ES2164667T3 - Peptidos derivados de somatostatina marcados radiologicamente para representar en imagenes y usos terapeuticos. - Google Patents

Peptidos derivados de somatostatina marcados radiologicamente para representar en imagenes y usos terapeuticos.

Info

Publication number
ES2164667T3
ES2164667T3 ES93918129T ES93918129T ES2164667T3 ES 2164667 T3 ES2164667 T3 ES 2164667T3 ES 93918129 T ES93918129 T ES 93918129T ES 93918129 T ES93918129 T ES 93918129T ES 2164667 T3 ES2164667 T3 ES 2164667T3
Authority
ES
Spain
Prior art keywords
peptides
somatostatin
images
represent
peptides derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93918129T
Other languages
English (en)
Inventor
Richard T Dean
John Lister-James
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diatide Inc
Original Assignee
Diatide Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Diatide Inc filed Critical Diatide Inc
Application granted granted Critical
Publication of ES2164667T3 publication Critical patent/ES2164667T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SE REFIERE A REACTIVOS TERAPEUTICOS Y PEPTIDOS, REACTIVOS DE RADIODIAGNOSTICOS Y PEPTIDOS, Y METODOS PARA LA OBTENCION DE AGENTES DE RADIODIAGNOSTICOS RADIOACTIVADOS. ESPECIFICAMENTE, LA INVENCION SE REFIERE A DERIVADOS DE PEPTIDOS Y ANALOGOS DE SOMATOSTATINA, Y VERSIONES DE TALES PEPTIDOS RADIOACTIVADOS CON TECNECIO-99M (TC-99M), ASI COMO METODOS Y EQUIPOS PARA PODER RADIOACTIVAR Y EMPLEAR TALES PEPTIDOS EN EMPLAZAMIENTOS DE IMAGENES EN UN CUERPO DE MAMIFERO. LA INVENCION TAMBIEN SE REFIERE A DERIVADOS DE PEPTIDOS Y ANALOGOS DE SOMATOSTANTINA RADIOACTIVADO, CON RONIO-186 (186RE), Y METODOS Y EQUIPOS PARA PODER, RADIOACTIVAR Y EMPLEAR TALES PEPTIDOS TERAPEUTICAMENTE EN UN CUERPO DE MAMIFERO.
ES93918129T 1992-06-23 1993-06-23 Peptidos derivados de somatostatina marcados radiologicamente para representar en imagenes y usos terapeuticos. Expired - Lifetime ES2164667T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,935 US5716596A (en) 1992-06-23 1992-06-23 Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses

Publications (1)

Publication Number Publication Date
ES2164667T3 true ES2164667T3 (es) 2002-03-01

Family

ID=25416650

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93918129T Expired - Lifetime ES2164667T3 (es) 1992-06-23 1993-06-23 Peptidos derivados de somatostatina marcados radiologicamente para representar en imagenes y usos terapeuticos.

Country Status (10)

Country Link
US (5) US5716596A (es)
EP (2) EP0649434B1 (es)
JP (1) JPH08503924A (es)
AT (1) ATE203754T1 (es)
AU (1) AU690071B2 (es)
CA (1) CA2138647C (es)
DE (1) DE69330521T2 (es)
DK (1) DK0649434T3 (es)
ES (1) ES2164667T3 (es)
WO (1) WO1994000489A2 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5645815A (en) 1991-02-08 1997-07-08 Diatide, Inc. Radiolabled compounds for thrombus imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5849261A (en) * 1991-02-08 1998-12-15 Diatide, Inc. Radiolabeled vasoactive intestinal peptides for diagnosis and therapy
US5736122A (en) * 1991-02-08 1998-04-07 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US5997844A (en) * 1991-02-08 1999-12-07 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
DK0570493T3 (da) * 1991-02-08 2000-06-26 Diatide Inc Technetium-99m-mærkede polypeptider til billeddannelse.
US6183722B1 (en) * 1991-11-27 2001-02-06 Diatide, Inc. Somatostatin analogs
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5968476A (en) * 1992-05-21 1999-10-19 Diatide, Inc. Technetium-99m labeled peptides for thrombus imaging
US6017512A (en) * 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5620675A (en) 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
DE69434832D1 (de) * 1993-06-23 2006-10-05 Diatide Inc Radioaktiv-markierte Peptidderivate des Somatostatins zur bildformenden und therapeutischen Verwendung
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
ATE196609T1 (de) * 1993-07-28 2000-10-15 Diatide Inc Radiomarkierte glukane
DK96493D0 (da) * 1993-08-26 1993-08-26 Mouritsen Og Elsner Aps Fremgangsmaade til at inducere antistofresponser mod selvproteiner og autovaccine fremstillet ved fremgangsmaaden
DE69529988T2 (de) * 1994-05-02 2003-12-11 Diatide, Inc. Technetium-99m markierte bildformungsmittel
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US5556939A (en) * 1994-10-13 1996-09-17 Merck Frosst Canada, Inc. TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
MY147327A (en) 1995-06-29 2012-11-30 Novartis Ag Somatostatin peptides
DE19536783A1 (de) * 1995-09-21 1997-03-27 Diagnostikforschung Inst Bifunktionelle Nicotinamid-Chelatbildner vom Typ N¶2¶S¶2¶ für radioaktive Isotope
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
CA2264007A1 (en) * 1996-08-23 1998-02-26 Patel, Cell & Receptor Technologies Inc. Agonist-dependent internalization of human somatostatin receptors types 1-5
WO1999055385A2 (de) * 1998-04-28 1999-11-04 Wolfgang Bergter Radioimmunpharmaka zur therapie der hepatitis c
US6652836B2 (en) 1998-10-15 2003-11-25 Fluoroprobe, Inc. Method for viewing tumor tissue located within a body cavity
US6870914B1 (en) * 1999-01-29 2005-03-22 Sbc Properties, L.P. Distributed text-to-speech synthesis between a telephone network and a telephone subscriber unit
MY133346A (en) * 1999-03-01 2007-11-30 Biogen Inc Kit for radiolabeling ligands with yttrium-90
US20020102208A1 (en) 1999-03-01 2002-08-01 Paul Chinn Radiolabeling kit and binding assay
US6254852B1 (en) 1999-07-16 2001-07-03 Dupont Pharmaceuticals Company Porous inorganic targeted ultrasound contrast agents
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
US7067111B1 (en) * 1999-10-25 2006-06-27 Board Of Regents, University Of Texas System Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
GB0018891D0 (en) 2000-08-01 2000-09-20 Novartis Ag Organic compounds
CN1292798C (zh) 2000-06-02 2007-01-03 德克萨斯州立大学董事会 乙二半胱氨酸(ec)－药物缀合物
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
FR2845389B1 (fr) * 2002-10-04 2007-01-12 Solvay Procede pour la synthese de peptides comprenant au moins une molecule de glycine
WO2004081031A2 (en) * 2003-03-10 2004-09-23 Biogen Idec Inc. Thiol-mediated drug attachment to targeting peptides
AR044852A1 (es) 2003-06-24 2005-10-05 Novartis Ag Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina
WO2005018682A2 (en) 2003-08-20 2005-03-03 The Regents Of The University Of California Somatostatin analogs with inhibitory activity to growth hormone release
US9050378B2 (en) * 2003-12-10 2015-06-09 Board Of Regents, The University Of Texas System N2S2 chelate-targeting ligand conjugates
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
CA2625196C (fr) 2005-10-07 2016-04-05 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8758723B2 (en) 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
US10925977B2 (en) * 2006-10-05 2021-02-23 Ceil>Point, LLC Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
US20100215581A1 (en) * 2006-10-25 2010-08-26 Koninklijke Philips Electronics N.V. Contrast agents for detecting prostate cancer
EP2197340A4 (en) * 2007-09-19 2015-10-21 Oncofluor Inc METHOD FOR THE PRESENTATION AND TREATMENT OF ORGANS AND WOVEN FABRICS
FR2942227B1 (fr) 2009-02-13 2011-04-15 Guerbet Sa Utilisation de tampons pour la complexation de radionucleides
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
FR2980364B1 (fr) 2011-09-26 2018-08-31 Guerbet Nanoemulsions et leur utilisation comme agents de contraste
US20140147381A1 (en) * 2012-11-29 2014-05-29 Gregory David Espenan 89zr compounds, to include somatostatin, apparatus and products comprising such compounds, methods of making same, and methods of using same for radio imaging and/or treatment
FR3001154B1 (fr) 2013-01-23 2015-06-26 Guerbet Sa Magneto-emulsion vectorisee
WO2014149069A1 (en) 2013-03-15 2014-09-25 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
CA2988591A1 (en) * 2015-06-30 2017-01-05 Tarveda Therapeutics, Inc. Targeted conjugates and particles and formulations thereof
WO2020007822A1 (en) 2018-07-02 2020-01-09 Conservatoire National Des Arts Et Metiers (Cnam) Bismuth metallic (0) nanoparticles, process of manufacturing and uses thereof

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH379524A (de) 1959-05-05 1964-07-15 Inventa Ag Verfahren zur Herstellung von Methionin
NL7607987A (nl) * 1975-08-08 1977-02-10 Merck & Co Inc Werkwijze voor het bereiden van peptiden.
CA1083143A (en) * 1976-01-02 1980-08-05 Nedumparambil A. Abraham Carba derivatives of somatostatin and process therefor
US4244947A (en) * 1979-08-13 1981-01-13 Ayerst Mckenna And Harrison Inc. Carba decapeptide derivatives of [TYR6 ]-somatostatin
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4444690A (en) * 1982-02-25 1984-04-24 University Patents, Inc. Technetium chelates
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
DE3379657D1 (en) * 1982-12-06 1989-05-24 Merck & Co Inc Dicyclic hexapeptides, processes for their preparation and pharmaceutical compositions containing them
US4485101A (en) * 1983-10-11 1984-11-27 Administrators Of The Tulane Educational Fund Peptides
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
HUT42101A (en) * 1985-01-07 1987-06-29 Sandoz Ag Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4611054A (en) * 1985-04-29 1986-09-09 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4612366A (en) * 1985-06-17 1986-09-16 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
JPH02504387A (ja) * 1987-04-02 1990-12-13 セントカー・カーデイオバスキユラー・イメージング・パートナーズ・エルピー 金属イオンで抗体を標識付けする方法
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
US5395946A (en) * 1988-02-09 1995-03-07 Goedemans; Wilhelmus T. Bifunctional chelating agents
AU3778989A (en) * 1988-04-29 1989-11-29 Mallinckrodt, Inc. Diaminedithiol chelating agents for radiopharmaceuticals
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
GB9111199D0 (en) * 1991-05-23 1991-07-17 Sandoz Ltd Improvements in or relating to organic compounds
MY106120A (en) * 1988-12-05 1995-03-31 Novartis Ag Peptide derivatives.
US5066716A (en) * 1988-12-13 1991-11-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Synthesis of chloroacetyl and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides
US5196510A (en) * 1988-12-29 1993-03-23 Cytogen Corporation Molecular recognition units
CA2012115C (en) * 1989-03-15 2001-07-03 Biomeasure, Inc. Iodinated somatostatins
US5095111A (en) * 1989-03-17 1992-03-10 The John Hopkins University Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
JP2882679B2 (ja) * 1989-04-26 1999-04-12 ジ・アドミニストレーターズ・オブ・ザ・ツーレイン・エデュケイショナル・ファンド 線状ソマトスタチン類似体
ES2070329T3 (es) * 1989-07-20 1995-06-01 Sandoz Ltd Derivados de polipeptidos.
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5460785A (en) * 1989-08-09 1995-10-24 Rhomed Incorporated Direct labeling of antibodies and other protein with metal ions
HUT59166A (en) * 1989-12-08 1992-04-28 Univ Tulane Process for producing octqpeptide somatostatine analogues with treonine at the 6 position and pharmaceutical compositions containing them
IL97459A0 (en) * 1990-03-09 1992-06-21 Hybritech Inc Trifunctional antibody-like compounds as a combined diagnostic and therapeutic agent
DK0450480T3 (da) * 1990-04-06 1995-08-14 Univ Tulane Somatostatinaloger
US5382654A (en) * 1992-02-05 1995-01-17 Mallinckrodt Medical, Inc. Radiolabelled peptide compounds
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
DE69229436T2 (de) * 1991-02-08 1999-11-25 Biomeasure, Inc. Verwendung von somatostatinanalogen zur behandlung von melanomen
US5409894A (en) * 1991-03-14 1995-04-25 Sandoz Ltd. Method of preventing balloon catheterization blood vessel damage
CA2102633A1 (en) * 1991-06-03 1992-12-04 Peter H. Cox Radiolabelled somatostatin derivatives, their preparation and use
DE69225597T2 (de) * 1991-08-09 1998-11-26 Kolbeck, Winfried, 81247 Muenchen Peptide mit einer lanthionin-brücke
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
DE69434832D1 (de) * 1993-06-23 2006-10-05 Diatide Inc Radioaktiv-markierte Peptidderivate des Somatostatins zur bildformenden und therapeutischen Verwendung
US5443806A (en) * 1994-03-22 1995-08-22 A. Ahlstrom Corporation Treating exhaust gas from a pressurized fluidized bed reaction system

Also Published As

Publication number Publication date
ATE203754T1 (de) 2001-08-15
WO1994000489A3 (en) 1994-03-31
EP1094074A2 (en) 2001-04-25
DE69330521T2 (de) 2002-05-16
US5814298A (en) 1998-09-29
JPH08503924A (ja) 1996-04-30
DK0649434T3 (da) 2001-11-12
EP1094074A3 (en) 2002-01-09
EP0649434A1 (en) 1995-04-26
US5820845A (en) 1998-10-13
US5833942A (en) 1998-11-10
AU4768893A (en) 1994-01-24
EP0649434B1 (en) 2001-08-01
CA2138647C (en) 2002-11-12
WO1994000489A2 (en) 1994-01-06
CA2138647A1 (en) 1994-01-06
AU690071B2 (en) 1998-04-23
US5843401A (en) 1998-12-01
US5716596A (en) 1998-02-10
DE69330521D1 (de) 2001-09-06

Similar Documents

Publication Publication Date Title
ES2164667T3 (es) Peptidos derivados de somatostatina marcados radiologicamente para representar en imagenes y usos terapeuticos.
ES2172513T3 (es) Peptidos marcados con tecnecio-99m para reproducir en imagenes.
ES2158897T3 (es) Peptidos radiomarcados derivados de somatostatina y utilizados en procedimientos de formacion de imagenes y terapeuticos.
CA2167678A1 (en) Radioactive peptides
CA2216851A1 (en) Radiolabeled peptides for diagnosis and therapy
CA2111863A1 (en) Technetium-99m labeled peptides for imaging
ATE237365T1 (de) Technetium-99-markierte peptide zur visualisierung vom entzuendungen
DE69329382D1 (de) Technetium-99m markierte peptide zur bilderzeugung von thrombus
DK0644778T3 (da) Technetium-99-mærkede peptider til imagografi
CA2195395A1 (en) Cyclic hexapeptide somatostatin analogues
BR9810907A (pt) Anticorpos monoclonais e policlonais, peptìdeo suscetìvel de gerar um anticorpo, agente imunogênico, sequência de nucleotìdeos, composição farmacêutica, uso de pelo menos um anticorpo, kit de diagnóstico, e, processo para preparar um agente imunogênico
CA2347670A1 (en) Radiolabeled somatostatin-derived peptides for imaging
ZA832293B (en) Chromophoric peptides,a process for their preparation,agents containing them and their use for determining dd-carboxypeptidases

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 649434

Country of ref document: ES