ES2121218T3 - Fenoxifenilciclopentenilhidroxiureas. - Google Patents

Fenoxifenilciclopentenilhidroxiureas.

Info

Publication number
ES2121218T3
ES2121218T3 ES94922374T ES94922374T ES2121218T3 ES 2121218 T3 ES2121218 T3 ES 2121218T3 ES 94922374 T ES94922374 T ES 94922374T ES 94922374 T ES94922374 T ES 94922374T ES 2121218 T3 ES2121218 T3 ES 2121218T3
Authority
ES
Spain
Prior art keywords
pct
date
above compounds
sec
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94922374T
Other languages
English (en)
Inventor
Akiyoshi Kawai
Rodney W Stevens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2121218T3 publication Critical patent/ES2121218T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Abstract

CIERTOS COMPUESTOS NUEVOS DE CICLOPENTENILHIDROXIUREAS SUSTITUIDAS CON FENILO PUEDEN INHIBIR LA ENZIMA 5-LIPOXIGENASA Y SER LOS ISOMEROS DEXTROGIROS DE LOS COMPUESTOS QUE TIENEN LA FORMULA (II) Y DE LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, EN DONDE R{SUP,1} ES HIDROGENO, FLUORO O CLORO; Y R{SUP,2} ES HIDROGENO O METILO. ESTOS COMPUESTOS SON UTILES PARA LA PREVENCION, TRATAMIENTO O ALIVIO DE ENFERMEDADES INFLAMATORIAS, ALERGIAS Y ENFERMEDADES CARDIOVASCULARES DE MAMIFEROS, Y COMO EL INGREDIENTE ACTIVO DE COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE TALES ESTADOS.
ES94922374T 1993-08-19 1994-08-15 Fenoxifenilciclopentenilhidroxiureas. Expired - Lifetime ES2121218T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20545393 1993-08-19

Publications (1)

Publication Number Publication Date
ES2121218T3 true ES2121218T3 (es) 1998-11-16

Family

ID=16507136

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94922374T Expired - Lifetime ES2121218T3 (es) 1993-08-19 1994-08-15 Fenoxifenilciclopentenilhidroxiureas.

Country Status (27)

Country Link
US (1) US5792882A (es)
EP (1) EP0720598B1 (es)
JP (1) JP2794343B2 (es)
KR (1) KR0170623B1 (es)
CN (1) CN1077568C (es)
AT (1) ATE171939T1 (es)
AU (1) AU674776B2 (es)
BR (1) BR9407314A (es)
CA (1) CA2169066C (es)
CO (1) CO4230229A1 (es)
CZ (1) CZ288358B6 (es)
DE (1) DE69413831T2 (es)
DK (1) DK0720598T3 (es)
EC (1) ECSP941144A (es)
EG (1) EG20530A (es)
ES (1) ES2121218T3 (es)
FI (1) FI114466B (es)
IL (1) IL110628A (es)
MY (1) MY111140A (es)
NO (1) NO305595B1 (es)
NZ (1) NZ269849A (es)
PE (1) PE57194A1 (es)
PL (1) PL176223B1 (es)
RU (1) RU2125987C1 (es)
TW (2) TW448144B (es)
WO (1) WO1995005360A1 (es)
ZA (1) ZA946253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100276570B1 (ko) * 1994-06-27 2001-02-01 사이토메드 인코포레이티드 심혈관질환염증성질환및면역성질환치료용화합물
EP0790981B1 (en) * 1994-11-10 1999-09-08 Pfizer Inc. Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
EP1741424B1 (en) 1997-08-11 2018-10-03 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailabilty
US6121323A (en) * 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
JP4903155B2 (ja) * 2004-12-02 2012-03-28 アモーレパシフィック コーポレイション Ｔｎｆ−アルファの生産を阻害する２−シクロペンテン−１−オンオキシム誘導体
KR101567571B1 (ko) 2007-12-03 2015-11-11 (주)아모레퍼시픽 2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 슬리밍 화장료 조성물
CR20170089A (es) 2009-04-03 2017-07-17 Plexxikon Inc Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas
US8512464B2 (en) * 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
MC2091A1 (fr) * 1989-02-03 1991-02-15 Wellcome Found Procedes pour la preparation de composes a action anti-inflammatoire et de formulations pharmaceutiques les contenant
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
JPH05163229A (ja) * 1991-12-13 1993-06-29 Pfizer Pharmaceut Co Ltd 新規なシクロプロピル誘導体
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Also Published As

Publication number Publication date
AU7350994A (en) 1995-03-14
EG20530A (en) 1999-07-31
FI943799A (fi) 1995-02-20
TW418089B (en) 2001-01-11
NZ269849A (en) 1997-10-24
PL313037A1 (en) 1996-05-27
CN1077568C (zh) 2002-01-09
IL110628A0 (en) 1994-11-11
JP2794343B2 (ja) 1998-09-03
DE69413831D1 (de) 1998-11-12
EP0720598A1 (en) 1996-07-10
NO960631L (no) 1996-02-16
RU2125987C1 (ru) 1999-02-10
NO305595B1 (no) 1999-06-28
NO960631D0 (no) 1996-02-16
KR0170623B1 (ko) 1999-03-30
DK0720598T3 (da) 1999-06-21
FI943799A0 (fi) 1994-08-18
ZA946253B (en) 1996-02-19
KR960703845A (ko) 1996-08-31
ATE171939T1 (de) 1998-10-15
CZ48396A3 (en) 1996-07-17
TW448144B (en) 2001-08-01
US5792882A (en) 1998-08-11
EP0720598B1 (en) 1998-10-07
CZ288358B6 (en) 2001-05-16
CA2169066A1 (en) 1995-02-23
IL110628A (en) 1998-12-27
JPH08511031A (ja) 1996-11-19
ECSP941144A (es) 1995-02-27
MY111140A (en) 1999-08-30
CN1129440A (zh) 1996-08-21
DE69413831T2 (de) 1999-02-25
FI114466B (fi) 2004-10-29
PL176223B1 (pl) 1999-05-31
PE57194A1 (es) 1995-02-07
BR9407314A (pt) 1996-04-16
CO4230229A1 (es) 1995-10-19
AU674776B2 (en) 1997-01-09
WO1995005360A1 (en) 1995-02-23
CA2169066C (en) 1999-06-22

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