AR073136A1 - Compuestos de pirrol - Google Patents

Compuestos de pirrol

Info

Publication number
AR073136A1
AR073136A1 ARP090103278A ARP090103278A AR073136A1 AR 073136 A1 AR073136 A1 AR 073136A1 AR P090103278 A ARP090103278 A AR P090103278A AR P090103278 A ARP090103278 A AR P090103278A AR 073136 A1 AR073136 A1 AR 073136A1
Authority
AR
Argentina
Prior art keywords
halogen
optionally substituted
group optionally
hydrogen atom
alkyl group
Prior art date
Application number
ARP090103278A
Other languages
English (en)
Inventor
Yasuyoshi Arikawa
Haruyuki Nishida
Ikuo Fujimori
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41508823&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR073136(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR073136A1 publication Critical patent/AR073136A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Abstract

La presente se refiere a un compuesto representado por la formula (1) en donde A es grupo piridilo que tiene al menos un sustituyente de formula (2) o (3) en donde R1, R2 y R3 son cada uno un átomo de hidrogeno, de halogeno, un grupo alquilo C1-6 opcionalmente sustituido con halogeno o un grupo alcoxi C1-6 opcionalmente sustituido con halogeno; R4 y R6 son cada uno un átomo de hidrogeno, de halogeno o un grupo alquilo C1-6, opcionalmente sustituido con halogeno; R5 es un átomo de hidrogeno, de halogeno, un grupo alquilo C1-6 opcionalmente sustituido con halogeno o un grupo alcoxi C1-6 opcionalmente sustituido con halogeno; y R7 es un átomo de hidrogeno o un grupo alquilo C1-6 opcionalmente sustituido con halogeno; o una de sus sales o una composicion farmacéutica que los contiene, utiles para suprimir la secrecion ácida.
ARP090103278A 2008-08-27 2009-08-26 Compuestos de pirrol AR073136A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008218851 2008-08-27
JP2008269099 2008-10-17

Publications (1)

Publication Number Publication Date
AR073136A1 true AR073136A1 (es) 2010-10-13

Family

ID=41508823

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103278A AR073136A1 (es) 2008-08-27 2009-08-26 Compuestos de pirrol

Country Status (39)

Country Link
US (3) US8592597B2 (es)
EP (1) EP2318390B1 (es)
JP (1) JP5638515B2 (es)
KR (1) KR101629181B1 (es)
CN (1) CN102197033B (es)
AR (1) AR073136A1 (es)
AU (1) AU2009284867B2 (es)
BR (1) BRPI0917705A2 (es)
CA (1) CA2735162C (es)
CL (1) CL2011000402A1 (es)
CO (1) CO6321166A2 (es)
CR (1) CR20110169A (es)
CY (1) CY1114452T1 (es)
DK (1) DK2318390T3 (es)
DO (1) DOP2011000061A (es)
EA (1) EA019741B1 (es)
EC (1) ECSP11010912A (es)
ES (1) ES2423289T3 (es)
GE (1) GEP20135786B (es)
HK (1) HK1157756A1 (es)
HR (1) HRP20130653T1 (es)
IL (1) IL211335A (es)
JO (1) JO2871B1 (es)
MA (1) MA32647B1 (es)
ME (1) ME01598B (es)
MX (1) MX2011001955A (es)
MY (1) MY152008A (es)
NZ (1) NZ591793A (es)
PE (2) PE20141174A1 (es)
PL (1) PL2318390T3 (es)
PT (1) PT2318390E (es)
RS (1) RS52872B (es)
SI (1) SI2318390T1 (es)
SM (1) SMT201300085B (es)
TW (1) TWI473798B (es)
UA (1) UA105185C2 (es)
UY (1) UY32074A (es)
WO (1) WO2010024451A1 (es)
ZA (1) ZA201101774B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010024451A1 (en) 2008-08-27 2010-03-04 Takeda Pharmaceutical Company Limited Pyrrole compounds
US20110229879A1 (en) * 2010-03-19 2011-09-22 University Of Rochester Methods and compositions for nuclear staining
CN102452979B (zh) * 2010-11-03 2015-04-01 天津药明康德新药开发有限公司 5-氟-3-吡啶磺酰氯的合成方法
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
WO2013119800A1 (en) 2012-02-07 2013-08-15 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
CA2877619C (en) 2012-06-27 2020-09-22 Takeda Pharmaceutical Company Limited Liquid preparations of amines and organic acids stabilized by salts
US9487485B2 (en) 2013-02-28 2016-11-08 Takeda Pharmaceutical Company Limited Method for producing sulfonyl chloride compound
US9724396B2 (en) 2013-03-15 2017-08-08 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
KR102084185B1 (ko) * 2013-08-29 2020-03-04 주식회사 대웅제약 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법
CN105367550A (zh) * 2014-08-11 2016-03-02 江苏柯菲平医药股份有限公司 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用
UY36547A (es) 2015-02-05 2016-06-01 Bayer Cropscience Ag Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
TWI710379B (zh) 2015-07-30 2020-11-21 日商武田藥品工業股份有限公司 錠劑
ES2882667T3 (es) 2015-08-07 2021-12-02 Bayer Cropscience Ag Derivados heterocíclicos condensados sustituidos por 2-(het)arilo como pesticidas
CN106430006B (zh) * 2016-08-18 2018-06-12 国网湖南省电力公司带电作业中心 配电线路移动式绝缘登高作业装置及方法
CN108203430A (zh) * 2016-12-16 2018-06-26 天地人和生物科技有限公司 一种新型可逆性质子泵抑制剂及其制备方法和用途
PE20200442A1 (es) 2017-07-10 2020-02-28 Takeda Pharmaceuticals Co Preparacion que comprende vonoprazan
CN113527536B (zh) * 2020-04-21 2024-03-22 杭州德柯医疗科技有限公司 一种含氟多糖高分子化合物及其制备方法
JP7404561B2 (ja) * 2020-06-17 2023-12-25 イルドン ファーマシューティカル カンパニー リミテッド 新規な酸分泌抑制剤及びその用途
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN113620930B (zh) * 2021-07-12 2022-08-16 南京烁慧医药科技有限公司 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用
WO2023113474A1 (ko) * 2021-12-15 2023-06-22 일동제약(주) 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물
WO2023113458A1 (en) * 2021-12-15 2023-06-22 Ildong Pharmaceutical Co., Ltd. Novel salt of 1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical composition comprising thereof
KR20230102353A (ko) * 2021-12-30 2023-07-07 주식회사 대웅제약 삼중음성유방암의 예방 또는 치료용 약학적 조성물

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0259085B1 (en) 1986-08-29 1991-08-21 Pfizer Inc. 2-guanidino-4-arylthiazoles for treatment of peptic ulcers
US5128366A (en) 1990-07-05 1992-07-07 Shinogi & Co., Ltd. Pyrrole derivatives
US5331006A (en) 1990-08-31 1994-07-19 Warner-Lambert Company Amino acid analogs as CCK antagonists
WO1992004025A1 (en) 1990-08-31 1992-03-19 Warner-Lambert Company Amino acid analogs as cck antagonists
SK44894A3 (en) 1991-10-18 1995-04-12 Monsanto Co Trisubstituted aromatic compounds, method of their preparation and fungicidal agents
ZA927272B (en) 1991-10-29 1994-03-23 Du Pont Herbicidal triazolecarboxamides
JPH06135961A (ja) 1992-10-23 1994-05-17 Nippon Iyakuhin Kogyo Kk 新規ジフェニルピロリルフラン誘導体
US5286742A (en) * 1992-11-03 1994-02-15 American Cyanamid Company Pyrrole thiocarboxamide insecticidal and acaricidal agents
US5480902A (en) 1993-08-31 1996-01-02 American Cyanamid Company Thienylpyrrole fungicidal agents
JPH08119936A (ja) 1994-10-18 1996-05-14 Fujisawa Pharmaceut Co Ltd 複素環式誘導体
JPH0930967A (ja) 1995-07-17 1997-02-04 Chugai Pharmaceut Co Ltd 抗潰瘍剤
RU2221782C2 (ru) 1996-08-28 2004-01-20 Дзе Проктер Энд Гэмбл Компани Замещенные циклические аминовые ингибиторы металлопротеаз
JP2001509145A (ja) 1996-12-23 2001-07-10 デュポン ファーマシューティカルズ カンパニー Ｘａ因子阻害剤としての窒素を含む複素環式芳香族化合物
JPH11209344A (ja) 1998-01-26 1999-08-03 Kyowa Hakko Kogyo Co Ltd 含窒素複素環化合物
GB9817548D0 (en) 1998-08-12 1998-10-07 Novartis Ag Organic compounds
DE60020226T2 (de) 1999-03-10 2006-02-02 Shionogi & Co., Ltd. Medizinische zubereitungen mit [2.2.1] und [3.1.1]bicycloskelett die antagonisten für sowohl pgd 2? als auch txa 2? rezeptoren sind
TW575561B (en) 1999-03-25 2004-02-11 Hoffmann La Roche 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives
AU3783100A (en) 1999-06-14 2000-12-21 Dow Agrosciences Llc Substituted triazoles, imidazoles and pyrazoles as herbicides
CA2383257C (en) * 1999-08-26 2010-09-28 Christopher J. Burns Substituted (aminoiminomethyl or aminomethyl) dihydrobenzofurans and benozopyrans
EP1284260A4 (en) 2000-05-22 2004-03-31 Takeda Chemical Industries Ltd TYROSINE PHOSPHATASE INHIBITORS
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
GB0016453D0 (en) 2000-07-04 2000-08-23 Hoffmann La Roche Pyrrole derivatives
CA2460594A1 (en) 2001-10-01 2003-04-10 Taisho Pharmaceutical Co., Ltd. Mch receptor antagonists
JP2005511613A (ja) 2001-11-08 2005-04-28 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー 疾患治療用アザビシクロ置換ヘテロアリール化合物
EP1451179A1 (en) 2001-11-22 2004-09-01 Ciba SC Holding AG Pyrrole synthesis
US20050101657A1 (en) 2001-12-28 2005-05-12 Takeda Chemical Industries Ltd. Androgen receptor antagonists
WO2003068738A1 (en) 2002-02-11 2003-08-21 Neurocrine Biosciences, Inc. Pyrrole derivatives as ligands of melanocortin receptors
WO2003068740A1 (en) * 2002-02-14 2003-08-21 Wyeth Pyrrolylalkylidene-hydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands
TW200306191A (en) 2002-02-22 2003-11-16 Teijin Ltd Pyrrolopyrimidine derivatives
CN100335477C (zh) 2002-06-13 2007-09-05 纳幕尔杜邦公司 吡唑甲酰胺杀虫剂
JP2006501217A (ja) * 2002-08-12 2006-01-12 スージェン・インコーポレーテッド 新規キナーゼ阻害剤としての３−ピロリル−ピリドピラゾールおよび３−ピロリル−インダゾール
JP2004315511A (ja) 2003-03-31 2004-11-11 Taisho Pharmaceut Co Ltd Ｍｃｈ受容体アンタゴニスト
EP1628957B1 (en) 2003-05-26 2010-09-29 Takeda Pharmaceutical Company Limited Sulfopyrroles
EP1803709B1 (en) 2004-09-30 2013-01-02 Takeda Pharmaceutical Company Limited Proton pump inhibitors
EP1655284A1 (en) 2004-10-26 2006-05-10 Aponetics AG 2-Phenylsulfopyrroles
ES2364498T3 (es) * 2005-08-30 2011-09-05 Takeda Pharmaceutical Company Limited Inhibidor de la secreción ácida.
US8512761B2 (en) * 2006-01-27 2013-08-20 Yale University Fast acting inhibitor of gastric acid secretion
US7994205B2 (en) * 2006-03-31 2011-08-09 Takeda Pharmaceutical Company Limited Aryl-or heteroaryl-sulfonyl compounds as acid secretion inhibitors
US8933105B2 (en) 2007-02-28 2015-01-13 Takeda Pharmaceutical Company Limited Pyrrole compounds
PE20090709A1 (es) 2007-09-28 2009-07-15 Takeda Pharmaceutical Compuestos heterociclico de 5 miembros
US20090318429A1 (en) * 2008-04-28 2009-12-24 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives
UY31830A (es) 2008-05-16 2010-01-05 Takeda Pharmaceutical Activadores de glucoquinasa
WO2010024451A1 (en) 2008-08-27 2010-03-04 Takeda Pharmaceutical Company Limited Pyrrole compounds

Also Published As

Publication number Publication date
EP2318390B1 (en) 2013-05-01
MX2011001955A (es) 2011-03-29
RS52872B (en) 2013-12-31
CO6321166A2 (es) 2011-09-20
AU2009284867A1 (en) 2010-03-04
KR101629181B1 (ko) 2016-06-13
CN102197033A (zh) 2011-09-21
CY1114452T1 (el) 2016-10-05
EA019741B1 (ru) 2014-05-30
US8969387B2 (en) 2015-03-03
DOP2011000061A (es) 2011-04-15
MY152008A (en) 2014-08-15
SMT201300085B (it) 2013-09-06
CA2735162A1 (en) 2010-03-04
ME01598B (me) 2014-09-20
US20100056577A1 (en) 2010-03-04
ECSP11010912A (es) 2011-04-29
CN102197033B (zh) 2014-07-16
TW201010993A (en) 2010-03-16
IL211335A (en) 2013-12-31
JP2012501296A (ja) 2012-01-19
CR20110169A (es) 2011-05-16
AU2009284867A2 (en) 2011-04-21
ES2423289T3 (es) 2013-09-19
EA201170384A1 (ru) 2011-10-31
SI2318390T1 (sl) 2013-08-30
BRPI0917705A2 (pt) 2016-02-16
TWI473798B (zh) 2015-02-21
AU2009284867B2 (en) 2014-08-28
HRP20130653T1 (en) 2013-08-31
CL2011000402A1 (es) 2011-07-29
US20140031393A1 (en) 2014-01-30
MA32647B1 (fr) 2011-09-01
HK1157756A1 (en) 2012-07-06
DK2318390T3 (da) 2013-07-08
US8592597B2 (en) 2013-11-26
PE20110300A1 (es) 2011-06-16
EP2318390A1 (en) 2011-05-11
PT2318390E (pt) 2013-07-10
JO2871B1 (en) 2015-03-15
US8993598B2 (en) 2015-03-31
CA2735162C (en) 2015-06-23
GEP20135786B (en) 2013-03-11
US20110172275A1 (en) 2011-07-14
KR20110071067A (ko) 2011-06-28
NZ591793A (en) 2012-11-30
JP5638515B2 (ja) 2014-12-10
ZA201101774B (en) 2012-06-27
IL211335A0 (en) 2011-04-28
PL2318390T3 (pl) 2013-09-30
WO2010024451A1 (en) 2010-03-04
PE20141174A1 (es) 2014-09-19
UA105185C2 (uk) 2014-04-25
UY32074A (es) 2010-03-26

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