DK0644778T3 - Technetium-99-mærkede peptider til imagografi - Google Patents

Technetium-99-mærkede peptider til imagografi

Info

Publication number
DK0644778T3
DK0644778T3 DK93915221.1T DK93915221T DK0644778T3 DK 0644778 T3 DK0644778 T3 DK 0644778T3 DK 93915221 T DK93915221 T DK 93915221T DK 0644778 T3 DK0644778 T3 DK 0644778T3
Authority
DK
Denmark
Prior art keywords
peptides
technetium
linker moiety
binding
polyvalent linker
Prior art date
Application number
DK93915221.1T
Other languages
Danish (da)
English (en)
Inventor
John Lister-James
Richard T Dean
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25402435&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0644778(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of DK0644778T3 publication Critical patent/DK0644778T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK93915221.1T 1992-06-05 1993-06-04 Technetium-99-mærkede peptider til imagografi DK0644778T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/893,981 US5508020A (en) 1992-06-05 1992-06-05 Technetium-99M labeled peptides for imaging
PCT/US1993/005372 WO1993025244A1 (en) 1992-06-05 1993-06-04 TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING

Publications (1)

Publication Number Publication Date
DK0644778T3 true DK0644778T3 (da) 1997-11-03

Family

ID=25402435

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93915221.1T DK0644778T3 (da) 1992-06-05 1993-06-04 Technetium-99-mærkede peptider til imagografi

Country Status (11)

Country Link
US (4) US5508020A (es)
EP (1) EP0644778B1 (es)
JP (1) JP2954354B2 (es)
AT (1) ATE152918T1 (es)
AU (1) AU688264B2 (es)
CA (1) CA2137009C (es)
DE (1) DE69310733T2 (es)
DK (1) DK0644778T3 (es)
ES (1) ES2105292T3 (es)
HK (1) HK1007685A1 (es)
WO (1) WO1993025244A1 (es)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792444A (en) * 1989-05-09 1998-08-11 The General Hospital Corporation Labeled chemotactic peptides to image focal sites of infection or inflammation
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5556609A (en) * 1992-02-20 1996-09-17 Rhomed Incorporated YIGSR peptide radiopharmaceutical applications
US5738838A (en) * 1992-02-20 1998-04-14 Rhomed Incorporated IKVAV peptide radiopharmaceutical applications
CA2131816C (en) * 1992-03-13 2001-08-28 Richard T. Dean Technetium-99m labeled peptides for imaging inflammation
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
AU709306B2 (en) * 1992-04-30 1999-08-26 Cis Bio International Radiolabeled compounds for thrombus imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
DK0665853T3 (da) * 1992-10-02 2002-11-04 Diatide Inc Multimere polyvalente antitrombotiske midler
WO1994023758A1 (en) * 1993-04-08 1994-10-27 Diatech, Inc. Radiolabeled compounds for thrombus imaging
ATE196609T1 (de) * 1993-07-28 2000-10-15 Diatide Inc Radiomarkierte glukane
EP0738158B1 (en) * 1994-01-12 2002-04-03 Amersham plc Biological targeting agents
US5569745A (en) * 1994-02-25 1996-10-29 Resolution Pharmaceuticals Inc. Peptide-Chelator conjugates
ZA952206B (en) * 1994-03-18 1995-12-12 Diatech Inc Scintigraphic imaging agents
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
US6126916A (en) * 1996-07-12 2000-10-03 Immunomedics, Inc. Radiometal-binding peptide analogues
GB9708265D0 (en) * 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
EP1905357B1 (en) 1997-04-30 2012-11-28 The Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US5886142A (en) * 1997-05-20 1999-03-23 Thomas Jefferson University Radiolabeled thrombus imaging agents
US6028056A (en) * 1998-02-06 2000-02-22 Diatide, Inc. Pharmaceutical compositions for imaging and treating thrombi
US6022857A (en) * 1998-06-19 2000-02-08 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
CA2464002C (en) * 2001-10-19 2011-06-28 Thomas Jefferson University Pacap compositions and methods for tumor imaging and therapy
MXPA04010487A (es) * 2002-04-22 2004-12-13 Thomson Licensing Sa Un navegador de red para usarse con un despliegue de television para evitar el quemado de pantalla.
WO2006017619A2 (en) * 2004-08-06 2006-02-16 The Regents Of The University Of California Receptor-binding cyclic peptides and methods of use
CN102088991A (zh) 2008-05-13 2011-06-08 堪萨斯大学 金属提取肽标签和相关方法
PT2744802T (pt) 2011-08-17 2017-03-15 Piramal Imaging Sa Compostos para ligação às glicoproteínas iib/iiia específicas de plaquetas e a sua utilização em imagiologia de trombos
WO2013181461A2 (en) 2012-06-01 2013-12-05 University Of Kansas Metal abstraction peptide with superoxide dismutase activity
JP2016508507A (ja) 2013-02-12 2016-03-22 バイエル・ファルマ・アクティエンゲゼルシャフト 血小板特異的糖タンパク質ＩＩｂ／ＩＩＩａに結合するための金属キレート化合物
DE102013113156A1 (de) * 2013-11-28 2015-05-28 Freie Universität Berlin Verbindung und Verfahren zur selektiven Radiomarkierung von Polypeptiden mittels Festphasensynthese

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4427646A (en) * 1981-04-02 1984-01-24 Research Corporation Use of radiolabeled peptide derived from crosslinked fibrin to locate thrombi in vivo
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4434151A (en) * 1982-11-08 1984-02-28 Medi-Physics, Inc. Bifunctional chelating agents
US4575556A (en) * 1982-11-08 1986-03-11 Medi-Physics, Inc. Bifunctional chelating agents
US4571430A (en) * 1982-11-08 1986-02-18 Medi-Physics, Inc. Homocysteine and homocysteinamide derivatives
US4673562A (en) * 1983-08-19 1987-06-16 The Children's Medical Center Corporation Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
US4748022A (en) 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4746505A (en) * 1985-04-26 1988-05-24 President And Fellows Of Harvard College Technetium radiodiagnostic fatty acids derived from bisamide bisthiol ligands
GB8525974D0 (en) * 1985-10-22 1985-11-27 Nyegaard & Co As Chemical substance
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
US4965392A (en) * 1987-03-26 1990-10-23 Neorx Corporation Chelating compounds for metal-radionuclide labeled proteins
EP0325639A4 (en) * 1987-07-07 1990-10-24 Cytrx Biopool Ltd. Fibrin-binding compound and method
CA1335725C (en) * 1987-09-25 1995-05-30 Stephen W. Hadley Method of diagnosing blood clots using fibrin-binding proteins
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes
US5648471A (en) * 1987-12-03 1997-07-15 Centocor, Inc. One vial method for labeling antibodies with Technetium-99m
WO1989005150A1 (en) * 1987-12-10 1989-06-15 La Jolla Cancer Research Foundation Conformationally stabilized cell adhesion peptides
EP0401302B1 (en) * 1988-02-09 1995-06-28 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
AU3778989A (en) * 1988-04-29 1989-11-29 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
EP0413766A4 (en) * 1988-05-02 1991-11-21 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
US5302700A (en) * 1988-05-23 1994-04-12 Duke University Radiohalogenation conjugate technology
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5218128A (en) * 1988-06-15 1993-06-08 Centocor, Inc. Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
AU3876789A (en) * 1988-06-20 1990-01-12 Washington University Use of modified tpa to detect blood clots
DE68909598T2 (de) 1988-06-23 1994-04-14 Du Pont Katalysiertes hydrofluorierungsverfahren.
WO1990001169A1 (en) * 1988-07-26 1990-02-08 Szekely Levente Device for measuring and recording acceleration data
US4925648A (en) * 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
ATE172796T1 (de) 1988-08-03 1998-11-15 Univ California Sonde für hohe auflösung nmr mit wiederorientierung der muster
US5169933A (en) * 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
JPH04500805A (ja) * 1988-10-04 1992-02-13 カンサー・リサーチ・キャンペーン・テクノロジー・リミテッド 標的剤
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
DE69023394T2 (de) * 1989-06-16 1996-07-04 Merck Frosst Canada Inc Chelat-Derivate von atrialnatriurethischem Faktor (ANF).
GB8914020D0 (en) * 1989-06-19 1989-08-09 Antisoma Ltd Synthetic peptides for use in thrombus detection
ES2070329T3 (es) * 1989-07-20 1995-06-01 Sandoz Ltd Derivados de polipeptidos.
FR2650672A1 (fr) * 1989-08-02 1991-02-08 Medgenix Group Sa Procede de marquage de proteines ou polypeptides au technetium-99m, conjugue obtenu, utilisation a titre d'agent d'imagerie, kit de reconstitution desdits conjugues
US4961869A (en) * 1989-08-03 1990-10-09 E. I. Du Pont De Nemours And Company Ternary azeotropic compositions of 2,3-dichloro-1,1,1,3,3-pentafluoropropane with trans-1,2-dichloroethylene and methanol
US5443816A (en) 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
US5273743A (en) * 1990-03-09 1993-12-28 Hybritech Incorporated Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
GB9012995D0 (en) * 1990-06-11 1990-08-01 Celltech Ltd Multivalent antigen-binding proteins
AU8721591A (en) * 1990-09-14 1992-04-15 Mallinckrodt Medical, Inc. Novel nitrogen-sulfur ligands useful in radiographic imaging agents
US5561220A (en) * 1991-02-08 1996-10-01 Diatech, Inc. Technetium-99m labeled peptides for imaging inflammation
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US6019958A (en) * 1991-02-08 2000-02-01 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
US5645815A (en) * 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US6107459A (en) * 1991-02-08 2000-08-22 Diatide, Inc. Technetium-99m labeled peptides for diagnostic imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5830856A (en) * 1991-02-08 1998-11-03 Diatide, Inc. Radiolabeled compounds for thrombus imaging
US5552525A (en) * 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5300280A (en) * 1992-02-14 1994-04-05 Mallinckrodt Medical, Inc. Stabilized radiopharmaceutical kits
US5989519A (en) * 1992-03-13 1999-11-23 Diatide, Inc. Technetium-99m labeled peptides for imaging inflammation
CA2131816C (en) * 1992-03-13 2001-08-28 Richard T. Dean Technetium-99m labeled peptides for imaging inflammation
US5326856A (en) * 1992-04-09 1994-07-05 Cytogen Corporation Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
DK0641222T3 (da) * 1992-05-21 2000-12-11 Diatide Inc Peptider mærket med technetium-99m til trombeafbildning
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
DK0665853T3 (da) * 1992-10-02 2002-11-04 Diatide Inc Multimere polyvalente antitrombotiske midler
WO1994023758A1 (en) * 1993-04-08 1994-10-27 Diatech, Inc. Radiolabeled compounds for thrombus imaging
US5951964A (en) * 1993-06-04 1999-09-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide, Inc. Technetium-99m markierte bildformungsmittel

Also Published As

Publication number Publication date
WO1993025244A1 (en) 1993-12-23
ATE152918T1 (de) 1997-05-15
US6113878A (en) 2000-09-05
AU688264B2 (en) 1998-03-12
AU4528793A (en) 1994-01-04
JPH07506592A (ja) 1995-07-20
HK1007685A1 (en) 1999-04-23
US5976494A (en) 1999-11-02
EP0644778B1 (en) 1997-05-14
DE69310733T2 (de) 1997-10-30
DE69310733D1 (de) 1997-06-19
US5508020A (en) 1996-04-16
ES2105292T3 (es) 1997-10-16
EP0644778A1 (en) 1995-03-29
US6667389B1 (en) 2003-12-23
CA2137009A1 (en) 1993-12-23
CA2137009C (en) 2001-11-27
JP2954354B2 (ja) 1999-09-27

Similar Documents

Publication Publication Date Title
DK0644778T3 (da) Technetium-99-mærkede peptider til imagografi
DK0762901T3 (da) Technetium-99m-mærkede peptider til imagografi
DE69329382D1 (de) Technetium-99m markierte peptide zur bilderzeugung von thrombus
ATE237365T1 (de) Technetium-99-markierte peptide zur visualisierung vom entzuendungen
CA2111863A1 (en) Technetium-99m labeled peptides for imaging
ATE325625T1 (de) Technetium-99m markierte peptide zur diagnostischen bilderzeugung von entzündungen
ATE340594T1 (de) Somatostatin bindende peptide-metallchelat konjugate
DK0649434T3 (da) Radioaktivt mærkede somatostatin-afledte peptider til billeddannende og terapeutiske anvendelser
MX9707426A (es) Peptidos marcados radioactivamente para diagnostico y terapia.
DK0570493T3 (da) Technetium-99m-mærkede polypeptider til billeddannelse.
DK0693941T3 (da) Radiomærkede forbindelser til trombe-billeddannelse
ES2194908T3 (es) Agentes de produccion de imagenes marcados con tecnecio-99m.
ATE246009T1 (de) Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis