ECSP941144A - Fenoxifenil ciclo-pentenil hidroxiureas - Google Patents

Fenoxifenil ciclo-pentenil hidroxiureas

Info

Publication number
ECSP941144A
ECSP941144A EC1994001144A ECSP941144A ECSP941144A EC SP941144 A ECSP941144 A EC SP941144A EC 1994001144 A EC1994001144 A EC 1994001144A EC SP941144 A ECSP941144 A EC SP941144A EC SP941144 A ECSP941144 A EC SP941144A
Authority
EC
Ecuador
Prior art keywords
pct
date
phenoxifenil
pentenil
hidroxiureas
Prior art date
Application number
EC1994001144A
Other languages
English (en)
Inventor
Akiyoshi Kawai
Rodney William Stevens
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of ECSP941144A publication Critical patent/ECSP941144A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Ciertos compuestos novedosos fenil-sustituídos ciclopentenil hidroxiurea que tienen la capacidad para inhibir la enzima 5-lipoxigenasa y son los isómeros dextrorrotatorios de los compuestos que tienen la fórmula y las sales farmacéuticamente aceptables de los mismos, en la cual R1 es hidrógeno, fluor o cloro; y R2 es hidrógeno o metilo. Estos compuestos son útiles en la prevención, tratamiento o alivio de enfermedades inflamatorias, alergia y enfermedades cardiovasculares en los mamíferos, y como ingrediente activo en las composiciones farmacéuticas para el tratamiento de tales condiciones.
EC1994001144A 1993-08-19 1994-08-17 Fenoxifenil ciclo-pentenil hidroxiureas ECSP941144A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP20545393 1993-08-19

Publications (1)

Publication Number Publication Date
ECSP941144A true ECSP941144A (es) 1995-02-27

Family

ID=16507136

Family Applications (1)

Application Number Title Priority Date Filing Date
EC1994001144A ECSP941144A (es) 1993-08-19 1994-08-17 Fenoxifenil ciclo-pentenil hidroxiureas

Country Status (27)

Country Link
US (1) US5792882A (es)
EP (1) EP0720598B1 (es)
JP (1) JP2794343B2 (es)
KR (1) KR0170623B1 (es)
CN (1) CN1077568C (es)
AT (1) ATE171939T1 (es)
AU (1) AU674776B2 (es)
BR (1) BR9407314A (es)
CA (1) CA2169066C (es)
CO (1) CO4230229A1 (es)
CZ (1) CZ288358B6 (es)
DE (1) DE69413831T2 (es)
DK (1) DK0720598T3 (es)
EC (1) ECSP941144A (es)
EG (1) EG20530A (es)
ES (1) ES2121218T3 (es)
FI (1) FI114466B (es)
IL (1) IL110628A (es)
MY (1) MY111140A (es)
NO (1) NO305595B1 (es)
NZ (1) NZ269849A (es)
PE (1) PE57194A1 (es)
PL (1) PL176223B1 (es)
RU (1) RU2125987C1 (es)
TW (2) TW418089B (es)
WO (1) WO1995005360A1 (es)
ZA (1) ZA946253B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL317873A1 (en) * 1994-06-27 1997-04-28 Cytomed Inc Compounds for and method of treating cardiovascular, inflammatory and immunological disorders
CA2205033C (en) * 1994-11-10 2001-12-11 Akiyoshi Kawai Aryloxycycloalkenyl and aryloxyiminocycloalkenylhydroxyureas as 5-lipoxygenase inhibitors
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
EP1745774A3 (en) 1997-08-11 2007-04-11 Pfizer Products Inc. Solid pharmaceutical dispersions with enhanced bioavailability
US6121323A (en) * 1997-12-03 2000-09-19 3M Innovative Properties Company Bishydroxyureas
US8013187B2 (en) * 2004-12-02 2011-09-06 Amorepacific Corporation 2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-α
KR101494488B1 (ko) * 2007-12-03 2015-02-24 (주)아모레퍼시픽 2-사이클로펜텐-1-온 옥심 유도체를 유효성분으로 포함하는 지방대사질환 예방 및 치료용 약학 조성물
WO2010114928A2 (en) 2009-04-03 2010-10-07 F.Hoffmann-La Roche Ag Compositions and uses thereof
US8512464B2 (en) * 2009-12-02 2013-08-20 3M Innovative Properties Company Functionalized zirconia nanoparticles and high index films made therefrom

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222168A (en) * 1986-10-20 1991-05-28 Oncogene Science Inc Tumour growth inhibiting protein related to tgf-#b#1 and tgf-#b#2, preparation by genetic engineering methods, antibodies and pharmaceutical compositions
FI900536A0 (fi) * 1989-02-03 1990-02-02 Wellcome Found Anti-inflammatoriska arylkompositioner.
US5120752A (en) * 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) * 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
JP3007138B2 (ja) * 1990-11-27 2000-02-07 ファイザー製薬株式会社 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物
JPH06256285A (ja) * 1990-12-11 1994-09-13 Pfizer Pharmaceut Co Ltd ヒドロキサム酸誘導体およびその用途
JPH05163229A (ja) * 1991-12-13 1993-06-29 Pfizer Pharmaceut Co Ltd 新規なシクロプロピル誘導体
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物

Also Published As

Publication number Publication date
DE69413831T2 (de) 1999-02-25
ES2121218T3 (es) 1998-11-16
EP0720598B1 (en) 1998-10-07
EP0720598A1 (en) 1996-07-10
CZ288358B6 (en) 2001-05-16
NO305595B1 (no) 1999-06-28
TW418089B (en) 2001-01-11
AU7350994A (en) 1995-03-14
DE69413831D1 (de) 1998-11-12
NZ269849A (en) 1997-10-24
ATE171939T1 (de) 1998-10-15
JPH08511031A (ja) 1996-11-19
CN1129440A (zh) 1996-08-21
PL176223B1 (pl) 1999-05-31
CN1077568C (zh) 2002-01-09
FI943799A0 (fi) 1994-08-18
IL110628A0 (en) 1994-11-11
TW448144B (en) 2001-08-01
RU2125987C1 (ru) 1999-02-10
CZ48396A3 (en) 1996-07-17
WO1995005360A1 (en) 1995-02-23
CA2169066A1 (en) 1995-02-23
PE57194A1 (es) 1995-02-07
MY111140A (en) 1999-08-30
KR0170623B1 (ko) 1999-03-30
KR960703845A (ko) 1996-08-31
DK0720598T3 (da) 1999-06-21
NO960631L (no) 1996-02-16
US5792882A (en) 1998-08-11
IL110628A (en) 1998-12-27
CO4230229A1 (es) 1995-10-19
PL313037A1 (en) 1996-05-27
EG20530A (en) 1999-07-31
ZA946253B (en) 1996-02-19
FI114466B (fi) 2004-10-29
CA2169066C (en) 1999-06-22
BR9407314A (pt) 1996-04-16
FI943799A (fi) 1995-02-20
JP2794343B2 (ja) 1998-09-03
NO960631D0 (no) 1996-02-16
AU674776B2 (en) 1997-01-09

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