ES2155057T3 - Dispositivo y metodo para medir el hdl-colesterol, por precipitacion en una fase solida. - Google Patents

Dispositivo y metodo para medir el hdl-colesterol, por precipitacion en una fase solida.

Info

Publication number
ES2155057T3
ES2155057T3 ES91913726T ES91913726T ES2155057T3 ES 2155057 T3 ES2155057 T3 ES 2155057T3 ES 91913726 T ES91913726 T ES 91913726T ES 91913726 T ES91913726 T ES 91913726T ES 2155057 T3 ES2155057 T3 ES 2155057T3
Authority
ES
Spain
Prior art keywords
fluid sample
hdl
matrix
vldl
ldl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913726T
Other languages
English (en)
Inventor
Ronald M Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cholestech Corp
Original Assignee
Cholestech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/554,147 external-priority patent/US5213965A/en
Application filed by Cholestech Corp filed Critical Cholestech Corp
Application granted granted Critical
Publication of ES2155057T3 publication Critical patent/ES2155057T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B01D39/2003—Glass or glassy material
    • B01D39/2017—Glass or glassy material the material being filamentary or fibrous
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B01D2239/0421—Rendering the filter material hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0471—Surface coating material
    • B01D2239/0492—Surface coating material on fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/90—Developer
    • C12Q2326/96—4-Amino-antipyrine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Geology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE MUESTRA UN DISPOSITIVO DE ENSAYO (14) PARA MEDIR LA CONCENTRACION DE UN ANALITICO SOLUBLE, COMO UN COLESTEROL ASOCIADO A HDL (LIPOPROTEINAS DE ALTA DENSIDAD), EN UNA MUESTRA DE FLUIDO QUE CONTIENE COMPUESTOS INTEFERENTES, COMO COLESTEROL ASOCIADO A LDL (LIPOPROTEINAS DE BAJA DENSIDAD) O A VLDL (LIPOPROTEINAS DE MUY BAJA DENSIDAD), QUE PUEDE PRECIPITARSE SELECTIVAMENTE. EL DISPOSITIVO INCLUYE UNA MATRIZ DE TAMIZADO (26) QUE PUEDE SEPARAR MATERIAL PRECIPITADO Y SOLUBLE QUE PASA POR LA MATRIZ, Y UN DEPOSITO (34) QUE CONTIENE UN AGENTE PRECIPITANTE QUE ES EFICAZ, EN UN MARGEN DE CONCENTRACION DADO, PARA PRECIPITAR SELECTIVAMENTE LOS COMPUESTOS INTERFERENTES. EL DEPOSITO SE DISEÑA PARA RETRASAR LA LIBERACION DE AGENTE, AL CONTACTO CON LA MUESTRA DE FLUIDO, PARA MANTENER LA CONCENTRACION DE AGENTE PRECIPITANTE EN CONTACTO CON LA MUESTRA DE FLUIDO DENTRO DEL MARGEN DE CONCENTRACION DADO. EL DISPOSITIVO ADEMAS INCLUYE UNA ALMOHADILLA DE ENSAYO (64, 66, 68, 70) EN DONDE SE PUEDE ENSAYAR EL ANALITICO PRESENTE EN LA MUESTRA DE FLUIDO. UN METODO DE SEPARACION DE HDL DE LDL Y VLDL EMPLEA UNA MATRIZ DE FIBRA DE VIDRIO RECUBIERTA QUE INHIBE LA AGLUTINACION DE HDL A MEDIDA QUE UNA MUESTRA DE FLUIDO SANGUINEO QUE CONTIENE HDL Y LDL Y VLDL PASA POR LA MATRIZ
ES91913726T 1990-07-16 1991-07-15 Dispositivo y metodo para medir el hdl-colesterol, por precipitacion en una fase solida. Expired - Lifetime ES2155057T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/554,147 US5213965A (en) 1990-07-16 1990-07-16 Solid-phase precipitation assay device
US07/729,447 US5213964A (en) 1990-07-16 1991-07-12 High-density lipoprotein solid-base precipitation assay method

Publications (1)

Publication Number Publication Date
ES2155057T3 true ES2155057T3 (es) 2001-05-01

Family

ID=27070513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913726T Expired - Lifetime ES2155057T3 (es) 1990-07-16 1991-07-15 Dispositivo y metodo para medir el hdl-colesterol, por precipitacion en una fase solida.

Country Status (9)

Country Link
US (3) US5213964A (es)
EP (2) EP0539495B1 (es)
JP (1) JP2981774B2 (es)
AT (1) ATE198796T1 (es)
AU (1) AU656733B2 (es)
CA (1) CA2087255C (es)
DE (2) DE9117297U1 (es)
ES (1) ES2155057T3 (es)
WO (1) WO1992001498A2 (es)

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AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
WO2003023354A2 (en) * 2001-09-07 2003-03-20 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
US7157049B2 (en) * 2001-11-20 2007-01-02 Nagaoka & Co., Ltd. Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
WO2003056163A1 (en) * 2001-12-21 2003-07-10 Polymer Technology Systems, Inc. Test strip and method for determining hdl cholesterol concentration from whole blood of plasma
EP1459064B1 (en) * 2001-12-28 2008-02-13 Polymer Technology Systems, Inc. Test strip for determining concentration of triglycerides
DE10204606C1 (de) * 2002-01-18 2003-10-16 Cholestech Corp Vorrichtung und Verfahren für Lipoproteine hoher Dichte
EP1357383B1 (en) * 2002-04-09 2005-11-09 Cholestech Corporation High-density lipoprotein assay device and method
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
AU2003293015A1 (en) * 2002-11-26 2004-06-18 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
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US20050074828A1 (en) * 2003-07-16 2005-04-07 Dimagno Theodore John Uae of lipase for high-density lipoprotein cholesterol detection
DE60319541T2 (de) * 2003-11-04 2009-05-07 Cholestech Corp., Hayward Reagenz-Membrane und -Laminate und Verfahren zur deren Herstellung
US7772007B2 (en) 2004-04-02 2010-08-10 Cholestech Corporation Assay device for direct measurement of LDL cholesterol
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US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
US7824879B2 (en) * 2007-01-09 2010-11-02 Cholestech Corporation Device and method for measuring LDL-associated cholesterol
WO2009037784A1 (ja) * 2007-09-21 2009-03-26 Tya K. K. 体液成分の分析器具
CN101855248B (zh) 2007-11-13 2012-08-22 生物技术通用（以色列）有限公司 用于粘弹性生物聚合物的稀释过滤灭菌方法
JP5313537B2 (ja) * 2008-04-10 2013-10-09 富士フイルム株式会社 高密度リポ蛋白コレステロール測定用乾式分析素子
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Also Published As

Publication number Publication date
EP1028319A3 (en) 2004-01-21
CA2087255A1 (en) 1992-01-17
WO1992001498A2 (en) 1992-02-06
ATE198796T1 (de) 2001-02-15
DE9117297U1 (de) 2000-08-03
US5213964A (en) 1993-05-25
EP0539495A1 (en) 1993-05-05
JP2981774B2 (ja) 1999-11-22
DE69132513T2 (de) 2001-08-23
WO1992001498A3 (en) 1992-03-05
EP0539495B1 (en) 2001-01-17
JPH06502911A (ja) 1994-03-31
DE69132513D1 (de) 2001-02-22
EP1028319A2 (en) 2000-08-16
AU656733B2 (en) 1995-02-16
US5451370A (en) 1995-09-19
AU8298691A (en) 1992-02-18
US5316916A (en) 1994-05-31
CA2087255C (en) 1999-08-31

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