ES2105292T3 - Peptidos marcados con tecnecio-99m para obtencion de imagenes. - Google Patents
Peptidos marcados con tecnecio-99m para obtencion de imagenes.Info
- Publication number
- ES2105292T3 ES2105292T3 ES93915221T ES93915221T ES2105292T3 ES 2105292 T3 ES2105292 T3 ES 2105292T3 ES 93915221 T ES93915221 T ES 93915221T ES 93915221 T ES93915221 T ES 93915221T ES 2105292 T3 ES2105292 T3 ES 2105292T3
- Authority
- ES
- Spain
- Prior art keywords
- reagents
- union
- peptides
- specific
- tecnecio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract 8
- 238000000034 method Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
ESTA INVENCION DESCRIBE REACTIVOS RADIOMARCADOS, INCLUYENDO SUS CASOS DE PEPTIDOS DE UNION ESPECIFICA, Y LOS METODOS PARA PRODUCIR Y APLICAR TALES REACTIVOS. ESPECIFICAMENTE, LA INVENCION DESCRIBE LOS REACTIVOS PARA PREPARAR AGENTES DE REPRESENTACION DE IMAGENES ESCINTOGRAFICAS PARA SITIOS DE REPRESENTACION DE IMAGENES EN UN CUERPO DE MAMIFERO. SE DESCRIBEN LOS REACTIVOS, LOS METODOS Y LAS HERRAMIENTAS PARA HACER TALES REACTIVOS, Y LOS METODOS PARA APLICAR TALES REACTIVOS MARCADOS CON TECNECIO-99M (TC-99M) POR PARTES DE UNION DE TC-99M QUE COMPRENDE DICHOS REACTIVOS. EN PARTICULAR, LOS PEPTIDOS DE UNION ESPECIFICA Y LAS PARTES DE UNION DE TC-99M QUE COMPRENDE LOS REACTIVOS DE LA INVENCION ESTAN UNIDOS COVALENTEMENTE A UNA PARTE LIGADORA POLIVALENTE, TAL QUE LA PARTE LIGADORA POLIVALENTE ESTA LIGADA COVALENTEMENTE A UNA MULTIPLICIDAD DE LOS PEPTIDOS DE UNION ESPECIFICA, Y LAS PARTES DE UNION DE TC-99M SON COVALENTEMENTE LIGADAS A UNA PLURALIDAD DE PEPTIDOS DE UNION ESPECIFICA, LA PARTE LIGADORA POLIVALENTE O A AMBOS PEPTIDOS DE UNION ESPECIFICA Y PARTE LIGADORA POLIVALENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/893,981 US5508020A (en) | 1992-06-05 | 1992-06-05 | Technetium-99M labeled peptides for imaging |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2105292T3 true ES2105292T3 (es) | 1997-10-16 |
Family
ID=25402435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93915221T Expired - Lifetime ES2105292T3 (es) | 1992-06-05 | 1993-06-04 | Peptidos marcados con tecnecio-99m para obtencion de imagenes. |
Country Status (11)
Country | Link |
---|---|
US (4) | US5508020A (es) |
EP (1) | EP0644778B1 (es) |
JP (1) | JP2954354B2 (es) |
AT (1) | ATE152918T1 (es) |
AU (1) | AU688264B2 (es) |
CA (1) | CA2137009C (es) |
DE (1) | DE69310733T2 (es) |
DK (1) | DK0644778T3 (es) |
ES (1) | ES2105292T3 (es) |
HK (1) | HK1007685A1 (es) |
WO (1) | WO1993025244A1 (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
US5700444A (en) * | 1992-02-20 | 1997-12-23 | Rhomed Incorporated | Chemotactic peptide pharmaceutical applications |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
WO1992013572A1 (en) * | 1991-02-08 | 1992-08-20 | Diatech, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5783170A (en) * | 1991-11-27 | 1998-07-21 | Diatide, Inc. | Peptide-metal chelate conjugates |
US5556609A (en) * | 1992-02-20 | 1996-09-17 | Rhomed Incorporated | YIGSR peptide radiopharmaceutical applications |
US5738838A (en) * | 1992-02-20 | 1998-04-14 | Rhomed Incorporated | IKVAV peptide radiopharmaceutical applications |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
AU709306B2 (en) * | 1992-04-30 | 1999-08-26 | Cis Bio International | Radiolabeled compounds for thrombus imaging |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5620675A (en) | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
US5716596A (en) * | 1992-06-23 | 1998-02-10 | Diatide, Inc. | Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses |
US6017512A (en) * | 1992-06-23 | 2000-01-25 | Diatide, Inc. | Radiolabeled peptides |
JPH08502261A (ja) * | 1992-10-02 | 1996-03-12 | ダイアテク,インコーポレイテッド | 多重多価抗血栓症剤 |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
US5814299A (en) * | 1993-07-28 | 1998-09-29 | Diatide, Inc. | Radiolabeled glucans comprising a single thiol containing moiety |
WO1995019187A1 (en) * | 1994-01-12 | 1995-07-20 | Amersham International Plc | Biological targeting agents |
US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
AU2186695A (en) * | 1994-03-18 | 1995-10-09 | Diatech, Inc. | Piperidyl-4-substituted thyrosine derivatives as scintigraphic imaging agents for the diagnosis of thrombosis |
US6051206A (en) * | 1994-06-03 | 2000-04-18 | Diatide, Inc | Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses |
IL113610A0 (en) * | 1994-06-03 | 1995-08-31 | Immunomedics Inc | A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same |
CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
US6331285B1 (en) | 1996-06-05 | 2001-12-18 | Palatin Technologies, Inc. | Structurally determined cyclic metallo-constructs and applications |
JP3647881B2 (ja) | 1996-07-12 | 2005-05-18 | イムノメディクス,インコーポレイテッド | 放射性金属元素結合ペプチドの類似化合物 |
GB9708265D0 (en) * | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
EP1905357B1 (en) | 1997-04-30 | 2012-11-28 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
US5886142A (en) * | 1997-05-20 | 1999-03-23 | Thomas Jefferson University | Radiolabeled thrombus imaging agents |
US6028056A (en) * | 1998-02-06 | 2000-02-22 | Diatide, Inc. | Pharmaceutical compositions for imaging and treating thrombi |
US6022857A (en) * | 1998-06-19 | 2000-02-08 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US7385025B2 (en) | 2000-12-19 | 2008-06-10 | Palatin Technologies, Inc. | Metallopeptide compounds |
JP2005514335A (ja) * | 2001-10-19 | 2005-05-19 | トマス ジェファソン ユニバーシティ | 腫瘍イメージング及び治療のためのpacap組成物及び方法 |
US7492355B2 (en) * | 2002-04-22 | 2009-02-17 | Thomson Licensing | Web browser for use with a television display for preventing screen burn |
US20060029544A1 (en) * | 2004-08-06 | 2006-02-09 | The Regents Of The University Of California Office Of Technology Transfer | Receptor-binding cyclic peptides and methods of use |
EP2300032A4 (en) | 2008-05-13 | 2012-12-05 | Univ Kansas | MARKER PRESENTING IN THE FORM OF A MAP PEPTIDE (METAL ABSTRACTION PEPTIDE) AND ASSOCIATED METHODS |
BR112014003366B1 (pt) | 2011-08-17 | 2020-08-04 | Life Molecular Imaging Sa | Compostos para ligação à glicoproteína iib/iiia específica de plaqueta, seus usos e seus métodos de fabricação, e kit |
US9187735B2 (en) | 2012-06-01 | 2015-11-17 | University Of Kansas | Metal abstraction peptide with superoxide dismutase activity |
US20160008490A1 (en) | 2013-02-12 | 2016-01-14 | Bayer Pharma Aktiengesellschaft | Metal chelate compounds for binding to the platelet specific glycoprotein iib/iiia |
DE102013113156A1 (de) | 2013-11-28 | 2015-05-28 | Freie Universität Berlin | Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese |
Family Cites Families (70)
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---|---|---|---|---|
US4427646A (en) * | 1981-04-02 | 1984-01-24 | Research Corporation | Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4444690A (en) * | 1982-02-25 | 1984-04-24 | University Patents, Inc. | Technetium chelates |
US4571430A (en) * | 1982-11-08 | 1986-02-18 | Medi-Physics, Inc. | Homocysteine and homocysteinamide derivatives |
US4434151A (en) * | 1982-11-08 | 1984-02-28 | Medi-Physics, Inc. | Bifunctional chelating agents |
US4575556A (en) * | 1982-11-08 | 1986-03-11 | Medi-Physics, Inc. | Bifunctional chelating agents |
US4673562A (en) * | 1983-08-19 | 1987-06-16 | The Children's Medical Center Corporation | Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents |
DE3680924D1 (de) * | 1985-01-14 | 1991-09-26 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
US4748022A (en) | 1985-03-25 | 1988-05-31 | Busciglio John A | Topical composition |
US4746505A (en) * | 1985-04-26 | 1988-05-24 | President And Fellows Of Harvard College | Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands |
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WO1989012615A1 (en) | 1988-06-23 | 1989-12-28 | E.I. Du Pont De Nemours And Company | Catalyzed hydrofluorination process |
WO1990001169A1 (en) * | 1988-07-26 | 1990-02-08 | Szekely Levente | Device for measuring and recording acceleration data |
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ATE172796T1 (de) | 1988-08-03 | 1998-11-15 | Univ California | Sonde für hohe auflösung nmr mit wiederorientierung der muster |
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US5180816A (en) * | 1988-08-24 | 1993-01-19 | Centocor | One vial method for labeling protein/linker conjugates with technetium-99M |
JPH04500805A (ja) * | 1988-10-04 | 1992-02-13 | カンサー・リサーチ・キャンペーン・テクノロジー・リミテッド | 標的剤 |
US5196510A (en) * | 1988-12-29 | 1993-03-23 | Cytogen Corporation | Molecular recognition units |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
DE69023394T2 (de) * | 1989-06-16 | 1996-07-04 | Merck Frosst Canada Inc | Chelat-Derivate von atrialnatriurethischem Faktor (ANF). |
GB8914020D0 (en) * | 1989-06-19 | 1989-08-09 | Antisoma Ltd | Synthetic peptides for use in thrombus detection |
ES2070329T3 (es) * | 1989-07-20 | 1995-06-01 | Sandoz Ltd | Derivados de polipeptidos. |
FR2650672A1 (fr) * | 1989-08-02 | 1991-02-08 | Medgenix Group Sa | Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues |
US4961869A (en) * | 1989-08-03 | 1990-10-09 | E. I. Du Pont De Nemours And Company | Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol |
US5443816A (en) | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5196404B1 (en) * | 1989-08-18 | 1996-09-10 | Biogen Inc | Inhibitors of thrombin |
IL97459A0 (en) * | 1990-03-09 | 1992-06-21 | Hybritech Inc | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
US5273743A (en) * | 1990-03-09 | 1993-12-28 | Hybritech Incorporated | Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent |
GB9012995D0 (en) * | 1990-06-11 | 1990-08-01 | Celltech Ltd | Multivalent antigen-binding proteins |
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US6019958A (en) * | 1991-02-08 | 2000-02-01 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5997844A (en) * | 1991-02-08 | 1999-12-07 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5561220A (en) * | 1991-02-08 | 1996-10-01 | Diatech, Inc. | Technetium-99m labeled peptides for imaging inflammation |
WO1992013572A1 (en) * | 1991-02-08 | 1992-08-20 | Diatech, Inc. | TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5645815A (en) * | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5830856A (en) * | 1991-02-08 | 1998-11-03 | Diatide, Inc. | Radiolabeled compounds for thrombus imaging |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
US6107459A (en) * | 1991-02-08 | 2000-08-22 | Diatide, Inc. | Technetium-99m labeled peptides for diagnostic imaging |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
US5989519A (en) * | 1992-03-13 | 1999-11-23 | Diatide, Inc. | Technetium-99m labeled peptides for imaging inflammation |
JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
US5326856A (en) * | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
DK0641222T3 (da) * | 1992-05-21 | 2000-12-11 | Diatide Inc | Peptider mærket med technetium-99m til trombeafbildning |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5620675A (en) * | 1992-06-23 | 1997-04-15 | Diatech, Inc. | Radioactive peptides |
JPH08502261A (ja) * | 1992-10-02 | 1996-03-12 | ダイアテク,インコーポレイテッド | 多重多価抗血栓症剤 |
DE69431052T2 (de) * | 1993-04-08 | 2003-03-13 | Diatide Inc | Radiomarkierte verbindungen zur thrombus-bilderzeugung |
US5951964A (en) * | 1993-06-04 | 1999-09-14 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
ATE234639T1 (de) * | 1994-05-02 | 2003-04-15 | Diatide Inc | Technetium-99m markierte bildformungsmittel |
-
1992
- 1992-06-05 US US07/893,981 patent/US5508020A/en not_active Expired - Lifetime
-
1993
- 1993-06-04 EP EP93915221A patent/EP0644778B1/en not_active Revoked
- 1993-06-04 ES ES93915221T patent/ES2105292T3/es not_active Expired - Lifetime
- 1993-06-04 WO PCT/US1993/005372 patent/WO1993025244A1/en active IP Right Grant
- 1993-06-04 DK DK93915221.1T patent/DK0644778T3/da active
- 1993-06-04 DE DE69310733T patent/DE69310733T2/de not_active Expired - Fee Related
- 1993-06-04 CA CA002137009A patent/CA2137009C/en not_active Expired - Fee Related
- 1993-06-04 JP JP6501622A patent/JP2954354B2/ja not_active Expired - Lifetime
- 1993-06-04 AU AU45287/93A patent/AU688264B2/en not_active Ceased
- 1993-06-04 AT AT93915221T patent/ATE152918T1/de not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/467,567 patent/US6113878A/en not_active Expired - Fee Related
- 1995-06-06 US US08/469,858 patent/US5976494A/en not_active Expired - Fee Related
-
1997
- 1997-07-08 US US08/889,212 patent/US6667389B1/en not_active Expired - Fee Related
-
1998
- 1998-06-26 HK HK98106974A patent/HK1007685A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0644778A1 (en) | 1995-03-29 |
JP2954354B2 (ja) | 1999-09-27 |
US6667389B1 (en) | 2003-12-23 |
EP0644778B1 (en) | 1997-05-14 |
CA2137009A1 (en) | 1993-12-23 |
DE69310733T2 (de) | 1997-10-30 |
US5508020A (en) | 1996-04-16 |
US6113878A (en) | 2000-09-05 |
US5976494A (en) | 1999-11-02 |
DK0644778T3 (da) | 1997-11-03 |
ATE152918T1 (de) | 1997-05-15 |
HK1007685A1 (en) | 1999-04-23 |
DE69310733D1 (de) | 1997-06-19 |
AU688264B2 (en) | 1998-03-12 |
WO1993025244A1 (en) | 1993-12-23 |
CA2137009C (en) | 2001-11-27 |
JPH07506592A (ja) | 1995-07-20 |
AU4528793A (en) | 1994-01-04 |
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