ES2061871T3 - Un procedimiento para la preparacion de una antraciclinona 4-sustituida. - Google Patents

Un procedimiento para la preparacion de una antraciclinona 4-sustituida.

Info

Publication number
ES2061871T3
ES2061871T3 ES89118648T ES89118648T ES2061871T3 ES 2061871 T3 ES2061871 T3 ES 2061871T3 ES 89118648 T ES89118648 T ES 89118648T ES 89118648 T ES89118648 T ES 89118648T ES 2061871 T3 ES2061871 T3 ES 2061871T3
Authority
ES
Spain
Prior art keywords
group
substituted
preparation
chem
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89118648T
Other languages
English (en)
Inventor
Walter Cabri
Bernardinis Silvia De
Franco Francalanci
Sergio Penco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Application granted granted Critical
Publication of ES2061871T3 publication Critical patent/ES2061871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE PRESENTAN NUEVAS ANTRACICLINONAS 4 - SUSTITUIDAS DE LA FORMULA (I) DONDE R REPRESENTA UN ALKIL RECTO O RAMIFICADO, UN GRUPO ALKENIL O ALKINIL DE MAS DE 16 ATOMOS DE CARBONO OPCIONALMENTE SUSTITUIDO POR (A) UN GRUPO ARIL QUE ESTE SUSTITUIDO O INSUSTITUIDO POR UN GRUPO INERTE TAL COMO UN GRUPO ALKIL, ALCOXIDO O NITRO. (B) UN GRUPO ALCOXIDO; (C) UN GRUPO TRIALKILSILIL; (D) UN GRUPO ESTER O (E) UN GRUPO AMIDO. ESTOS COMPUESTOS SON INTERMEDIOS EN LA PREPARACION DE GLICOXIDOS DE ANTRACICLINA ANTITUMORALES DE FORMULA (IX), EN DONDE R ES COMO SE HA DEFINIDO ANTERIORMENTE Y R'' ES UN ATOMO DE HIDROGENO O UN GRUPO HIDROXIDO Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS.
ES89118648T 1988-10-25 1989-10-06 Un procedimiento para la preparacion de una antraciclinona 4-sustituida. Expired - Lifetime ES2061871T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888824947A GB8824947D0 (en) 1988-10-25 1988-10-25 New 4-substituted anthracyclinones & process for preparing them

Publications (1)

Publication Number Publication Date
ES2061871T3 true ES2061871T3 (es) 1994-12-16

Family

ID=10645743

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89118648T Expired - Lifetime ES2061871T3 (es) 1988-10-25 1989-10-06 Un procedimiento para la preparacion de una antraciclinona 4-sustituida.

Country Status (18)

Country Link
US (1) US5587495A (es)
EP (1) EP0366973B1 (es)
JP (1) JPH04501414A (es)
KR (1) KR900701812A (es)
AT (1) ATE99318T1 (es)
AU (1) AU624444B2 (es)
DE (1) DE68911855T2 (es)
DK (1) DK168597B1 (es)
ES (1) ES2061871T3 (es)
FI (1) FI93364C (es)
GB (1) GB8824947D0 (es)
HU (1) HU207733B (es)
IE (1) IE64161B1 (es)
IL (1) IL92052A (es)
NZ (1) NZ231052A (es)
PT (1) PT92080B (es)
WO (1) WO1990004601A1 (es)
ZA (1) ZA898052B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8803301D0 (en) * 1988-02-12 1988-03-09 Erba Carlo Spa Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin
GB8808475D0 (en) * 1988-04-11 1988-05-11 Erba Carlo Spa Process for preparing 4-demethoxydauno-mycinone
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
US7053191B2 (en) 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
CN100379749C (zh) * 2003-05-21 2008-04-09 獀洛克斯股份有限公司 4-r-取代的4-去甲氧基柔红霉素的制备方法
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1500421A (en) * 1975-01-22 1978-02-08 Farmaceutici Italia Optically active anthracyclinones
US4116981A (en) * 1977-05-02 1978-09-26 Yuh-Geng Tsay 5,12-epoxy-naphthacene-6,11-dione derivatives
AU567978B2 (en) * 1983-10-19 1987-12-10 Anti-Cancer Council Of Victoria Carminomycinone precursors and analogues and derivatives thereof.
IT1177014B (it) * 1983-10-19 1987-08-26 Univ Melbourne Composti organici che comprendono antracicline e antraciclinoni

Also Published As

Publication number Publication date
DE68911855D1 (de) 1994-02-10
IL92052A0 (en) 1990-07-12
FI93364B (fi) 1994-12-15
JPH04501414A (ja) 1992-03-12
ZA898052B (en) 1990-08-29
PT92080A (pt) 1990-04-30
GB8824947D0 (en) 1988-11-30
NZ231052A (en) 1991-04-26
FI93364C (fi) 1995-03-27
AU624444B2 (en) 1992-06-11
PT92080B (pt) 1995-06-30
IE893407L (en) 1990-04-25
HU207733B (en) 1993-05-28
KR900701812A (ko) 1990-12-04
HU896397D0 (en) 1991-07-29
IE64161B1 (en) 1995-07-12
EP0366973B1 (en) 1993-12-29
ATE99318T1 (de) 1994-01-15
DK168597B1 (da) 1994-05-02
US5587495A (en) 1996-12-24
WO1990004601A1 (en) 1990-05-03
IL92052A (en) 1994-06-24
EP0366973A1 (en) 1990-05-09
DK75291A (da) 1991-06-20
FI911952A0 (fi) 1991-04-22
HUT57228A (en) 1991-11-28
DE68911855T2 (de) 1994-04-21
AU4496289A (en) 1990-05-14
DK75291D0 (da) 1991-04-24

Similar Documents

Publication Publication Date Title
PT83843B (pt) Processo para a preparacao de promedicamentos de rapamicina
ES2186672T3 (es) Procedimiento para la produccion de derivados 13-eter de milbemicinas, e intermedios de los mismos.
RO93855A (ro) Procedeu pentru prepararea de arilciclobutilalchilamina
DK0488513T3 (da) Anvendelse af dioxabicyclo(3.3.0)octanderivater til fremstilling af et medikament til inhibering af cholesterolmetabolismen
ES2061871T3 (es) Un procedimiento para la preparacion de una antraciclinona 4-sustituida.
KR900016098A (ko) 카페인산의 유도체 및 이를 함유하는 약제학적 조성물
UA27108A1 (uk) Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя
FI91762C (fi) 4-substituoidut antrasyklinonit ja -antrasykliiniglykosidit ja niiden valmistaminen
PL306849A1 (en) Compounds belonging to the d-vitamins group and method of obtaining them
ES2096572T3 (es) Nuevos derivados de glucosidos de antraciclina y procedimiento para su preparacion.
PT90291A (pt) Processo para a preparacao de compostos afins das avermectinas uteis como agentes antiparasiticos
ES2026548T3 (es) Un procedimiento para preparar penemos.
LU88449I2 (fr) Fleroxacine et ses dérivés pharmaceutiquement acceptables.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 366973

Country of ref document: ES