382183A2 (es)
CR (1) CR11815A (es)
EC (1) ECSP10010709A (es)
ES (1) ES2552320T3 (es)
HK (2) HK1152940A1 (es)
IL (1) IL209141A0 (es)
MA (1) MA32487B1 (es)
MX (1) MX2010013191A (es)
NZ (2) NZ588819A (es)
PE (1) PE20100851A1 (es)
RU (1) RU2500680C2 (es)
TW (1) TWI396537B (es)
UA (1) UA103327C2 (es)
WO (1) WO2009156284A1 (es)
ZA (1) ZA201007816B (es)

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