BR112015005361A2 - inibidores de tirosina quinase de bruton - Google Patents
inibidores de tirosina quinase de brutonInfo
- Publication number
- BR112015005361A2 BR112015005361A2 BR112015005361A BR112015005361A BR112015005361A2 BR 112015005361 A2 BR112015005361 A2 BR 112015005361A2 BR 112015005361 A BR112015005361 A BR 112015005361A BR 112015005361 A BR112015005361 A BR 112015005361A BR 112015005361 A2 BR112015005361 A2 BR 112015005361A2
- Authority
- BR
- Brazil
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- bruton tyrosine
- bruton
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261700373P | 2012-09-13 | 2012-09-13 | |
| PCT/EP2013/068659 WO2014040965A1 (en) | 2012-09-13 | 2013-09-10 | Inhibitors of bruton's tyrosine kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015005361A2 true BR112015005361A2 (pt) | 2017-07-04 |
Family
ID=49118551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015005361A BR112015005361A2 (pt) | 2012-09-13 | 2013-09-10 | inibidores de tirosina quinase de bruton |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9499548B2 (pt) |
| EP (1) | EP2895473A1 (pt) |
| JP (1) | JP2015531781A (pt) |
| KR (1) | KR20150054994A (pt) |
| CN (1) | CN104619696A (pt) |
| AR (1) | AR092536A1 (pt) |
| BR (1) | BR112015005361A2 (pt) |
| CA (1) | CA2881761A1 (pt) |
| HK (1) | HK1210461A1 (pt) |
| MX (1) | MX2015002901A (pt) |
| RU (1) | RU2015111133A (pt) |
| TW (1) | TW201416361A (pt) |
| WO (1) | WO2014040965A1 (pt) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2882741B1 (en) | 2012-08-10 | 2018-10-24 | Boehringer Ingelheim International GmbH | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
| MX2015006162A (es) * | 2012-11-16 | 2015-08-14 | Hoffmann La Roche | Inhibidores de la tirosina-cinasa de bruton. |
| RU2015141360A (ru) * | 2013-03-05 | 2017-04-10 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы тирозинкиназы брутона |
| CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
| WO2016050921A1 (en) * | 2014-10-02 | 2016-04-07 | F. Hoffmann-La Roche Ag | Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk) |
| US10570118B2 (en) | 2016-01-13 | 2020-02-25 | Boehringer Ingelheim International Gmbh | Isoquinolones as BTK inhibitors |
| US11479556B1 (en) | 2018-10-15 | 2022-10-25 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway |
| KR20210149757A (ko) | 2019-04-09 | 2021-12-09 | 누릭스 테라퓨틱스 인코포레이티드 | Cbl-b 억제용의 3-치환된 피페리딘 화합물, 및 암 백신 및/또는 종양용해 바이러스와 조합된 cbl-b 억제제의 용도 |
| CN114206855A (zh) | 2019-05-17 | 2022-03-18 | 紐力克斯治疗公司 | 用于Cbl-b抑制的氰基环丁基类化合物及其用途 |
| US20230024442A1 (en) * | 2019-11-08 | 2023-01-26 | Nurix Therapeutics, Inc. | Bifunctional compounds for grading btk via ubiquitin proteosome pathway |
| WO2021113557A1 (en) | 2019-12-04 | 2021-06-10 | Nurix Therapeutics, Inc. | Bifunctional compounds for degrading btk via ubiquitin proteosome pathway |
| WO2022206924A1 (zh) * | 2021-04-02 | 2022-10-06 | 南京明德新药研发有限公司 | 含氮三并环双功能化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| NZ586916A (en) * | 2008-02-05 | 2012-06-29 | Hoffmann La Roche | Novel pyridinones and pyridazinones |
| CA2728016C (en) * | 2008-06-24 | 2017-02-28 | F. Hoffmann-La Roche Ag | Novel substituted pyridin-2-ones and pyridazin-3-ones |
| JP5490789B2 (ja) * | 2008-07-02 | 2014-05-14 | エフ．ホフマン−ラ ロシュ アーゲー | キナーゼ阻害剤としての新規なフェニルピラジノン |
| US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
| AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
-
2013
- 2013-09-10 EP EP13759240.8A patent/EP2895473A1/en not_active Withdrawn
- 2013-09-10 KR KR1020157009295A patent/KR20150054994A/ko not_active Application Discontinuation
- 2013-09-10 BR BR112015005361A patent/BR112015005361A2/pt not_active IP Right Cessation
- 2013-09-10 JP JP2015531530A patent/JP2015531781A/ja active Pending
- 2013-09-10 MX MX2015002901A patent/MX2015002901A/es unknown
- 2013-09-10 WO PCT/EP2013/068659 patent/WO2014040965A1/en active Application Filing
- 2013-09-10 CN CN201380047474.5A patent/CN104619696A/zh active Pending
- 2013-09-10 US US14/427,501 patent/US9499548B2/en not_active Expired - Fee Related
- 2013-09-10 RU RU2015111133A patent/RU2015111133A/ru not_active Application Discontinuation
- 2013-09-10 CA CA2881761A patent/CA2881761A1/en not_active Abandoned
- 2013-09-11 TW TW102132819A patent/TW201416361A/zh unknown
- 2013-09-12 AR ARP130103257A patent/AR092536A1/es unknown
-
2015
- 2015-11-11 HK HK15111138.3A patent/HK1210461A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR092536A1 (es) | 2015-04-22 |
| CN104619696A (zh) | 2015-05-13 |
| RU2015111133A (ru) | 2016-11-10 |
| US20150210704A1 (en) | 2015-07-30 |
| JP2015531781A (ja) | 2015-11-05 |
| HK1210461A1 (en) | 2016-04-22 |
| US9499548B2 (en) | 2016-11-22 |
| KR20150054994A (ko) | 2015-05-20 |
| WO2014040965A1 (en) | 2014-03-20 |
| EP2895473A1 (en) | 2015-07-22 |
| TW201416361A (zh) | 2014-05-01 |
| CA2881761A1 (en) | 2014-03-20 |
| MX2015002901A (es) | 2015-06-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112014000653A2 (pt) | inibidores de tirosina quinase de bruton | |
| BR112013029620A2 (pt) | inibidores de tirosina quinase de bruton | |
| IL277951A (en) | Pyrimidinyls are tyrosine kinase inhibitors | |
| CO6970602A2 (es) | Inhibidores de quinasa | |
| HK1211293A1 (en) | Brutons tyrosine kinase inhibitors | |
| CO6950481A2 (es) | Inhibidores de proteínas quinasas | |
| HK1215577A1 (zh) | 蛋白激酶抑制劑 | |
| DK2710007T3 (da) | Kinasehæmmere | |
| DK2903618T3 (da) | Rho-kinase-inhibitorer | |
| DK2841428T3 (da) | Dna-pk-inhibitorer | |
| SMT201600114B (it) | Inibitori di beta-secretasi | |
| DK3321262T3 (da) | Serin-/threoninkinasehæmmere | |
| BR112015005361A2 (pt) | inibidores de tirosina quinase de bruton | |
| DK2895484T3 (da) | Glucosylceramidsynthase-inhibitorer | |
| BR112015002709A2 (pt) | novos compostos de pirrolopirimidina como inibidores de proteínas quinases | |
| DK3527563T3 (da) | Dna-pk-inhibitorer | |
| SI2710005T1 (sl) | Zaviralci tirozinske kinaze | |
| BRPI1009112A2 (pt) | inibidores de tirosina quinase de bruton | |
| DK2917210T3 (da) | Alk kinase-inhibitorer | |
| CO6880068A2 (es) | Aminoquinazolinas como inhibidores de quinasa | |
| HK1209726A1 (en) | Protein kinase inhibitors | |
| CO6890101A2 (es) | Inhibidores de pde10 de pirimidina | |
| CO6990735A2 (es) | Inhibidores de pirazina cinasa | |
| DK2986611T3 (da) | Bestemte proteinkinaseinhibitorer | |
| BR112014023606A2 (pt) | Bandeja de testemunho |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11N | Dismissal: publication cancelled | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law | ||
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2478 DE 03-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |