ES2171416T3 - Remedio contra la trombocitopenia. - Google Patents

Remedio contra la trombocitopenia.

Info

Publication number
ES2171416T3
ES2171416T3 ES93919687T ES93919687T ES2171416T3 ES 2171416 T3 ES2171416 T3 ES 2171416T3 ES 93919687 T ES93919687 T ES 93919687T ES 93919687 T ES93919687 T ES 93919687T ES 2171416 T3 ES2171416 T3 ES 2171416T3
Authority
ES
Spain
Prior art keywords
thrombocitopenia
remedy against
remedy
indolocarbazol
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93919687T
Other languages
English (en)
Inventor
Tatsuya Tamaoki
Yukimasa Shiotsu
Chikara Murakata
Shiro Akinaga
Masami Okabe
Yutaka Saitoh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of ES2171416T3 publication Critical patent/ES2171416T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Abstract

UN REMEDIO DE TROMBOCITOPENIA QUE CONTIENE UN DERIVADO DEL INDOLOCARBAZOL REPRESENTADO POR LA FORMULA GENERAL (I) O UNA SAL DEL MISMO FARMACOLOGICAMENTE ACEPTABLE COMO INGREDIENTE ACTIVO, Y UN NUEVO DERIVADO DEL INDOLOCARBAZOL.
ES93919687T 1992-09-21 1993-09-20 Remedio contra la trombocitopenia. Expired - Lifetime ES2171416T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP25094192 1992-09-21

Publications (1)

Publication Number Publication Date
ES2171416T3 true ES2171416T3 (es) 2002-09-16

Family

ID=17215289

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93919687T Expired - Lifetime ES2171416T3 (es) 1992-09-21 1993-09-20 Remedio contra la trombocitopenia.

Country Status (6)

Country Link
US (1) US5674867A (es)
EP (1) EP0630898B1 (es)
CA (1) CA2123895A1 (es)
DE (2) DE69331228D1 (es)
ES (1) ES2171416T3 (es)
WO (1) WO1994006799A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0675125A1 (en) * 1994-03-18 1995-10-04 Kyowa Hakko Kogyo Co., Ltd. A therapeutic agent for thrombocytopenia and indolocarbazole derivatives
US5604219A (en) * 1994-03-18 1997-02-18 Kyowa Hakko Kogyo Co., Ltd. Indolocarbazole derivatives that stimulate platelet production
JPH10500394A (ja) * 1994-06-01 1998-01-13 チバ−ガイギー アクチェンゲゼルシャフト 多重薬剤耐性細胞を抗腫瘍剤に対して感受性にするための多環式ラクタム誘導体
AU2565795A (en) * 1994-06-01 1995-12-21 Ciba-Geigy Ag Carbazole derivatives as agents against multi-drug resistance
WO1995032975A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents
US5686444A (en) * 1995-04-05 1997-11-11 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US5650407A (en) * 1995-04-05 1997-07-22 Cephalon, Inc. Selected soluble esters of hydroxyl-containing indolocarbazoles
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
US6127401A (en) * 1998-06-05 2000-10-03 Cephalon, Inc. Bridged indenopyrrolocarbazoles
US6806266B1 (en) 1999-07-13 2004-10-19 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) * 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
WO2002077255A1 (en) * 2001-03-22 2002-10-03 Bristol-Myers Squibb Company Topoisomerase i selective cytotoxic sugar derivatives of indolopyrrolocarbazoles
JP2008504292A (ja) 2004-06-24 2008-02-14 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 免疫増強用の化合物
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
AR060358A1 (es) 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
JP2011506560A (ja) 2007-12-20 2011-03-03 ノバルティス アーゲー Ｐｉ３キナーゼ阻害剤として用いられるチアゾール誘導体
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
US8987257B2 (en) 2011-01-31 2015-03-24 Novartis Ag Heterocyclic derivatives
EP2771342B1 (en) 2011-10-28 2016-05-18 Novartis AG Purine derivatives and their use in the treatment of disease
US10213432B2 (en) 2012-05-16 2019-02-26 Novartis Ag Dosage regimen for a PI-3 kinase inhibitor
PL3076969T3 (pl) 2013-12-06 2022-01-17 Novartis Ag Schemat dawkowania selektywnego inhibitora 3-kinazy fosfatydynozytolu alfa-izoformy
TWI538914B (zh) * 2014-10-03 2016-06-21 國立交通大學 蛋白質激酶之選擇性抑制劑、其醫藥組成物及其用途
CA3002954A1 (en) 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
WO2022006220A1 (en) * 2020-07-02 2022-01-06 Baylor University Indolocarbazole analogs of staurosporine and methods of synthesis thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5373501A (en) * 1976-12-11 1978-06-30 Kitasato Inst Novel antibiotics amm2282 and process for preparing same
JPS6041489A (ja) * 1983-08-12 1985-03-05 Kyowa Hakko Kogyo Co Ltd 新規生理活性物質ｋ―２５２
JPS62120388A (ja) * 1985-11-19 1987-06-01 Meiji Seika Kaisha Ltd Ｓｆ−２３７０物質ハロゲン化誘導体とその製造法
JPS62155284A (ja) * 1985-12-27 1987-07-10 Kyowa Hakko Kogyo Co Ltd 生理活性物質ｋ−２５２の誘導体
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
JPH0826037B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
JPH0826036B2 (ja) * 1987-01-22 1996-03-13 協和醗酵工業株式会社 生理活性物質ｋ−２５２の誘導体
WO1988007045A1 (en) * 1987-03-09 1988-09-22 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
IL86632A0 (en) * 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
JPS6420388A (en) * 1987-07-14 1989-01-24 Nakatsuka Kogyo Method for expressing grain pattern on fabric
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
JP2766360B2 (ja) * 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体
JPH0372485A (ja) * 1989-05-23 1991-03-27 Asahi Chem Ind Co Ltd スタウロスポリンの誘導体
JPH03220194A (ja) * 1989-11-30 1991-09-27 Asahi Chem Ind Co Ltd スタウロスポリンカルボン酸誘導体
JPH04145085A (ja) * 1990-09-25 1992-05-19 Asahi Chem Ind Co Ltd スタウロスポリンのγ―ラクタム環誘導体とそのアンモニウム塩
EP0540185A1 (en) * 1991-10-10 1993-05-05 Schering Corporation 4'-(N-substituted-N-oxide)staurosporine derivatives
DE69326388T2 (de) * 1992-06-22 1999-12-30 Kyowa Hakko Kogyo Kk Verfahren zur Herstellung von Staurosporin-Derivaten

Also Published As

Publication number Publication date
EP0630898B1 (en) 2001-11-28
DE69331228D1 (en) 2002-01-10
US5674867A (en) 1997-10-07
DE69331228T2 (de) 2002-05-23
EP0630898A4 (en) 1995-04-26
DE69331228T4 (de) 2002-09-05
WO1994006799A1 (fr) 1994-03-31
EP0630898A1 (en) 1994-12-28
CA2123895A1 (en) 1994-03-31

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